LOCUS       NM_012775               5724 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus transforming growth factor, beta receptor 1
            (Tgfbr1), mRNA.
ACCESSION   NM_012775 XM_003749940 XM_003754027 XM_006225297
VERSION     NM_012775.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5724)
  AUTHORS   Zhao,Q., Yang,W., Li,X., Yuan,H., Guo,J., Wang,Y. and Shan,Z.
  TITLE     MicroRNA-499-5p inhibits transforming growth factor-beta1-induced
            Smad2 signaling pathway and suppresses fibroblast proliferation and
            collagen synthesis in rat by targeting TGFbeta-R1
  JOURNAL   Mol Biol Rep 50 (12), 9757-9767 (2023)
   PUBMED   37676431
  REMARK    GeneRIF: MicroRNA-499-5p inhibits transforming growth
            factor-beta1-induced Smad2 signaling pathway and suppresses
            fibroblast proliferation and collagen synthesis in rat by targeting
            TGFbeta-R1.
REFERENCE   2  (bases 1 to 5724)
  AUTHORS   Wang,Z., Jiang,P., Liu,F., Du,X., Ma,L., Ye,S., Cao,H., Sun,P.,
            Su,N., Lin,F., Zhang,R. and Li,C.
  TITLE     GDF11 Regulates PC12 Neural Stem Cells via ALK5-Dependent PI3K-Akt
            Signaling Pathway
  JOURNAL   Int J Mol Sci 23 (20), 12279 (2022)
   PUBMED   36293138
  REMARK    GeneRIF: GDF11 Regulates PC12 Neural Stem Cells via ALK5-Dependent
            PI3K-Akt Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5724)
  AUTHORS   Maher,J.M., Zhang,R., Palanisamy,G., Perkins,K., Liu,L.,
            Brassil,P., McNamara,A., Lo,A., Hughes,A.D., Kanodia,J., Kulyk,S.,
            Nikula,K.J., Dengler,H.S., Scandurra,A., Lua,I. and Harstad,E.
  TITLE     Lung-restricted ALK5 inhibition avoids systemic toxicities
            associated with TGFbeta pathway inhibition
  JOURNAL   Toxicol Appl Pharmacol 438, 115905 (2022)
   PUBMED   35122773
  REMARK    GeneRIF: Lung-restricted ALK5 inhibition avoids systemic toxicities
            associated with TGFbeta pathway inhibition.
REFERENCE   4  (bases 1 to 5724)
  AUTHORS   Zhao,K., Mao,Y., Ye,X., Ma,J., Sun,L., Li,P. and Li,Y.
  TITLE     MicroRNA-210-5p alleviates cardiac fibrosis via targeting
            transforming growth factor-beta type I receptor in rats on high
            sodium chloride (NaCl)-based diet
  JOURNAL   Eur J Pharmacol 912, 174587 (2021)
   PUBMED   34678242
  REMARK    GeneRIF: MicroRNA-210-5p alleviates cardiac fibrosis via targeting
            transforming growth factor-beta type I receptor in rats on high
            sodium chloride (NaCl)-based diet.
REFERENCE   5  (bases 1 to 5724)
  AUTHORS   Shi,X., Li,J., Min,B., Yang,R., He,C. and Yang,Y.
  TITLE     Application of ultrasound elastography for monitoring the effects
            of TbetaR1 shRNA therapy on hepatic fibrosis in a rat model
  JOURNAL   PLoS One 16 (6), e0253150 (2021)
   PUBMED   34181670
  REMARK    GeneRIF: Application of ultrasound elastography for monitoring the
            effects of TbetaR1 shRNA therapy on hepatic fibrosis in a rat
            model.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5724)
  AUTHORS   Eppert,K., Scherer,S.W., Ozcelik,H., Pirone,R., Hoodless,P.,
            Kim,H., Tsui,L.C., Bapat,B., Gallinger,S., Andrulis,I.L.,
            Thomsen,G.H., Wrana,J.L. and Attisano,L.
