LOCUS       NM_001025707            2291 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus transcription factor EB (Tfeb), mRNA.
ACCESSION   NM_001025707 XM_236936
VERSION     NM_001025707.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2291)
  AUTHORS   Chen,Q., Zhou,Y., Yu,M., Zhu,S., Sun,J., Du,W., Chen,Z., Tao,J.,
            Feng,X., Zhang,Q. and Zhao,Y.
  TITLE     Transcription factor EB-mediated autophagy affects cell migration
            and inhibits apoptosis to promote endometriosis
  JOURNAL   Apoptosis 29 (5-6), 757-767 (2024)
   PUBMED   38358580
  REMARK    GeneRIF: Transcription factor EB-mediated autophagy affects cell
            migration and inhibits apoptosis to promote endometriosis.
REFERENCE   2  (bases 1 to 2291)
  AUTHORS   Chen,L., Ma,Y., Ma,X., Liu,L., Jv,X., Li,A., Shen,Q., Jia,W.,
            Qu,L., Shi,L. and Xie,J.
  TITLE     TFEB regulates cellular labile iron and prevents ferroptosis in a
            TfR1-dependent manner
  JOURNAL   Free Radic Biol Med 208, 445-457 (2023)
   PUBMED   37683766
  REMARK    GeneRIF: TFEB regulates cellular labile iron and prevents
            ferroptosis in a TfR1-dependent manner.
REFERENCE   3  (bases 1 to 2291)
  AUTHORS   Liu,C., Zhou,D., Zhang,Q., Wei,H., Lu,Y., Li,B., Zhan,H., Cheng,J.,
            Wang,C., Yang,Y., Li,S., Hu,C. and Liao,X.
  TITLE     Transcription factor EB (TFEB) improves ventricular remodeling
            after myocardial infarction by inhibiting Wnt/beta-catenin
            signaling pathway
  JOURNAL   PeerJ 11, e15841 (2023)
   PUBMED   37609444
  REMARK    GeneRIF: Transcription factor EB (TFEB) improves ventricular
            remodeling after myocardial infarction by inhibiting
            Wnt/beta-catenin signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2291)
  AUTHORS   Liu,Y., Che,X., Yu,X., Shang,H., Cui,P., Fu,X., Lu,X., Liu,Y.,
            Wu,C. and Yang,J.
  TITLE     Phosphorylation of STAT3 at Tyr705 contributes to TFEB-mediated
            autophagy-lysosomal pathway dysfunction and leads to ischemic
            injury in rats
  JOURNAL   Cell Mol Life Sci 80 (6), 160 (2023)
   PUBMED   37210406
  REMARK    GeneRIF: Phosphorylation of STAT3 at Tyr705 contributes to
            TFEB-mediated autophagy-lysosomal pathway dysfunction and leads to
            ischemic injury in rats.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2291)
  AUTHORS   Zhang,J., Tang,Y., Hu,Z., Xu,W., Ma,Y., Xu,P., Xing,H. and Niu,Q.
  TITLE     The inhibition of TRPML1/TFEB leads to lysosomal biogenesis
            disorder, contributes to developmental fluoride neurotoxicity
  JOURNAL   Ecotoxicol Environ Saf 250, 114511 (2023)
   PUBMED   36608573
  REMARK    GeneRIF: The inhibition of TRPML1/TFEB leads to lysosomal
            biogenesis disorder, contributes to developmental fluoride
            neurotoxicity.
REFERENCE   6  (bases 1 to 2291)
  AUTHORS   Settembre,C., Di Malta,C., Polito,V.A., Garcia Arencibia,M.,
            Vetrini,F., Erdin,S., Erdin,S.U., Huynh,T., Medina,D., Colella,P.,
            Sardiello,M., Rubinsztein,D.C. and Ballabio,A.
  TITLE     TFEB links autophagy to lysosomal biogenesis
  JOURNAL   Science 332 (6036), 1429-1433 (2011)
   PUBMED   21617040
REFERENCE   7  (bases 1 to 2291)
  AUTHORS   Sardiello,M., Palmieri,M., di Ronza,A., Medina,D.L., Valenza,M.,
            Gennarino,V.A., Di Malta,C., Donaudy,F., Embrione,V.,
            Polishchuk,R.S., Banfi,S., Parenti,G., Cattaneo,E. and Ballabio,A.
