LOCUS       NM_022712               4805 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus transferrin receptor (Tfrc), mRNA.
ACCESSION   NM_022712 XM_001072774 XM_340999
VERSION     NM_022712.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4805)
  AUTHORS   Xing,P., Zhou,M., Sun,J., Wang,D., Huang,W. and An,P.
  TITLE     NAT10-mediated ac4C acetylation of TFRC promotes sepsis-induced
            pulmonary injury through regulating ferroptosis
  JOURNAL   Mol Med 30 (1), 140 (2024)
   PUBMED   39251905
  REMARK    GeneRIF: NAT10-mediated ac[4]C acetylation of TFRC promotes
            sepsis-induced pulmonary injury through regulating ferroptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4805)
  AUTHORS   Ma,H., Huang,Y., Tian,W., Liu,J., Yan,X., Ma,L. and Lai,J.
  TITLE     Endothelial transferrin receptor 1 contributes to thrombogenesis
            through cascade ferroptosis
  JOURNAL   Redox Biol 70, 103041 (2024)
   PUBMED   38241836
  REMARK    GeneRIF: Endothelial transferrin receptor 1 contributes to
            thrombogenesis through cascade ferroptosis.
REFERENCE   3  (bases 1 to 4805)
  AUTHORS   Chen,L., Ma,Y., Ma,X., Liu,L., Jv,X., Li,A., Shen,Q., Jia,W.,
            Qu,L., Shi,L. and Xie,J.
  TITLE     TFEB regulates cellular labile iron and prevents ferroptosis in a
            TfR1-dependent manner
  JOURNAL   Free Radic Biol Med 208, 445-457 (2023)
   PUBMED   37683766
  REMARK    GeneRIF: TFEB regulates cellular labile iron and prevents
            ferroptosis in a TfR1-dependent manner.
REFERENCE   4  (bases 1 to 4805)
  AUTHORS   Zhang,L., Wang,X., Che,W., Zhou,S. and Feng,Y.
  TITLE     METTL3 silenced inhibited the ferroptosis development via
            regulating the TFRC levels in the Intracerebral hemorrhage
            progression
  JOURNAL   Brain Res 1811, 148373 (2023)
   PUBMED   37105375
  REMARK    GeneRIF: METTL3 silenced inhibited the ferroptosis development via
            regulating the TFRC levels in the Intracerebral hemorrhage
            progression.
REFERENCE   5  (bases 1 to 4805)
  AUTHORS   Wei,X.B., Jiang,W.Q., Zeng,J.H., Huang,L.Q., Ding,H.G., Jing,Y.W.,
            Han,Y.L., Li,Y.C. and Chen,S.L.
  TITLE     Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated
            Encephalopathy by Promoting Ferroptosis Through Regulating
            miR-9-5p/TFRC and GOT1 Axis
  JOURNAL   Mol Neurobiol 59 (3), 1954-1969 (2022)
   PUBMED   35038133
  REMARK    GeneRIF: Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated
            Encephalopathy by Promoting Ferroptosis Through Regulating
            miR-9-5p/TFRC and GOT1 Axis.
            Erratum:[Mol Neurobiol. 2022 Aug;59(8):5252. doi:
            10.1007/s12035-022-02931-2.. PMID: 35727437]
REFERENCE   6  (bases 1 to 4805)
  AUTHORS   Kennard,M.L., Richardson,D.R., Gabathuler,R., Ponka,P. and
            Jefferies,W.A.
  TITLE     A novel iron uptake mechanism mediated by GPI-anchored human p97
  JOURNAL   EMBO J 14 (17), 4178-4186 (1995)
   PUBMED   7556058
REFERENCE   7  (bases 1 to 4805)
  AUTHORS   Baynes,R.D., Shih,Y.J., Hudson,B.G. and Cook,J.D.
  TITLE     Characterization of transferrin receptor released by K562
            erythroleukemia cells
  JOURNAL   Proc Soc Exp Biol Med 197 (4), 416-423 (1991)
   PUBMED   1871153
REFERENCE   8  (bases 1 to 4805)
  AUTHORS   Mechtersheimer,G., Kruger,K.H., Born,I.A. and Moller,P.
  TITLE     Antigenic profile of mammary fibroadenoma and cystosarcoma
            phyllodes. A study using antibodies to estrogen- and progesterone
            receptors and to a panel of cell surface molecules
  JOURNAL   Pathol Res Pract 186 (4), 427-438 (1990)
   PUBMED   2174150
REFERENCE   9  (bases 1 to 4805)
  AUTHORS   Roberts,K.P. and Griswold,M.D.
