LOCUS       NM_017200               1226 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus tissue factor pathway inhibitor (Tfpi),
            transcript variant 1, mRNA.
ACCESSION   NM_017200
VERSION     NM_017200.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1226)
  AUTHORS   Muto,M., Chakraborty,D., Varberg,K.M., Moreno-Irusta,A., Iqbal,K.,
            Scott,R.L., McNally,R.P., Choudhury,R.H., Aplin,J.D., Okae,H.,
            Arima,T., Matsumoto,S., Ema,M., Mast,A.E., Grundberg,E. and
            Soares,M.J.
  TITLE     Intersection of regulatory pathways controlling hemostasis and
            hemochorial placentation
  JOURNAL   Proc Natl Acad Sci U S A 118 (50) (2021)
   PUBMED   34876522
  REMARK    GeneRIF: Intersection of regulatory pathways controlling hemostasis
            and hemochorial placentation.
REFERENCE   2  (bases 1 to 1226)
  AUTHORS   Smith,S.A., Travers,R.J. and Morrissey,J.H.
  TITLE     How it all starts: Initiation of the clotting cascade
  JOURNAL   Crit Rev Biochem Mol Biol 50 (4), 326-336 (2015)
   PUBMED   26018600
  REMARK    Review article
REFERENCE   3  (bases 1 to 1226)
  AUTHORS   Parunov,L.A., Soshitova,N.P., Fadeeva,O.A., Balandina,A.N.,
            Kopylov,K.G., Kumskova,M.A., Gilbert,J.C., Schaub,R.G.,
            McGinness,K.E., Ataullakhanov,F.I. and Panteleev,M.A.
  TITLE     Drug-drug interaction of the anti-TFPI aptamer BAX499 and factor
            VIII: studies of spatial dynamics of fibrin clot formation in
            hemophilia A
  JOURNAL   Thromb Res 133 (1), 112-119 (2014)
   PUBMED   24263002
REFERENCE   4  (bases 1 to 1226)
  AUTHORS   Ogiwara,K., Nogami,K., Matsumoto,T. and Shima,M.
  TITLE     Tissue factor pathway inhibitor in activated prothrombin complex
            concentrates (aPCC) moderates the effectiveness of therapy in some
            severe hemophilia A patients with inhibitor
  JOURNAL   Int J Hematol 99 (5), 577-587 (2014)
   PUBMED   24687919
REFERENCE   5  (bases 1 to 1226)
  AUTHORS   Mukai,Y. and Sato,S.
  TITLE     Effect of nitric oxide deficiency on tissue-type plasminogen
            activator expression in the umbilical cord in a pregnancy-induced
            hypertension rat model
  JOURNAL   Pregnancy Hypertens 2 (1), 53-58 (2012)
   PUBMED   26104991
REFERENCE   6  (bases 1 to 1226)
  AUTHORS   Elsayed,Y.A., Nakagawa,K., Kamikubo,Y.I., Enjyoji,K.I., Kato,H. and
            Sueishi,K.
  TITLE     Effects of recombinant human tissue factor pathway inhibitor on
            thrombus formation and its in vivo distribution in a rat DIC model
  JOURNAL   Am J Clin Pathol 106 (5), 574-583 (1996)
   PUBMED   8929465
REFERENCE   7  (bases 1 to 1226)
  AUTHORS   Saito,M., Morishita,E., Asakura,H., Jokaji,H., Uotani,C.,
            Kumabashiri,I., Yamazaki,M., Aoshima,K. and Matsuda,T.
  TITLE     [Analysis of behaviors of plasma tissue factor and tissue factor
            pathway inhibitor in patients with various diseases]
  JOURNAL   Rinsho Ketsueki 37 (9), 794-798 (1996)
   PUBMED   8914465
REFERENCE   8  (bases 1 to 1226)
  AUTHORS   Kobayashi,M., Wada,H., Wakita,Y., Shimura,M., Nakase,T.,
            Hiyoyama,K., Nagaya,S., Minami,N., Nakano,T. and Shiku,H.
  TITLE     Decreased plasma tissue factor pathway inhibitor levels in patients
            with thrombotic thrombocytopenic purpura
  JOURNAL   Thromb Haemost 73 (1), 10-14 (1995)
   PUBMED   7740478
REFERENCE   9  (bases 1 to 1226)
  AUTHORS   Bregengard,C., Nordfang,O., Wildgoose,P., Svendsen,O., Hedner,U.
            and Diness,V.
  TITLE     The effect of two-domain tissue factor pathway inhibitor on
            endotoxin-induced disseminated intravascular coagulation in rabbits
  JOURNAL   Blood Coagul Fibrinolysis 4 (5), 699-706 (1993)
   PUBMED   8292719
REFERENCE   10 (bases 1 to 1226)
  AUTHORS   Enjyoji,K., Emi,M., Mukai,T. and Kato,H.
