LOCUS       NM_001191840            1972 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus transforming growth factor beta 1 induced
            transcript 1 (Tgfb1i1), mRNA.
ACCESSION   NM_001191840 XM_341934
VERSION     NM_001191840.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1972)
  AUTHORS   Miyauchi,A., Noguchi,M., Lei,X.F., Sakaki,M., Kobayashi-Tanabe,M.,
            Haraguchi,S., Miyazaki,A. and Kim-Kaneyama,J.R.
  TITLE     Knockdown of mechanosensitive adaptor Hic-5 ameliorates
            post-traumatic osteoarthritis in rats through repression of MMP-13
  JOURNAL   Sci Rep 13 (1), 7446 (2023)
   PUBMED   37156857
  REMARK    GeneRIF: Knockdown of mechanosensitive adaptor Hic-5 ameliorates
            post-traumatic osteoarthritis in rats through repression of MMP-13.
            Erratum:[Sci Rep. 2023 Jun 13;13(1):9589. doi:
            10.1038/s41598-023-36393-w.. PMID: 37311826]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1972)
  AUTHORS   Varney,S.D., Betts,C.B., Zheng,R., Wu,L., Hinz,B., Zhou,J. and Van
            De Water,L.
  TITLE     Hic-5 is required for myofibroblast differentiation by regulating
            mechanically dependent MRTF-A nuclear accumulation
  JOURNAL   J Cell Sci 129 (4), 774-787 (2016)
   PUBMED   26759173
  REMARK    GeneRIF: the reciprocal regulation of MRTF-A localization by Hic-5
            and Hic-5 expression by MRTF-A, plays a crucial role in
            myofibroblast differentiation in response to TGF-beta.
REFERENCE   3  (bases 1 to 1972)
  AUTHORS   Hornigold,N. and Mooney,A.
  TITLE     Extracellular matrix-induced Hic-5 expression in glomerular
            mesangial cells leads to a prosclerotic phenotype independent of
            TGF-beta
  JOURNAL   FASEB J 29 (12), 4956-4967 (2015)
   PUBMED   26405299
  REMARK    GeneRIF: data indicate that there is a prosclerotic feedback loop
            in mesangial cells dependent on matrix-derived signals in which
            Hic-5 is a pivotal signaling protein. This feedback loop is
            TGF-beta-independent
REFERENCE   4  (bases 1 to 1972)
  AUTHORS   Hornigold,N., Johnson,T.S., Huang,L., Haylor,J.L., Griffin,M. and
            Mooney,A.
  TITLE     Inhibition of collagen I accumulation reduces glomerulosclerosis by
            a Hic-5-dependent mechanism in experimental diabetic nephropathy
  JOURNAL   Lab Invest 93 (5), 553-565 (2013)
   PUBMED   23508044
  REMARK    GeneRIF: Hypothesized that reducing collagen I accumulation in
            glomerulosclerosis would lower Hic-5 expression,reducing apoptosis,
            and maintain glomerular integrity. NTU281 treatment reduced
            glomerular col I accumulation, Hic-5 and alpha-SMA expression, and
            apoptosis.
REFERENCE   5  (bases 1 to 1972)
  AUTHORS   Shola,D.T., Wang,H., Wahdan-Alaswad,R. and Danielpour,D.
  TITLE     Hic-5 controls BMP4 responses in prostate cancer cells through
            interacting with Smads 1, 5 and 8
  JOURNAL   Oncogene 31 (19), 2480-2490 (2012)
   PUBMED   21996749
  REMARK    GeneRIF: these results provide the first evidence for a physical
            and mutual functional interaction between Hic-5 and the BMP
            signaling pathway.
REFERENCE   6  (bases 1 to 1972)
  AUTHORS   Wang,H., Song,K., Sponseller,T.L. and Danielpour,D.
  TITLE     Novel function of androgen receptor-associated protein 55/Hic-5 as
            a negative regulator of Smad3 signaling
  JOURNAL   J Biol Chem 280 (7), 5154-5162 (2005)
   PUBMED   15561701
  REMARK    GeneRIF: the C terminus of ARA55 is critical for suppression of
            Smad3 activity
REFERENCE   7  (bases 1 to 1972)
  AUTHORS   Drori,S., Girnun,G.D., Tou,L., Szwaya,J.D., Mueller,E., Xia,K.,
            Shivdasani,R.A. and Spiegelman,B.M.
