LOCUS       NM_021578               1482 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus transforming growth factor, beta 1 (Tgfb1), mRNA.
ACCESSION   NM_021578
VERSION     NM_021578.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1482)
  AUTHORS   Hu,H.J., Wang,X.H., Zhang,Z.Z., Ou,Y., Ning,Z.H., Yang,J.Y.,
            Huang,H., Tang,H.F. and Jiang,Z.S.
  TITLE     SIRT3 sulfhydration using hydrogen sulfide inhibited angiotensin
            II-induced atrial fibrosis and vulnerability to atrial fibrillation
            via suppression of the TGF-beta1/smad2/3 signalling pathway
  JOURNAL   Eur J Pharmacol 982, 176900 (2024)
   PUBMED   39168432
  REMARK    GeneRIF: SIRT3 sulfhydration using hydrogen sulfide inhibited
            angiotensin II-induced atrial fibrosis and vulnerability to atrial
            fibrillation via suppression of the TGF-beta1/smad2/3 signalling
            pathway.
REFERENCE   2  (bases 1 to 1482)
  AUTHORS   Zhang,W., Cai,S., Wu,F., Luo,Y., Xiao,H., Yu,D., Zhong,X., Tao,P.
            and Huang,S.
  TITLE     Combining experiments and bioinformatics to identify transforming
            growth factor-beta1 as a key regulator in angiotensin II-induced
            trophoblast senescence
  JOURNAL   Placenta 152, 31-38 (2024)
   PUBMED   38781757
  REMARK    GeneRIF: Combining experiments and bioinformatics to identify
            transforming growth factor-beta1 as a key regulator in angiotensin
            II-induced trophoblast senescence.
REFERENCE   3  (bases 1 to 1482)
  AUTHORS   He,C., Gu,L., Li,A., Li,Y., Xiao,R., Liao,J., Mu,J., Gan,Y.,
            Peng,M., Mohan,G., Liu,W., Xu,L. and Guo,S.
  TITLE     Recombinant Slit2 attenuates tracheal fibroblast activation in
            benign central airway obstruction by inhibiting the TGF-beta1/Smad3
            signaling pathway
  JOURNAL   Mol Cell Probes 73, 101947 (2024)
   PUBMED   38122948
  REMARK    GeneRIF: Recombinant Slit2 attenuates tracheal fibroblast
            activation in benign central airway obstruction by inhibiting the
            TGF-beta1/Smad3 signaling pathway.
REFERENCE   4  (bases 1 to 1482)
  AUTHORS   Chi,C., Liang,X., Cui,T., Gao,X., Liu,R. and Yin,C.
  TITLE     SKIL/SnoN attenuates TGF-beta1/SMAD signaling-dependent collagen
            synthesis in hepatic fibrosis
  JOURNAL   Biomol Biomed 23 (6), 1014-1025 (2023)
   PUBMED   37389959
  REMARK    GeneRIF: SKIL/SnoN attenuates TGF-beta1/SMAD signaling-dependent
            collagen synthesis in hepatic fibrosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1482)
  AUTHORS   El-Malkey,N.F., Aref,M., Goda,N.I.A., Hussien,M.H., Samy,W. and
            Hadhod,S.
  TITLE     Sleep deprivation disturbs uterine contractility and structure in
            pregnant rats: role of matrix metalloproteinase 9 and transforming
            growth factor-beta
  JOURNAL   Can J Physiol Pharmacol 101 (11), 574-588 (2023)
   PUBMED   37433223
  REMARK    GeneRIF: Sleep deprivation disturbs uterine contractility and
            structure in pregnant rats: role of matrix metalloproteinase 9 and
            transforming growth factor-beta.
REFERENCE   6  (bases 1 to 1482)
  AUTHORS   Wrana,J.L., Attisano,L., Carcamo,J., Zentella,A., Doody,J.,
            Laiho,M., Wang,X.F. and Massague,J.
  TITLE     TGF beta signals through a heteromeric protein kinase receptor
            complex
  JOURNAL   Cell 71 (6), 1003-1014 (1992)
   PUBMED   1333888
REFERENCE   7  (bases 1 to 1482)
  AUTHORS   Shull,M.M., Ormsby,I., Kier,A.B., Pawlowski,S., Diebold,R.J.,
            Yin,M., Allen,R., Sidman,C., Proetzel,G., Calvin,D. et al.
  TITLE     Targeted disruption of the mouse transforming growth factor-beta 1
            gene results in multifocal inflammatory disease
  JOURNAL   Nature 359 (6397), 693-699 (1992)
   PUBMED   1436033
REFERENCE   8  (bases 1 to 1482)
  AUTHORS   Thompson,T.C., Truong,L.D., Timme,T.L., Kadmon,D., McCune,B.K.,
            Flanders,K.C., Scardino,P.T. and Park,S.H.
  TITLE     Transforming growth factor beta 1 as a biomarker for prostate
            cancer
  JOURNAL   J Cell Biochem Suppl 16H, 54-61 (1992)
   PUBMED   1289674
  REMARK    Review article
REFERENCE   9  (bases 1 to 1482)
  AUTHORS   Robinson,S.D., Silberstein,G.B., Roberts,A.B., Flanders,K.C. and
            Daniel,C.W.