  TITLE     A gene network regulating lysosomal biogenesis and function
  JOURNAL   Science 325 (5939), 473-477 (2009)
   PUBMED   19556463
REFERENCE   8  (bases 1 to 2291)
  AUTHORS   Huan,C., Kelly,M.L., Steele,R., Shapira,I., Gottesman,S.R. and
            Roman,C.A.
  TITLE     Transcription factors TFE3 and TFEB are critical for CD40 ligand
            expression and thymus-dependent humoral immunity
  JOURNAL   Nat Immunol 7 (10), 1082-1091 (2006)
   PUBMED   16936731
REFERENCE   9  (bases 1 to 2291)
  AUTHORS   Huan,C., Sashital,D., Hailemariam,T., Kelly,M.L. and Roman,C.A.
  TITLE     Renal carcinoma-associated transcription factors TFE3 and TFEB are
            leukemia inhibitory factor-responsive transcription activators of
            E-cadherin
  JOURNAL   J Biol Chem 280 (34), 30225-30235 (2005)
   PUBMED   15994295
REFERENCE   10 (bases 1 to 2291)
  AUTHORS   Steingrimsson,E., Tessarollo,L., Reid,S.W., Jenkins,N.A. and
            Copeland,N.G.
  TITLE     The bHLH-Zip transcription factor Tfeb is essential for placental
            vascularization
  JOURNAL   Development 125 (23), 4607-4616 (1998)
   PUBMED   9806910
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099102.1.
            
            [WARNING] On Jul 27, 2024 this sequence was replaced by
            NM_001025707.2.
            
            On Jul 22, 2005 this sequence version replaced XM_236936.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099102.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2291
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..2291
                     /gene="Tfeb"
                     /gene_synonym="Tcfeb"
                     /note="transcription factor EB"
                     /db_xref="GeneID:316214"
                     /db_xref="RGD:1309583"
     exon            1..459
                     /gene="Tfeb"
                     /gene_synonym="Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1677
                     /gene="Tfeb"
                     /gene_synonym="Tcfeb"
                     /codon_start=1
                     /product="transcription factor EB"
                     /protein_id="NP_001020878.1"
                     /db_xref="GeneID:316214"
                     /db_xref="RGD:1309583"
                     /translation="MAQLAQRSWANPFCPDSVSPYAQWEQPYLGQPTLKDSEDDEYFM
                     DLSSLDCREPESTAAMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQ
                     QLGGPPTPAINTPVHFQSPPPVPGEVLKVQSYLENPTSYHLQQSQHQKVREYLSETYG
                     NKFAAHVSPAQGSPKPPPAASPGVRAGHVLSTSAGNSAPNSPMAMLHISSNPEKEFDD
                     VIDNIMRLDSVLGYINPEMQMPNTLPLSSSHLNVYSGDPQVTASLVGVTSSSCPADLT
                     QKRELTDAESRALAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKANDLDVRWNKG
                     TILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQARVHGLPTTSP
                     SGVNMAELAQQVVKQELPSEDNPGETLMLGSEVPDPEPMPALPPQAPLPSAAQPQSPF
                     HHLDFSHGLSFGGGGDEGPAGYPDPLGTEHGSPFPNLSKKDLDLMLLDDSLLPLASDP
                     LFSTMSPEASKASSRRSSFSMEEGDVL"
     exon            460..714
                     /gene="Tfeb"
                     /gene_synonym="Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     exon            715..795
                     /gene="Tfeb"
                     /gene_synonym="Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     exon            796..916
                     /gene="Tfeb"
