LOCUS       NM_012671               4222 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus transforming growth factor alpha (Tgfa), mRNA.
ACCESSION   NM_012671
VERSION     NM_012671.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4222)
  AUTHORS   Yu,Y., Chen,E., Weiss,R.M., Felder,R.B. and Wei,S.G.
  TITLE     Transforming Growth Factor-alpha Acts in Hypothalamic
            Paraventricular Nucleus to Upregulate ERK1/2 Signaling and
            Expression of Sympathoexcitatory Mediators in Heart Failure Rats
  JOURNAL   Neuroscience 483, 13-23 (2022)
   PUBMED   34968668
  REMARK    GeneRIF: Transforming Growth Factor-alpha Acts in Hypothalamic
            Paraventricular Nucleus to Upregulate ERK1/2 Signaling and
            Expression of Sympathoexcitatory Mediators in Heart Failure Rats.
REFERENCE   2  (bases 1 to 4222)
  AUTHORS   Naito,K., Moteki,H., Kimura,M., Natsume,H. and Ogihara,M.
  TITLE     Serotonin 5-HT2B Receptor-Stimulated DNA Synthesis and
            Proliferation Are Mediated by Autocrine Secretion of Transforming
            Growth Factor-alpha in Primary Cultures of Adult Rat Hepatocytes
  JOURNAL   Biol Pharm Bull 39 (4), 570-577 (2016)
   PUBMED   26804134
  REMARK    GeneRIF: 5-HT stimulates DNA synthesis and proliferation in primary
            cultures of adult rat hepatocytes by acting via autocrine secretion
            of TGF-alpha induced by the serotonin 5-HT2B receptor/Gq/PLC/Ca2+
            pathway.
REFERENCE   3  (bases 1 to 4222)
  AUTHORS   Ni,W., Lin,N., He,H., Zhu,J. and Zhang,Y.
  TITLE     Lipopolysaccharide induces up-regulation of TGF-alpha through HDAC2
            in a rat model of bronchopulmonary dysplasia
  JOURNAL   PLoS One 9 (3), e91083 (2014)
   PUBMED   24595367
  REMARK    GeneRIF: Lipopolysaccharide exposure led to a suppression of both
            HDAC1 and HDAC2 expression and activity, induced TGFa expression,
            and disrupted alveolar morphology.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4222)
  AUTHORS   Wong,H.H. and Lemoine,N.R.
  TITLE     Pancreatic cancer: molecular pathogenesis and new therapeutic
            targets
  JOURNAL   Nat Rev Gastroenterol Hepatol 6 (7), 412-422 (2009)
   PUBMED   19506583
  REMARK    Review article
REFERENCE   5  (bases 1 to 4222)
  AUTHORS   Kimura,M., Okamoto,H., Natsume,H. and Ogihara,M.
  TITLE     IP receptor agonist-induced DNA synthesis and proliferation in
            primary cultures of adult rat hepatocytes: the involvement of
            endogenous transforming growth factor-alpha
  JOURNAL   J Pharmacol Sci 109 (4), 618-629 (2009)
   PUBMED   19346670
REFERENCE   6  (bases 1 to 4222)
  AUTHORS   Korc,M., Chandrasekar,B., Yamanaka,Y., Friess,H., Buchier,M. and
            Beger,H.G.
  TITLE     Overexpression of the epidermal growth factor receptor in human
            pancreatic cancer is associated with concomitant increases in the
            levels of epidermal growth factor and transforming growth factor
            alpha
  JOURNAL   J Clin Invest 90 (4), 1352-1360 (1992)
   PUBMED   1401070
REFERENCE   7  (bases 1 to 4222)
  AUTHORS   Luetteke,N.C. and Lee,D.C.
  TITLE     Transforming growth factor alpha: expression, regulation and
            biological action of its integral membrane precursor
  JOURNAL   Semin Cancer Biol 1 (4), 265-275 (1990)
   PUBMED   2103501
  REMARK    Review article
REFERENCE   8  (bases 1 to 4222)
  AUTHORS   Blasband,A.J., Rogers,K.T., Chen,X.R., Azizkhan,J.C. and Lee,D.C.
  TITLE     Characterization of the rat transforming growth factor alpha gene
            and identification of promoter sequences
  JOURNAL   Mol Cell Biol 10 (5), 2111-2121 (1990)
   PUBMED   2325647
REFERENCE   9  (bases 1 to 4222)
  AUTHORS   Gentry,L.E., Twardzik,D.R., Lim,G.J., Ranchalis,J.E. and Lee,D.C.
  TITLE     Expression and characterization of transforming growth factor alpha
            precursor protein in transfected mammalian cells
  JOURNAL   Mol Cell Biol 7 (5), 1585-1591 (1987)
   PUBMED   3299049
REFERENCE   10 (bases 1 to 4222)
  AUTHORS   Lee,D.C., Rose,T.M., Webb,N.R. and Todaro,G.J.
  TITLE     Cloning and sequence analysis of a cDNA for rat transforming growth
            factor-alpha
  JOURNAL   Nature 313 (6002), 489-491 (1985)
   PUBMED   3855503
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M31076.1 and JAXUCZ010000004.1.
