LOCUS       NM_001108959            2607 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus transglutaminase 3 (Tgm3), mRNA.
ACCESSION   NM_001108959 XM_001079010 XM_345432
VERSION     NM_001108959.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2607)
  AUTHORS   U Basmanav,F.B., Cau,L., Tafazzoli,A., Mechin,M.C., Wolf,S.,
            Romano,M.T., Valentin,F., Wiegmann,H., Huchenq,A., Kandil,R.,
            Garcia Bartels,N., Kilic,A., George,S., Ralser,D.J., Bergner,S.,
            Ferguson,D.J.P., Oprisoreanu,A.M., Wehner,M., Thiele,H.,
            Altmuller,J., Nurnberg,P., Swan,D., Houniet,D., Buchner,A.,
            Weibel,L., Wagner,N., Grimalt,R., Bygum,A., Serre,G.,
            Blume-Peytavi,U., Sprecher,E., Schoch,S., Oji,V., Hamm,H.,
            Farrant,P., Simon,M. and Betz,R.C.
  TITLE     Mutations in Three Genes Encoding Proteins Involved in Hair Shaft
            Formation Cause Uncombable Hair Syndrome
  JOURNAL   Am J Hum Genet 99 (6), 1292-1304 (2016)
   PUBMED   27866708
REFERENCE   2  (bases 1 to 2607)
  AUTHORS   Henry,J., Hsu,C.Y., Haftek,M., Nachat,R., de Koning,H.D.,
            Gardinal-Galera,I., Hitomi,K., Balica,S., Jean-Decoster,C.,
            Schmitt,A.M., Paul,C., Serre,G. and Simon,M.
  TITLE     Hornerin is a component of the epidermal cornified cell envelopes
  JOURNAL   FASEB J 25 (5), 1567-1576 (2011)
   PUBMED   21282207
REFERENCE   3  (bases 1 to 2607)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 2607)
  AUTHORS   Hitomi,K., Presland,R.B., Nakayama,T., Fleckman,P., Dale,B.A. and
            Maki,M.
  TITLE     Analysis of epidermal-type transglutaminase (transglutaminase 3) in
            human stratified epithelia and cultured keratinocytes using
            monoclonal antibodies
  JOURNAL   J Dermatol Sci 32 (2), 95-103 (2003)
   PUBMED   12850301
REFERENCE   5  (bases 1 to 2607)
  AUTHORS   Ahvazi,B., Boeshans,K.M., Idler,W., Baxa,U. and Steinert,P.M.
  TITLE     Roles of calcium ions in the activation and activity of the
            transglutaminase 3 enzyme
  JOURNAL   J Biol Chem 278 (26), 23834-23841 (2003)
   PUBMED   12679341
REFERENCE   6  (bases 1 to 2607)
  AUTHORS   Kim,I.G., Gorman,J.J., Park,S.C., Chung,S.I. and Steinert,P.M.
  TITLE     The deduced sequence of the novel protransglutaminase E (TGase3) of
            human and mouse
  JOURNAL   J Biol Chem 268 (17), 12682-12690 (1993)
   PUBMED   8099584
REFERENCE   7  (bases 1 to 2607)
  AUTHORS   Rice,R.H. and Green,H.
  TITLE     Relation of protein synthesis and transglutaminase activity to
            formation of the cross-linked envelope during terminal
            differentiation of the cultured human epidermal keratinocyte
  JOURNAL   J Cell Biol 76 (3), 705-711 (1978)
   PUBMED   24643
REFERENCE   8  (bases 1 to 2607)
  AUTHORS   Steck,T.L.
