LOCUS       NM_031132               2416 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus transforming growth factor, beta receptor 2
            (Tgfbr2), mRNA.
ACCESSION   NM_031132 XM_001077015
VERSION     NM_031132.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2416)
  AUTHORS   Shu,D.Y., Hutcheon,A.E.K., Zieske,J.D. and Guo,X.
  TITLE     Epidermal Growth Factor Stimulates Transforming Growth Factor-Beta
            Receptor Type II Expression In Corneal Epithelial Cells
  JOURNAL   Sci Rep 9 (1), 8079 (2019)
   PUBMED   31147562
  REMARK    GeneRIF: Epidermal Growth Factor Stimulates Transforming Growth
            Factor-Beta Receptor Type II Expression In Corneal Epithelial
            Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2416)
  AUTHORS   Fan,F., Qi,J., Liu,N., Wang,Z., Wang,W., Liu,H., Xu,X., Chen,G.,
            Wang,X., Yang,H., Johnson,M., Tu,Y., Liu,T. and Fu,J.
  TITLE     TGF-beta/TGF-beta RII/CLC-3 axis promotes cognitive disorders in
            diabetes
  JOURNAL   Front Biosci (Landmark Ed) 24 (3), 482-493 (2019)
   PUBMED   30468668
  REMARK    GeneRIF: Data suggest that the chloride channel-3 (CLC-3) might be
            modulated by transforming growth factor beta (TGF-beta) / TGF-beta
            Receptor II (TGF- beta RII) signaling pathway during the
            development of diabetic encephalopathy (DE).
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2416)
  AUTHORS   Farouk,S., Sabet,S., Abu Zahra,F.A. and El-Ghor,A.A.
  TITLE     Bone marrow derived-mesenchymal stem cells downregulate IL17A
            dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver
            fibrosis
  JOURNAL   PLoS One 13 (10), e0206130 (2018)
   PUBMED   30346985
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2416)
  AUTHORS   Yu,H., Xu,M., Dong,Y., Liu,J., Li,Y., Mao,W., Wang,J. and Wang,L.
  TITLE     1,25(OH)2D3 attenuates pulmonary arterial hypertension via
            microRNA-204 mediated Tgfbr2/Smad signaling
  JOURNAL   Exp Cell Res 362 (2), 311-323 (2018)
   PUBMED   29196166
  REMARK    GeneRIF: Findings outlined in the current study demonstrated that
            1,25(OH)2D3 was a promising therapeutic modality for treatment of
            Pulmonary arterial hypertension, function of which was exerted
            through miR-204 mediated Tgfbr2 signaling.
REFERENCE   5  (bases 1 to 2416)
  AUTHORS   Maletzki,C., Huehns,M., Bauer,I., Ripperger,T., Mork,M.M.,
            Vilar,E., Klocking,S., Zettl,H., Prall,F. and Linnebacher,M.
  TITLE     Frameshift mutational target gene analysis identifies similarities
            and differences in constitutional mismatch repair-deficiency and
            Lynch syndrome
  JOURNAL   Mol Carcinog 56 (7), 1753-1764 (2017)
   PUBMED   28218421
REFERENCE   6  (bases 1 to 2416)
  AUTHORS   Zhao,Y. and Young,S.L.
  TITLE     Expression of transforming growth factor-beta type II receptor in
            rat lung is regulated during development
  JOURNAL   Am J Physiol 269 (3 Pt 1), L419-L426 (1995)
   PUBMED   7573476
REFERENCE   7  (bases 1 to 2416)
  AUTHORS   Markowitz,S., Wang,J., Myeroff,L., Parsons,R., Sun,L.,
            Lutterbaugh,J., Fan,R.S., Zborowska,E., Kinzler,K.W., Vogelstein,B.
            et al.
  TITLE     Inactivation of the type II TGF-beta receptor in colon cancer cells
            with microsatellite instability
  JOURNAL   Science 268 (5215), 1336-1338 (1995)
   PUBMED   7761852
REFERENCE   8  (bases 1 to 2416)
  AUTHORS   Lin,H.Y., Moustakas,A., Knaus,P., Wells,R.G., Henis,Y.I. and
            Lodish,H.F.
  TITLE     The soluble exoplasmic domain of the type II transforming growth
            factor (TGF)-beta receptor. A heterogeneously glycosylated protein
            with high affinity and selectivity for TGF-beta ligands
  JOURNAL   J Biol Chem 270 (6), 2747-2754 (1995)
   PUBMED   7852346
REFERENCE   9  (bases 1 to 2416)
  AUTHORS   Wrana,J.L., Attisano,L., Carcamo,J., Zentella,A., Doody,J.,
            Laiho,M., Wang,X.F. and Massague,J.
