LOCUS       NM_057129                463 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Rattus norvegicus trefoil factor 1 (Tff1), mRNA.
ACCESSION   NM_057129
VERSION     NM_057129.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Huang,C., Wang,L. and Wu,G.
  TITLE     Trefoil factor 1 (TFF1) reduces cerebral edema and gastric mucosal
            injury by regulating the EGFR/Src/FAK pathway in an intracerebral
            hemorrhage rat model
  JOURNAL   Neuropeptides 107, 102460 (2024)
   PUBMED   39142164
  REMARK    GeneRIF: Trefoil factor 1 (TFF1) reduces cerebral edema and gastric
            mucosal injury by regulating the EGFR/Src/FAK pathway in an
            intracerebral hemorrhage rat model.
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Esposito,R., Morello,S., Vllahu,M., Eletto,D., Porta,A. and
            Tosco,A.
  TITLE     Gastric TFF1 Expression from Acute to Chronic Helicobacter
            Infection
  JOURNAL   Front Cell Infect Microbiol 7, 434 (2017)
   PUBMED   29085807
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 463)
  AUTHORS   Jensen,P., Ducray,A.D., Widmer,H.R. and Meyer,M.
  TITLE     Effects of Forskolin on Trefoil factor 1 expression in cultured
            ventral mesencephalic dopaminergic neurons
  JOURNAL   Neuroscience 310, 699-708 (2015)
   PUBMED   26459015
  REMARK    GeneRIF: Distinct populations of cultured dopaminergic neurons
            express trefoil factor 1, and their numbers can be increased by
            factors known to influence survival and differentiation of
            dopaminergic cells.
REFERENCE   4  (bases 1 to 463)
  AUTHORS   Wu,J.F., Zhang,J., Xue,G. and Zhang,H.Q.
  TITLE     Expression and localization of trefoil factor family genes in rat
            submandibular glands
  JOURNAL   Biotech Histochem 89 (6), 424-432 (2014)
   PUBMED   24588600
  REMARK    GeneRIF: Substantial amounts of TFF1 were detected only in the
            cytoplasm of epithelial cells in the submandibular glands granular
            convoluted tubules (GCT), while TFF2 and TFF3 were widely
            distributed in the cytoplasm of epithelial cells of intercalated
            ducts
REFERENCE   5  (bases 1 to 463)
  AUTHORS   Jensen,P., Heimberg,M., Ducray,A.D., Widmer,H.R. and Meyer,M.
  TITLE     Expression of trefoil factor 1 in the developing and adult rat
            ventral mesencephalon
  JOURNAL   PLoS One 8 (10), e76592 (2013)
   PUBMED   24116124
  REMARK    GeneRIF: Data indicate that trefoil factor 1 (TFF1) expression is
            restricted to neurons.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 463)
  AUTHORS   Koshiyama,M., Yoshida,M., Konishi,M., Takemura,M., Yura,Y.,
            Matsushita,K., Hayashi,M. and Tauchi,K.
  TITLE     Expression of pS2 protein in endometrial carcinomas: correlation
            with clinicopathologic features and sex steroid receptor status
  JOURNAL   Int J Cancer 74 (3), 237-244 (1997)
   PUBMED   9221798
REFERENCE   7  (bases 1 to 463)
  AUTHORS   Speiser,P., Mayerhofer,K., Kucera,E., Roch,G., Mittelbock,M.,
            Gitsch,G. and Zeillinger,R.
  TITLE     pS2 and PAI-1 in ovarian cancer: correlation to pathohistological
            parameters
  JOURNAL   Anticancer Res 17 (1B), 679-683 (1997)
   PUBMED   9066601
REFERENCE   8  (bases 1 to 463)
  AUTHORS   Lefebvre,O., Chenard,M.P., Masson,R., Linares,J., Dierich,A.,
            LeMeur,M., Wendling,C., Tomasetto,C., Chambon,P. and Rio,M.C.
  TITLE     Gastric mucosa abnormalities and tumorigenesis in mice lacking the
            pS2 trefoil protein
  JOURNAL   Science 274 (5285), 259-262 (1996)
   PUBMED   8824193
REFERENCE   9  (bases 1 to 463)
  AUTHORS   Itoh,H., Tomita,M., Uchino,H., Kobayashi,T., Kataoka,H., Sekiya,R.
            and Nawa,Y.
  TITLE     cDNA cloning of rat pS2 peptide and expression of trefoil peptides
            in acetic acid-induced colitis
  JOURNAL   Biochem J 318 (Pt 3) (Pt 3), 939-944 (1996)
   PUBMED   8836141
REFERENCE   10 (bases 1 to 463)
  AUTHORS   Lipponen,P.K. and Eskelinen,M.J.
  TITLE     Expression of pS2 protein in transitional cell bladder tumours
  JOURNAL   J Pathol 173 (4), 327-332 (1994)
   PUBMED   7965392
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 27, 2020 this sequence version replaced NM_057129.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D83231.1, SRR26643294.60925.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345238, SAMN09345329
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               JAXUCZ010000020.1  9240852-9240956     c
            106-258             JAXUCZ010000020.1  9238372-9238524     c
            259-463             JAXUCZ010000020.1  9237095-9237299     c
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..463
                     /gene="Tff1"
                     /gene_synonym="Ps2"
                     /note="trefoil factor 1"
                     /db_xref="GeneID:117270"
                     /db_xref="RGD:620707"
     exon            1..105
                     /gene="Tff1"
                     /gene_synonym="Ps2"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..275
                     /gene="Tff1"
                     /gene_synonym="Ps2"
                     /note="protein pS2"
                     /codon_start=1
                     /product="trefoil factor 1 precursor"
                     /protein_id="NP_476470.1"
                     /db_xref="GeneID:117270"
                     /db_xref="RGD:620707"
                     /translation="MEHKVTCVLAMVLMLALSSLAQNQEETCAVIPRERINCGFPGVT
                     AQQCKEKGCCFDDSVRGFPWCFRPLVIENQQEEECPF"
     exon            106..258
                     /gene="Tff1"
                     /gene_synonym="Ps2"
                     /inference="alignment:Splign:2.1.0"
     exon            259..463
                     /gene="Tff1"
                     /gene_synonym="Ps2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcactcgtg gtcttccctg gaagctgcca tggagcacaa ggtgacctgt gtcctcgcca
       61 tggtcctcat gctggctctc agcagccttg cccagaacca ggaagaaaca tgtgccgtga
      121 tcccccggga gagaataaat tgtggcttcc ccggtgtcac cgcccagcag tgcaaggaaa
      181 agggttgctg ttttgatgac agtgtccggg ggttcccatg gtgcttccga cctctggtca
      241 ttgagaacca gcaagaagaa gaatgtccct tctaaggtcc atccgagaga actggttaca
      301 tcaagactcg gcaccccctc ccccaaacct ggaccctgga gccacctggc ccacctgctt
      361 catacacacc tgttcggtgg ctggatctgg cctggtgaca cagttcaacc tctcagactt
      421 ttaaccctca aattcggcct gattattaaa agatatgaat gct
//
