LOCUS       NM_001271227            3356 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus transcription factor binding to IGHM enhancer 3
            (Tfe3), mRNA.
ACCESSION   NM_001271227 XM_002727531 XM_002730205 XM_228760
VERSION     NM_001271227.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3356)
  AUTHORS   Cinque,L., De Leonibus,C., Iavazzo,M., Krahmer,N., Intartaglia,D.,
            Salierno,F.G., De Cegli,R., Di Malta,C., Svelto,M., Lanzara,C.,
            Maddaluno,M., Wanderlingh,L.G., Huebner,A.K., Cesana,M., Bonn,F.,
            Polishchuk,E., Hubner,C.A., Conte,I., Dikic,I., Mann,M.,
            Ballabio,A., Sacco,F., Grumati,P. and Settembre,C.
  TITLE     MiT/TFE factors control ER-phagy via transcriptional regulation of
            FAM134B
  JOURNAL   EMBO J 39 (17), e105696 (2020)
   PUBMED   32716134
  REMARK    GeneRIF: MiT/TFE factors control ER-phagy via transcriptional
            regulation of FAM134B.
REFERENCE   2  (bases 1 to 3356)
  AUTHORS   Willett,R., Martina,J.A., Zewe,J.P., Wills,R., Hammond,G.R.V. and
            Puertollano,R.
  TITLE     TFEB regulates lysosomal positioning by modulating TMEM55B
            expression and JIP4 recruitment to lysosomes
  JOURNAL   Nat Commun 8 (1), 1580 (2017)
   PUBMED   29146937
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3356)
  AUTHORS   Wada,S., Neinast,M., Jang,C., Ibrahim,Y.H., Lee,G., Babu,A., Li,J.,
            Hoshino,A., Rowe,G.C., Rhee,J., Martina,J.A., Puertollano,R.,
            Blenis,J., Morley,M., Baur,J.A., Seale,P. and Arany,Z.
  TITLE     The tumor suppressor FLCN mediates an alternate mTOR pathway to
            regulate browning of adipose tissue
  JOURNAL   Genes Dev 30 (22), 2551-2564 (2016)
   PUBMED   27913603
REFERENCE   4  (bases 1 to 3356)
  AUTHORS   Kawano,H., Ito,Y., Kanai,F., Nakamura,E., Tada,N., Takai,S.,
            Horie,S., Kobayashi,T. and Hino,O.
  TITLE     Aberrant differentiation of Tsc2-deficient teratomas associated
            with activation of the mTORC1-TFE3 pathway
  JOURNAL   Oncol Rep 34 (5), 2251-2258 (2015)
   PUBMED   26352760
  REMARK    GeneRIF: TFE3 activation by mTORC1 signaling is involved in the
            development of abnormal ductal structures in Tsc2 knockout
            teratomas.
REFERENCE   5  (bases 1 to 3356)
  AUTHORS   Fujimoto,Y., Nakagawa,Y., Satoh,A., Okuda,K., Shingyouchi,A.,
            Naka,A., Matsuzaka,T., Iwasaki,H., Kobayashi,K., Yahagi,N.,
            Shimada,M., Yatoh,S., Suzuki,H., Yogosawa,S., Izumi,T., Sone,H.,
            Urayama,O., Yamada,N. and Shimano,H.
  TITLE     TFE3 controls lipid metabolism in adipose tissue of male mice by
            suppressing lipolysis and thermogenesis
  JOURNAL   Endocrinology 154 (10), 3577-3588 (2013)
   PUBMED   23885019
REFERENCE   6  (bases 1 to 3356)
  AUTHORS   Hong,S.B., Oh,H., Valera,V.A., Baba,M., Schmidt,L.S. and
            Linehan,W.M.
  TITLE     Inactivation of the FLCN tumor suppressor gene induces TFE3
            transcriptional activity by increasing its nuclear localization
  JOURNAL   PLoS One 5 (12), e15793 (2010)
   PUBMED   21209915
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3356)
  AUTHORS   Huan,C., Kelly,M.L., Steele,R., Shapira,I., Gottesman,S.R. and
            Roman,C.A.
  TITLE     Transcription factors TFE3 and TFEB are critical for CD40 ligand
            expression and thymus-dependent humoral immunity
  JOURNAL   Nat Immunol 7 (10), 1082-1091 (2006)
   PUBMED   16936731
REFERENCE   8  (bases 1 to 3356)
  AUTHORS   Huan,C., Sashital,D., Hailemariam,T., Kelly,M.L. and Roman,C.A.
  TITLE     Renal carcinoma-associated transcription factors TFE3 and TFEB are
            leukemia inhibitory factor-responsive transcription activators of
            E-cadherin
  JOURNAL   J Biol Chem 280 (34), 30225-30235 (2005)
   PUBMED   15994295
REFERENCE   9  (bases 1 to 3356)
  AUTHORS   Argani,P., Lui,M.Y., Couturier,J., Bouvier,R., Fournet,J.C. and
            Ladanyi,M.
