LOCUS       NM_031131               2868 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Rattus norvegicus transforming growth factor, beta 2 (Tgfb2), mRNA.
ACCESSION   NM_031131
VERSION     NM_031131.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2868)
  AUTHORS   Geng,J., Zhang,X., Zhang,Y., Meng,X., Sun,J., Zhou,B. and Ma,J.
  TITLE     TGFbeta2 mediates oxidative stress-induced
            epithelial-to-mesenchymal transition of bladder smooth muscle
  JOURNAL   In Vitro Cell Dev Biol Anim 60 (7), 793-804 (2024)
   PUBMED   38409639
  REMARK    GeneRIF: TGFbeta2 mediates oxidative stress-induced
            epithelial-to-mesenchymal transition of bladder smooth muscle.
REFERENCE   2  (bases 1 to 2868)
  AUTHORS   Zhang,J., Zhou,K., Cheng,R., Yang,M., Shen,X., Luo,X. and Xu,L.
  TITLE     Maternal Perinatal Exposure to Dibutyl Phthalate Promotes Ovarian
            Dysfunction in Adult Female Offspring via Downregulation of
            TGF-beta2 and TGF-beta3
  JOURNAL   Reprod Sci 29 (8), 2401-2413 (2022)
   PUBMED   35028925
  REMARK    GeneRIF: Maternal Perinatal Exposure to Dibutyl Phthalate Promotes
            Ovarian Dysfunction in Adult Female Offspring via Downregulation of
            TGF-beta2 and TGF-beta3.
REFERENCE   3  (bases 1 to 2868)
  AUTHORS   Ibrahim,S., Johnson,M., Stephens,C.H., Xu,J., Moore,R., Mariani,A.,
            Contreras,C., Syed,F., Mirmira,R.G., Anderson,R.M. and Sims,E.K.
  TITLE     beta-Cell pre-mir-21 induces dysfunction and loss of cellular
            identity by targeting transforming growth factor beta 2 (Tgfb2) and
            Smad family member 2 (Smad2) mRNAs
  JOURNAL   Mol Metab 53, 101289 (2021)
   PUBMED   34246804
  REMARK    GeneRIF: beta-Cell pre-mir-21 induces dysfunction and loss of
            cellular identity by targeting transforming growth factor beta 2
            (Tgfb2) and Smad family member 2 (Smad2) mRNAs.
REFERENCE   4  (bases 1 to 2868)
  AUTHORS   Kudipudi,P.K., Galuska,S.P., Dietze,R., Scheiner-Bobis,G.,
            Loveland,K.L. and Konrad,L.
  TITLE     Betaglycan (TbetaRIII) is a Key Factor in TGF-beta2 Signaling in
            Prepubertal Rat Sertoli Cells
  JOURNAL   Int J Mol Sci 20 (24), 6214 (2019)
   PUBMED   31835434
  REMARK    GeneRIF: Betaglycan shedding serves a major role in TGF-beta2
            signaling in Sertoli cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2868)
  AUTHORS   Kerola,A., Lohi,J., Heikkila,P., Mutanen,A., Jalanko,H. and
            Pakarinen,M.P.
  TITLE     Divergent expression of liver transforming growth factor
            superfamily cytokines after successful portoenterostomy in biliary
            atresia
  JOURNAL   Surgery 165 (5), 905-911 (2019)
   PUBMED   30686515
REFERENCE   6  (bases 1 to 2868)
  AUTHORS   Lin,H.Y., Moustakas,A., Knaus,P., Wells,R.G., Henis,Y.I. and
            Lodish,H.F.
  TITLE     The soluble exoplasmic domain of the type II transforming growth
            factor (TGF)-beta receptor. A heterogeneously glycosylated protein
            with high affinity and selectivity for TGF-beta ligands
  JOURNAL   J Biol Chem 270 (6), 2747-2754 (1995)
   PUBMED   7852346
REFERENCE   7  (bases 1 to 2868)
  AUTHORS   Wang,J., Kuliszewski,M., Yee,W., Sedlackova,L., Xu,J., Tseu,I. and
            Post,M.
  TITLE     Cloning and expression of glucocorticoid-induced genes in fetal rat
            lung fibroblasts. Transforming growth factor-beta 3
  JOURNAL   J Biol Chem 270 (6), 2722-2728 (1995)
   PUBMED   7852342
REFERENCE   8  (bases 1 to 2868)
  AUTHORS   Lopez-Casillas,F., Payne,H.M., Andres,J.L. and Massague,J.