  TITLE     MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related
            protein that is functionally mutated in colorectal carcinoma
  JOURNAL   Cell 86 (4), 543-552 (1996)
   PUBMED   8752209
REFERENCE   7  (bases 1 to 5724)
  AUTHORS   Bassing,C.H., Yingling,J.M., Howe,D.J., Wang,T., He,W.W.,
            Gustafson,M.L., Shah,P., Donahoe,P.K. and Wang,X.F.
  TITLE     A transforming growth factor beta type I receptor that signals to
            activate gene expression
  JOURNAL   Science 263 (5143), 87-89 (1994)
   PUBMED   8272871
REFERENCE   8  (bases 1 to 5724)
  AUTHORS   He,W.W., Gustafson,M.L., Hirobe,S. and Donahoe,P.K.
  TITLE     Developmental expression of four novel serine/threonine kinase
            receptors homologous to the activin/transforming growth factor-beta
            type II receptor family
  JOURNAL   Dev Dyn 196 (2), 133-142 (1993)
   PUBMED   8395914
REFERENCE   9  (bases 1 to 5724)
  AUTHORS   Wrana,J.L., Attisano,L., Carcamo,J., Zentella,A., Doody,J.,
            Laiho,M., Wang,X.F. and Massague,J.
  TITLE     TGF beta signals through a heteromeric protein kinase receptor
            complex
  JOURNAL   Cell 71 (6), 1003-1014 (1992)
   PUBMED   1333888
REFERENCE   10 (bases 1 to 5724)
  AUTHORS   Cheifetz,S., Bellon,T., Cales,C., Vera,S., Bernabeu,C., Massague,J.
            and Letarte,M.
  TITLE     Endoglin is a component of the transforming growth factor-beta
            receptor system in human endothelial cells
  JOURNAL   J Biol Chem 267 (27), 19027-19030 (1992)
   PUBMED   1326540
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB804748.1, BC087035.1 and CK844086.1.
            
            [WARNING] On Apr 24, 2024 this sequence was replaced by
            NM_012775.3.
            
            On or before Dec 15, 2013 this sequence version replaced
            XM_006225297.1, XM_003749940.1, XM_003754027.1, NM_012775.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087035.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132274, SAMD00132282
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                CB804748.1         45-102
            59-5704             BC087035.1         1-5646
            5705-5724           CK844086.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..5724
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..5724
                     /gene="Tgfbr1"
                     /gene_synonym="Alk5; Skr4; tbetaR-I; Tgfr-1"
                     /note="transforming growth factor, beta receptor 1"
                     /db_xref="GeneID:29591"
                     /db_xref="RGD:3852"
     exon            1..167
                     /gene="Tgfbr1"
                     /gene_synonym="Alk5; Skr4; tbetaR-I; Tgfr-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1576
                     /gene="Tgfbr1"
                     /gene_synonym="Alk5; Skr4; tbetaR-I; Tgfr-1"
                     /EC_number="2.7.11.30"
                     /note="transforming growth factor, beta receptor I;
                     TGF-beta receptor type-1; TGF-beta receptor type I;
                     TGF-beta type I receptor; activin receptor-like kinase 5;
                     serine/threonine-protein kinase receptor R4; transforming
