LOCUS       NM_019386               3509 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus transglutaminase 2 (Tgm2), mRNA.
ACCESSION   NM_019386
VERSION     NM_019386.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3509)
  AUTHORS   Da Silva Lodge,M., Pullen,N., Pereira,M. and Johnson,T.S.
  TITLE     Urinary levels of pro-fibrotic transglutaminase 2 (TG2) may help
            predict progression of chronic kidney disease
  JOURNAL   PLoS One 17 (1), e0262104 (2022)
   PUBMED   35041708
  REMARK    GeneRIF: Urinary levels of pro-fibrotic transglutaminase 2 (TG2)
            may help predict progression of chronic kidney disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3509)
  AUTHORS   Orr,A.N., Thompson,J.M., Lyttle,J.M. and Watts,S.W.
  TITLE     Transglutaminases Are Active in Perivascular Adipose Tissue
  JOURNAL   Int J Mol Sci 22 (5), 2649 (2021)
   PUBMED   33808023
  REMARK    GeneRIF: Transglutaminases Are Active in Perivascular Adipose
            Tissue.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3509)
  AUTHORS   Shi,W., Que,Y., Lv,D., Bi,S., Xu,Z., Wang,D. and Zhang,Z.
  TITLE     Overexpression of TG2 enhances the differentiation of
            ectomesenchymal stem cells into neuron-like cells and promotes
            functional recovery in adult rats following spinal cord injury
  JOURNAL   Mol Med Rep 20 (3), 2763-2773 (2019)
   PUBMED   31322240
  REMARK    GeneRIF: Immunofluorescence staining and western blot analyses
            demonstrated that Tgm2 overexpression had beneficial effects on the
            rate of Ectomesenchymal stem cells (EMSCs) neurogenesis, and that
            the proliferative capacity of Tgm2 EMSCs was higher than that of
            controls.
REFERENCE   4  (bases 1 to 3509)
  AUTHORS   Li,Z.Y., Xiao,L., Lin,G., Tang,J., Chen,Y., Chen,L., Li,B., Wu,M.,
            Liu,S., Huang,C., Ferrandon,D. and Li,Z.
  TITLE     Contribution of tissue transglutaminase to the severity of hepatic
            fibrosis resulting from Schistosoma japonicum infection through the
            regulation of IL-33/ST2 expression
  JOURNAL   Parasit Vectors 12 (1), 302 (2019)
   PUBMED   31200771
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3509)
  AUTHORS   Serrano,R.L., Yu,W., Graham,R.M., Bryan,R.L. and Terkeltaub,R.
  TITLE     A vascular smooth muscle cell X-box binding protein 1 and
            transglutaminase 2 regulatory circuit limits neointimal hyperplasia
  JOURNAL   PLoS One 14 (4), e0212235 (2019)
   PUBMED   30943188
  REMARK    GeneRIF: Cultured Xbp1-deficient vascular smooth muscle cells
            (VSMCs) demonstrated decreased levels of TG2 protein, in
            association with increased TG2 polyubiquitination. Moreover,
            IRE1alpha, and TG2-specific transamidation cross-links were
            increased in carotid artery neointima in Xbp1fl/fl SM22alpha-CRE+
            mice. Cultured TG2-deficient VSMCs had decreased Xbp1 associated
            with increased IRE1alpha, and increased migration in respons...
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3509)
  AUTHORS   Citron,B.A., SantaCruz,K.S., Davies,P.J. and Festoff,B.W.
  TITLE     Intron-exon swapping of transglutaminase mRNA and neuronal Tau
            aggregation in Alzheimer's disease
  JOURNAL   J Biol Chem 276 (5), 3295-3301 (2001)
   PUBMED   11013236
REFERENCE   7  (bases 1 to 3509)
  AUTHORS   Ou,H., Haendeler,J., Aebly,M.R., Kelly,L.A., Cholewa,B.C.,
            Koike,G., Kwitek-Black,A., Jacob,H.J., Berk,B.C. and Miano,J.M.