  TITLE     Betaglycan can act as a dual modulator of TGF-beta access to
            signaling receptors: mapping of ligand binding and GAG attachment
            sites
  JOURNAL   J Cell Biol 124 (4), 557-568 (1994)
   PUBMED   8106553
REFERENCE   9  (bases 1 to 2868)
  AUTHORS   Wrana,J.L., Attisano,L., Carcamo,J., Zentella,A., Doody,J.,
            Laiho,M., Wang,X.F. and Massague,J.
  TITLE     TGF beta signals through a heteromeric protein kinase receptor
            complex
  JOURNAL   Cell 71 (6), 1003-1014 (1992)
   PUBMED   1333888
REFERENCE   10 (bases 1 to 2868)
  AUTHORS   Bodmer,S., Podlisny,M.B., Selkoe,D.J., Heid,I. and Fontana,A.
  TITLE     Transforming growth factor-beta bound to soluble derivatives of the
            beta amyloid precursor protein of Alzheimer's disease
  JOURNAL   Biochem Biophys Res Commun 171 (2), 890-897 (1990)
   PUBMED   2119582
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            [WARNING] On Oct 11, 2024 this sequence was replaced by
            NM_031131.3.
            
            On Nov 26, 2020 this sequence version replaced NM_031131.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF153012.2, SRR26643295.47887.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-654               JAXUCZ010000013.1  100792032-100792685 c
            655-738             JAXUCZ010000013.1  100775585-100775668 c
            739-902             JAXUCZ010000013.1  100723122-100723285 c
            903-1035            JAXUCZ010000013.1  100701205-100701337 c
            1036-1146           JAXUCZ010000013.1  100700984-100701094 c
            1147-1324           JAXUCZ010000013.1  100699110-100699287 c
            1325-1478           JAXUCZ010000013.1  100697378-100697531 c
            1479-2868           JAXUCZ010000013.1  100692953-100694342 c
FEATURES             Location/Qualifiers
     source          1..2868
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..2868
                     /gene="Tgfb2"
                     /gene_synonym="TGF-B2"
                     /note="transforming growth factor, beta 2"
                     /db_xref="GeneID:81809"
                     /db_xref="RGD:70491"
     exon            1..654
                     /gene="Tgfb2"
                     /gene_synonym="TGF-B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..1637
                     /gene="Tgfb2"
                     /gene_synonym="TGF-B2"
                     /note="TGF-beta-2; TGF beta 2 protein; transforming growth
                     factor beta-2 proprotein"
                     /codon_start=1
                     /product="transforming growth factor beta-2 proprotein
                     precursor"
                     /protein_id="NP_112393.2"
                     /db_xref="GeneID:81809"
                     /db_xref="RGD:70491"
                     /translation="MHYCVLRTFLLLHLVPVALSLSTCSTLDMDQFMRKRIEAIRGQI
                     LSKLKLTSPPEDYPEPDEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKE
                     VYKIDMPSHFPSETVCPVVTTSSGSVGSFCSRQSQVLCGYLDAIPPTFYRPYFRIVRF
                     DVSTMEKNASNLVKAEFRVFRLQNPKARVAEQRIELYQILKSKDLTSPTQRYIDSKVV
                     KTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFIPSNNYIIPNKSQELEA
                     RFAGIDGTSTYASGDQKTIKSTRKKSSGKTPHLLLMLLPSYRLESQQSSRRRKRALDA
                     AYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHTKVL
                     SLYNTINPEASASPCCVSQDLEPLTILYYIGNTPKIEQLSNMIVKSCKCS"
     exon            655..738
                     /gene="Tgfb2"
                     /gene_synonym="TGF-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            739..902
                     /gene="Tgfb2"
                     /gene_synonym="TGF-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1035
                     /gene="Tgfb2"
                     /gene_synonym="TGF-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1146
                     /gene="Tgfb2"
                     /gene_synonym="TGF-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1324
