LOCUS       NM_013174               2619 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus transforming growth factor, beta 3 (Tgfb3), mRNA.
ACCESSION   NM_013174
VERSION     NM_013174.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2619)
  AUTHORS   Zhu,T., Li,Y., Zhu,L., Xu,J., Feng,Z., Chen,H., Shi,S., Liu,C.,
            Ou,Q., Gao,F., Zhang,J., Jin,C., Xu,J., Li,J., Zhang,J., Bi,Y.,
            Xu,G.T., Wang,J., Tian,H. and Lu,L.
  TITLE     GMFB/AKT/TGF-beta3 in Muller cells mediated early retinal
            degeneration in a streptozotocin-induced rat diabetes model
  JOURNAL   Glia 72 (3), 504-528 (2024)
   PUBMED   37904673
  REMARK    GeneRIF: GMFB/AKT/TGF-beta3 in Muller cells mediated early retinal
            degeneration in a streptozotocin-induced rat diabetes model.
REFERENCE   2  (bases 1 to 2619)
  AUTHORS   Zhang,J., Zhou,K., Cheng,R., Yang,M., Shen,X., Luo,X. and Xu,L.
  TITLE     Maternal Perinatal Exposure to Dibutyl Phthalate Promotes Ovarian
            Dysfunction in Adult Female Offspring via Downregulation of
            TGF-beta2 and TGF-beta3
  JOURNAL   Reprod Sci 29 (8), 2401-2413 (2022)
   PUBMED   35028925
  REMARK    GeneRIF: Maternal Perinatal Exposure to Dibutyl Phthalate Promotes
            Ovarian Dysfunction in Adult Female Offspring via Downregulation of
            TGF-beta2 and TGF-beta3.
REFERENCE   3  (bases 1 to 2619)
  AUTHORS   Wu,L.M., Wang,J.K., Liu,J., Fan,C.C., Wang,Y.J. and Xiong,Y.
  TITLE     Gait analysis combined with the expression of TGF-beta1, TGF-beta3
            and CREB during Achilles tendon healing in rat
  JOURNAL   Chin J Traumatol 24 (6), 360-367 (2021)
   PUBMED   34696976
  REMARK    GeneRIF: Gait analysis combined with the expression of TGF-beta1,
            TGF-beta3 and CREB during Achilles tendon healing in rat.
REFERENCE   4  (bases 1 to 2619)
  AUTHORS   Jiang,K., Li,Y., Xiang,C., Xiong,Y. and Jia,J.
  TITLE     TGF-beta3 regulates adhesion formation through the JNK/c-Jun
            pathway during flexor tendon healing
  JOURNAL   BMC Musculoskelet Disord 22 (1), 843 (2021)
   PUBMED   34592976
  REMARK    GeneRIF: TGF-beta3 regulates adhesion formation through the
            JNK/c-Jun pathway during flexor tendon healing.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2619)
  AUTHORS   Zhang,J., Yin,J., Chen,X., Mao,X., Xu,J., Cheng,R. and Wu,J.
  TITLE     Down-regulation of miR-140-3p can alleviate neonatal repetitive
            pain in rats via inhibiting TGF-beta3
  JOURNAL   Biochem Biophys Res Commun 515 (4), 627-635 (2019)
   PUBMED   31176490
  REMARK    GeneRIF: down-regulation of miR-140-3p can inhibit painful tactile
            stimulation of rat pups by inhibiting TGF-beta
REFERENCE   6  (bases 1 to 2619)
  AUTHORS   Kaartinen,V., Voncken,J.W., Shuler,C., Warburton,D., Bu,D.,
            Heisterkamp,N. and Groffen,J.
  TITLE     Abnormal lung development and cleft palate in mice lacking TGF-beta
            3 indicates defects of epithelial-mesenchymal interaction
  JOURNAL   Nat Genet 11 (4), 415-421 (1995)
   PUBMED   7493022
REFERENCE   7  (bases 1 to 2619)
  AUTHORS   Proetzel,G., Pawlowski,S.A., Wiles,M.V., Yin,M., Boivin,G.P.,
            Howles,P.N., Ding,J., Ferguson,M.W. and Doetschman,T.
  TITLE     Transforming growth factor-beta 3 is required for secondary palate
            fusion
  JOURNAL   Nat Genet 11 (4), 409-414 (1995)
   PUBMED   7493021
REFERENCE   8  (bases 1 to 2619)
  AUTHORS   Begue-Kirn,C., Smith,A.J., Loriot,M., Kupferle,C., Ruch,J.V. and
            Lesot,H.