  TITLE     Retinoic acid-induced tissue transglutaminase and apoptosis in
            vascular smooth muscle cells
  JOURNAL   Circ Res 87 (10), 881-887 (2000)
   PUBMED   11073883
REFERENCE   8  (bases 1 to 3509)
  AUTHORS   Nakaoka,H., Perez,D.M., Baek,K.J., Das,T., Husain,A., Misono,K.,
            Im,M.J. and Graham,R.M.
  TITLE     Gh: a GTP-binding protein with transglutaminase activity and
            receptor signaling function
  JOURNAL   Science 264 (5165), 1593-1596 (1994)
   PUBMED   7911253
REFERENCE   9  (bases 1 to 3509)
  AUTHORS   Phillips,M.A., Qin,Q., Mehrpouyan,M. and Rice,R.H.
  TITLE     Keratinocyte transglutaminase membrane anchorage: analysis of
            site-directed mutants
  JOURNAL   Biochemistry 32 (41), 11057-11063 (1993)
   PUBMED   8105889
REFERENCE   10 (bases 1 to 3509)
  AUTHORS   Thacher,S.M. and Rice,R.H.
  TITLE     Keratinocyte-specific transglutaminase of cultured human epidermal
            cells: relation to cross-linked envelope formation and terminal
            differentiation
  JOURNAL   Cell 40 (3), 685-695 (1985)
   PUBMED   2578891
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_019386.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062062.1, SRR22582416.1518996.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                JAXUCZ010000003.1  167221780-167221845 c
            67-246              JAXUCZ010000003.1  167218626-167218805 c
            247-489             JAXUCZ010000003.1  167214221-167214463 c
            490-608             JAXUCZ010000003.1  167209616-167209734 c
            609-737             JAXUCZ010000003.1  167207814-167207942 c
            738-915             JAXUCZ010000003.1  167206774-167206951 c
            916-1051            JAXUCZ010000003.1  167204628-167204763 c
            1052-1155           JAXUCZ010000003.1  167203936-167204039 c
            1156-1398           JAXUCZ010000003.1  167202629-167202871 c
            1399-1668           JAXUCZ010000003.1  167200055-167200324 c
            1669-1829           JAXUCZ010000003.1  167196055-167196215 c
            1830-1966           JAXUCZ010000003.1  167194997-167195133 c
            1967-3509           JAXUCZ010000003.1  167192612-167194154 c
FEATURES             Location/Qualifiers
     source          1..3509
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..3509
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /note="transglutaminase 2"
                     /db_xref="GeneID:56083"
                     /db_xref="RGD:621081"
     exon            1..66
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..2117
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /EC_number="2.3.2.13"
                     /EC_number="3.5.1.44"
                     /note="tissue-type transglutaminase; transglutaminase 2, C
                     polypeptide; glutamine gamma-glutamyltransferase 2;
                     tTgase; TGase 2; TGase II; protein G(h); isopeptidase
                     TGM2; protein G alpha(h); transglutaminase II; tissue
                     transglutaminase; protein-glutamine deamidase TGM2;
                     protein-glutamine dopaminyltransferase TGM2;
                     protein-glutamine serotonyltransferase TGM2;
                     protein-glutamine histaminyltransferase TGM2;
