LOCUS       NM_001105916            2964 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus transferrin receptor 2 (Tfr2), mRNA.
ACCESSION   NM_001105916 XM_001068938 XM_222022
VERSION     NM_001105916.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2964)
  AUTHORS   Radziejewska,A., Suliburska,J., Kolodziejski,P. and Chmurzynska,A.
  TITLE     Role of Slc19a1 and Tfr2 in liver transport of iron and folate: A
            rat model of folate/iron deficiency followed by supplementation
  JOURNAL   J Trace Elem Med Biol 62, 126568 (2020)
   PUBMED   32521439
  REMARK    GeneRIF: Role of Slc19a1 and Tfr2 in liver transport of iron and
            folate: A rat model of folate/iron deficiency followed by
            supplementation.
REFERENCE   2  (bases 1 to 2964)
  AUTHORS   Guo,S., Yang,C., Jiang,S., Ni,Y., Zhao,R. and Ma,W.
  TITLE     Repeated Restraint Stress Enhances Hepatic TFR2 Expression and
            Induces Hepatic Iron Accumulation in Rats
  JOURNAL   Biol Trace Elem Res 196 (2), 590-596 (2020)
   PUBMED   31707638
  REMARK    GeneRIF: Repeated Restraint Stress Enhances Hepatic TFR2 Expression
            and Induces Hepatic Iron Accumulation in Rats.
REFERENCE   3  (bases 1 to 2964)
  AUTHORS   Chen,J. and Enns,C.A.
  TITLE     CD81 promotes both the degradation of transferrin receptor 2 (TfR2)
            and the Tfr2-mediated maintenance of hepcidin expression
  JOURNAL   J Biol Chem 290 (12), 7841-7850 (2015)
   PUBMED   25635054
REFERENCE   4  (bases 1 to 2964)
  AUTHORS   Bartnikas,T.B., Wildt,S.J., Wineinger,A.E., Schmitz-Abe,K.,
            Markianos,K., Cooper,D.M. and Fleming,M.D.
  TITLE     A novel rat model of hereditary hemochromatosis due to a mutation
            in transferrin receptor 2
  JOURNAL   Comp Med 63 (2), 143-155 (2013)
   PUBMED   23582421
  REMARK    GeneRIF: A mutation with the Tfr2 gene causes hemochromatosis in
            the rat.
REFERENCE   5  (bases 1 to 2964)
  AUTHORS   Vujic Spasic,M., Sparla,R., Mleczko-Sanecka,K., Migas,M.C.,
            Breitkopf-Heinlein,K., Dooley,S., Vaulont,S., Fleming,R.E. and
            Muckenthaler,M.U.
  TITLE     Smad6 and Smad7 are co-regulated with hepcidin in mouse models of
            iron overload
  JOURNAL   Biochim Biophys Acta 1832 (1), 76-84 (2013)
   PUBMED   22960056
REFERENCE   6  (bases 1 to 2964)
  AUTHORS   Goswami,T. and Andrews,N.C.
  TITLE     Hereditary hemochromatosis protein, HFE, interaction with
            transferrin receptor 2 suggests a molecular mechanism for mammalian
            iron sensing
  JOURNAL   J Biol Chem 281 (39), 28494-28498 (2006)
   PUBMED   16893896
REFERENCE   7  (bases 1 to 2964)
  AUTHORS   Weizer-Stern,O., Adamsky,K., Amariglio,N., Rachmilewitz,E.,
            Breda,L., Rivella,S. and Rechavi,G.
  TITLE     mRNA expression of iron regulatory genes in beta-thalassemia
            intermedia and beta-thalassemia major mouse models
  JOURNAL   Am J Hematol 81 (7), 479-483 (2006)
   PUBMED   16755567
REFERENCE   8  (bases 1 to 2964)
  AUTHORS   Nakamaki,T., Kawabata,H., Saito,B., Matsunawa,M., Suzuki,J.,
            Adachi,D., Tomoyasu,S. and Phillip Koeffler,H.
  TITLE     Elevated levels of transferrin receptor 2 mRNA, not transferrin
            receptor 1 mRNA, are associated with increased survival in acute
            myeloid leukaemia
  JOURNAL   Br J Haematol 125 (1), 42-49 (2004)
   PUBMED   15015967
REFERENCE   9  (bases 1 to 2964)
  AUTHORS   Griffiths,W.J. and Cox,T.M.
