LOCUS       NP_001008294             397 aa            linear   ROD 03-APR-2024
DEFINITION  dimethyladenosine transferase 2, mitochondrial [Rattus norvegicus].
ACCESSION   NP_001008294 XP_213965
VERSION     NP_001008294.1
DBSOURCE    REFSEQ: accession NM_001008293.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 397)
  AUTHORS   Hillen,H.S., Morozov,Y.I., Sarfallah,A., Temiakov,D. and Cramer,P.
  TITLE     Structural Basis of Mitochondrial Transcription Initiation
  JOURNAL   Cell 171 (5), 1072-1081 (2017)
   PUBMED   29149603
REFERENCE   2  (residues 1 to 397)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (residues 1 to 397)
  AUTHORS   Watanabe,A., Arai,M., Koitabashi,N., Niwano,K., Ohyama,Y.,
            Yamada,Y., Kato,N. and Kurabayashi,M.
  TITLE     Mitochondrial transcription factors TFAM and TFB2M regulate Serca2
            gene transcription
  JOURNAL   Cardiovasc Res 90 (1), 57-67 (2011)
   PUBMED   21113058
  REMARK    GeneRIF: Mitochondrial transcription factors TFAM and TFB2M
            regulate Serca2 gene transcription in cardiac myocytes.
REFERENCE   4  (residues 1 to 397)
  AUTHORS   Litonin,D., Sologub,M., Shi,Y., Savkina,M., Anikin,M.,
            Falkenberg,M., Gustafsson,C.M. and Temiakov,D.
  TITLE     Human mitochondrial transcription revisited: only TFAM and TFB2M
            are required for transcription of the mitochondrial genes in vitro
  JOURNAL   J Biol Chem 285 (24), 18129-18133 (2010)
   PUBMED   20410300
REFERENCE   5  (residues 1 to 397)
  AUTHORS   Bogenhagen,D.F., Rousseau,D. and Burke,S.
  TITLE     The layered structure of human mitochondrial DNA nucleoids
  JOURNAL   J Biol Chem 283 (6), 3665-3675 (2008)
   PUBMED   18063578
REFERENCE   6  (residues 1 to 397)
  AUTHORS   Falkenberg,M., Gaspari,M., Rantanen,A., Trifunovic,A., Larsson,N.G.
            and Gustafsson,C.M.
  TITLE     Mitochondrial transcription factors B1 and B2 activate
            transcription of human mtDNA
  JOURNAL   Nat Genet 31 (3), 289-294 (2002)
   PUBMED   12068295
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085870.1.
            
            On Dec 16, 2004 this sequence version replaced XP_213965.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085870.1, SRR8487227.24141.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     Protein         1..397
                     /product="dimethyladenosine transferase 2, mitochondrial"
                     /note="mtTFB2; dimethyladenosine transferase 2,
                     mitochondrial-like; mitochondrial 12S rRNA dimethylase 2;
                     mitochondrial transcription factor B2;
                     S-adenosylmethionine-6-N', N'-adenosyl(rRNA)
                     dimethyltransferase 2"
                     /calculated_mol_wt=41186
     transit_peptide 1..44
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q5U2T7.1)"
                     /calculated_mol_wt=4854
     mat_peptide     45..397
                     /product="Dimethyladenosine transferase 2, mitochondrial.
                     /id=PRO_0000273181"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T7.1)"
                     /calculated_mol_wt=41186
     Region          82..380
                     /region_name="RsmA"
                     /note="16S rRNA A1518 and A1519 N6-dimethyltransferase
                     RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase
                     activity) [Translation, ribosomal structure and
                     biogenesis]; COG0030"
                     /db_xref="CDD:439801"
     Region          329..330
                     /region_name="DNA-binding.
                     /evidence=ECO:0000250|UniProtKB:Q9H5Q4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5U2T7.1)"
     CDS             1..397
                     /gene="Tfb2m"
                     /coded_by="NM_001008293.1:91..1284"
                     /db_xref="GeneID:289307"
                     /db_xref="RGD:1307091"
ORIGIN      
        1 mrglamrlpp rlalsvlagr gpscilgsga atrkdwqern rrsfsdlytq plpdcdfees
       61 sswthksrse ptrhiackks arnlvrdlle hqnpshqlil ecnpgpgilt gallkagarv
      121 vafesekmfi phleslrkna dgelqvvhcd ffkidpryqe lvrpdvnsht ifqnlgikav
      181 pwsagvpikv fgilpnkher rllwkilfdl yscesiyryg rvelnmfise kefrkliatp
      241 krpdlyqvlg vlwqvaceik flhmepwssf svhaenghle kskhseslnl lkqnlylvrm
      301 tprrtlften lsplnydmff hlvkhcfgkr napiihhlrs lstvdpinil rqirkrpgdt
      361 aakmyphdfk rlfetierse dsvfkwiydy csddsel
//
