LOCUS       NM_173141               1130 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus tissue factor pathway inhibitor 2 (Tfpi2), mRNA.
ACCESSION   NM_173141 XM_346686 XM_347366
VERSION     NM_173141.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1130)
  AUTHORS   Xu,Z., Zhu,X., Mu,S., Fan,R., Wang,B., Gao,W. and Kang,T.
  TITLE     FTO overexpression expedites wound healing and alleviates
            depression in burn rats through facilitating keratinocyte migration
            and angiogenesis via mediating TFPI-2 demethylation
  JOURNAL   Mol Cell Biochem 479 (2), 325-335 (2024)
   PUBMED   37074506
  REMARK    GeneRIF: FTO overexpression expedites wound healing and alleviates
            depression in burn rats through facilitating keratinocyte migration
            and angiogenesis via mediating TFPI-2 demethylation.
REFERENCE   2  (bases 1 to 1130)
  AUTHORS   Jang,Y.J., Kim,H.K., Choi,B.C., Song,S.J., Park,J.I., Chun,S.Y. and
            Cho,M.K.
  TITLE     Expression of tissue factor and tissue factor pathway inhibitors
            during ovulation in rats: a relevance to the ovarian
            hyperstimulation syndrome
  JOURNAL   Reprod Biol Endocrinol 19 (1), 52 (2021)
   PUBMED   33794911
  REMARK    GeneRIF: Expression of tissue factor and tissue factor pathway
            inhibitors during ovulation in rats: a relevance to the ovarian
            hyperstimulation syndrome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1130)
  AUTHORS   Liu,Z., Zhang,J., Gao,Y., Pei,L., Zhou,J., Gu,L., Zhang,L., Zhu,B.,
            Hattori,N., Ji,J., Yuasa,Y., Kim,W., Ushijima,T., Shi,H. and
            Deng,D.
  TITLE     Large-scale characterization of DNA methylation changes in human
            gastric carcinomas with and without metastasis
  JOURNAL   Clin Cancer Res 20 (17), 4598-4612 (2014)
   PUBMED   25009298
REFERENCE   4  (bases 1 to 1130)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   5  (bases 1 to 1130)
  AUTHORS   Jian,P., Yan,W.S., Chao,S.L., Liang,P., Zhen,L., Ling,Q.B.,
            Hong,L.Y., Ping,L.Y., Jian,W., Fang,J.M., Ling,L., Dong,W.X.,
            Ming,Z.X. and Jian,N.
  TITLE     Promoter of TFPI-2 is hypermethylated in Chinese pediatric acute
            myeloid leukemia
  JOURNAL   J Pediatr Hematol Oncol 34 (1), 43-46 (2012)
   PUBMED   22052167
REFERENCE   6  (bases 1 to 1130)
  AUTHORS   Ekstrand,J., Razuvaev,A., Folkersen,L., Roy,J. and Hedin,U.
  TITLE     Tissue factor pathway inhibitor-2 is induced by fluid shear stress
            in vascular smooth muscle cells and affects cell proliferation and
            survival
  JOURNAL   J Vasc Surg 52 (1), 167-175 (2010)
   PUBMED   20537494
  REMARK    GeneRIF: TFPI-2 influences smooth muscle cell proliferation and
            apoptosis in vitro in response to fluid shear stress.
REFERENCE   7  (bases 1 to 1130)
  AUTHORS   Obata,R., Yanagi,Y., Tamaki,Y., Hozumi,K., Mutoh,M. and Tanaka,Y.
  TITLE     Retinal degeneration is delayed by tissue factor pathway
            inhibitor-2 in RCS rats and a sodium-iodate-induced model in
            rabbits
  JOURNAL   Eye (Lond) 19 (4), 464-468 (2005)
   PUBMED   15184935
REFERENCE   8  (bases 1 to 1130)
  AUTHORS   Hisaka,T., Kisiel,W. and Rosenbaum,J.
  TITLE     cDNA cloning and tissue distribution of the rat ortholog of tissue
            factor pathway inhibitor-2
  JOURNAL   Thromb Haemost 88 (2), 356-357 (2002)
   PUBMED   12195712
REFERENCE   9  (bases 1 to 1130)
  AUTHORS   Konduri,S.D., Rao,C.N., Chandrasekar,N., Tasiou,A., Mohanam,S.,
            Kin,Y., Lakka,S.S., Dinh,D., Olivero,W.C., Gujrati,M., Foster,D.C.,
            Kisiel,W. and Rao,J.S.