  TITLE     Co-localization of the mammalian hemochromatosis gene product (HFE)
            and a newly identified transferrin receptor (TfR2) in intestinal
            tissue and cells
  JOURNAL   J Histochem Cytochem 51 (5), 613-624 (2003)
   PUBMED   12704209
REFERENCE   10 (bases 1 to 2964)
  AUTHORS   Camaschella,C., Roetto,A., Cali,A., De Gobbi,M., Garozzo,G.,
            Carella,M., Majorano,N., Totaro,A. and Gasparini,P.
  TITLE     The gene TFR2 is mutated in a new type of haemochromatosis mapping
            to 7q22
  JOURNAL   Nat Genet 25 (1), 14-15 (2000)
   PUBMED   10802645
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473973.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_222022.4, XM_001068938.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC166451.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760400, SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2964
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2964
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="transferrin receptor 2"
                     /db_xref="GeneID:288562"
                     /db_xref="RGD:1310152"
     exon            1..124
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            125..171
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            172..225
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..2589
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /codon_start=1
                     /product="transferrin receptor protein 2"
                     /protein_id="NP_001099386.1"
                     /db_xref="GeneID:288562"
                     /db_xref="RGD:1310152"
                     /translation="MEQRWGLLRKVQQWSPRPSQTIYRRVEGPQLENLEEEDREEGEE
                     LPAQFCPMELKGPERLGSCPGRSIPIPWAAAGRKAAPYLVLTTLLIFTGAFLLGYVAF
                     RGSCQACGDSVLVVGEDVNSEDSSRGTLYWSDLQDMFLRFLGEGRMEDTIRLTSLRER
                     VAGSARMATLVQDILDKLSRQKLDHVWTDTHYVGLQFPDPAHPNTLHWVGADGSVQEQ
                     LPLEDPEVYCPYSATGNATGKLVYAHYGRREDLQDLKAKDVELAGSLLLVRAGITSFA
                     QKVAIAQDFGAHGVLIYPDPADFSQDPHKPGLSSDRAVYGHVHLGTGDPYTPGFPSFN
                     QTQFPPVESSGLPNIPAQPISADVADRLLRKLTGPVAPQEWKGRLSDSPYRLGPGPGL
                     RLVVNNHRTSTPISNIFACIEGFAEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVR
                     TFSSMVSSGFRPRRSLLFISWDGGDFGSVGATEWLEGYLSVLHLKAVVYVSLDNSVLG
                     DGKFHAKTSPLLVSLIENILKQVDSPNHSGQTLYDQVAFTHPSWDAEVIQPLPMDSSA
                     YSFTAFAGVPAVEFSFMEDDRVYPFLHTKEDTYENLHKMLRGRLPAVVLAVAQLAGQL
                     LIRLSHDHLLPLDFGRYGDVVLRHIGNLNEFSGDLKARGLTLQWVYSARGDYIRAAEK
                     LRKEIYSSEQSDERLMRMYNVRIMRVEFYFLSQYVSPADSPFRHIFLGQGDHTLGALV
                     EHLRMLRSDGSGAASSGLSPGLGFQESRFRRQLALLTWTLQGAANALSGDVWNIDNNF
                     "
     exon            226..472
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            473..650
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            651..791
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            792..903
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1026
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1143
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1283
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1447
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1567
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1650
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1714
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1782
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1859
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1944
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2172
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2313
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2964