            
            On Jun 13, 2010 this sequence version replaced NM_012671.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M31076.1, SRR26643288.19572.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-804               M31076.1           1-804
            805-4222            JAXUCZ010000004.1  120254920-120258337
FEATURES             Location/Qualifiers
     source          1..4222
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..4222
                     /gene="Tgfa"
                     /gene_synonym="RATTGFAA; TGFAA"
                     /note="transforming growth factor alpha"
                     /db_xref="GeneID:24827"
                     /db_xref="RGD:3849"
     exon            1..184
                     /gene="Tgfa"
                     /gene_synonym="RATTGFAA; TGFAA"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..624
                     /gene="Tgfa"
                     /gene_synonym="RATTGFAA; TGFAA"
                     /note="protransforming growth factor alpha"
                     /codon_start=1
                     /product="protransforming growth factor alpha
                     preproprotein"
                     /protein_id="NP_036803.1"
                     /db_xref="GeneID:24827"
                     /db_xref="RGD:3849"
                     /translation="MVPAAGQLALLALGILVAVCQALENSTSPLSDSPVAAAVVSHFN
                     KCPDSHTQYCFHGTCRFLVQEEKPACVCHSGYVGVRCEHADLLAVVAASQKKQAITAL
                     VVVSIVALAVLIITCVLIHCCQVRKHCEWCRALVCRHEKPSALLKGRTACCHSETVV"
     exon            185..238
                     /gene="Tgfa"
                     /gene_synonym="RATTGFAA; TGFAA"
                     /inference="alignment:Splign:2.1.0"
     exon            239..356
                     /gene="Tgfa"
                     /gene_synonym="RATTGFAA; TGFAA"
                     /inference="alignment:Splign:2.1.0"
     exon            357..506
                     /gene="Tgfa"
                     /gene_synonym="RATTGFAA; TGFAA"
                     /inference="alignment:Splign:2.1.0"
     exon            507..616
                     /gene="Tgfa"
                     /gene_synonym="RATTGFAA; TGFAA"
                     /inference="alignment:Splign:2.1.0"
     exon            617..4222
                     /gene="Tgfa"
                     /gene_synonym="RATTGFAA; TGFAA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggaggcg cggtcgtccc tccgcccgcg cgccgggggc cggccctgtc gcctgcgcct
       61 ttttcccccg cgcacaccgc ggcggcgcgc ggccactcgc caaccgcaaa gagcgcggtg
      121 gctgcagcgc cctgcgctcg gaagatggtc cccgcggccg gacagctcgc tctgctagcg
      181 ctgggtatcc tggtagctgt gtgtcaggct ctggagaaca gcacgtcccc cctgagtgac
      241 tcacccgtgg cggctgcagt ggtgtctcac ttcaacaagt gcccagattc ccacactcag
      301 tattgtttcc atgggacctg caggtttttg gtgcaggaag agaagccagc atgtgtctgc
      361 cactctgggt acgtgggtgt tcgctgtgag catgcagatc tcctggcagt ggtggctgcc
      421 agccagaaga agcaggccat cactgccctg gtggtagtct ccattgtggc cctggctgtc
      481 ctcattatca cctgtgtgct gatccactgc tgtcaggtcc gcaagcactg tgagtggtgc
      541 cgtgccctcg tctgcagaca cgagaagccc agcgccctcc tgaaaggaag gactgcctgc
      601 tgccactctg agacagtggt ctgaagatcc cagaggagga atttggccag gtggccgatg
      661 acagcccaac caaggaaagg tgtctcagga caacaccacc agcagtgccc aggccccggg
      721 acatgctggg agaccttccc cctcaatgta caaccacctg ggcagctctc tgtcctttac
      781 gagcttcaaa actgtgtgat aaagctgccc gctgggcacc ctagagaaga ggccagtaga
      841 caacatttga acgacaagtt gaacaagaac ctcaaagggc tggccttctt gctaacccac
      901 accaagaagg ctgtccgtgg actccaaact gtttcttctc catgggccgt ctaacccccc
      961 acagagactc cacgcttggt gtacaaaatg gacaagggga aacatctatt gtcctttgaa
     1021 gacaccatgg ccccggcatg agccctgaca tctcctcaaa cggttgccag gatgatgtgt
     1081 cttatgtatt aggtggatga cgcggttttg tttgtattct ctttatgtca gtatcgggca
     1141 tccatgttaa tgatccacga gcggctggct gtgaagttac accaaataga aatgttcagc