  TITLE     Regulated expression and growth inhibitory effects of transforming
            growth factor-beta isoforms in mouse mammary gland development
  JOURNAL   Development 113 (3), 867-878 (1991)
   PUBMED   1821856
REFERENCE   10 (bases 1 to 1482)
  AUTHORS   Thompson,A.M., Kerr,D.J. and Steel,C.M.
  TITLE     Transforming growth factor beta 1 is implicated in the failure of
            tamoxifen therapy in human breast cancer
  JOURNAL   Br J Cancer 63 (4), 609-614 (1991)
   PUBMED   2021547
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC076380.1.
            
            On Jun 10, 2007 this sequence version replaced NM_021578.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076380.1, X52498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1482
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1482
                     /gene="Tgfb1"
                     /gene_synonym="Tgfb"
                     /note="transforming growth factor, beta 1"
                     /db_xref="GeneID:59086"
                     /db_xref="RGD:69051"
     exon            1..500
                     /gene="Tgfb1"
                     /gene_synonym="Tgfb"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1318
                     /gene="Tgfb1"
                     /gene_synonym="Tgfb"
                     /note="TGF-beta-1; transforming growth factor beta-1
                     proprotein"
                     /codon_start=1
                     /product="transforming growth factor beta-1 proprotein
                     precursor"
                     /protein_id="NP_067589.1"
                     /db_xref="GeneID:59086"
                     /db_xref="RGD:69051"
                     /translation="MPPSGLRLLPLLLPLPWLLVLTPGRPAAGLSTCKTIDMELVKRK
                     RIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESADPEPEPEAD
                     YYAKEVTRVLMVDRNNAIYDKTKDITHSIYMFFNTSDIREAVPEPPLLSRAELRLQRF
                     KSTVEQHVELYQKYSNNSWRYLGNRLLTPTDTPEWLSFDVTGVVRQWLNQGDGIQGFR
                     FSAHCSCDSKDNVLHVEINGISPKRRGDLGTIHDMNRPFLLLMATPLERAQHLHSSRH
                     RRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDT
                     QYSKVLALYNQHNPGASASPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS"
     exon            501..661
                     /gene="Tgfb1"
                     /gene_synonym="Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            662..779
                     /gene="Tgfb1"
                     /gene_synonym="Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            780..857
                     /gene="Tgfb1"
                     /gene_synonym="Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1005
                     /gene="Tgfb1"
                     /gene_synonym="Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1159
                     /gene="Tgfb1"
                     /gene_synonym="Tgfb"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1457
                     /gene="Tgfb1"
                     /gene_synonym="Tgfb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caacctcaaa ttattcagga ctatcaccta cctttccttg ggagacccca ccccacccca
       61 caagccctgc aggggcgggg cctccgcatc ccacctttgc ccggggttcg cgctctccga
      121 agttccgtgg ggcgccgcct cccccatgcc gccctcgggg ctgcggctgc tgccgcttct
      181 gctcccactc ccgtggcttc tagtgctgac gcccgggagg ccagccgcgg gactctccac
      241 ctgcaagacc atcgacatgg agctggtgaa acggaagcgc atcgaagcca tccgtggcca
      301 gatcctgtcc aaactaaggc tcgccagtcc cccgagccag ggggaggtac cgccgggccc
      361 gctgcccgag gcggtgctcg ctttgtacaa cagcacccgc gaccgggtgg caggcgagag
      421 cgctgacccg gagcccgagc ccgaggcgga ctactacgcc aaagaagtca cccgcgtgct
      481 aatggtggac cgcaacaacg caatctatga caaaaccaaa gacatcacac acagtatata
      541 tatgttcttc aatacgtcag acattcggga agcagtgcca gaacccccat tgctgtcccg
      601 tgcagagctg cgcctgcaga gattcaagtc aactgtggag caacacgtag aactctacca
      661 gaaatatagc aacaattcct ggcgttacct tggtaaccgg ctgctgaccc ccactgatac
      721 gcctgagtgg ctgtcttttg acgtcactgg agttgtccgg cagtggctga accaaggaga
      781 cggaatacag ggctttcgct tcagtgctca ctgctcttgt gacagcaaag ataatgtact
      841 ccacgtggaa atcaatggga tcagtcccaa acgtcgaggt gacctgggca ccatccatga
      901 catgaaccga cccttcctgc tcctcatggc cacccccctg gaaagggctc aacacctgca
      961 cagctccagg caccggagag ccctggatac caactactgc ttcagctcca cagagaagaa
     1021 ctgctgtgta cggcagctgt acattgactt taggaaggac ctgggttgga agtggatcca
     1081 cgagcccaag ggctaccatg ccaacttctg tctggggccc tgcccctaca tttggagcct
     1141 ggacacacag tacagcaagg tccttgccct ctacaaccaa cacaacccgg gtgcttccgc
     1201 atcaccgtgc tgcgtgccgc aggctttgga gccactgccc atcgtctact acgtgggtcg
     1261 caagcccaag gtggagcagt tgtccaacat gatcgtgcgc tcctgcaagt gcagctgagg
     1321 ccccgccccc gccccgcccc gcccctcccg gcaggcccgg ccccgccccc gccccgcccg
     1381 cagtgcccgg ggctgtattt aaggacacct gcaccccccc caagcccatc tgggggccca
     1441 ttaaaggtga cagaggaaaa aaaaaaaaaa aaaaaaaaaa aa
//