  TITLE     Characterization of rat transferrin receptor cDNA: the regulation
            of transferrin receptor mRNA in testes and in Sertoli cells in
            culture
  JOURNAL   Mol Endocrinol 4 (4), 531-542 (1990)
   PUBMED   2126342
REFERENCE   10 (bases 1 to 4805)
  AUTHORS   FitzGerald,D.J., Bjorn,M.J., Ferris,R.J., Winkelhake,J.L.,
            Frankel,A.E., Hamilton,T.C., Ozols,R.F., Willingham,M.C. and
            Pastan,I.
  TITLE     Antitumor activity of an immunotoxin in a nude mouse model of human
            ovarian cancer
  JOURNAL   Cancer Res 47 (5), 1407-1410 (1987)
   PUBMED   3493065
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB762571.1, CB809947.1, BP500872.1, FM033330.1, CB700894.1,
            CV117527.1, CV111368.1, CV117299.1, FM123390.1, CO398424.1,
            AI029320.1 and CA509549.1.
            
            On or before Dec 17, 2009 this sequence version replaced
            XM_340999.3, XM_001072774.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760396
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               CB762571.1         13-336
            325-371             CB809947.1         319-365
            372-1011            BP500872.1         30-669
            1012-1314           FM033330.1         292-594
            1315-1602           CB700894.1         14-301
            1603-2094           CV117527.1         127-618
            2095-2707           CV111368.1         62-674
            2708-3249           CV117299.1         100-641
            3250-3890           FM123390.1         35-675
            3891-4471           CO398424.1         56-636
            4472-4785           AI029320.1         15-328              c
            4786-4805           CA509549.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..4805
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..4805
                     /gene="Tfrc"
                     /gene_synonym="Trfr"
                     /note="transferrin receptor"
                     /db_xref="GeneID:64678"
                     /db_xref="RGD:70488"
     exon            1..111
                     /gene="Tfrc"
                     /gene_synonym="Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            112..169
                     /gene="Tfrc"
                     /gene_synonym="Trfr"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..2419
                     /gene="Tfrc"
                     /gene_synonym="Trfr"
                     /note="TR; tfR; tfR1"
                     /codon_start=1
                     /product="transferrin receptor protein 1"
                     /protein_id="NP_073203.1"
                     /db_xref="GeneID:64678"
                     /db_xref="RGD:70488"
                     /translation="MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAADE
                     EENADSNMKASVRKPKRFNGRLCFATIAVVIFFLIGFMIGYLGYCKRVEQKEECVRLA
                     EAEEADKSENDETEYVPKSSRLFWADLKTLLSEKLNSIEFTDIIKQLSQNTYTPREAG
                     SQKDENLAYYIENLFHDFKFSKVWRDEHYVKIQVKNSVSQNLVTINSGSNIDPVEAPE
                     GYVAFSKAGEVTGKLVHANFGTKKDFEELNYSVNGSLVIVRAGKITFAEKVANAQSFN
                     AIGVLIYMDRNTFPVVEADLQFFGHAHLGTGDPYTPGFPSFNHTQFPPSQSSGLPSIP
                     VQTISRAAAEKLFKNMEGNCPPSWNIDSSCKLELSQNQNVKLTVNNVLKETRILNIFG
                     VIKGYEEPDRYIVVGAQRDAWGPGVAKSSVGTGLLLKLAQVFSDMISKDGFRPSRSII
                     FASWTAGDYGAVGATEWLEGYLSSLHLKAFTYINLDKVVLGTSNFKVSASPLLYTLMG
                     KIMQDVKHPIDGKYLYRDSNWISKIEELSLDNAAFPFLAYSGIPAVSFCFCEDEDYPY
                     LGTKLDTYEILIQKVPQLNQMVRTAAEVAGQFIIKLTHDIELTLDYEMYNSKLLSFMK
                     DLNQFKADIKDMGLSLQWLYSARGDYFRATSRLTTDFHNAEKTNRFVMREINDRIMKV
                     EYHFLSPYVSPRESPFRHIFWGSGSHTLSALVENLRLRQKNITAFNETLFRNQLALAT
                     WTIQGVANALSGDIWNIDNEF"
     exon            170..371
                     /gene="Tfrc"
                     /gene_synonym="Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            372..573
                     /gene="Tfrc"