  TITLE     cDNA cloning and expression of rat tissue factor pathway inhibitor
            (TFPI)
  JOURNAL   J Biochem 111 (5), 681-687 (1992)
   PUBMED   1639767
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D10926.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D10926.1, SRR8487231.148988.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676809 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1226
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..1226
                     /gene="Tfpi"
                     /note="tissue factor pathway inhibitor"
                     /db_xref="GeneID:29436"
                     /db_xref="RGD:61914"
     exon            1..86
                     /gene="Tfpi"
                     /inference="alignment:Splign:2.1.0"
     exon            87..206
                     /gene="Tfpi"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..997
                     /gene="Tfpi"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; EPI; LACI; extrinsic pathway inhibitor;
                     lipoprotein-associated coagulation inhibitor"
                     /codon_start=1
                     /product="tissue factor pathway inhibitor isoform 1
                     precursor"
                     /protein_id="NP_058896.1"
                     /db_xref="GeneID:29436"
                     /db_xref="RGD:61914"
                     /translation="MTNKLKKDHAFWAAVCLLLSIVPELLNALPEEDDDTINTDSELR
                     PMKPLHTFCAMKAEDGPCKAMIRSYYFNMNSHQCEEFIYGGCRGNKNRFDTLEECRKT
                     CIPGYKKTTIKTTSGAEKPDFCFLEEDPGICRGFMTRYFYNNQSKQCEQFKYGGCLGN
                     SNNFETLEECRNTCEDPVNEVQKGDYVTNQITVTDRTTVNNVVIPQATKAPSQWDYDG
                     PSWCLEPADSGLCKASEKRFYYNPAIGKCRQFNYTGCGGNNNNFTTKQDCNRACKKDS
                     SKKSSKRAKTQRRRKSFVKVMYENIH"
     exon            207..404
                     /gene="Tfpi"
                     /inference="alignment:Splign:2.1.0"
     exon            405..443
                     /gene="Tfpi"
                     /inference="alignment:Splign:2.1.0"
     exon            444..620
                     /gene="Tfpi"
                     /inference="alignment:Splign:2.1.0"
     exon            621..731
                     /gene="Tfpi"
                     /inference="alignment:Splign:2.1.0"
     exon            732..911
                     /gene="Tfpi"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1226
                     /gene="Tfpi"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1205..1210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfpi"
     polyA_site      1226
                     /gene="Tfpi"
ORIGIN      
        1 ggacctgtct ccggatttct tctgaagacc gtataatttt gggatctcat ctccagatct
       61 cttttgagga cgactgactc atcaagaaat gactaacaaa ctgaagaaag accacgcctt
      121 ctgggcggct gtgtgtctgc tgcttagcat tgttcctgag cttcttaatg ctctgcccga
      181 ggaagacgat gatacaataa acacagattc cgagctgcgg ccaatgaaac cgttgcatac
      241 attctgtgca atgaaggcgg aagacgggcc ctgcaaagca atgatacgga gttattattt
      301 caatatgaac agtcaccagt gtgaagaatt tatatacggg ggatgcagag gaaacaagaa
      361 ccgatttgat actctggaag agtgtaggaa aacatgcata ccaggttata aaaagacaac
      421 tataaagaca acatctggag cagaaaagcc agatttctgc ttcttggaag aggatcctgg
      481 aatctgccga ggtttcatga ccaggtattt ttataacaac cagtcaaagc agtgtgaaca
      541 attcaagtac ggcggttgcc tgggcaacag caacaacttt gagaccttgg aggagtgcag
      601 gaacacctgt gaggatccag tgaatgaggt acagaagggt gactacgtaa ctaatcaaat
      661 tactgtaact gatcgcacta ctgtaaataa cgtggtgatt cctcaggcta ccaaagcgcc
      721 cagccaatgg gactatgatg gcccttcatg gtgtcttgaa ccagcagaca gtggattatg
      781 taaagccagt gagaaaagat tctactacaa cccagccatt gggaaatgcc gtcaatttaa
      841 ctacactgga tgtgggggaa ataataataa ttttactacc aaacaagatt gtaatagagc
      901 atgtaaaaaa gattcctcca aaaaaagctc aaaaagagca aagacccaaa gaagaaggaa
      961 gtctttcgtg aaagtcatgt acgaaaatat tcattagtgc taagatataa gcacatgaca
     1021 tttttacatt agtttcacta aatattccta taaggtgttt tcactatgat ttctactctt
     1081 ctacaaacca gtttcttgtt tccattggtg accatctact ggaagatata ttttcatcgg
     1141 ttatgatcac aaacattaca tacccttgac agtctaaatc ttctctaatg attttatttt
     1201 taacaataaa atcttttatc ctgagc
//