     1201 cactttgata aagtaaggct gtggggatgg gagcctccca ggggctgtag agacagaact
     1261 caaaagtgca ttctgctggg aaccaaactg ctaccaggag gttgtgccca ctaagacagg
     1321 aaagtccctg gatatatgct gtggcaaagt tagcaagggc aagaggacaa gagagcctgt
     1381 gtgggcactg agggaggacg cacattccat cactcgatta agttggatta gcctcctcgt
     1441 gagcccagct ccagcatcag ccatgagccg tgggccaaat ccgtgaaggt gaccccctct
     1501 ttattggttt ctgctcattt ttagaaggag aaatttacct ttcctattta ttttcaagca
     1561 ttaagagaaa tagcccccct gtcttgtttt gttttgtttc ccctttcaga atgttggcat
     1621 tactaatgaa atcgctacca agcctctcca ctcccctccg gggaaggagc tatgttccct
     1681 gagcactgga gggcgctctg acccattgag cccacctcct ccctgtgctg ctcaggactg
     1741 tcaggagaca gtaaatacat ccagctgctt gtggaggagg ccattctcca actcagaact
     1801 taaagggccc tccaccctcc agagccttta acgtaacgtc aggaaaaggg gtgtttgaca
     1861 taccaaattc tcagcaagtt ctgcctgttc ctcattcttc tccattccac ctttctctgt
     1921 gaatgttttc ttttctcata tgacctagat atcaatctgc ccaggtctta accctggctc
     1981 cctttgttaa caatgcctca agctccacaa gaagaaagtg ggttggttca gtgctgacct
     2041 ctaactactc agtcgacgtg gctccaggcg gaaatcgtca cttgtgttgt tattattatt
     2101 attattttgg tttgatgttt tatcttgttt tgtgagacaa ggtcttgctg tgtagcccag
     2161 gttggccttg aagttaagat cctcctgctt cagcatcctg agagctgggc ttactggtgt
     2221 acagcaccgc acccagcaga gtctttacgg ttattaaaga agacaggtta agtttgcttt
     2281 ccttgggtcg tgcatgtggg tcaaggccaa gtgtagcctg ctgctcagac acccatcgac
     2341 ctcactggac gttggccctc tattgggccc ccaatgcaga ccctgtatga agtactagct
     2401 caccagggcc aacacaaagg gaggggcttg ttttaattta gttcacaccg ttagcttccg
     2461 atgataagtc tttcctggtc tgttggaagc tcctgggtgt ctgacttctt ttaaagagtt
     2521 tgaactgata tcaaaatatc attgggaatt tcttcaccta gtgtcccatc ctgaagatat
     2581 taccatgcaa gactcagcag aggtgggaaa agttagtaca aacctttaat ggtggaggca
     2641 gaggatcttg ggaggacctc agctttagtg tctgaacatt ccggttctca ggtccagcca
     2701 gtcacagcag ccagtaccat cccagtaccc atacacagat gcagccggct caaacgtctc
     2761 ccagaagtgc cttccccacc agtcataccc tctgaagagt cagaagctga gactaagttg
     2821 aggcaaatct ggttggacat cgtccctgcc ctgacataag acagccctgc ttctttggtg
     2881 actctgattc ttggaagtca gacaaatgct gacagcacaa atctcacagc acagttagac
     2941 ctgggtagct gtcccagcac ctcctgtcag gtcacactgg ccctcttgat actcagtgca
     3001 gctactgagt caggagcact cgtcagcaga cacacaggtc agtggacagt gactcagagg
     3061 actgtgaaca ttcccattaa atggattgaa attaattctg gagtcattaa gagagctcag
     3121 ttaagaatgg cacttaccaa tatccctgag aacatgagtt caatcccctg ggacccatct
     3181 ggtggaagga gagaaccaac ttgcccagga tgtcttctga attctacata cacaacacac
     3241 acacacacac acacacacac acacacacac acacacccct ctagctgtaa ctttaaacac
     3301 atgatgggac atgttctctc catgcaaaac tacaatgggg actcagtctg aaagatagat
     3361 tctaggtgga catacgcaga cccaaaccat aagtcagttt gtcatgtgcc cagaaaaagg
     3421 tggtaacaat agtcccaatg tcctttttct cctaaaaagg ttgtggggag gcatggttgg
     3481 tacccaccca cccacactgg tgagggaagt gactgtgtcc ctgagtctta gatggtgatg
     3541 ttgttccctg caagtcccca ggccaggttt cctagtgcct gtgagccact aggtggaccg
     3601 gcaacacgct gacactgcct acaggcccca gtcccatggt gaatagtaag gttacctctc
     3661 tcaaaggcca aggggaggcc acatgagaca acacgttttt cacacagggt ttcactgtat
     3721 agcccaggcc agcctcaaac ccatgattcc cctgcctcag cctactgggt tacaggtgtg
     3781 cactgccata cctggctcac gtttgttttt taatgttctg gtgtaacatg tattccctga
     3841 agccattgat ctatctcaaa gacacagtgt tgtacgcata catgtgcgca cgtacacaca
     3901 ccaaactgga aagcgacccc tctccatagt gtgataagtt tattataagt ttattataag
     3961 gaccctatgc tgtttttaga actcatcttt ctgacttctg tatatgatgc actgaaggtt
     4021 aatatgtaat attttaattt attttatgtg gtaagttaat tttggttttc tgtaatgtat
     4081 taatgtgatt agaagctttt ttccttaata tctgaattat acttaaagag tagtgaggaa
     4141 tataagatac tgttgtgtat tgttactcag ttgtattgta ccttgtttgg aaggatgaag
     4201 gaatgaaccc tttttttttt tc
//