  TITLE     TGF beta signals through a heteromeric protein kinase receptor
            complex
  JOURNAL   Cell 71 (6), 1003-1014 (1992)
   PUBMED   1333888
REFERENCE   10 (bases 1 to 2416)
  AUTHORS   Cheifetz,S., Bellon,T., Cales,C., Vera,S., Bernabeu,C., Massague,J.
            and Letarte,M.
  TITLE     Endoglin is a component of the transforming growth factor-beta
            receptor system in human endothelial cells
  JOURNAL   J Biol Chem 267 (27), 19027-19030 (1992)
   PUBMED   1326540
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 25, 2020 this sequence version replaced NM_031132.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S67770.1, L09653.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760476,
                                           SAMEA5760494 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-450               JAXUCZ010000008.1  124761020-124761469 c
            451-619             JAXUCZ010000008.1  124717606-124717774 c
            620-810             JAXUCZ010000008.1  124715637-124715827 c
            811-1610            JAXUCZ010000008.1  124694054-124694853 c
            1611-1752           JAXUCZ010000008.1  124690272-124690413 c
            1753-1880           JAXUCZ010000008.1  124677849-124677976 c
            1881-2416           JAXUCZ010000008.1  124674986-124675521 c
FEATURES             Location/Qualifiers
     source          1..2416
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2416
                     /gene="Tgfbr2"
                     /gene_synonym="TGF-beta 2; Tgfbr2T"
                     /note="transforming growth factor, beta receptor 2"
                     /db_xref="GeneID:81810"
                     /db_xref="RGD:69651"
     exon            1..450
                     /gene="Tgfbr2"
                     /gene_synonym="TGF-beta 2; Tgfbr2T"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..2060
                     /gene="Tgfbr2"
                     /gene_synonym="TGF-beta 2; Tgfbr2T"
                     /EC_number="2.7.11.30"
                     /note="TGF-beta receptor type-2; transforming growth
                     factor-beta type II receptor; transforming growth factor
                     beta receptor type II; TGFR-2; transforming growth factor,
                     beta receptor II; tbetaR-II; TGF-beta receptor type II;
                     TGF-beta type II receptor; transforming growth factor-b
                     type II receptor; transforming growth factor, beta
                     receptor IIT"
                     /codon_start=1
                     /product="TGF-beta receptor type-2 precursor"
                     /protein_id="NP_112394.4"
                     /db_xref="GeneID:81810"
                     /db_xref="RGD:69651"
                     /translation="MGRGLLRGLWPLHIVLWTRIASTIPPHVPKSVNSDLMAGDNSGA
                     VKLPQLCKFCDVTLSTCDNQKSCMSNCSVTSICEKPQEVCVAVWRKNDKNITLETVCH
                     DPKFTYHGFTLEDATSPTCVMKEKKRAGETFFMCSCNTEECNDYIIFNEEYTTSSPDL
                     LLVIIQVTGVSLLPPLGIAIAVIAIFYCYRVHRQQKLSPSWESSKPRKLMDFSDNCAI
                     ILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAV
                     KIFPYEEYSSWKTEKDIFSDINLKHENILQFLTAEERKTEMGKQYWLITAFHAKGNLQ
                     EYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLT
                     CCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENMESFKQTDVYSM
                     ALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQ
                     GIQIVCETLTECWDHDPEARLTAQCVAERFSELEHPDRLSGRSCSQEKIPEDGSLNTT
                     K"
     exon            451..619
                     /gene="Tgfbr2"
                     /gene_synonym="TGF-beta 2; Tgfbr2T"
                     /inference="alignment:Splign:2.1.0"
     exon            620..810
