LOCUS       NM_001008293            2092 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus transcription factor B2, mitochondrial (Tfb2m),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001008293 XM_213965
VERSION     NM_001008293.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2092)
  AUTHORS   Hillen,H.S., Morozov,Y.I., Sarfallah,A., Temiakov,D. and Cramer,P.
  TITLE     Structural Basis of Mitochondrial Transcription Initiation
  JOURNAL   Cell 171 (5), 1072-1081 (2017)
   PUBMED   29149603
REFERENCE   2  (bases 1 to 2092)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2092)
  AUTHORS   Watanabe,A., Arai,M., Koitabashi,N., Niwano,K., Ohyama,Y.,
            Yamada,Y., Kato,N. and Kurabayashi,M.
  TITLE     Mitochondrial transcription factors TFAM and TFB2M regulate Serca2
            gene transcription
  JOURNAL   Cardiovasc Res 90 (1), 57-67 (2011)
   PUBMED   21113058
  REMARK    GeneRIF: Mitochondrial transcription factors TFAM and TFB2M
            regulate Serca2 gene transcription in cardiac myocytes.
REFERENCE   4  (bases 1 to 2092)
  AUTHORS   Litonin,D., Sologub,M., Shi,Y., Savkina,M., Anikin,M.,
            Falkenberg,M., Gustafsson,C.M. and Temiakov,D.
  TITLE     Human mitochondrial transcription revisited: only TFAM and TFB2M
            are required for transcription of the mitochondrial genes in vitro
  JOURNAL   J Biol Chem 285 (24), 18129-18133 (2010)
   PUBMED   20410300
REFERENCE   5  (bases 1 to 2092)
  AUTHORS   Bogenhagen,D.F., Rousseau,D. and Burke,S.
  TITLE     The layered structure of human mitochondrial DNA nucleoids
  JOURNAL   J Biol Chem 283 (6), 3665-3675 (2008)
   PUBMED   18063578
REFERENCE   6  (bases 1 to 2092)
  AUTHORS   Falkenberg,M., Gaspari,M., Rantanen,A., Trifunovic,A., Larsson,N.G.
            and Gustafsson,C.M.
  TITLE     Mitochondrial transcription factors B1 and B2 activate
            transcription of human mtDNA
  JOURNAL   Nat Genet 31 (3), 289-294 (2002)
   PUBMED   12068295
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085870.1.
            
            On Dec 16, 2004 this sequence version replaced XM_213965.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085870.1, SRR8487227.24141.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2092
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..2092
                     /gene="Tfb2m"
                     /note="transcription factor B2, mitochondrial"
                     /db_xref="GeneID:289307"
                     /db_xref="RGD:1307091"
     exon            1..403
                     /gene="Tfb2m"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1284
                     /gene="Tfb2m"
                     /note="mtTFB2; dimethyladenosine transferase 2,
                     mitochondrial-like; mitochondrial 12S rRNA dimethylase 2;
                     mitochondrial transcription factor B2;
                     S-adenosylmethionine-6-N', N'-adenosyl(rRNA)
                     dimethyltransferase 2"
                     /codon_start=1
                     /product="dimethyladenosine transferase 2, mitochondrial"
                     /protein_id="NP_001008294.1"
                     /db_xref="GeneID:289307"
                     /db_xref="RGD:1307091"
                     /translation="MRGLAMRLPPRLALSVLAGRGPSCILGSGAATRKDWQERNRRSF
                     SDLYTQPLPDCDFEESSSWTHKSRSEPTRHIACKKSARNLVRDLLEHQNPSHQLILEC
                     NPGPGILTGALLKAGARVVAFESEKMFIPHLESLRKNADGELQVVHCDFFKIDPRYQE
                     LVRPDVNSHTIFQNLGIKAVPWSAGVPIKVFGILPNKHERRLLWKILFDLYSCESIYR
                     YGRVELNMFISEKEFRKLIATPKRPDLYQVLGVLWQVACEIKFLHMEPWSSFSVHAEN