  TITLE     Hic-5 regulates an epithelial program mediated by PPARgamma
  JOURNAL   Genes Dev 19 (3), 362-375 (2005)
   PUBMED   15687259
  REMARK    Erratum:[Genes Dev. 2005 Apr 1;19(7):875. Kia, Xia [corrected to
            Xia, Kai]]
REFERENCE   8  (bases 1 to 1972)
  AUTHORS   Hagel,M., George,E.L., Kim,A., Tamimi,R., Opitz,S.L., Turner,C.E.,
            Imamoto,A. and Thomas,S.M.
  TITLE     The adaptor protein paxillin is essential for normal development in
            the mouse and is a critical transducer of fibronectin signaling
  JOURNAL   Mol Cell Biol 22 (3), 901-915 (2002)
   PUBMED   11784865
REFERENCE   9  (bases 1 to 1972)
  AUTHORS   Jia,Y., Ransom,R.F., Shibanuma,M., Liu,C., Welsh,M.J. and
            Smoyer,W.E.
  TITLE     Identification and characterization of hic-5/ARA55 as an hsp27
            binding protein
  JOURNAL   J Biol Chem 276 (43), 39911-39918 (2001)
   PUBMED   11546764
REFERENCE   10 (bases 1 to 1972)
  AUTHORS   Fujimoto,N., Yeh,S., Kang,H.Y., Inui,S., Chang,H.C., Mizokami,A.
            and Chang,C.
  TITLE     Cloning and characterization of androgen receptor coactivator,
            ARA55, in human prostate
  JOURNAL   J Biol Chem 274 (12), 8316-8321 (1999)
   PUBMED   10075738
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jul 17, 2010 this sequence version replaced XM_341934.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.4342.1,
                                           SRR26643299.4645.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                JAXUCZ010000001.1  192259106-192259145
            41-156              JAXUCZ010000001.1  192260254-192260369
            157-209             JAXUCZ010000001.1  192260495-192260547
            210-352             JAXUCZ010000001.1  192260653-192260795
            353-440             JAXUCZ010000001.1  192260943-192261030
            441-546             JAXUCZ010000001.1  192261146-192261251
            547-741             JAXUCZ010000001.1  192261362-192261556
            742-915             JAXUCZ010000001.1  192264086-192264259
            916-997             JAXUCZ010000001.1  192264486-192264567
            998-1146            JAXUCZ010000001.1  192264758-192264906
            1147-1972           JAXUCZ010000001.1  192265078-192265903
FEATURES             Location/Qualifiers
     source          1..1972
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..1972
                     /gene="Tgfb1i1"
                     /gene_synonym="Ara55; Hic-5"
                     /note="transforming growth factor beta 1 induced
                     transcript 1"
                     /db_xref="GeneID:84574"
                     /db_xref="RGD:620173"
     exon            1..40
                     /gene="Tgfb1i1"
                     /gene_synonym="Ara55; Hic-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1413
                     /gene="Tgfb1i1"
                     /gene_synonym="Ara55; Hic-5"
                     /note="hydrogen peroxide-inducible clone 5 protein;
                     androgen receptor-associated protein of 55 kDa"
                     /codon_start=1
                     /product="transforming growth factor beta-1-induced
                     transcript 1 protein"
                     /protein_id="NP_001178769.1"
                     /db_xref="GeneID:84574"
                     /db_xref="RGD:620173"
                     /translation="MEDLDALLSDLETTTSHMSRLGAPKERPPETLTPPPPYGHQPQT
                     GSGESSGASGDKDHLYSTVCKPRSPKSVAPVAPPFSSSSGVLGNGLCELDRLLQELNA
                     TQFNITDEIMSQFPSSKMAEGEGKEDQSEDKSITTVPSSTFPAPSKPSATSATQELDR
                     LMASLSDFRVQNHLPASGPPQPPAVSPTREGCPSPPGQTNKGSLDTMLGLLQSDLSRR
                     GVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFLCRGCSTTLGGSSFFEKDGAPFCP
                     ECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGEEGFHEREGRPYC
                     RRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECLAPFSGGSFFEHEGRPL
                     CENHFHAQRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERASKP
                     YCQPCFLKLFG"
     exon            41..156