                     /gene_synonym="Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     exon            917..973
                     /gene="Tfeb"
                     /gene_synonym="Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1049
                     /gene="Tfeb"
                     /gene_synonym="Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1197
                     /gene="Tfeb"
                     /gene_synonym="Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..2266
                     /gene="Tfeb"
                     /gene_synonym="Tcfeb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggactcc tgcggtcact gaaggacaga gtcttcacct ctaatctcga agtcggggaa
       61 ctaggggcca tggctcagct tgctcagcgg tcttgggcaa atcccttctg tccggactca
      121 gtttctcctt atgcacaatg ggagcaaccg tacttaggcc agcccacgct taaagactcc
      181 gaggatgatg agtacttcat ggacctgtct tccctcgact gcagggagcc ggaatcaacc
      241 gctgccatgg cgtcgcgcat cgggctgcgc atgcagctca tgcgggagca ggcgcagcag
      301 gaggagcagc gagagcgcat gcagcagcag gccgtcatgc attacatgca gcagcagcaa
      361 cagcagcagc agcagcagct gggaggccct cccaccccag ccatcaacac cccagttcac
      421 ttccagtcgc caccaccagt gcctggggag gtgctgaagg tgcagtccta cctggagaac
      481 cccacctcct accacctgca gcagtctcag catcagaaag tccgagagta cctgtccgag
      541 acctacggca acaagtttgc tgcccacgtc agcccagccc aaggctcccc gaagcctcca
      601 ccagcagcat cccctggggt gcgggctgga catgtactgt ccacctcggc cggcaacagt
      661 gcccccaaca gtcccatggc catgctacac atcagctcca atcctgagaa agagtttgat
      721 gatgtcatcg acaacattat gcgcctggac agcgtgctgg gctacatcaa ccccgaaatg
      781 cagatgccta acacgctacc cctgtccagc agccacctga acgtgtacag tggtgacccc
      841 caggtcacgg cttccctggt aggtgtcacc agcagttcct gccctgccga cctgactcag
      901 aagcgagagc taacagatgc tgagagccgg gccctggcca aggaacggca gaagaaagac
      961 aatcacaact taattgagag aagacgcagg ttcaacatca atgacagaat caaggagctg
     1021 ggaatgctga tccccaaggc caatgacctg gacgtgcgct ggaacaaggg caccatcctc
     1081 aaggcctctg tggattacat ccggaggatg cagaaagacc tgcagaagtc ccgggagctg
     1141 gagaaccact ctcggcgcct ggagatgacc aacaagcagc tctggcttcg catccaggag
     1201 ctggagatgc aggcacgcgt gcacggtctt cccaccacct caccgtccgg tgtgaatatg
     1261 gccgagctgg cccaacaggt ggtgaagcaa gagctgccca gtgaagataa cccaggggag
     1321 accctgatgc tggggtccga ggtccctgac cctgagccca tgccggctct cccaccccag
     1381 gccccgctgc cctcagccgc ccagccacag tctccgttcc atcacctgga cttcagccat
     1441 ggcctgagct ttgggggtgg gggcgatgag gggcccgcag gctaccctga tcccctgggg
     1501 acagagcatg gctccccttt ccccaacctg tccaagaagg atctggactt aatgctccta
     1561 gatgactcct tgctccccct ggcctctgat cccctctttt ctaccatgtc tcctgaggcc
     1621 tccaaggcta gcagccggcg aagcagcttc agcatggagg agggcgacgt tctgtgaccc
     1681 tggctgcccc cgtgccaagg agcagggctg cctgggagct gggaggactg ggcagagccc
     1741 tcccatcctt caggctgcac ttggtgtgaa gtagctgcct ctctccttcc ccttggttgc
     1801 tcccccccac ccctgtttgg acttagtgcc tgcctggcag tcgacggggc tggaaagctc
     1861 tcccctcggc ttcgggcccc ctcctctggc ggcagtccta tgatggggaa ggacaggggt
     1921 gaggcagaag agaaataaga agaaaccctg ctaggggagc ccctctcttc tgagcctggg
     1981 ctttcccatg aagggcattt tggagaaggg ggtacaagta cctctgaggc agcagctggt
     2041 ctgggggtgc ccaggcctgc cttcctggga ctagatggca cccagcctgt ccccccagcc
     2101 tgaatttccc cacaagtggg cacccacccc catttggtgc taacagctct cccctggtgg
     2161 tatgagggtg gggtggccag aagaggagtc tgggttcagg gtggtgagca ctcccacccc
     2221 cagacctccc actttgtgcc tttagtaaac actgtgcttt gtagtaaaaa aaaaaaaaaa
     2281 aaaaaaaaaa a
//