  TITLE     A novel CLTC-TFE3 gene fusion in pediatric renal adenocarcinoma
            with t(X;17)(p11.2;q23)
  JOURNAL   Oncogene 22 (34), 5374-5378 (2003)
   PUBMED   12917640
REFERENCE   10 (bases 1 to 3356)
  AUTHORS   Steingrimsson,E., Tessarollo,L., Pathak,B., Hou,L., Arnheiter,H.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip
            transcription factors, have important but functionally redundant
            roles in osteoclast development
  JOURNAL   Proc Natl Acad Sci U S A 99 (7), 4477-4482 (2002)
   PUBMED   11930005
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On or before Sep 9, 2012 this sequence version replaced
            XM_002727531.2, XM_228760.6, XM_002730205.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.21254.1,
                                           SRR26643291.43968.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840108,
                                           SAMN12840109 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               JAXUCZ010000021.1  17414291-17414685   c
            396-509             JAXUCZ010000021.1  17411806-17411919   c
            510-810             JAXUCZ010000021.1  17410564-17410864   c
            811-1056            JAXUCZ010000021.1  17409792-17410037   c
            1057-1161           JAXUCZ010000021.1  17409483-17409587   c
            1162-1279           JAXUCZ010000021.1  17407929-17408046   c
            1280-1336           JAXUCZ010000021.1  17406424-17406480   c
            1337-1412           JAXUCZ010000021.1  17406179-17406254   c
            1413-1560           JAXUCZ010000021.1  17404723-17404870   c
            1561-3356           JAXUCZ010000021.1  17401466-17403261   c
FEATURES             Location/Qualifiers
     source          1..3356
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..3356
                     /gene="Tfe3"
                     /gene_synonym="RGD1559642; Tcfe3"
                     /note="transcription factor binding to IGHM enhancer 3"
                     /db_xref="GeneID:317376"
                     /db_xref="RGD:1559642"
     exon            1..395
                     /gene="Tfe3"
                     /gene_synonym="RGD1559642; Tcfe3"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..2001
                     /gene="Tfe3"
                     /gene_synonym="RGD1559642; Tcfe3"
                     /codon_start=1
                     /product="transcription factor E3"
                     /protein_id="NP_001258156.1"
                     /db_xref="GeneID:317376"
                     /db_xref="RGD:1559642"
                     /translation="MSHATETARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLL
                     PESGIVADIELENILDPDSFYELKSQPLSLRSSLPISLQATPTTPATLSASSSAGGSR
                     TPAMSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASPAISVIGVSAGG
                     HTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPP
                     PGPSSAQPLPAPETAHATGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYND
                     EMLSYLPGGTAGLQLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISE
                     TEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPEMRWNKGTILKASV
                     DYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPNPGLLSLA
                     TSSVSDSLKPEQLDIEEEGRPSTTTFHVSGGPTQNAPPQQPPAPPSDTLLDLHFPSDH
                     LGDLGDPFHLGLEDILMEEEGMVGGLSGGALSPLRAASDPLLSSVSPAVSKSSSRRSS
                     FSMEDES"
     exon            396..509
                     /gene="Tfe3"
                     /gene_synonym="RGD1559642; Tcfe3"
                     /inference="alignment:Splign:2.1.0"
     exon            510..810
                     /gene="Tfe3"
                     /gene_synonym="RGD1559642; Tcfe3"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1056
                     /gene="Tfe3"
                     /gene_synonym="RGD1559642; Tcfe3"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1161
                     /gene="Tfe3"
                     /gene_synonym="RGD1559642; Tcfe3"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1279
                     /gene="Tfe3"
                     /gene_synonym="RGD1559642; Tcfe3"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1336
                     /gene="Tfe3"
                     /gene_synonym="RGD1559642; Tcfe3"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1412
                     /gene="Tfe3"
                     /gene_synonym="RGD1559642; Tcfe3"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1560