                     /gene="Tgfb2"
                     /gene_synonym="TGF-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1478
                     /gene="Tgfb2"
                     /gene_synonym="TGF-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..2868
                     /gene="Tgfb2"
                     /gene_synonym="TGF-B2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagagccac tcaccctctc ccttccagga gaaaaaacaa acctttctta ctccttaaag
       61 tgagagatcc ccctcctgcc tccctagcat cgcatattaa tatctccacg ttgggaacgc
      121 gttgcatttt cttttttaaa ggaatcctag ccagggacgt ttttctattg ggcattgact
      181 ttcaactgct ttgcaaaagt ttcgtattaa aaacaactct acctgacccg ctctgagaat
      241 tactagtttc tttttatatt tttttcttac tttaaacaac aacaacaacg tttcctcctt
      301 ttaaaaacat gcactactgt gtgctgagaa cctttttgct cctgcatctg gtcccggtgg
      361 cgctcagtct gtctacctgc agcaccctcg acatggacca gtttatgcgc aagaggatcg
      421 aggccatccg cgggcagatc ctgagcaagc tgaagctcac cagccccccg gaagactatc
      481 cggagccgga tgaggtcccc ccggaggtga tttccatcta caacagtacc agggacttac
      541 tgcaggagaa ggcaagccgg agggcagccg cctgcgagcg cgagcgaagc gacgaggagt
      601 actacgccaa ggaggtttat aaaatcgaca tgccgtccca cttcccctcc gaaactgtct
      661 gcccagttgt tacaacatcc tctggctcag tgggcagctt ttgctccaga cagtcccagg
      721 tgctctgtgg gtaccttgat gccatcccgc ccactttcta cagaccctac ttcagaatcg
      781 tccgcttcga tgtctcaaca atggagaaga atgcttcaaa tctggtgaag gcagagttca
      841 gggtctttcg cttgcagaac cccaaggcca gagtggctga acaacggatt gaactgtatc
      901 agatccttaa atccaaagac ctaacatctc caacccagcg ctacattgat agcaaggttg
      961 tgaaaaccag agccgagggg gaatggctct ccttcgacgt gacagacgcc gtgcacgagt
     1021 ggcttcacca caaagacagg aacctgggat ttaaaataag tttacactgc ccctgctgta
     1081 ccttcatacc gtctaataat tacatcatcc caaataagag ccaagagctg gaggcgagat
     1141 tcgcaggtat cgatggcacc tccacatatg ccagtggtga tcagaaaact ataaagtcca
     1201 ctaggaaaaa aagcagtggg aagaccccgc atctcctgct aatgttgttg ccctcctaca
     1261 gactggagtc ccagcagtcc agccggcgac ggaagcgggc tttggatgcc gcctattgct
     1321 ttaggaatgt gcaggataat tgctgccttc gccctcttta cattgatttt aagagggatc
     1381 ttggatggaa atggatccat gaacccaaag gatacaatgc taacttctgt gctggggcat
     1441 gcccttatct gtggagttca gacacacaac acaccaaagt cctcagcctg tacaacacca
     1501 taaaccccga agcttctgct tccccttgct gtgtgtccca ggatctggaa ccactgacca
     1561 tcctctacta cattggcaat acgcccaaga tcgaacaact ttccaacatg atcgtcaagt
     1621 cttgtaaatg cagctaaagt cctcgggaaa gccaggatga aaatcacggt gacaatgacg
     1681 tatgacgaca atgacgatga taatgttcgt gacgtgaggg agttttgatt catcagtgtt
     1741 gaaaaaaaaa ttggaggaaa aaaaaatcgg tactagttca aacactttgc aagcttgtgt
     1801 tctgtttgtt aaaactggca tctgggatta cagcaacaac agccacaaaa atggaaggcg
     1861 ttagtctgca tctcacctac ttcctgagag acacaaaaag aaaacatctt ttttttttta
     1921 aaggaaaaaa taaacactgg aagaatttgt tagtgttaat tatgtgaaag aaaaaacaaa
     1981 acaaaacagg aaaatccgtt cagtggagtt gtatgtattg tttccacccc attcttcacc
     2041 ccacgcctct cttgtttcct ctgtattgct ctgcaatggg cgccctcccc atcccttcct
     2101 ctgagttaac agtgggttat ttattgtgtt actatataat gaacctttca ttgcccttgg
     2161 aaaataaaac aggtgtataa gtggagacca aatactttgc cacaaactca tggatggctt
     2221 aaggaatttg gactcaaata agccaggggg aaggaggtca tactggatga ccccctgtga
     2281 gccgttatag aactgagcaa gtctgagaaa aaaaatcaaa gccccagaaa acatgtgctg
     2341 tgcactgcct gccgaagctt catgagcagc catctgtcca gaaggcctgt taacaagaaa
     2401 acttggaatc agtgggaatc tggaagattg gttttttttc cttctaattg taaatggttc
     2461 tttgccagtt taagcaagcc ggtgaaatgg tgacctgctt ggatgtgtat tgtcagactt
     2521 ttgaccgtga agtggctgtt gatctacaat acaggttttt ttttcccttt gtcttggtat
     2581 acgtaattac atggatatta ttaaaataga cgggtctaga agccagcatg atgaaaacac
     2641 actgcaaatc tgttttacaa actattaaat cgaaacagta actactttac atgtaatgtg
     2701 tagatcttac cacattttta aatattctgt aataatgatt atgatttaga ttgaacttaa
     2761 atttgaactc tctctctttt tttaatgatc attcagactg tatgtttgcc tcctttagct
     2821 ggccagtacc tttgaataaa acccctagat tttgacttgc actacaaa
//