                     growth factor-beta receptor type I; TGF-beta receptor
                     type-1-like"
                     /codon_start=1
                     /product="TGF-beta receptor type-1 precursor"
                     /protein_id="NP_036907.2"
                     /db_xref="GeneID:29591"
                     /db_xref="RGD:3852"
                     /translation="MEAASAALRRCLLLIVLVAAATLLPGAKALQCFCHLCTKDNFTC
                     ETDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGAVTYCCNQDHCNK
                     IELPTTEKQSAGLGPVELAAVIAGPVCFVCIALMLMVYICHNRTVIHHRVPNEEDPSL
                     DRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKW
                     RGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDY
                     HEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNIL
                     VKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKR
                     ADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPN
                     RWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM"
     exon            168..407
                     /gene="Tgfbr1"
                     /gene_synonym="Alk5; Skr4; tbetaR-I; Tgfr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            408..638
                     /gene="Tgfbr1"
                     /gene_synonym="Alk5; Skr4; tbetaR-I; Tgfr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..869
                     /gene="Tgfbr1"
                     /gene_synonym="Alk5; Skr4; tbetaR-I; Tgfr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1037
                     /gene="Tgfbr1"
                     /gene_synonym="Alk5; Skr4; tbetaR-I; Tgfr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1194
                     /gene="Tgfbr1"
                     /gene_synonym="Alk5; Skr4; tbetaR-I; Tgfr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1319
                     /gene="Tgfbr1"
                     /gene_synonym="Alk5; Skr4; tbetaR-I; Tgfr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1450
                     /gene="Tgfbr1"
                     /gene_synonym="Alk5; Skr4; tbetaR-I; Tgfr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..5706
                     /gene="Tgfbr1"
                     /gene_synonym="Alk5; Skr4; tbetaR-I; Tgfr-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggggcga ggagaggcga ggcttgttga ggagaagctg aggccggggc cgggccgggc
       61 cacaaacagt ggcagcggga ccatggaggc ggcgtcggct gctttgcgtc gctgcctgct
      121 tctcatcgtg ttggtggcgg cggcgacgct gctcccgggg gcgaaggcat tacagtgttt
      181 ctgccacctc tgtacaaagg acaattttac ttgtgagaca gatggtctct gctttgtctc
      241 agtcaccgag accacagaca aagttataca caatagcatg tgtatagctg aaatcgacct
      301 aattccccga gacaggccat ttgtttgtgc accatcttca aaaacagggg cagttacgta
      361 ttgctgcaat caggatcact gcaataaaat agaactccca actacagaaa agcagtcagc
      421 tggcctcggt cctgtggagc tggcagctgt cattgctggt ccagtctgct tcgtctgcat
      481 tgcacttatg ctgatggtct atatctgcca taaccgcact gtcattcacc accgcgtacc
      541 aaatgaagag gatccctcac tagatcgccc tttcatttca gagggcacca ccttaaaaga
      601 tttaatttat gatatgacaa catcagggtc tggatcaggt ttaccactgc ttgttcaaag
