LOCUS       NM_001007635            4123 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus GTPase activating protein testicular GAP1
            (Tgap1), mRNA.
ACCESSION   NM_001007635 XM_226945
VERSION     NM_001007635.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4123)
  AUTHORS   Modarressi,M.H., Cheng,M., Tarnasky,H.A., Lamarche-Vane,N., de
            Rooij,D.G., Ruan,Y. and van der Hoorn,F.A.
  TITLE     A novel testicular RhoGAP-domain protein induces apoptosis
  JOURNAL   Biol Reprod 71 (6), 1980-1990 (2004)
   PUBMED   15306557
  REMARK    GeneRIF: tGAP1 efficiently induces apoptosis, which is the first
            such demonstration for a RhoGAP protein. Based on its subcellular
            location in spermatids and its activity, tGAP1 may play role in
            nuclear import/export.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 3, 2020 this sequence version replaced NM_001007635.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY631396.1, SRR26643293.11135.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000002.1  92287219-92287318
            101-142             JAXUCZ010000002.1  92288271-92288312
            143-224             JAXUCZ010000002.1  92288904-92288985
            225-302             JAXUCZ010000002.1  92292522-92292599
            303-366             JAXUCZ010000002.1  92294214-92294277
            367-549             JAXUCZ010000002.1  92297280-92297462
            550-728             JAXUCZ010000002.1  92299583-92299761
            729-890             JAXUCZ010000002.1  92300169-92300330
            891-1000            JAXUCZ010000002.1  92301295-92301404
            1001-1190           JAXUCZ010000002.1  92301796-92301985
            1191-1449           JAXUCZ010000002.1  92303400-92303658
            1450-1589           JAXUCZ010000002.1  92304598-92304737
            1590-1748           JAXUCZ010000002.1  92306002-92306160
            1749-1858           JAXUCZ010000002.1  92309082-92309191
            1859-2045           JAXUCZ010000002.1  92310496-92310682
            2046-2283           JAXUCZ010000002.1  92313929-92314166
            2284-2417           JAXUCZ010000002.1  92319136-92319269
            2418-2576           JAXUCZ010000002.1  92320511-92320669
            2577-2686           JAXUCZ010000002.1  92323318-92323427
            2687-2873           JAXUCZ010000002.1  92324514-92324700
            2874-3111           JAXUCZ010000002.1  92328004-92328241
            3112-3242           JAXUCZ010000002.1  92333945-92334075
            3243-3401           JAXUCZ010000002.1  92335315-92335473
            3402-3511           JAXUCZ010000002.1  92337877-92337986
            3512-3698           JAXUCZ010000002.1  92339084-92339270
            3699-3936           JAXUCZ010000002.1  92342599-92342836
            3937-4123           JAXUCZ010000002.1  92343601-92343787
FEATURES             Location/Qualifiers
     source          1..4123
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q23"
     gene            1..4123
                     /gene="Tgap1"
                     /note="GTPase activating protein testicular GAP1"
                     /db_xref="GeneID:294892"
                     /db_xref="RGD:1359558"
     exon            1..100
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            101..142
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..3971
                     /gene="Tgap1"
                     /codon_start=1
                     /product="GTPase activating protein testicular GAP1"
                     /protein_id="NP_001007636.3"
                     /db_xref="GeneID:294892"
                     /db_xref="RGD:1359558"
                     /translation="MEQTIWWYFFLQRSIREAKKHNKIEIPMQIFTEDIACCDTPLYV
                     TATNFDTVNDIISKLLPMIRKHNTEDYQLWFCPGPGKAPRLLQGHEYPHDIRMINIQK
                     NFSSRDLRNFTAVPSLPGVIMKYLNADVHGKFILKPRNSTRSQQQKNMKEKTFKKQRT
                     SITSWLDRGSVPHQDKVCTIPQVKKGGKLFGRELSSICQDGDLPSAILDMLYLLKKEG
                     PTTKGVFIEPPSTTLFQTVKDKLDSGEEVDIEKQSVHVVAWIFKDFLQNIEGSLMTSK
