LOCUS       NM_053844                579 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus trefoil factor 2 (Tff2), mRNA.
ACCESSION   NM_053844 XM_346598
VERSION     NM_053844.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 579)
  AUTHORS   Esposito,R., Morello,S., Vllahu,M., Eletto,D., Porta,A. and
            Tosco,A.
  TITLE     Gastric TFF1 Expression from Acute to Chronic Helicobacter
            Infection
  JOURNAL   Front Cell Infect Microbiol 7, 434 (2017)
   PUBMED   29085807
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 579)
  AUTHORS   Wu,J.F., Zhang,J., Xue,G. and Zhang,H.Q.
  TITLE     Expression and localization of trefoil factor family genes in rat
            submandibular glands
  JOURNAL   Biotech Histochem 89 (6), 424-432 (2014)
   PUBMED   24588600
  REMARK    GeneRIF: Substantial amounts of TFF1 were detected only in the
            cytoplasm of epithelial cells in the submandibular glands granular
            convoluted tubules (GCT), while TFF2 and TFF3 were widely
            distributed in the cytoplasm of epithelial cells of intercalated
            ducts
REFERENCE   3  (bases 1 to 579)
  AUTHORS   Wills-Karp,M., Rani,R., Dienger,K., Lewkowich,I., Fox,J.G.,
            Perkins,C., Lewis,L., Finkelman,F.D., Smith,D.E., Bryce,P.J.,
            Kurt-Jones,E.A., Wang,T.C., Sivaprasad,U., Hershey,G.K. and
            Herbert,D.R.
  TITLE     Trefoil factor 2 rapidly induces interleukin 33 to promote type 2
            immunity during allergic asthma and hookworm infection
  JOURNAL   J Exp Med 209 (3), 607-622 (2012)
   PUBMED   22329990
REFERENCE   4  (bases 1 to 579)
  AUTHORS   Menheniott,T.R., Peterson,A.J., O'Connor,L., Lee,K.S.,
            Kalantzis,A., Kondova,I., Bontrop,R.E., Bell,K.M. and Giraud,A.S.
  TITLE     A novel gastrokine, Gkn3, marks gastric atrophy and shows evidence
            of adaptive gene loss in humans
  JOURNAL   Gastroenterology 138 (5), 1823-1835 (2010)
   PUBMED   20138039
REFERENCE   5  (bases 1 to 579)
  AUTHORS   Ortiz-Masia,D., Hernandez,C., Quintana,E., Velazquez,M.,
            Cebrian,S., Riano,A., Calatayud,S., Esplugues,J.V. and
            Barrachina,M.D.
  TITLE     iNOS-derived nitric oxide mediates the increase in TFF2 expression
            associated with gastric damage: role of HIF-1
  JOURNAL   FASEB J 24 (1), 136-145 (2010)
   PUBMED   19741170
  REMARK    GeneRIF: iNOS-derived NO associated with NSAID-induced gastric
            injury is implicated in mucosal restitution via the HIF-1-mediated
            induction of TFF2 genes.
REFERENCE   6  (bases 1 to 579)
  AUTHORS   Xia,H.H., Yang,Y., Lam,S.K., Wong,W.M., Leung,S.Y., Yuen,S.T.,
            Elia,G., Wright,N.A. and Wong,B.C.
  TITLE     Aberrant epithelial expression of trefoil family factor 2 and mucin
            6 in Helicobacter pylori infected gastric antrum, incisura, and
            body and its association with antralisation
  JOURNAL   J Clin Pathol 57 (8), 861-866 (2004)
   PUBMED   15280409
REFERENCE   7  (bases 1 to 579)
  AUTHORS   Nie,S.N., Qian,X.M., Wu,X.H., Yang,S.Y., Tang,W.J., Xu,B.H.,
            Huang,F., Lin,X., Sun,D.Y., Sun,H.C. and Li,Z.S.
  TITLE     Role of TFF in healing of stress-induced gastric lesions
  JOURNAL   World J Gastroenterol 9 (8), 1772-1776 (2003)
   PUBMED   12918118
  REMARK    GeneRIF: TFF may not only participate in the early phase of
            epithelial repair known as restitution (maked by increased cell
            migration), but also play an important role in the subsequent,
            protracted phase of glandular renewal(made by cell proliferation).