  TITLE     Cross-linking the major proteins of the isolated erythrocyte
            membrane
  JOURNAL   J Mol Biol 66 (2), 295-305 (1972)
   PUBMED   5038456
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_345432.3, XM_001079010.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132271, SAMD00132280
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2607
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..2607
                     /gene="Tgm3"
                     /gene_synonym="RGD1561831; TG(E); TGE"
                     /note="transglutaminase 3"
                     /db_xref="GeneID:366189"
                     /db_xref="RGD:1561831"
     exon            1..61
                     /gene="Tgm3"
                     /gene_synonym="RGD1561831; TG(E); TGE"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..2136
                     /gene="Tgm3"
                     /gene_synonym="RGD1561831; TG(E); TGE"
                     /EC_number="2.3.2.13"
                     /note="TGase E; TGase-3; transglutaminase E;
                     transglutaminase 3, E polypeptide; glutamine
                     gamma-glutamyltransferase E"
                     /codon_start=1
                     /product="protein-glutamine gamma-glutamyltransferase E"
                     /protein_id="NP_001102429.1"
                     /db_xref="GeneID:366189"
                     /db_xref="RGD:1561831"
                     /translation="MSALEVQNINWQMPMNRRAHHTDKFSSQDFIVRRGQPWEVILLC
                     NRSLESGDNLNFIVSTGPQPSESARTKAVFSISGRNTSGWSAALKASNGNNLFIAIAS
                     PVSAPIGLYTLNVEVSSKGRVSSVKLGTFTVLFNPWQQGDDVFMSNHAERQEYVEEDS
                     GIIYVGSTNRIGMVGWNFGQFEEDILSISLSILDRSLNFRRDPATDVARRNDPKYVCR
                     VLSAMINANDDSGVLSGNWSGNYSGGVDPRTWNGSVEILKNWKKSGFRPVQFGQCWVF
                     AGTLNTVLRCLGVPSRVITNFNSAHDTDRNLSVDVYYDAMGNPLEKGSDSVWNFHVWN
                     EGWFVRTDLGPSYNGWQVLDATPQERSQGVFQCGPASVNAIKDGEVDQNFDMIFIFAE
                     VNADRITWIYNNRDGSQKQNSVDTYSIGKYISTKAVGSNSRMDVTIKYKHPEGSKEER
                     QVQQKAMNKLKPNASFGATSSRGPQGEEKEPSISGKFKVTGVLAVGKEVSLALILKNT
                     TSDRKTVTTNMTAWTIVYNGTLVHEVWKDSATISLDPEEEIQYPVKIAYSQYDRYLKA
                     DNMIRITAVCKVPDEAEVVVERDVILDNPTLTLEVLDQAQLRKPVVVQMLFSNPLDEP
                     VKNCVLMVEGSGLLRGSLKIDVPALRPKEKSRVRFEIFPTRIGIKQLLADFSCNKFPA
                     IKAMLVIEVSE"
     exon            62..235
                     /gene="Tgm3"
                     /gene_synonym="RGD1561831; TG(E); TGE"
                     /inference="alignment:Splign:2.1.0"
     exon            236..475
                     /gene="Tgm3"
                     /gene_synonym="RGD1561831; TG(E); TGE"
                     /inference="alignment:Splign:2.1.0"
     exon            476..594
                     /gene="Tgm3"
                     /gene_synonym="RGD1561831; TG(E); TGE"
                     /inference="alignment:Splign:2.1.0"
     exon            595..723
                     /gene="Tgm3"
                     /gene_synonym="RGD1561831; TG(E); TGE"
                     /inference="alignment:Splign:2.1.0"
     exon            724..901
                     /gene="Tgm3"
                     /gene_synonym="RGD1561831; TG(E); TGE"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1037
                     /gene="Tgm3"
                     /gene_synonym="RGD1561831; TG(E); TGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1141
                     /gene="Tgm3"
                     /gene_synonym="RGD1561831; TG(E); TGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1387
                     /gene="Tgm3"
                     /gene_synonym="RGD1561831; TG(E); TGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1696
                     /gene="Tgm3"
