LOCUS       NM_013042                477 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus trefoil factor 3 (Tff3), mRNA.
ACCESSION   NM_013042
VERSION     NM_013042.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Wu,X., Zheng,H., Yang,R., Luan,X., Zhang,L., Jin,Q., Jin,Y. and
            Xue,J.
  TITLE     Mouse trefoil factor 3 ameliorated high-fat-diet-induced hepatic
            steatosis via increasing peroxisome proliferator-activated
            receptor-alpha-mediated fatty acid oxidation
  JOURNAL   Am J Physiol Endocrinol Metab 317 (3), E436-E445 (2019)
   PUBMED   31211621
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Winkel,L., Bagge,A., Larsen,L., Haase,T.N., Rasmussen,M., Lykke,J.,
            Holmgaard,D.B., Thim,L., Nielsen,J.H. and Dalgaard,L.T.
  TITLE     Trefoil factor 3 in perinatal pancreas is increased by gestational
            low protein diet and associated with accelerated beta-cell
            maturation
  JOURNAL   Islets 10 (3), e1472186 (2018)
   PUBMED   29723130
  REMARK    GeneRIF: These results suggest that TFF3 may promote adhesion and
            spreading of cells to accelerate beta-cell maturation. This study
            indicates a functional role for TFF3 in pancreatic beta-cell
            maturation in the perinatal period, which is altered by low protein
            diet during gestation.
REFERENCE   3  (bases 1 to 477)
  AUTHORS   Hu,J., Shi,Y., Wang,C., Wan,H., Wu,D., Wang,H. and Peng,X.
  TITLE     Role of intestinal trefoil factor in protecting intestinal
            epithelial cells from burn-induced injury
  JOURNAL   Sci Rep 8 (1), 3201 (2018)
   PUBMED   29453360
  REMARK    GeneRIF: ITF can improve cytomorphosis ability for promoting cell
            migration with limited effect on cell proliferation, which can be
            enhanced with addition of mucin. The main mechanism of ITF in
            maintaining intestinal mucosal barrier may be attributed to
            acceleration of cell migration.
            Erratum:[Sci Rep. 2020 Jul 24;10(1):12741. doi:
            10.1038/s41598-020-69648-x.. PMID: 32704055]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 477)
  AUTHORS   Esposito,R., Morello,S., Vllahu,M., Eletto,D., Porta,A. and
            Tosco,A.
  TITLE     Gastric TFF1 Expression from Acute to Chronic Helicobacter
            Infection
  JOURNAL   Front Cell Infect Microbiol 7, 434 (2017)
   PUBMED   29085807
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 477)
  AUTHORS   Fu,T., Stellmacher,A., Znalesniak,E.B., Dieterich,D.C.,
            Kalbacher,H. and Hoffmann,W.
  TITLE     Tff3 is expressed in neurons and microglial cells
  JOURNAL   Cell Physiol Biochem 34 (6), 1912-1919 (2014)
   PUBMED   25504043
  REMARK    GeneRIF: The expression in activated microglial cells, which is
            demonstrated here for the first time, points towards a possible
            function for Tff3 in immune reactions in the CNS
REFERENCE   6  (bases 1 to 477)
  AUTHORS   Sands,B.E., Ogata,H., Lynch-Devaney,K., deBeaumont,M., Ezzell,R.M.
            and Podolsky,D.K.
  TITLE     Molecular cloning of the rat intestinal trefoil factor gene.
            Characterization of an intestinal goblet cell-associated promoter
  JOURNAL   J Biol Chem 270 (16), 9353-9361 (1995)
   PUBMED   7721858
REFERENCE   7  (bases 1 to 477)
  AUTHORS   Podolsky,D.K., Lynch-Devaney,K., Stow,J.L., Oates,P., Murgue,B.,
            DeBeaumont,M., Sands,B.E. and Mahida,Y.R.