      661 aacaattgca aggaccattg tgctacaaga aagcatcggc aaaggtcggt ttggagaagt
      721 ttggcgaggc aaatggcggg gagaagaagt tgccgtgaag atattctctt ctagagaaga
      781 acgttcatgg ttccgagagg cagagattta tcagactgta atgttacgcc atgaaaatat
      841 cctggggttt atagcagcag acaacaaaga caatggtaca tggactcagc tgtggttggt
      901 gtcggattat catgagcatg gatccctttt cgattacttg aatagataca ctgttactgt
      961 ggaaggaatg atcaaactcg ctctgtccac ggcaagtggt cttgcccatc ttcacatgga
     1021 gattgttggt acccaaggaa aaccagctat tgcccataga gatttgaaat caaagaatat
     1081 cttggtgaag aaaaatggaa cctgttgtat tgcagatttg ggacttgctg tgagacatga
     1141 ttctgccaca gatacaattg atattgctcc aaaccacaga gtaggcacta aaaggtatat
     1201 ggcccctgaa gttctagatg attccataaa tatgaaacat tttgaatcct tcaaacgtgc
     1261 tgacatctat gcaatgggct tagtattctg ggaaatcgct cgacgctgtt ccattggcgg
     1321 aatccacgaa gactaccagt tgccttacta tgatcttgta ccttctgatc catccgttga
     1381 agaaatgaga aaagtagttt gtgaacagaa gttaaggcca aatattccca acagatggca
     1441 gagctgtgag gccttgagag tgatggccaa aattatgaga gaatgttggt atgccaatgg
     1501 agcagctagg ctgacagctt tgcgaattaa aaaaacattg tcacagctca gccaacagga
     1561 aggcatcaaa atgtaactga aacttcgtgg gaactctgct ctcttcaaat ctgctcctgg
     1621 gtgttttgga ggccggttgt tctacctcac tgagagaacg gagggctctg ctcctctcgc
     1681 tacagtggaa tatggccaac tgaaagcttc ccagggtttc tctgggccca gaggcagcca
     1741 tggggatcct ttctgtgcac tatggatact tcttcccaga cagttacaga atgttgtgta
     1801 gtctacttct gtttttatta acaaagcttg tttttaaaga cgaccggcag cccttaggga
     1861 gctgctgtgc tgttgacggc ctgtagggtg aaggagctgg agcaaggagt tagaggaagc
     1921 acttctgatt cccactcttg gtacattctc agaggactcc gaaccactgg tgttcccttg
     1981 attcacttgg aatgtactgt tctatagttt ttcaagatct taaactaaca cttaaaactc
     2041 tatggtctaa aaaataggac ctcctgtagg tgtggggcac agtggtcagc tgtattgtgt
     2101 acagctcctg ctccttcatg ctctgaacac aacacgcctt cagaagggtg tgctacacca
     2161 gtaagtgcca cttctgcgtc tttctaaatg gaaacgaaca gagctgctta aagtctgtta
     2221 gtcctgtatc attttcattc agaaagttta tttttctgcg taacctaaac cttttctggg
     2281 tttgttttta tttttaagag tttttgtggt agatgtcatt cagtatttat gcctttctcc
     2341 tacccaaatg tgcttgaacc actgaggcaa tgctgtagca ttaataagca gtaactcttg
     2401 tgggaacatc cccacacaga gctcgtgagc tttgcagttg agatgtttag cctgagtgga
     2461 ttttaagaag tgaagtggca ccccagccat gtacagtgct tcacggattt aatcattgcg
     2521 gtatacagac tctttctgaa agaggagcta gtctatgctg aagaacagtt gtgtgctatt
     2581 ctgtaagcca tttctttttc tttatctgat caaagacagt gttttgtttt gtcttttctc
     2641 ttttggaaag gaattgcatt taaaattcaa atgtggttaa tgttaaataa taggcctttt
     2701 tctgggaagg cagagctagc taatttgaat atacaacaag tgtaggtgac tttcacatgc
     2761 tatatagctg taagtatttg tggattctat cttgggaagg gcagagttag gtggagtttt
     2821 gaggtctcac tacactttga ggagggcagc ttttaattca gtctttttat ctcatatgtg
     2881 cagatcttgc aacttgcttg atttacctgg tagcactgaa ttcagtggca ggcttgatac
     2941 taggagaagc ggcagctaat agctgttctg agtagaggct cttttatgta ttcttggtca
     3001 tatgaaatgt cagtcagccc attgggtctc ctcactggtg ctggagttag gtggttaagc
     3061 ctgggtttta cttcagtgct gtcaagtctc tacaggactt gtatggcttt taaagtcctt
     3121 tttatcactg tgatcatatt cttgggggga aatgttgtca ttgcttcaga caaaatgttg