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaatccagag acctgttgct gagttgaact tggctgctgt gtcttcccac tcaggactcg
       61 gctttgacag gcacgaggca gggactgggg tgagccccta cctctcagat ctttctggac
      121 ctggctgcgg gtcctgggat cttcagcgcg gcttggattt caaactggag gggttcagga
      181 gggggcacaa gcatggaaca acgttggggt ctacttcgga aagtgcaaca gtggtcccca
      241 agaccctctc agaccatcta cagacgtgtg gaaggccctc aactggagaa cctagaggag
      301 gaagataggg aggaagggga ggagcttcct gcccagttct gccccatgga actcaaaggc
      361 cctgagcgct taggctcctg tcctgggagg tccattccca taccctgggc tgcagcaggt
      421 cgaaaggctg ctccctatct ggtcctgacc accctgctaa tcttcactgg ggccttcctc
      481 ctgggctacg tggcctttcg agggtcctgc caggcatgtg gggactctgt gttggtggtt
      541 ggtgaagatg tcaactctga ggactccagc cggggcacgt tgtactggag tgacctccag
      601 gacatgtttc tccggttcct tggggaggga cgcatggagg acaccatcag gctgaccagc
      661 ctccgggaac gcgtggccgg ctcagccaga atggccaccc tggtccaaga catcctcgat
      721 aagctctcgc gccagaagct ggaccacgtg tggactgaca cgcactatgt gggacttcag
      781 ttcccggacc cggctcaccc taacaccctg cactgggtgg gtgcagacgg gagcgtccaa
      841 gagcagctac cgctggagga tccggaagtc tactgtccct acagcgccac gggcaacgcc
      901 acgggcaagc ttgtgtacgc ccactacggg cggcgggagg acctgcagga cctgaaagcc
      961 aaggacgtgg agctggccgg cagcctcctg ctagtgcgtg ctgggattac aagcttcgcc
     1021 cagaaggtag ccattgccca ggactttggg gcccacggag tgctgatata ccctgaccca
     1081 gcggacttct cccaagaccc ccacaagcca ggcctgtcta gtgacagggc tgtgtatgga
     1141 catgtgcacc tgggaactgg ggacccttac acgcctggct tcccgtcctt caatcaaacc
     1201 cagttccctc cagtagaatc atcggggctt cccaacatcc ctgcccagcc catcagtgcc
     1261 gacgttgctg atcgcttgct caggaaactc acaggtcccg tggctcctca ggaatggaag
     1321 ggtcgcctct cagactctcc gtatcgcctg ggacctgggc caggcttacg ccttgtggtc
     1381 aacaaccaca gaacctctac tcccatcagt aacatctttg cgtgcatcga gggcttcgca
     1441 gagccagatc actatgtcgt tatcggggcc cagagggatg cctggggccc aggagcagcc
     1501 aagtctgcag tggggactgc catcctcctg gagctggttc ggaccttttc ctccatggtc
     1561 agcagtggct ttagacctcg aagaagtctt ttgttcatca gctgggacgg aggtgacttt
     1621 ggcagcgtgg gagccacgga gtggttggag ggctacctca gcgtgctaca cctcaaagct
     1681 gtcgtgtatg tgagcctgga caactccgtg ttgggagacg gcaaattcca tgctaagacc
     1741 agcccccttc tcgtcagcct cattgagaat atcctgaagc aggtggattc ccctaaccac
     1801 agtggacaga cactctacga tcaagtggca ttcacccacc caagctggga tgctgaagtg
     1861 atccagcccc tgcccatgga cagcagcgca tattccttca cagcttttgc gggcgtccca
     1921 gctgtggagt tctccttcat ggaggacgat agggtgtacc cattcctgca cacgaaggag
     1981 gacacgtatg agaatctgca caagatgctg cgaggtcgcc tgcccgccgt ggtcctagca
     2041 gtggctcagc tcgctggtca gctcctcatc cgactgagcc acgatcacct actgccgctg
     2101 gacttcggcc gctacggaga cgtggtcctc aggcacatcg gcaaccttaa tgagttctct
     2161 ggggacctca aggcgcgcgg gctgaccctg cagtgggtgt actctgcaag gggggactat
     2221 atccgggcgg cggagaagct gcggaaggag atttacagct cggagcagag cgatgagcgt
     2281 ctgatgcgca tgtacaacgt gcgcatcatg agggtggagt tctacttcct gtcccagtac
     2341 gtgtcgccgg ccgactcccc attccgccac attttcctag gccaaggcga ccacactttg
     2401 ggtgccctgg tggaacacct acggatgctg cgctccgatg gctcaggagc tgcctcttct
     2461 gggttgagcc caggtctggg cttccaggag agtcgcttcc ggcgacagct ggcgctgctc
     2521 acgtggacgc tacagggggc agccaacgca ctcagtggcg acgtttggaa catcgacaat
     2581 aacttttgag gccagaagtc ctccatgggc cccacgtgat tctcctttct ccctatttga
     2641 gtggtgcagg caacggaggt gcctgagagc aacctatcct cattaacaac cttggtcctg
     2701 caacgccagt gagacatatt ttctcagtgt gactgttata ccactgttta tccagaaagc
     2761 ggttttcttc ccatcactgg cctctctgcc ttcaggagca tagttcccca tatctagaaa
     2821 ccatctagac actgggatcc agctctctta gcgggtgaga tggatagcgt cattttctta
     2881 tgacacacaa gtggtatgtg ggtggcccaa gggggattag atgtcaataa accatttacc
     2941 tggtaacctc tgttgtccat aagc
//