                     protein-glutamine noradrenalinyltransferase TGM2"
                     /codon_start=1
                     /product="protein-glutamine gamma-glutamyltransferase 2"
                     /protein_id="NP_062259.3"
                     /db_xref="GeneID:56083"
                     /db_xref="RGD:621081"
                     /translation="MAEELNLERCDLEIQANGRDHHTADLCQQKLVLRRGQRFRLTLY
                     FEGRGYEASVDRLTFGAVTGPDPSEEAGTKARFSLSDDVEEGSWSASVLDQQDNVLSL
                     QLCTPANAPVGQYRLSLETSTGYQGSSFMLGHFILLFNAWCPADDVYLDSEAERREYV
                     LTQQGFIYQGSVKFIKSVPWNFGQFEDGILDACLMLLDVNPKFLKDRSRDCSRRSSPI
                     YVGRVVSGMVNCNDDQGVLLGRWDNNYGDGISPMAWIGSVDILRRWKEHGCQQVKYGQ
                     CWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEYGELESNKSEMIWNF
                     HCWVESWMTRPDLQPGYEGWQAIDPTPQEKSEGTYCCGPVSVRAIKEGDLSTKYDASF
                     VFAEVNADVVDWIRQSDGSVLKSINNSLVVGQKISTKSVGRDDREDITYTYKYPEGSP
                     EEREVFTRANHLNKLAEKEETGVAMRIRVGDGMSLGNDFDVFAHIGNDTSESRECRLL
                     LCARTVSYNGVLGPECGTEDINLTLDPYSENSIPLRILYEKYSGCLTESNLIKVRGLL
                     VEPAANSYLLAERDLYLENPEIKIRILGEPKQNRKLVAEVSLKNPLSDSLYDCVFTVE
                     GAGLTKEQKSVEVSDPVPAGDAVKVRVDLFPTDIGLHKLVVNFQCDKLKSVKGYRNII
                     IGPA"
     exon            67..246
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            247..489
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            490..608
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            609..737
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            738..915
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1051
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1155
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1398
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1668
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1829
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1966
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..3509
                     /gene="Tgm2"
                     /gene_synonym="TgaseII; TGII; tTG"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggtgatccg cgcccgagtg tcccgctgcg tccgagctgt cgccgctagc ttggccatgg
       61 ccgaggagct gaacctggag aggtgcgact tggagataca ggccaatggc cgtgatcacc
      121 acacggccga cctgtgccaa cagaaactgg tgctgcggcg aggccagcgc ttccggctga
      181 cactgtactt cgagggccgt ggctatgagg ccagcgtgga cagacttaca tttggtgccg
      241 tgaccggccc agatcccagt gaagaggcag ggaccaaggc ccgattctca ctgtctgacg
      301 atgtggagga gggatcctgg tcagcctctg tgctggacca acaggacaat gtcctctcgc
      361 tgcagctctg caccccagcc aatgctcctg ttggccagta ccgcctcagc ctggagactt
      421 ctactggcta ccaaggctcc agcttcatgc tgggtcactt catcctgctc ttcaatgcct
      481 ggtgcccagc ggatgacgtg tacctagatt cagaggcgga gcgccgggaa tacgtcctca
      541 cacagcaggg cttcatctac cagggctctg tcaagttcat caagagtgtg ccttggaact
      601 ttgggcagtt tgaggatggg atcctggatg cctgcctgat gctcttggat gtgaacccca
      661 agttcctgaa ggaccgtagc cgggactgct cacgacgcag cagtcccatc tatgtgggcc
      721 gcgtggtgag cggcatggtc aactgcaatg atgaccaggg tgtgcttctg ggtcgctggg
      781 acaacaatta tggggacggt atcagtccca tggcctggat cggcagcgtg gacattctgc
      841 ggcgctggaa ggaacacggc tgtcagcaag tgaagtatgg ccagtgctgg gtgtttgcgg