  TITLE     Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin,
            osteonectin and bone sialoprotein gene expression during normal and
            in vitro-induced odontoblast differentiation
  JOURNAL   Int J Dev Biol 38 (3), 405-420 (1994)
   PUBMED   7848824
REFERENCE   9  (bases 1 to 2619)
  AUTHORS   Wrana,J.L., Attisano,L., Carcamo,J., Zentella,A., Doody,J.,
            Laiho,M., Wang,X.F. and Massague,J.
  TITLE     TGF beta signals through a heteromeric protein kinase receptor
            complex
  JOURNAL   Cell 71 (6), 1003-1014 (1992)
   PUBMED   1333888
REFERENCE   10 (bases 1 to 2619)
  AUTHORS   Robinson,S.D., Silberstein,G.B., Roberts,A.B., Flanders,K.C. and
            Daniel,C.W.
  TITLE     Regulated expression and growth inhibitory effects of transforming
            growth factor-beta isoforms in mouse mammary gland development
  JOURNAL   Development 113 (3), 867-878 (1991)
   PUBMED   1821856
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Apr 1, 2010 this sequence version replaced NM_013174.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U03491.1, BC092195.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676784,
                                           SAMN16676787 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-750               JAXUCZ010000006.1  111456197-111456946 c
            751-914             JAXUCZ010000006.1  111446627-111446790 c
            915-1044            JAXUCZ010000006.1  111446242-111446371 c
            1045-1152           JAXUCZ010000006.1  111440744-111440851 c
            1153-1324           JAXUCZ010000006.1  111438910-111439081 c
            1325-1478           JAXUCZ010000006.1  111437274-111437427 c
            1479-2619           JAXUCZ010000006.1  111435170-111436310 c
FEATURES             Location/Qualifiers
     source          1..2619
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..2619
                     /gene="Tgfb3"
                     /gene_synonym="TGF-B3"
                     /note="transforming growth factor, beta 3"
                     /db_xref="GeneID:25717"
                     /db_xref="RGD:3851"
     exon            1..750
                     /gene="Tgfb3"
                     /gene_synonym="TGF-B3"
                     /inference="alignment:Splign:2.1.0"
     CDS             399..1637
                     /gene="Tgfb3"
                     /gene_synonym="TGF-B3"
                     /note="TGF-beta-3; transforming growth factor beta-3
                     proprotein"
                     /codon_start=1
                     /product="transforming growth factor beta-3 proprotein
                     preproprotein"
                     /protein_id="NP_037306.1"
                     /db_xref="GeneID:25717"
                     /db_xref="RGD:3851"
                     /translation="MKMHLQRALVVLALLNLATVSLSLSTCTTLDFGHIKKKRVEAIR
                     GQILSKLRLTSPPEPSVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQETSESEYYA
                     KEIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNGTNLFRAEFRVLRVPNPS
                     SKRTEQRIELFQILRPDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESN
                     LGLEISIHCPCHTFQPNGDILENVHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNP
                     HLILMMIPPHRLDSPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVH
                     EPKGYYANFCSGPCPYLRSSDTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYV
                     GRTPKVEQLSNMVVKSCKCS"
     exon            751..914
                     /gene="Tgfb3"
                     /gene_synonym="TGF-B3"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1044
                     /gene="Tgfb3"
                     /gene_synonym="TGF-B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1152