                     /gene="Tfe3"
                     /gene_synonym="RGD1559642; Tcfe3"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..3356
                     /gene="Tfe3"
                     /gene_synonym="RGD1559642; Tcfe3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttcctgtg gagtttcccc agcccaagga ggagggggaa agaggacgag agggaggcga
       61 gcggtcgttc ggggttaggt tggggggtgt cggtccgttc agggcgggtg atgactcacg
      121 gcccatccca tcttcccgac gccgcccgcc cacgcagagc tagctccatg gcttaacgga
      181 ggaggcagcg gcaagcgggg ggagggggac tcttattttg ttagggggac cgggccaagg
      241 cccgaccggc ctggcagggc tcgcccgggg ccgggcgtca tgtctcatgc aactgagaca
      301 gctcgggacg gcgtagaggc cagcgcggag ggccctcgag ccgtgttcgt gctgttggaa
      361 gagcgcaggc cagctgactc ggcccagctg ctcagcctga attctttgct tccggaatcc
      421 gggattgttg ctgacatcga gttagaaaac atccttgatc ctgacagctt ctacgagctc
      481 aaaagccagc ctctatccct tcgctccagc cttccaatat cactgcaggc cactccgacc
      541 accccagcta cactctctgc atcgtcttct gcagggggct cccggacccc tgccatgtca
      601 tcctcctcct cacgggtctt gctgcggcag cagcttatga gggcccaggc acaggaacag
      661 gagaggcgtg agcggcggga acaggcagcg gccgctccgt tccccagtcc tgcacctgcc
      721 tcaccagcca tctcagtgat tggtgtgtct gctggtggcc acacattgag tcgtccaccc
      781 cctgctcagg tgcccaggga ggtactcaag gttcaaaccc acctagagaa ccctacacgc
      841 taccacttgc agcaagctcg ccggcaacag gtgaaacagt acttgtctac tacacttggg
      901 cccaagctgg cttcacaggc cctcacccca ccaccagggc cttccagtgc tcagccactt
      961 cctgcccctg aaactgctca tgccaccggc cctacaggca gtgctcctaa cagccccatg
     1021 gcattgctca ccattgggtc cagctcagag aaggagattg atgatgtcat tgatgagatc
     1081 atcagcctgg agtccagtta caacgatgag atgctcagct atcttcctgg aggcactgca
     1141 gggctgcagc tccccagcac gctgcctgtg tcaggaaatc tacttgatgt gtacagcagt
     1201 cagggtgtgg ccaccccagc catcactgtc agcaattcct gtcctgctga gctgcctaac
     1261 atcaaacggg agatctcgga aaccgaggca aaggcccttt tgaaggagcg acagaagaaa
     1321 gacaatcaca acctaattga acgacgcagg cgattcaaca ttaacgatag gatcaaagag
     1381 ctgggcaccc tcatccccaa gtccaatgat ccggagatgc gctggaacaa gggaaccatc
     1441 ctgaaggcat ctgtggatta tatccgcaaa ttacagaagg aacagcagcg ctctaaagac
     1501 ctggagagcc ggcagcggtc cctggagcaa gccaaccgaa gcctgcagct ccgaattcag
     1561 gagctggaac tacaggcaca gatccatggt ctgccggtcc ctcccaaccc aggactgctc
     1621 tccctagcca ccagctcggt ctctgacagc ctcaagccgg aacaactgga cattgaggag
     1681 gagggcaggc caagcacaac aacatttcat gtgtcagggg ggcctaccca gaatgctcct
     1741 ccacaacagc ctccggcacc gccttcggat acccttctgg acctgcactt tcccagcgac
     1801 cacttggggg acctggggga ccccttccac ctagggctag aggacattct gatggaggag
     1861 gaggggatgg tgggaggact gtcagggggt gccctgtccc cactgcgggc tgcttccgac
     1921 cccctgcttt cttcagtatc cccggctgtt tccaagtcga gcagccggcg cagcagcttc
     1981 agcatggaag acgagtcctg atcaggcctc actcctcccc tcgggcttcc ccacccaggg
     2041 aaggagaaca agcctggatg agaccctacc ctcctgtgac actgtcctgt ccaggagatc
     2101 tggggaacga ggagttgcaa tcaggcccca accctgtact aggccaggag gaggaatcag
     2161 gtgaggccct gccacttttc cagaggacct gccttgtgca ggtatttgtg agggagaagg
     2221 caggggagaa ctgggaaagg tcagttcatc acttgagcat catagcctta ccccttgtcc
     2281 ctggtcctac tcctgcctcg gtgagggaag gaggcaggac aaggtatgcc cctggtcact
     2341 agggaccctt ataaacctgt ttataaaggt ctcccaagga aaggagatgc cagggtgccg
     2401 ctccattcct tctctgggaa gtgccaggcc agcttttcct ggcactggag gaagaaaagt
     2461 aaaaatagtg tctcacccct ggagggttga tccctatccc taccttatga cccctgactt
     2521 gttctggcaa ggaacagaag taaggatgtg atccagccca ttgccctggg ccccatccct
     2581 tctccatagg aaaagctcag cacaggtatt tcaggtagag aggaatgact aggctctgat
     2641 ctcccacgta gaggctccag ccccagccct gacccttagc atcataccgt gcaagcattc
     2701 cattcagttc ctaagctccc tgtcttaacc tgggaccagc ctggaacctg acatatgagg
     2761 gctctgtgct gaccttattc ttgaggaagg gaacagattt cgaaatcttg tggattgaca
     2821 ttctagacct agatcaagtg agacttagat cctcaccctt gagaagatct tgccttttct
     2881 gccttgaggg ccaatttggg ggagatgata gggattagtg tagacccagt ctaggtaccc
     2941 caatacttcc cttcaagttg tagaaaatgg taaagaaagg gcgtgtccag gctgtttatc
     3001 agtccaggga aaaatagaaa tctccctaaa aggcagggac ctgaaggaat ggtggcaaaa
     3061 gtatattgta tcgctcattt gtttgtgaat tttttattga acccacctac tcaaaagcta
     3121 ggtcaccccg gacctctgtc ccatccacac cgttctccat ctgggggact aaccctgttt
     3181 cagagccagt ccttagagcc agtccctacc tactagtccc atccatgcca cctacatcca
     3241 aggtcttcag ctttaaactg ctggggccag gccccaagga gggtttactg aggggtccgt
     3301 aggtttgact aaaataataa atgctaggcg tgtttgatgc gcttttaact ttggca
//