                     /gene="Tgfbr2"
                     /gene_synonym="TGF-beta 2; Tgfbr2T"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1610
                     /gene="Tgfbr2"
                     /gene_synonym="TGF-beta 2; Tgfbr2T"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1752
                     /gene="Tgfbr2"
                     /gene_synonym="TGF-beta 2; Tgfbr2T"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1880
                     /gene="Tgfbr2"
                     /gene_synonym="TGF-beta 2; Tgfbr2T"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2416
                     /gene="Tgfbr2"
                     /gene_synonym="TGF-beta 2; Tgfbr2T"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaggtcct gcccagctgt tggcgaggag tttcctgttt ccctcccggc gcccgggtaa
       61 agttgatgag tgagtcactc gcgcgcaccg accgacgaca ccccccgcgc gcgcacacgc
      121 tcgcctgggg gacggagccc cagcctcctg cgcagctctc ctcggccgcc gggggcctcc
      181 tccgggcctc cgagctccgg ggatcgccgg ccacatctgg cccgcacctc tgcccagcgc
      241 gctccgggcg gcgcaggcat cctgagaggg cgaggaataa aggcgcagcc cggggtcccc
      301 gaggctcggt tcgcggcgcc ccaggggccg gtctatgacg agcgacgggg gctgccatgg
      361 gtcgggggct gctccggggc ctgtggccgc tgcacatcgt cctgtggacg cgcatcgcca
      421 gcacgatccc gccgcacgtt cccaagtcgg ttaacagcga tctgatggcg ggtgacaaca
      481 gcggtgcggt caagcttcca cagctgtgca agttttgcga cgtgacactg tccacttgtg
      541 acaaccagaa gtcttgcatg agcaactgca gcgtcacctc catctgtgag aagccgcagg
      601 aagtctgcgt ggccgtgtgg aggaagaacg acaagaacat tactctggag accgtttgcc
      661 acgaccccaa gttcacctac cacggcttca ctctggaaga tgccacttct cccacgtgcg
      721 tcatgaagga aaagaaaagg gcaggcgaga ccttcttcat gtgctcctgt aacacagagg
      781 agtgtaacga ttacatcatc tttaatgaag aatacaccac cagcagtcct gacctgttgc
      841 tggtcattat ccaagtgacg ggcgtcagcc tcctgcctcc gctggggatt gccatagctg
      901 tcattgccat cttctactgt taccgtgtcc accggcagca gaagttgagc ccctcctggg
      961 agagcagcaa gccccggaag ctcatggatt tcagcgacaa ctgcgccatc atcctggagg
     1021 acgaccgctc tgacatcagc tctacgtgcg ccaacaacat caatcacaat acggaactgc
     1081 tgcccatcga gctggacacg ctggtgggga agggccgctt cgccgaggtc tacaaggcca
     1141 agctgaagca gaacacttca gagcagtttg agaccgtggc tgtcaagatc ttcccctacg
     1201 aggaatactc ctcgtggaaa acggagaagg acatcttctc tgacatcaac ctgaaacacg
     1261 agaacatcct gcagttcctg acggccgagg agcggaagac ggagatgggc aagcagtact
     1321 ggctgatcac ggcgtttcat gctaagggca acctgcagga gtacctcact aggcacgtca
     1381 tcagctggga ggacctgcgg aagctgggca gctccctggc ccggggcatc gcccatctgc
     1441 acagtgacca cactccttgt gggaggccca agatgcccat tgttcacagg gacctcaaga
     1501 gctctaacat cctagtgaag aacgatttga cctgttgcct gtgtgacttc gggctgtcct
     1561 tgcgcctgga ccctactctg tctgtggatg acctggccaa cagcgggcag gtgggaacag
     1621 cgagatacat ggccccggaa gttctagaat ccaggatgaa tttggagaac atggagtcct
     1681 tcaagcagac ggatgtctac tccatggctc tggtactctg ggaaatgacg tctcgctgca
     1741 acgctgtggg agaagtgaaa gattatgagc ccccatttgg ttccaaggtg cgggagcacc
     1801 cctgtgtgga gagcatgaaa gacaacgtgc tgagagaccg aggacggcct gaaatcccca
     1861 gcttctggct caaccaccag ggcatccaga tcgtgtgtga gacactgacc gagtgctggg
     1921 accacgaccc cgaggcccgt ctcacagccc agtgtgtggc agagcgcttc agtgaactgg
     1981 agcacccaga tagactctcc gggaggagct gctcccagga gaagattcca gaagacggct
     2041 ccctgaacac taccaaatag ctttttctgg gcaggctggg ccaagactcc ggaagccgtc
     2101 ctctaaccaa agaccagagg cagcaggatt gctttcctga ctgatgcttc tggaaaacca
     2161 aggacttgct cccttcttcc ctagtagctg ctccatgttc agaagcagca gtggcagcgg
     2221 tggcagcagc aaccatagca gaagcggtgg gggaacgagt gacagaaggc atcctatgcc
     2281 ttgggtgttg tcctggcata agctgtgcta gcacctcctc aggaaatgag attgattttt
     2341 tttacaacag ccaataacgt ttgcacttta ttaatgcctg tgtgtaaata cgaatagcta
     2401 tgttttatat atatct
//