                     LYDEWIAVTEKVNDEEKLVAVQSLLDKMPPENAALLRQLFRILYEIKNNSAVNEMSSY
                     HLSVGLAPCLLFVPSSCNNGMTNDISKKISLVKFMIENSPQFFGEDLAAVWHGASLYH
                     RPGAKSLCPQSTPTNSGNVKETKHGLSSSPSGRTCTPGYNTLRRRSAALLPHEGIIDS
                     QKHEVNVYTKPTVPSLNPPQAKQKCLFGKSLTSLFEDKKLPTPILDMLSIIAEKGHES
                     DHIFKILPKESHWSLRYRLDSEQHIDWDEECVLVIASVLKDFIINIDGSLLTLEFYEN
                     WLSIPDEGTLAEKINAIQSLLQQIPEPNFILLKHLVYVLVIIKDSSMNNLDSYRLSLR
                     IAPHVLWGKTSRDSLFGTDVLRKLSIMQIMIDNYHEIFGNDDMFIKHTDKESNDLRMN
                     EESKSSSDKSPVMTNVIACCTGTTCDNNEKLNISCAALQEEGPPEKCEDNEYSNPPVR
                     CLFPLRPAKKCLFGQPLTSIFEDKKIPTPIFDMLSIIAEKGKDTDHIFKTLSEYSHWS
                     LRDKIDTYQYINWNEERVLVIASVLKDFITHIDGSLLTCELYESWLSVPDEGTLAEQI
                     NAIQRLLQKIPEPNFILLKHLICVLVIIKDSSTNKLDTNRLSLRLGPHLLWGWTSSDA
                     FFGKNVSRKLSIIQIMIDNYHQIFGNDDMFIKHTDKESDDLKMNEESKSSSDKSPVMT
                     NVIACCTGTTCDKNEKFNISYAALQVAGPTEKQKSNIYTKPPEYSNPTPSRKKCLFGK
                     NLTSIYVDSKLPAPILEMLSIIAEKGKESDQIFAILPENSHWSLRERIESEELIDWNE
                     EGILVIASVLKDFITNIEGSLLTSDLYESWLSVPDEGTLAGKINAIQRLLLKIPQANF
                     ILLKHLICVLVKIRDSSMNNLDSNNLSVRIAPYVLWNQTPKDTLFGSDVSRKMSIIQI
                     MIDNYSQIFGNDSIFCKGIDKRPEDLKTCPDSINASGKSPIMNEFLGGRNRKTYDNSE
                     NFKISSIALQEEGPTGQDTKTATYKW"
     exon            143..224
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            225..302
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            303..366
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..549
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            550..728
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..890
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1000
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1190
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1449
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1589
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1748
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1858
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..2045
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2283
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2417
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2576
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2686
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2873
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..3111
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3242
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3401
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            3402..3511
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3698
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            3699..3936
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            3937..4123
                     /gene="Tgap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggccggac caacggctcc tccacccagc accagcgtcc tttatgtttt gatctgcgat
       61 gtacatcaag actctacaag atccatggga caggacagag ttccatggaa cagaccattt
      121 ggtggtattt ctttctacaa agatccattc gtgaagccaa gaagcacaac aaaatagaaa
      181 tacccatgca gatatttact gaggacattg catgctgtga cactcctcta tatgtaacag
      241 caacaaactt cgatacagtg aatgacataa tcagcaagtt actgccaatg ataagaaaac
      301 ataacactga agattaccaa ctgtggttct gtcctggccc tggaaaagct ccaagactac
      361 tccaagggca tgaatatcca catgacatta gaatgataaa tattcaaaag aacttcagtt
      421 cacgggactt aagaaatttt acagcagtcc cttccctacc tggggtaatc atgaaatatc
      481 taaacgctga tgtacatggg aaattcatct taaagcccag aaactcaaca agaagccagc
      541 aacaaaaaaa tatgaaggaa aaaactttta agaaacaaag aacttctata acatcgtggt
      601 tggacagggg ctctgtgccc caccaggaca aagtatgcac catcccacaa gttaaaaagg
      661 gaggaaaact gtttggaaga gaactcagct ccatttgtca ggatggcgac ctgccctcag
      721 caatcctgga catgctgtac ctactaaaaa aggaagggcc cacaaccaag ggtgttttta
      781 tagaacctcc aagtacaact ttgttccaaa cagtaaagga caaattggat tcgggagaag
      841 aggtggatat cgagaagcaa tcagttcatg tagtggcgtg gatctttaag gacttcctcc