                     GHLEKSKHSESLNLLKQNLYLVRMTPRRTLFTENLSPLNYDMFFHLVKHCFGKRNAPI
                     IHHLRSLSTVDPINILRQIRKRPGDTAAKMYPHDFKRLFETIERSEDSVFKWIYDYCS
                     DDSEL"
     exon            404..492
                     /gene="Tfb2m"
                     /inference="alignment:Splign:2.1.0"
     exon            493..643
                     /gene="Tfb2m"
                     /inference="alignment:Splign:2.1.0"
     exon            644..792
                     /gene="Tfb2m"
                     /inference="alignment:Splign:2.1.0"
     exon            793..882
                     /gene="Tfb2m"
                     /inference="alignment:Splign:2.1.0"
     exon            883..945
                     /gene="Tfb2m"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1106
                     /gene="Tfb2m"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..2067
                     /gene="Tfb2m"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtgaagtat gtgcacgtgt gatgtggtgc tccgtgttct tcgcagaggc tacactgtta
       61 actggtgatt ggggtggaca ttagaggagg atgaggggac tggcgatgag gctgcccccg
      121 cggctggcgc tgtcagtgtt ggcgggccgc ggcccgtctt gcattctggg gtccggagcg
      181 gcgacgcgga aggactggca agagaggaac cggcgtagct tctctgacct ctacactcaa
      241 ccgttgcctg attgtgattt cgaggagtcg tcctcgtgga cacacaagag tcgatcagag
      301 cctacgcgtc acatagcatg taagaaatcg gccaggaacc tggtacgaga cctgctggag
      361 caccaaaacc catcccatca acttatacta gagtgcaatc caggtccagg aatcctgact
      421 ggggcattac ttaaagctgg tgccagagtg gttgcctttg aaagtgaaaa gatgtttatt
      481 ccacatttgg agtccttaag gaagaatgcg gatggagagt tacaagtggt tcactgtgac
      541 ttctttaaaa tagatcctag gtatcaggag ctagtacgac cggatgtgaa ttcacacaca
      601 atttttcaga acctgggaat aaaagcagtt ccttggtcag caggtgttcc tataaaagta
      661 tttggaattc taccaaataa acatgaaaga cgattgcttt ggaaaatcct gtttgatctg
      721 tactcctgcg aatctatata cagatatgga cgagtagaac tgaatatgtt cattagtgaa
      781 aaagaattcc ggaaactaat agcaactcct aaaaggccag atttatatca agtattgggt
      841 gtgctttggc aagtggcttg tgaaattaag tttctgcaca tggagccttg gtcgtcattt
      901 agtgtgcatg ccgaaaatgg gcacttggaa aagtcaaagc actcggaatc attaaattta
      961 ctgaaacaaa acctatatct tgttcgaatg actcctcgta ggacattatt tacagaaaac
     1021 ctaagtcctt tgaactatga tatgtttttc cacttggtaa agcactgctt tgggaaacgc
     1081 aatgccccaa taatacacca tttacgttcc ctgagtacgg ttgaccccat taatatacta
     1141 aggcagataa ggaaaagacc tggagacacg gctgctaaaa tgtatcctca cgacttcaaa
     1201 agactttttg aaactataga acgttcagaa gactctgtct ttaaatggat ctatgactac
     1261 tgctcggacg acagtgagct ctagggaaaa cgtctacaag ccatgaatga gctgtttgtc
     1321 tattaatttt gaaattatgt gatgaatgaa aactgaattt caagatgttc atatcctttt
     1381 agcagaagag aaactatcct tgtttggcac agatgaagcg aataatttcc tcttaagttg
     1441 atacctttga tacacaggaa aaaccatggc tgcaggttta ttcaaagtta aataaaacaa
     1501 aaacttgtca gttcagtaag atcaaatgtg ctttgtttta aattacttct gctgtagatc
     1561 agtggtagaa catgagccta ggtgtccaag gttctggttt tgctttccag tacaggaaat
     1621 tttaagaaat ttctcttcac tgcaaaggcc cataggtgtg gaacatttcc tatgggaatt
     1681 tatttacttt agaaatggaa acctttgggc caaacatctt tcaatatgca cttttcacca
     1741 ctgccaatgg cttgactctc cctccagttt caatactgtt acacttagaa tgtgcattga
     1801 tttgggcaga cgtggtggtg caagtcccag gactcgtgag gtagagggcc caccagttca
     1861 atgccagttc aactgtggaa ttgagtgtga ggccagtttg ggctaagaaa agacctggtc
     1921 aaaacaagac aaaacaataa aaacttattt cagaaagtga ttagattatc ttttatgttg
     1981 aagtggatta tcaggtacta tgcaatccaa ttgtttaaat tctagtatgt tttaaaattt
     2041 tttgagaaat aaagaatttg cacatttaaa aaaaaaaaaa aaaaaaaaaa aa
//