      901 cggtagcctg cacagtgctg cggtgccttg gcatccctac cagagtggtg accaactaca
      961 actccgccca cgaccagaac agcaacctgc tcatcgagta cttccgaaac gagtacgggg
     1021 agctggagag caacaagagc gagatgatct ggaatttcca ctgctgggtg gagtcctgga
     1081 tgaccaggcc agacctacag ccaggctatg aggggtggca ggccattgac cccacaccgc
     1141 aggagaagag cgaaggaaca tactgttgtg gcccagtctc agtgcgggcc atcaaggagg
     1201 gtgacctgag caccaagtat gatgcgtcct tcgtgtttgc cgaggtcaac gctgatgtgg
     1261 tggactggat ccggcagtca gatgggtctg tgctcaaatc catcaacaat tccctggtcg
     1321 tggggcagaa gatcagcact aagagcgtgg gccgtgatga ccgggaggac atcacctata
     1381 cctacaagta cccagagggg tccccagagg agagggaagt cttcaccaga gccaaccacc
     1441 tgaacaaact ggcagagaaa gaggagacag gggtggccat gcggatccga gtgggggatg
     1501 gtatgagctt gggcaatgac tttgacgtgt ttgcccacat cggcaacgac acctcggaga
     1561 gccgtgagtg ccgcctcctg ctctgtgccc gcactgtcag ctacaacggc gtgctggggc
     1621 ccgagtgtgg cactgaggac atcaacctga ccctggatcc ctactctgag aacagcatcc
     1681 cccttcgcat cctctacgag aagtacagcg gttgcctgac cgagtcaaac ctcatcaagg
     1741 tgcggggtct cctcgtcgag ccagctgcta acagctacct gctggctgag agagatctct
     1801 acctggagaa tcctgaaatc aagatccgga tcctggggga gcccaagcag aaccgcaaac
     1861 tggtggctga ggtgtccctg aagaacccac tttctgattc cctgtatgac tgtgtcttca
     1921 ctgtggaggg ggctggcctg accaaggaac agaagtctgt ggaggtctca gaccctgtgc
     1981 cagcaggaga tgcggtcaag gtgcgggttg acctgttccc gactgatatt ggcctccaca
     2041 agttggtggt gaacttccag tgtgacaagc tgaagtcggt caagggttac cggaatatca
     2101 tcatcggccc ggcctaaggg acccccttca cccagactca gcccatcacc tgccagccct
     2161 caactcaacc tggttttatc cccagataat gagcgacgac tgcaccccat tcgggctgac
     2221 atgactgcct cggggctttt cagaagacaa tgtacttctg gcccatcctg ttcctctgga
     2281 tctatttccc catctgtccc cttagctgtg aggaatgttc tgtgctgata cagccagtac
     2341 cctggcgaga gtaagaggag agccattatt accagcactc tgtatctgtg tattgtttga
     2401 actgtctcta gagcctcaga gtgagtgcaa acggatggtg agcccgttgg ctcaacgaag
     2461 gaactcagct gcctctccaa cagtttccca cccgcctccc ctctgaaggg gaactgtatg
     2521 tgctaggcac cttgagttct aacagggaca gcaacctgtt ggatgtccat gagaaacttc
     2581 agggtgggaa ctgaggctgc ccgtgctgta ctgtgtcagt aggacaggcc agccatcact
     2641 tgcagggcca gtgggtgagc ttagaaacac cacctgtgtc atctggcttg gaatttagca
     2701 ctctatctgt gacaccagct ttgacccgag ggtgtcagag aggccatctc ttccggcctt
     2761 ctccggaagg acacggttag ggtgaggagg tgagggagga gcggggaggc ttgagagctg
     2821 ggagtcagag cctgggttta agccccaagg agggctacac tctatcctcc tcttctgggc
     2881 ttgatcctcc tatatcagag cagagattga caagccctcc tccagggttt cctggtccca
     2941 tacttctaaa gccttccatc caaggctagg gcacttctgg ggtgtcctgc ttctcacctg
     3001 tgcctgggct cctcagatac agttccagga caacccacaa gctactcaca tagtgcctag
     3061 actagatttc acagaaggag ccttaaatgt ccatgctggt ccctacccac cagggccacc
     3121 cctccatgcc cctcctcctt ggtaagcaca cctagacaca gcatttgtct ctagaaaagc
     3181 acagaagcct atgggtcatc atccgagtta gcctactcct acccctctgt ggctgggccc
     3241 tcaagctgga aggctgcagt gtggaggggt ttctaggggg tgaggtcaga gactctggga
     3301 tcccctgaaa tcccagagaa gaacttggga agaatcacac tgctgcattt aacacgttcc
     3361 gctttatgca gagaatcgca ccgtgagtct tgtatctgcc ctgtccccac acggttccat
     3421 ttcttttgat ctgtgcaagc ttcaggcagt aggcatgctt tcgaagcaca tgtgaacacc
     3481 gaaataaagg tctatttttc acactcaaa
//