      901 aaaacatcga gggaagtcta atgacttcaa aactatatga tgagtggatt gctgtaaccg
      961 aaaaagtcaa tgatgaagag aaattagtcg cagtgcagag tcttttagat aaaatgccac
     1021 ctgaaaatgc agctcttctg aggcaacttt ttcgtatatt atatgaaatt aaaaataatt
     1081 ctgctgttaa tgaaatgtcg tcttaccacc tatctgttgg gttagcccca tgtctcttat
     1141 tcgtgcccag ctcctgcaat aatggaatga caaatgatat tagcaaaaag atttctctag
     1201 tgaagtttat gatcgaaaat tcgccacagt tttttggcga ggacttggct gcagtgtggc
     1261 atggagcatc actatatcat cgtcccggag caaagtcctt gtgtccccag agtactccaa
     1321 caaatagtgg gaacgtgaag gaaaccaaac atggactcag cagctccccc agtggcagga
     1381 catgcactcc tggctataat acactgcgga gaagatcagc tgctcttctt ccccatgagg
     1441 gcattataga ttcacaaaaa cacgaagtca atgtatatac taaaccaaca gtaccatctc
     1501 ttaatccacc acaagcaaaa cagaaatgtt tgtttggcaa atctcttaca agtctttttg
     1561 aagacaaaaa gttgcctact ccaatacttg atatgctatc cataattgca gagaaaggac
     1621 atgaatcgga tcacatattc aaaattctac ctaaagaatc acactggtcc ctgaggtata
     1681 ggcttgacag tgaacaacac attgactggg acgaggaatg cgttcttgta atagcatccg
     1741 ttttaaagga ttttattatt aatattgatg gaagcttact aaccttggaa ttctatgaaa
     1801 attggcttag catcccagac gaaggaactc tggctgaaaa aattaatgcc atccaaagcc
     1861 ttttgcaaca gatcccagaa ccaaacttta tactattaaa acatctcgtg tatgtattag
     1921 taataattaa agattcttcc atgaataatt tagacagtta caggttatct ttgcgaatag
     1981 ctccacatgt actgtggggt aagacttcga gagactcatt atttgggact gacgtcttaa
     2041 gaaagttgtc cattatgcaa atcatgatcg acaactacca tgaaatattt ggaaatgatg
     2101 atatgtttat taaacatact gacaaagagt ctaatgactt aaggatgaat gaagaatcaa
     2161 aaagttcttc tgacaaatca cctgttatga caaatgtcat agcatgctgc accgggacaa
     2221 cctgtgataa caatgaaaaa ttaaatattt catgtgctgc tctgcaggag gaaggtcctc
     2281 cagagaaatg tgaagacaat gaatattcca acccaccagt acgttgtcta tttccattac
     2341 gacctgcaaa gaaatgtttg tttggtcaac ctcttacaag tatttttgaa gacaaaaaga
     2401 tacctactcc aatatttgat atgttgtcta taattgcaga aaagggaaaa gatacagatc
     2461 acatatttaa aactctatct gaatattcac attggtcctt gagagacaag atagacacct
     2521 atcaatatat caattggaat gaggaacgcg tgcttgtaat agcatccgta ttaaaggact
     2581 tcattaccca tatagatgga agtttgctta catgtgaatt atatgaaagt tggcttagcg
     2641 tcccagatga gggaactctg gctgaacaaa ttaatgccat acaaagactt cttcaaaaaa
     2701 tcccagaacc gaactttata ttgttaaaac acctcatctg tgtattagta ataataaaag
     2761 actcatccac gaataagtta gacactaaca ggttatcact ccgccttggc ccacatttgc
     2821 tatggggttg gacttcgagt gatgcatttt ttggaaaaaa tgtctcaaga aagttgtcca
     2881 ttatacaaat catgatcgac aactaccatc aaatatttgg aaatgatgat atgtttatta
     2941 aacatactga caaagagtct gatgatttaa agatgaatga agaatcaaaa agttcttctg
     3001 acaaatcacc tgttatgaca aatgtcatag catgctgcac cgggacaacc tgtgataaga
     3061 atgaaaaatt caatatttca tatgctgcac tgcaggtggc aggtcctaca gagaaacaga
     3121 aaagcaatat atataccaag ccaccagaat attctaatcc aacaccatca agaaagaaat
     3181 gtttatttgg caaaaatctt acaagcattt atgtcgacag taagctgcct gctccaatac
     3241 ttgaaatgct atccataatt gcagagaaag gaaaagaatc agatcagata tttgcaattc
     3301 tacctgaaaa ttcacattgg agcctcagag agaggataga gagtgaagaa ctcatagact
     3361 ggaatgaaga aggcatacta gttatagcct ctgttttaaa ggacttcatt acaaatatcg
     3421 aaggaagttt acttacttct gacttatatg aaagttggct tagcgtccca gatgagggaa
     3481 cactggctgg aaaaattaat gccattcaaa gacttttact gaagattcct caggcaaact
     3541 ttatccttct aaagcatctc atctgtgtgt tagtaaaaat aagagactca tccatgaata
     3601 acttagacag taacaattta tctgtccgca tagctcctta tgttttgtgg aatcagactc
     3661 caaaggacac attgtttggg agtgatgtat caagaaagat gtccattata caaatcatga
     3721 tcgacaacta tagtcaaata tttggaaatg acagtatatt ttgtaaaggt attgacaaaa
     3781 gacctgagga tttaaagacg tgtccagatt caataaatgc ttctggaaaa tcacctatta
     3841 tgaacgaatt cctaggtggc cgcaacagga aaacatatga taatagtgaa aattttaaaa
     3901 tttcatccat tgctctgcag gaggaaggtc ctacaggaca ggacacaaaa actgccacgt
     3961 ataagtggta gaggatgact gaagacacta aaaggtcatt ctattttaat gttcccttct
     4021 accttccact taatcttagc aaacaaatta ttgcaacatc cttcttcagc atttatgcca
     4081 tatgttattc aatgtttgct atcataataa acattacaat aaa
//