                     /gene_synonym="RGD1561831; TG(E); TGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1854
                     /gene="Tgm3"
                     /gene_synonym="RGD1561831; TG(E); TGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1988
                     /gene="Tgm3"
                     /gene_synonym="RGD1561831; TG(E); TGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2607
                     /gene="Tgm3"
                     /gene_synonym="RGD1561831; TG(E); TGE"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatcatctc tgtcattccc agaggagccc caggaaaggc agaagaagcc gaacatgagt
       61 gctttagagg tccaaaacat caactggcag atgccaatga atcgaagggc acatcacaca
      121 gacaagttct ccagccaaga tttcattgta cggagaggac agccctggga ggtaatactg
      181 ctctgcaacc gaagtcttga gtctggagac aatctgaact tcatcgtttc cacaggtccc
      241 cagccctctg agtcagccag gacaaaggct gtattttcca tctctgggag aaatacaagt
      301 ggctggagtg cagcgctcaa agccagcaat ggcaataatc tgttcattgc tattgccagt
      361 cctgtcagcg ctcccatcgg attgtacaca ctgaatgttg aggtctcctc caagggcagg
      421 gtctcctctg tgaaacttgg cacattcaca gtgctcttca acccatggca acaaggggat
      481 gatgtcttta tgagtaacca tgctgaaaga caagagtatg ttgaggaaga ttctggcatc
      541 atctacgtgg gcagcacaaa tcgaattggc atggttggct ggaactttgg acagtttgaa
      601 gaagatattc tgagcatcag cctctccatt ttggatagaa gtctgaattt ccgtcgtgac
      661 ccggcgactg atgtggcccg cagaaatgat cccaaatatg tttgccgggt gctgagtgcc
      721 atgattaatg ccaatgacga cagcggcgtt ctttctggga attggagcgg taactacagc
      781 ggtggtgtag acccaagaac ctggaacggt agtgtggaga tcctcaagaa ctggaaaaaa
      841 tctggcttca gaccagtcca atttggccag tgctgggtct ttgctgggac cctcaacaca
      901 gtgctgcggt gcttgggggt tccctctcgg gtgatcacca acttcaactc agctcacgac
      961 acagatcgca acctcagtgt ggatgtgtac tatgacgcca tgggaaatcc cttggagaaa
     1021 ggcagtgata gcgtgtggaa ttttcatgtc tggaatgaag gatggttcgt gcggactgac
     1081 ctaggtccct catacaacgg atggcaggtg ctggatgcca cccctcagga gagaagtcaa
     1141 ggtgtgttcc agtgtggtcc tgcttccgtt aatgcaatca aagatggtga ggtggaccag
     1201 aacttcgaca tgatcttcat cttcgcggag gttaacgctg atcgcatcac ttggatctac
     1261 aataataggg atggcagcca gaagcagaat tctgtggata cttactccat tggcaaatac
     1321 atcagcacca aggcagtagg cagcaactct cgcatggatg tcacgatcaa gtacaagcac
     1381 ccagaaggtt ccaaggagga aagacaagtg cagcaaaagg ctatgaacaa actcaaacct
     1441 aatgcatctt ttggcgcaac gtcttcgagg ggtccccagg gggaagaaaa ggagcccagc
     1501 atttctggga agttcaaggt cactggggta ctggcagtag gcaaagaagt cagtctggcc
     1561 ctgatactca aaaacacgac tagtgatagg aagacagtga caacaaatat gacagcctgg
     1621 accatcgtct acaatggtac ccttgtccac gaagtgtgga aggactctgc cacaatatcc
     1681 ttggatcctg aagaagaaat acagtatcca gtgaagattg catactctca gtatgataga
     1741 tacctaaagg cagacaacat gatccggatc acagccgtat gcaaggtgcc tgatgaggct
     1801 gaggtggtcg tggagcggga tgtcatcctg gacaacccca ctttgaccct ggaggtgctg
     1861 gaccaggctc agttacgaaa gccggtggtc gtgcagatgc ttttctccaa ccccctggat
     1921 gaaccagtga agaactgtgt gctgatggtg gaaggcagtg gcctgctgcg tggcagcctc
     1981 aaaatcgatg tgccggccct gcgccccaag gagaagtccc gggtccgatt tgagattttc
     2041 cccactcgga ttggcatcaa gcaactgctg gccgactttt cctgcaataa attccctgca
     2101 atcaaggcca tgctggtcat tgaggtgtcc gagtgaccgg cctagcggca ctcccacaga
     2161 gctgggtaac acagaccaga cagtgctctc ctgtggagtg aaactgttac ctatgctgtc
     2221 cagcctgaga agtcctccat gtccccaagg ctgccagaca tggacttcca gcaagccccc
     2281 atacccaacc cccctcactt caagctaggc caggttgcct ctggtctggg acttgatcag
     2341 ttttgcacat ttcctgattg ccttcctgtt ctgtgaaccc ttgaccctgt cgatccctta
     2401 tacccggcac tgctgcgaac agaacagcac cgaacagcac cagagctcaa cacattggga
     2461 agaagccagc ctggaccgct tgctgatccc agcctgcaat tcggataccc tgttcctccc
     2521 tcagcctcca cggaaggcgg ggagtattat ataccacacc actcacatcc ttacagtcgt
     2581 aataaatgcc aaacaagtgc aatcctc
//