  TITLE     A novel function of tissue factor pathway inhibitor-2 (TFPI-2) in
            human glioma invasion
  JOURNAL   Oncogene 20 (47), 6938-6945 (2001)
   PUBMED   11687973
REFERENCE   10 (bases 1 to 1130)
  AUTHORS   Miyagi,Y., Yasumitsu,H., Mizushima,H., Koshikawa,N., Matsuda,Y.,
            Itoh,H., Hori,T.A., Aoki,I., Misugi,K. and Miyazaki,K.
  TITLE     Cloning of the cDNA encoding mouse PP5/TFPI-2 and mapping of the
            gene to chromosome 6
  JOURNAL   DNA Cell Biol 15 (11), 947-954 (1996)
   PUBMED   8945635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_173141.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ428954.1, SRR26643285.15233.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               JAXUCZ010000004.1  32941137-32941276   c
            141-323             JAXUCZ010000004.1  32940732-32940914   c
            324-506             JAXUCZ010000004.1  32938998-32939180   c
            507-677             JAXUCZ010000004.1  32937658-32937828   c
            678-1130            JAXUCZ010000004.1  32936854-32937306   c
FEATURES             Location/Qualifiers
     source          1..1130
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q13"
     gene            1..1130
                     /gene="Tfpi2"
                     /note="tissue factor pathway inhibitor 2"
                     /db_xref="GeneID:286926"
                     /db_xref="RGD:628629"
     exon            1..140
                     /gene="Tfpi2"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..745
                     /gene="Tfpi2"
                     /codon_start=1
                     /product="tissue factor pathway inhibitor 2 precursor"
                     /protein_id="NP_775164.2"
                     /db_xref="GeneID:286926"
                     /db_xref="RGD:628629"
                     /translation="MDPATSLRLWNLPLLLVGSALGLASVSAQGNNLEICLLPLDMGP
                     CKALIPKFYYDRDQKKCRRFKYGGCLGNANNFHSRKLCEHTCGNKEKVPWVCRSAVRT
                     YPCDKPNTEFFFNLKTMTCEPLRPGLCSRTTNVFPEEAMCKSLCEPRKSIPSFCSSPK
                     DEGLCSANVTRYYFNSRNKACETFTYTGCGGNENNFYYLDACNRACVKALKKPKRRKI
                     GDFLPRFWKLRS"
     exon            141..323
                     /gene="Tfpi2"
                     /inference="alignment:Splign:2.1.0"
     exon            324..506
                     /gene="Tfpi2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..677
                     /gene="Tfpi2"
                     /inference="alignment:Splign:2.1.0"
     exon            678..1130
                     /gene="Tfpi2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcactctcc tccctctctc cgcgcatcca ggcagccgca ccacccggtc gtatggaccc
       61 tgctacatcc ctgagactgt ggaatctgcc gctgctcctg gtgggttcag ctcttggtct
      121 cgcttcagta tctgcccaag ggaataactt agagatctgc ctcttgcctt tggacatggg
      181 accttgtaag gccctcatcc ccaagttcta ctatgacagg gaccagaaga aatgccgcag
      241 attcaagtat ggaggctgcc tgggcaatgc caacaatttc cacagtcgga aactctgcga
      301 acacacttgc ggaaataagg agaaagttcc ttgggtttgt cgatcagcag tcagaacgta
      361 tccgtgtgat aaacccaata cagagttttt cttcaatctg aaaactatga catgtgagcc
      421 tcttaggcct ggtctgtgta gcaggactac gaatgtgttc cccgaggaag ctatgtgtaa
      481 gagcttatgt gaaccaagga aaagtatccc atcattttgc tccagtccaa aagatgaagg
      541 cctgtgttct gctaatgtga cccgctatta ttttaattca agaaacaaag cctgcgagac
      601 cttcacctac actggctgtg gtggcaatga aaataacttt tattacctgg atgcttgcaa
      661 ccgtgcctgt gttaaagcct tgaagaagcc caagagaagg aagataggtg atttcctgcc
      721 gagattttgg aagcttcgtt cttaagcatt ttctcatact caaggaaaca agtcattagt
      781 aatttgcttt tcttgtttta ctgatgtgcc aatatttttt gaatctgtgt gtttttattt
      841 attccaagct gctttccaaa tgtgaaattt tcattttcaa tgtactgttc aaatatttaa
      901 gagactgaat acttgtggtg tatcagatat gaatgtgaac atgacttgcc caacttcttg
      961 ggatagctag cactaagttc agaagacgat ggttactaaa ataacagaag gcaatatacg
     1021 tgtgcaatct taacgtgtct cagcatcaac atggcaaaac catttcatta tgaacttata
     1081 gatttggatt aaattttagg ttccaggaga caagaagctg atttatgaac
//