REFERENCE   8  (bases 1 to 579)
  AUTHORS   Fernandez-Estivariz,C., Gu,L.H., Gu,L., Jonas,C.R., Wallace,T.M.,
            Pascal,R.R., Devaney,K.L., Farrell,C.L., Jones,D.P., Podolsky,D.K.
            and Ziegler,T.R.
  TITLE     Trefoil peptide expression and goblet cell number in rat intestine:
            effects of KGF and fasting-refeeding
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 284 (2), R564-R573 (2003)
   PUBMED   12388439
  REMARK    GeneRIF: Keratinocyte growth factor enhances TFF2 expression in
            proximal small bowel and increases goblet cell number and TFF3
            protein content throughout the intestine independent of food intake
REFERENCE   9  (bases 1 to 579)
  AUTHORS   Farrell,J.J., Taupin,D., Koh,T.J., Chen,D., Zhao,C.M.,
            Podolsky,D.K. and Wang,T.C.
  TITLE     TFF2/SP-deficient mice show decreased gastric proliferation,
            increased acid secretion, and increased susceptibility to NSAID
            injury
  JOURNAL   J Clin Invest 109 (2), 193-204 (2002)
   PUBMED   11805131
REFERENCE   10 (bases 1 to 579)
  AUTHORS   Jeffrey,G.P., Oates,P.S., Wang,T.C., Babyatsky,M.W. and Brand,S.J.
  TITLE     Spasmolytic polypeptide: a trefoil peptide secreted by rat gastric
            mucous cells
  JOURNAL   Gastroenterology 106 (2), 336-345 (1994)
   PUBMED   8299900
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053844.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M97255.1, BI291285.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN06621351,
                                           SAMN11044071 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               JAXUCZ010000020.1  9220872-9220979     c
            109-258             JAXUCZ010000020.1  9220127-9220276     c
            259-405             JAXUCZ010000020.1  9219142-9219288     c
            406-579             JAXUCZ010000020.1  9217110-9217283     c
FEATURES             Location/Qualifiers
     source          1..579
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..579
                     /gene="Tff2"
                     /note="trefoil factor 2"
                     /db_xref="GeneID:116592"
                     /db_xref="RGD:620709"
     exon            1..108
                     /gene="Tff2"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..419
                     /gene="Tff2"
                     /note="SP; spasmolytic polypeptide; trefoil factor 2
                     (spasmolytic protein 1)"
                     /codon_start=1
                     /product="trefoil factor 2 precursor"
                     /protein_id="NP_446296.2"
                     /db_xref="GeneID:116592"
                     /db_xref="RGD:620709"
                     /translation="MGPRGAPLLVVVLVLGLHALAEGEKPSPCRCSRMTPSNRKNCGF
                     PGITSDQCFNLGCCFDSSVAGVPWCFHPLPNQASEQCVMEVSAREDCGYPGISPEDCA
                     SRHCCFSNLIFEVPWCFFPQSVDDCHY"
     exon            109..258
                     /gene="Tff2"
                     /inference="alignment:Splign:2.1.0"
     exon            259..405
                     /gene="Tff2"
                     /inference="alignment:Splign:2.1.0"
     exon            406..579
                     /gene="Tff2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaacacc caggtccagt ggagcagaca tgggccctcg aggtgcccct ctcttggtag
       61 tggtccttgt cttggggctg catgccctgg cggaaggcga gaaaccttct ccctgtcggt
      121 gctccaggat gacgccctcc aacagaaaga actgtggctt cccgggcatc accagtgacc
      181 agtgctttaa tcttggatgc tgctttgact ctagtgtcgc tggggtcccc tggtgtttcc
      241 acccacttcc aaaccaagcg tcggaacaat gtgtcatgga ggtgtcagcc cgcgaggact
      301 gtgggtaccc gggcatcagc cctgaggact gtgccagccg acactgctgc ttttccaacc
      361 tgatcttcga agtgccctgg tgtttcttcc cacagtctgt ggatgattgt cactactgaa
      421 gggcactgct gctgagacca tcaccgggag ctgcaagccg gaagaagaaa gcctccacca
      481 gactgcgtcg atctctgggg tttcttaaac tctcttgagc cccagcagtg gctggacaca
      541 gtgtctttcc aagtaaagaa aacctttgaa aaacctggc
//