                     /gene_synonym="Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            574..723
                     /gene="Tfrc"
                     /gene_synonym="Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            724..823
                     /gene="Tfrc"
                     /gene_synonym="Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            824..937
                     /gene="Tfrc"
                     /gene_synonym="Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1036
                     /gene="Tfrc"
                     /gene_synonym="Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1176
                     /gene="Tfrc"
                     /gene_synonym="Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1334
                     /gene="Tfrc"
                     /gene_synonym="Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1454
                     /gene="Tfrc"
                     /gene_synonym="Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1540
                     /gene="Tfrc"
                     /gene_synonym="Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1604
                     /gene="Tfrc"
                     /gene_synonym="Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1672
                     /gene="Tfrc"
                     /gene_synonym="Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1731
                     /gene="Tfrc"
                     /gene_synonym="Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1813
                     /gene="Tfrc"
                     /gene_synonym="Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..2035
                     /gene="Tfrc"
                     /gene_synonym="Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2176
                     /gene="Tfrc"
                     /gene_synonym="Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..4787
                     /gene="Tfrc"
                     /gene_synonym="Trfr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccggcccg ggggcggggc cggcctatat gcttgggtag gaggcagcgc tcctttcaga
       61 aggcgtgtgg agcgcgggcc gctgcattgc ggactgagga ggtgcttcag agtgctccct
      121 tgtacaactg agaatgatgg atcaagccag atcagcattc tctaacttgt ttggagggga
      181 gccattgtca tacacccggt ttagccttgc tcggcaagta gatggagata acagtcatgt
      241 ggagatgaaa ctggctgcag atgaggaaga aaatgctgac agtaacatga aggctagtgt
      301 cagaaaaccc aaaaggttta atggaagact ctgctttgcg actattgcag tagtcatctt
      361 ttttttgatt ggatttatga tcggctacct gggctattgt aagcgcgtag aacaaaaaga
      421 ggagtgtgtg agactggctg aagcggaaga ggcggacaag tcagaaaacg acgaaacaga
      481 atatgttcct aaatcttctc gcttattttg ggcagacctc aaaacactgt tgtcagagaa
      541 attgaattcc atagagttca ctgacatcat caagcagctg agccagaata catatactcc
      601 tcgtgaggct ggatctcaga aagacgagaa tcttgcctat tatattgaaa atctgttcca
      661 tgactttaaa ttcagcaaag tctggcgaga tgaacattat gtgaagattc aagtgaaaaa
      721 cagtgtttct caaaacttgg tgaccataaa ttcaggtagt aacattgacc cagtggaggc
      781 tcctgagggt tatgtggcat ttagtaaagc tggagaagtt actggtaaac tggtccatgc
      841 taattttggc actaaaaagg actttgaaga attaaattat tctgtgaatg gatctttagt
      901 gattgttaga gcagggaaaa ttacttttgc agaaaaggtt gcaaatgccc aaagctttaa
      961 tgcaattggt gtcctcatct acatggacag gaatacgttc cccgttgttg aggcagacct
     1021 tcaattcttt ggacatgctc atctaggaac tggggatcca tatacacctg gctttccttc
     1081 tttcaaccat actcagtttc cgccatctca gtcatctgga ttgccttcta tacctgtgca
     1141 gacgatctca agagctgctg cagaaaagct attcaaaaac atggaaggaa actgtcctcc
     1201 tagttggaat atagattcct catgtaagct ggaactttca cagaatcaaa atgtgaagct
     1261 cactgtgaac aatgtactga aagaaacaag aatacttaac atctttggcg ttattaaagg
     1321 ctatgaggaa ccagaccgct acattgtagt aggagcccag agagacgctt ggggccctgg
     1381 tgttgcgaag tccagtgtgg gaacaggtct tctgttgaaa cttgcccaag tattctcaga
     1441 tatgatttca aaagatggat ttagacccag caggagtatt atctttgcca gctggactgc
     1501 aggagactat ggagctgttg gtgccactga gtggctggag gggtaccttt catctttgca
     1561 tctaaaggct ttcacttaca ttaatctgga taaagtcgtc ctgggtacta gcaacttcaa