                     /gene="Tgfb3"
                     /gene_synonym="TGF-B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1324
                     /gene="Tgfb3"
                     /gene_synonym="TGF-B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1478
                     /gene="Tgfb3"
                     /gene_synonym="TGF-B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..2619
                     /gene="Tgfb3"
                     /gene_synonym="TGF-B3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccaagcggc gtttggcaat atcagatatc cgctctattt atttttacct aaggaaaaac
       61 tccagctctc ttcccactcc cagctgcctt gccacccctc ccaaccctcg gcttgccctc
      121 cacctggcct gctgggagtc agagcccggc agaacctgtt tagatatatg gacaagaatc
      181 ccagcgctac acagcacaca gtccgctact tcgtcccggg gttgccagcg cttcctggga
      241 gtcctgaagc tcacacagcg cagtgagttc atgcaccctc ttgccaagcc tcagtctttg
      301 ggatctgggg aggacgcctg gttttcctcc ccctttctac tggggtctcc tccttgccag
      361 gcctccccag tcccctggcc tcgttcctgg gttcacacat gaagatgcac ttacaaaggg
      421 ctctggtggt cctggccctg ctgaacttgg ccacagtcag cctctctctg tccacttgca
      481 ccaccttgga cttcggccac atcaagaaga agagggtgga agccattagg ggacagatct
      541 tgagcaagct caggctcacc agcccccctg agccgtcggt gatgacccac gtcccctatc
      601 aggtcctggc actttacaac agcacccggg agttgctgga agagatgcac ggggagaggg
      661 aagaaggctg cactcaggaa acctcggagt cagagtacta tgccaaagag atccataaat
      721 tcgacatgat ccaggggctg gcggagcaca atgaactggc agtctgcccc aagggaatta
      781 cctctaaggt tttccgtttc aatgtgtcct cagtggagaa aaatggaacc aatctgttcc
      841 gggcggagtt ccgggtcttg cgggtgccca accccagctc caagcgcaca gagcagagaa
      901 tcgagctctt ccagatactt cgacctgatg aacacatagc caagcagcgc tacataggtg
      961 gcaagaatct gcccacgaga ggcaccgcag agtggctgtc cttcgatgtc actgacactg
     1021 tgcgcgagtg gctgttgcgg agagagtcca acttgggtct ggaaatcagc atccactgtc
     1081 catgtcatac ctttcagccc aatggagaca tactggaaaa tgttcacgag gtgatggaaa
     1141 tcaaattcaa aggagtggac aacgaagatg accatggccg tggagacctg gggcgtctca
     1201 agaagcagaa ggatcaccac aacccgcacc tgatcctcat gatgattcct ccacaccgac
     1261 tggacagccc aggccagggc gggcagagga agaagagggc cctggacacc aattactgct
     1321 tccgcaactt ggaggagaac tgctgtgtgc gccccctcta cattgacttc cggcaggatc
     1381 taggctggaa atgggtccac gaacctaagg gttactatgc caacttctgc tcaggccctt
     1441 gcccttacct ccgcagctca gacacaaccc acagcacggt gcttggacta tacaacaccc
     1501 tgaacccgga ggcatcggcc tcgccatgct gtgtgcccca agacctggag cctctgacca
     1561 tcttgtacta tgttggcaga acccccaagg tggagcagct gtccaacatg gtggtgaagt
     1621 cgtgtaagtg cagctgaggc cagtctgcaa cagaggaggg gaaactgcca ccaccgactg
     1681 ctgctccttg gaaaaccaaa gcaacagacc tcaccctaga ggcctggagc ccacaagccc
     1741 tggctcccga tggcgaaagg ccgagaggga ggcttccttc tggaacattt ctttctgcta
     1801 gctctgagaa tcactgtggt aaagaaagtg tgggttggtt aggggaaggc aaactggtga
     1861 gaacatggat ttctgtggtg caggcagagg tggtggggta gagaagagat aatgagtgga
     1921 cgttgtgagt ggcaaggggc ctccggctac cctagggaag atgaagggca gagtggtcag
     1981 gtgaaggcca gactggaagg cacttcagat atgaggtcag ctttgctcat ggcagtacat
     2041 ctgctctagg gaatcgggat gttgttaaag gcaacagcat ttttcttcag tttaccaagc
     2101 caaagtcccc tggaattgta tcttgaactg cctggaatta aggacaatct gttcttttgc
     2161 aaacagtctt ttcacctcga tcagcatcat gagtcattac agataatgta attagtttct
     2221 gggccagcaa ctagctatct caggtccctc agagatgctg gactcaaagg cagaggtcag
     2281 aattggttct ctcatgtatt ccctcgggcc ccctccttct gccttccttc ttggccgtat
     2341 ttccccttgg acatttggct agacaccttc cgggtcaggg tgcattctct ggattctgga
     2401 tccacacagc ctggggcatc agacatcgtt tccctcctac cctagacccc gtgctccccg
     2461 ggtgttcctg gaagcaggtg ctacatgcag agtatccggg gagcctccca tgtctgacat
     2521 gatgactcgg ccccagatgc acagactgaa gtatacagac aaatacaaat attactctca
     2581 gaatctttgt ataaataaat atttttgggg aatcatgga
//