     3181 gacatagtga tgttgattct cagataaaaa ggtcacaata gcctttagtg tttagccaag
     3241 aggagattat gactgttgat ttgaagcagc tgagcgctgt taacatctta tctcaaacct
     3301 agcataaatt gaagactatt tggtcttaaa ccaaagtaac tgtatagtga atgacatgtt
     3361 acctaggcat tcgtgtcagt ttcacacatt taaaagcatc atgggaaaaa gtacttagag
     3421 attagtattt ttaatgcaaa gctgagtttc tttctgcaat tctcatgatt tcatcagtgt
     3481 aagggtttgc tgttatggtt ctatcacctg cttaatacgc tcttgtgctg tcatcaggta
     3541 cttttgggga cttggtttgt tttctgtttt gttttgtttt gtttttttcc cacttctaac
     3601 cgttcgagat ctgctttata gaaatccagg gaccaatgca ttttatcact aaaactgttt
     3661 ttatataatt ttaagactat accaaaagtt gtctgagtta aagttgtaat atgtttctta
     3721 ctttattgca aggaaatggg attttgctga agacacttct catgacatct gaggttgaag
     3781 aatcattatg tttttcttac ctaagtggat gaaatgtgct ttgatgaatc agggaatttt
     3841 ttaaagttgg aatttagttc taaattgagt ttacatgttt acagctaatt ttttgtgtag
     3901 ggatagtttg ataatctcta tgtggccaat actaaatatg aaaataactt aaaaactgag
     3961 ataggtcatg gctaatgcag ctatgactgt agatagatct aattatagga atacttctgt
     4021 atcattttgt agtgcagtct gttgtttctg ttgccaatca gaaacatgca cacccccaag
     4081 atgtagtatg actaagacag ttctgacaac tacatatcat cacgtcagga cctggctgaa
     4141 ctagtgtgaa ggaaggatga cttacagagg cttagacaac ttgactccct tgtatcttca
     4201 gctctctttt tcccactctg cctttctgct gccccctggc ccagagactt attgtccctg
     4261 acccgcctcc agcctttgga cctaagagct acttttgaga cctaaaatga agtgattgat
     4321 ggaagctgtg tgacattttc cacttccttg agtcactggg tatcatgggg agtaatctgc
     4381 aaattggagt tggggatgct cctgctggta gccctgcttt gatgtcagct ctgggcaaag
     4441 attagggtga cagccaagtg gcagtggtag ttggcctcag aagcagtggc cagctgtgtc
     4501 cctagtagga cagcaaaggc acgatgagct gagcctgtaa tcctgctact acagtagtac
     4561 tcaaaaagtg ccttgaggcc ctgcctgggg ccatggccat cgagagttcc acactttggt
     4621 tctcactgca gacttaaacg gccatttggc catttttgta atccatacat gtttgactct
     4681 ttcctctgca aattgtcaga catgtaaaac caatggcaaa ctactactta ccatgcactc
     4741 cagggtctgc ccagaagaca ttgtgattca cccagtgccc tgagggaatg gttgtaaacc
     4801 tttgttcctc agtcgtggga gtattctggg agtattctgg ctcgtactgt ggagattcca
     4861 gatgcgctgt cacagcccgg cacacagtca gtgcggtgag agtctggaga gtagtctggg
     4921 aatgagtgca gcttcatgtg ttggatgttg aaactcttgt gggcctctcg agggaagctg
     4981 agggctgtca gcacattgtt ttcaatccta acaggactct tacttacaaa catttaaaaa
     5041 atattgtcat aacattcaat ctctttctta aagtgaattt gcttttattt tcaatgagat
     5101 ttgtgagttt aatattatga actgtgtttt aataatccct ttttcacatt gtgccaatgg
     5161 aatggaatat ttgatatttc tttatatgtc aaggagatgc ttcaatgtgt catttgcttt
     5221 aaacttaaat tacctctcaa gagaccaagg tacatttacc tcattgtgta tataatgtct
     5281 aatatttgtc agcatccgcc aggtttgcag ttttatttct ataaagtgtg agtattatgt
     5341 tgctaagtta ctcagatggt actgtactgt ttatatttgt acccaaaata acatcatcta
     5401 tacttggttt tctgtatttt attgtatttg tgcaaaagtc ttttaactct gttggtgtga
     5461 tctctgccct ttcagatatg tacaggtgtc catagaaatt ttcatttaag ttgagtggtt
     5521 ttgagaagcc tatgaagaga gaaaaaacat aaactgtgtt tccccatcag tttttaaatg
     5581 tacattgtat gtgtagtaat attccagatg aattgtaaat aaaaattagg gagatgctta
     5641 agtttcatcc taacactaca gtagaaaaca gaagcattgc aaataaatga cttttttccc
     5701 accagtaaaa aaaaaaaaaa aaaa
//