                     /gene="Tgfb1i1"
                     /gene_synonym="Ara55; Hic-5"
                     /inference="alignment:Splign:2.1.0"
     exon            157..209
                     /gene="Tgfb1i1"
                     /gene_synonym="Ara55; Hic-5"
                     /inference="alignment:Splign:2.1.0"
     exon            210..352
                     /gene="Tgfb1i1"
                     /gene_synonym="Ara55; Hic-5"
                     /inference="alignment:Splign:2.1.0"
     exon            353..440
                     /gene="Tgfb1i1"
                     /gene_synonym="Ara55; Hic-5"
                     /inference="alignment:Splign:2.1.0"
     exon            441..546
                     /gene="Tgfb1i1"
                     /gene_synonym="Ara55; Hic-5"
                     /inference="alignment:Splign:2.1.0"
     exon            547..741
                     /gene="Tgfb1i1"
                     /gene_synonym="Ara55; Hic-5"
                     /inference="alignment:Splign:2.1.0"
     exon            742..915
                     /gene="Tgfb1i1"
                     /gene_synonym="Ara55; Hic-5"
                     /inference="alignment:Splign:2.1.0"
     exon            916..997
                     /gene="Tgfb1i1"
                     /gene_synonym="Ara55; Hic-5"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1146
                     /gene="Tgfb1i1"
                     /gene_synonym="Ara55; Hic-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1972
                     /gene="Tgfb1i1"
                     /gene_synonym="Ara55; Hic-5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccaagctg tccgccagcg caccgccatg gaggacctgg atgccctact ctctgacctg
       61 gagaccacca cttcacacat gtcacggtta ggggctccaa aagagcgccc accagagaca
      121 ctcacacctc ccccacccta tggccaccag ccacagacag ggtctggaga atcttcagga
      181 gcctctgggg acaaggatca tctatacagc acagtatgca agcctcggtc cccaaagtct
      241 gtagcccctg tggctcctcc gttctcctct tccagtggtg tgttgggcaa tggactctgt
      301 gagctagacc gtctacttca ggaacttaat gccacccagt tcaacattac agatgaaatc
      361 atgtctcagt tcccatctag taagatggct gaaggggaag gaaaggagga ccaatctgaa
      421 gacaagagca taaccactgt cccttccagc acattccctg ccccctcaaa gccttcagcc
      481 acctcagcca ctcaggagct agatagactg atggcatcgc tctctgactt tcgtgtccag
      541 aaccatcttc cggcctcagg gccacctcag cctccagcag tgagccccac ccgtgaggga
      601 tgcccatctc caccaggaca gaccaacaag ggcagtctgg acaccatgct gggcctgctg
      661 cagtctgacc tcagccgccg tggtgttccc actcaggcca agggcctctg tggctcctgc
      721 aataaaccta ttgctgggca agtggttacc gccctgggta gagcctggca tccggagcac
      781 ttcctttgca gaggttgttc cacaaccctg ggaggcagca gtttcttcga gaaggatggg
      841 gctccctttt gccctgagtg ctactttgag cgcttctccc cacgatgtgg cttctgcaac
      901 caacccatcc gacataaaat ggtcaccgcc ttgggcaccc actggcaccc agaacatttc
      961 tgctgtgtca gctgcgggga gccttttgga gaagagggtt tccacgagcg ggagggccgc
     1021 ccctactgcc ggcgggactt cctgcagctg ttcgccccgc gctgccaggg ctgccaagga
     1081 cccattttgg ataactacat ctcggcactc agcgcgctct ggcacccaga ctgcttcgtg
     1141 tgcagggaat gcctcgcgcc cttctccgga ggcagcttct ttgagcacga gggtcgccca
     1201 ctgtgtgaaa accatttcca cgctcagcgt ggttcgttgt gtgccacgtg tggcctccct
     1261 gtgactggcc gctgtgtatc tgctctgggc cgccgcttcc acccagatca ctttacctgc
     1321 accttctgcc tacgcccact caccaaaggc tccttccagg agcgtgccag caagccttac
     1381 tgccagcctt gcttcctgaa gctctttggc tgacctcctc ttgggatcac agacctccaa
     1441 aaccacgcct ccaaaaacct gttctccctg aaaaagactg ggccctccag atccctagct
     1501 ctggagctgc ccaggcattc ttgcctgtac tcccacctcc atccccacta tggcccggcc
     1561 actggagagt gctccaggtt tgtcaagctc agcaagggcc ccactagctc tcactttgac
     1621 acgattctgg ttttctaatc tgacggatta gaggccaaga tgtcccagtt cacccatggc
     1681 tcactgttct gtactttttt tttctacaaa cataaaaaca cgctccacat ctcacagtgc
     1741 cagcgatcct tgctttacta cccagagccc ttgctctgtg ctccgagggc tccaggccac
     1801 agtcctgtga ggggacagag gtgctcctcc ctgggataac agcaaataac agatgaaggc
     1861 aggcatgggg aggtgtgtct gaaatcccaa cacggaggcc ggggcagatg atcctaagct
     1921 gcatagcaaa actgaggcca ggttgggtac ataagactat ctcaaaacaa aa
//