     1621 ggtttctgcc agccccctat tatatacact tatggggaag ataatgcagg acgtaaagca
     1681 tccgattgat ggaaaatatc tatatcgaga cagtaattgg attagcaaaa ttgaggaact
     1741 ttccttggac aatgctgcat tcccttttct tgcatattca ggaatcccag cagtttcttt
     1801 ctgtttttgt gaggatgagg actatcctta tttgggcact aaactagata cctatgagat
     1861 attaattcag aaagttcctc agctcaacca aatggttcgt acagcagcag aggtggccgg
     1921 tcagttcatt attaaactta cccatgacat tgagttgacc ctggactatg agatgtacaa
     1981 cagcaaacta ctgtcattta tgaaggatct gaaccagttc aaagcagata tcaaagatat
     2041 gggtctaagt ctacaatggc tgtattctgc tcgtggagac tacttccgtg ctacttctag
     2101 actaacaact gattttcata atgctgagaa aacaaacaga ttcgtcatga gggaaatcaa
     2161 tgatcgtatt atgaaagtgg agtatcactt cctgtcaccc tatgtatctc caagagagtc
     2221 tcctttccga cacatcttct ggggctctgg ctctcacacc ctctcagctt tagtggagaa
     2281 cctgagactt cgtcagaaaa atatcactgc tttcaatgaa acgctcttca gaaaccagtt
     2341 ggccctggct acgtggacta ttcagggagt tgcaaatgcc ctctctggtg acatttggaa
     2401 tattgacaat gagttttaaa tgtaatgtgc ataattaagt gagagagggt agtctgtttc
     2461 tagacttgag ctggttgtgc taaattttca ttagagctct aaaacctaat gttaaaaatt
     2521 ctacccaatc atctaatgtg tttaggcagc agcttttagt gcagggttgg acccacactt
     2581 caagttacag tggacaacac tttccatgtt catgatacct tcttagatta tctttagaat
     2641 tttgagtctt ttgtaatacc ttgctctttg cttcatggtc atgaaaatgt cagaaccagt
     2701 tgtaagaaca ttgctataag tcctgagggc actactagta tcttgaggtg ggaggaagag
     2761 ggtgtatgtg aggggcagag tggtcgctgg gtgtgattcc ccatctccat ctgaccctca
     2821 ctgggattct ccaattgagc tgtatgcctg aaggatttag ctggcttcca ttcccctaaa
     2881 gtagacagtt acttttcaga agaggtgcaa cttgttttct tgccagcaag gttgaactag
     2941 gtccttctgc tggataaaag aaaggaagtt tgtctgttta caggaataag gccttattgg
     3001 tttaaccttt gtgttattta ggatgagacc agaagccaaa gacttcaagt tttctctcca
     3061 ctgtcatcta cccagtagtc tttagttctt tgggttgttt tgtttttgtt ttgtttttct
     3121 tttccaacac tttctgaaaa agaacaggtt tagactcagt ctgtcagcag aacacactgc
     3181 cgagctctgg ccaaagtgct ggtcttcagg gaagctctgt cgtttttggc actgagatat
     3241 ttattgttta tttatcagtg acagagttca ctataaatag tgttttttta atagaagata
     3301 attatcggaa gcagtgcctt ccataattat gacagttata ctgtcgtttt cttttaataa
     3361 aagcagcatc tgctaatgag acccacagat actggaagtt ttgcacttac ggtcagcact
     3421 tgcgggcttt agaaaggaga aagccacaag ccaaacaata tccgatgagc tagaagagga
     3481 ttgggttaaa taagagattc ctagttgagt tggaaaaaaa tgataattct aagtccagtg
     3541 agttgtggcc aagttaaatg tcatttaaag gctatgatag tacatcaaca aaattctata
     3601 gctcagttta ttcaagatgt aactcaaatc caattttgca aaatttccag tacctttgtc
     3661 acaaacttaa ctcacattat cgggagcagt gtcttccata atgtataaag aacaaggtag
     3721 tttttgccta ccacagtgtc tatatcggag acagtgacct ccatatgtta cactaagggt
     3781 gtacgtaatt atcgggaaca gtgtttccca taattttctt catgcgatga catcttcaaa
     3841 gcttgaagat cgttagtatc taacatgaat tcccaacttc ctgtagcgcc ttagttttag
     3901 ttgcaaaaac atttgtggtc gttgagcatt tggtgagtaa atgcaaccgc tatacaataa
     3961 aatcattact tccaatatcc tgttttaaaa catgggtgtt ctgttatctg gtttatggaa
     4021 tggaagcata cgttaagaat atttgctggt gacaaaggga tttaactgtc tccctttatt
     4081 tgcatgttat ttcttaaatg tagttcttag tctgaattca tttttggttt ttggaagggt
     4141 agagagtaga gaataacggg tgttgggaaa caaagcttgc aaaaggatct ttatgtacct
     4201 gcccatcact atggtggcta taaattatgt aaataatgag caagatcaaa ttaacaaaga
     4261 ctagttaccc agcattccgc atctagtcag ttttgtcatg gggcagttca aagctgccac
     4321 ctgagaacat cactaggctc tcagggttct tggcaccact cacccaagtt acatccacca
     4381 gattattttc agtcttcaca agtatcacca tgcatagtgg gattttcagc catgaataaa
     4441 gggcgtgcgt tttgccatat cagtctctaa aataaccttt gctaatcaat gcagtgagtt
     4501 gctaaggttt agtcttgggt aaaatgtgtg tctgaataac agcttctgtt actcataagg
     4561 ttattatcgg gtaaaatgta tatcttgaac ataagaatag agcgcgcctt tatcatgatt
     4621 cactgctaga attcgcatga cctttactgt gttagctttt gaatatcttt gggacttgct
     4681 aacctatact cagccatctt tgctgacatg cccttataga tgtatacagc tggtgtttaa
     4741 caatgtgaag attccttacc tgacttaata aaatacttcg atatactaaa aaaaaaaaaa
     4801 aaaaa
//