  TITLE     Identification of human intestinal trefoil factor. Goblet
            cell-specific expression of a peptide targeted for apical secretion
  JOURNAL   J Biol Chem 268 (9), 6694-6702 (1993)
   PUBMED   8454642
  REMARK    Erratum:[J Biol Chem. 1993 Jun 5;268(16):12230.. PMID: 8505343]
REFERENCE   8  (bases 1 to 477)
  AUTHORS   Chinery,R., Poulsom,R., Rogers,L.A., Jeffery,R.E., Longcroft,J.M.,
            Hanby,A.M. and Wright,N.A.
  TITLE     Localization of intestinal trefoil-factor mRNA in rat stomach and
            intestine by hybridization in situ
  JOURNAL   Biochem J 285 (Pt 1) (Pt 1), 5-8 (1992)
   PUBMED   1637322
REFERENCE   9  (bases 1 to 477)
  AUTHORS   Poulsom,R., Chinery,R., Sarraf,C., Lalani,E.N., Stamp,G., Elia,G.
            and Wright,N.
  TITLE     Trefoil peptide expression in intestinal adaptation and renewal
  JOURNAL   Scand J Gastroenterol Suppl 192, 17-28 (1992)
   PUBMED   1439565
REFERENCE   10 (bases 1 to 477)
  AUTHORS   Suemori,S., Lynch-Devaney,K. and Podolsky,D.K.
  TITLE     Identification and characterization of rat intestinal trefoil
            factor: tissue- and cell-specific member of the trefoil protein
            family
  JOURNAL   Proc Natl Acad Sci U S A 88 (24), 11017-11021 (1991)
   PUBMED   1763017
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP490107.1 and BC078873.1.
            
            On May 10, 2012 this sequence version replaced NM_013042.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078873.1, FM067094.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BP490107.1         1-20
            21-477              BC078873.1         1-457
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..477
                     /gene="Tff3"
                     /gene_synonym="ITF"
                     /note="trefoil factor 3"
                     /db_xref="GeneID:25563"
                     /db_xref="RGD:3847"
     exon            1..123
                     /gene="Tff3"
                     /gene_synonym="ITF"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..284
                     /gene="Tff3"
                     /gene_synonym="ITF"
                     /note="polypeptide P1.B; intestinal trefoil factor;
                     trefoil factor 3, intestinal"
                     /codon_start=1
                     /product="trefoil factor 3 precursor"
                     /protein_id="NP_037174.2"
                     /db_xref="GeneID:25563"
                     /db_xref="RGD:3847"
                     /translation="METRAFWITLLLVLVAGSSCKAQEFVGLSPSQCMVPANVRVDCG
                     YPTVTSEQCNNRGCCFDSSIPNVPWCFKPLQETECTF"
     exon            124..270
                     /gene="Tff3"
                     /gene_synonym="ITF"
                     /inference="alignment:Splign:2.1.0"
     exon            271..455
                     /gene="Tff3"
                     /gene_synonym="ITF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccacgcatc ctcgggatac cgaagtttgc ctgctgccat ggagaccaga gccttctgga
       61 taaccctgct gctggtcctg gttgctgggt cctcctgcaa agcccaggaa tttgttggcc
      121 tatctccaag ccaatgtatg gtcccggcaa atgtcagggt ggactgtggc taccccactg
      181 tcacatcaga gcagtgtaac aaccgtggtt gctgttttga ctccagcatc ccaaatgtgc
      241 cctggtgctt caaacctctg caagagacag aatgtacgtt ttgaagctgt ccaggctcca
      301 ggaagggagc tccacaccct ggactcttgc tgatggtagt ggcccagggt aacactcacc
      361 cctgatctgc tccctgccgc cggccaatat aggagctggg agtccagaag aataaagacc
      421 ttacagtcag cacaaggctg ttctaattgc ggaaaaaaaa aaaaaaaaaa aaaaaaa
//
