LOCUS       NM_181474               1660 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus transcription factor B1, mitochondrial (Tfb1m),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_181474
VERSION     NM_181474.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1660)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1660)
  AUTHORS   Surovtseva,Y.V. and Shadel,G.S.
  TITLE     Transcription-independent role for human mitochondrial RNA
            polymerase in mitochondrial ribosome biogenesis
  JOURNAL   Nucleic Acids Res 41 (4), 2479-2488 (2013)
   PUBMED   23303773
REFERENCE   3  (bases 1 to 1660)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1660)
  AUTHORS   Bogenhagen,D.F., Rousseau,D. and Burke,S.
  TITLE     The layered structure of human mitochondrial DNA nucleoids
  JOURNAL   J Biol Chem 283 (6), 3665-3675 (2008)
   PUBMED   18063578
REFERENCE   5  (bases 1 to 1660)
  AUTHORS   Seidel-Rogol,B.L., McCulloch,V. and Shadel,G.S.
  TITLE     Human mitochondrial transcription factor B1 methylates ribosomal
            RNA at a conserved stem-loop
  JOURNAL   Nat Genet 33 (1), 23-24 (2003)
   PUBMED   12496758
REFERENCE   6  (bases 1 to 1660)
  AUTHORS   Falkenberg,M., Gaspari,M., Rantanen,A., Trifunovic,A., Larsson,N.G.
            and Gustafsson,C.M.
  TITLE     Mitochondrial transcription factors B1 and B2 activate
            transcription of human mtDNA
  JOURNAL   Nat Genet 31 (3), 289-294 (2002)
   PUBMED   12068295
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070907.1.
            
            On Jun 20, 2004 this sequence version replaced NM_181474.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070907.1, AY198392.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1660
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..1660
                     /gene="Tfb1m"
                     /note="transcription factor B1, mitochondrial"
                     /db_xref="GeneID:308140"
                     /db_xref="RGD:727795"
     exon            1..153
                     /gene="Tfb1m"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1058
                     /gene="Tfb1m"
                     /EC_number="2.1.1.-"
                     /note="mtTFB1; mitochondrial 12S rRNA dimethylase 1;
                     mitochondrial transcription factor B1;
                     S-adenosylmethionine-6-N', N'-adenosyl(rRNA)
                     dimethyltransferase 1"
                     /codon_start=1
                     /product="dimethyladenosine transferase 1, mitochondrial"
                     /protein_id="NP_852139.2"
                     /db_xref="GeneID:308140"
                     /db_xref="RGD:727795"
                     /translation="MAASGKLGTFRLPPLPTIREIIKLFGLRAAKQLSQNFLLDLRLT
                     DKIVRKAGSLADVYVYEVGPGPGGITRSILNADIAELLVVEKDTRFIPGLQMLSDAAP
                     GKLRIVHGDVLTYKIEKAFPDNIRRQWEDDPPNVHIIGNLPFSVSTPLIIKWLENISL
                     KNGPFVYGRTKMTLTFQKEVAERLVATTGSKQRSRLSIMAQYLCNVEHLFTIPGKAFV
                     PKPEVDVGVVHLMPLVQPKIKQPFKLVEKVVQNVFQFRRKYCHRGLGMLFPEAQRLES
                     TGRLLQLADIDPTLRPTHLSLMHFKSLCDVYRKMCDEDPQLFAYNFREELKQKKRKGQ
                     EKDGDSESCGF"
     exon            154..305
                     /gene="Tfb1m"
                     /inference="alignment:Splign:2.1.0"
     exon            306..414
                     /gene="Tfb1m"
                     /inference="alignment:Splign:2.1.0"
     exon            415..566
                     /gene="Tfb1m"
                     /inference="alignment:Splign:2.1.0"
     exon            567..686
                     /gene="Tfb1m"
                     /inference="alignment:Splign:2.1.0"
     exon            687..814
                     /gene="Tfb1m"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1585
                     /gene="Tfb1m"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgtgtgta tgtaggtctc atggctgcct cgggaaagct cggcactttc cgcctccccc
       61 cgttacccac cattcgagaa atcattaagt tgttcggact gcgagcggcg aagcagcttt
      121 cccagaattt cctcctggac ttgaggctga cagacaaaat tgtaaggaaa gctggcagtc
      181 tagcagatgt ttatgtttat gaagtgggtc cggggcccgg gggaatcaca agatccatcc
      241 tcaatgctga tattgccgag cttctggtgg ttgaaaagga tactcggttt attccaggat
      301 tacagatgct ttctgatgca gcacctggaa aactccgaat tgttcatgga gatgtgctga
      361 cgtataagat agaaaaggct tttccagaca acattagaag acagtgggaa gatgatcctc
      421 caaatgtaca tattattgga aacctgcctt ttagtgtttc aaccccactg attatcaagt
      481 ggcttgaaaa tatttctctt aaaaatggcc ctttcgttta cggcagaact aagatgacgt
      541 taacatttca aaaggaagtg gcggagagac ttgtagccac tacaggaagc aaacagcgca
      601 gtcgtctttc cattatggcc cagtacctct gcaatgttga gcacctcttt acaatcccag
      661 gaaaggcttt tgttcccaaa ccagaggttg atgtaggagt ggtgcacctt atgcccttgg
      721 tacagcccaa gatcaagcag ccattcaagc tggtagaaaa agttgtccag aatgtgtttc
      781 agtttcgaag gaaatattgc caccgagggc ttggaatgtt attccctgaa gcacagcgcc
      841 tggaaagcac tggaaggctg ttacagctag ctgacattga tccaacgctc cggcccactc
      901 acctctcgct catgcatttt aagagtttat gtgatgtgta cagaaaaatg tgtgatgaag
      961 acccacaact ctttgcttat aacttcagag aagagctcaa gcaaaagaaa aggaaaggtc
     1021 aagaaaaaga tggtgactca gaaagctgtg ggttctaact gctgtcttag ggctcccgac
     1081 tggcagtctc gatccacagt gtggatctcc acatgtggac atgtgcttcc ctcccactct
     1141 gtaaagacaa atactgatga cctcatgcca agtagatcca atgcatgcaa gctttttctt
     1201 taaatacata tatatatgta tatatatata tattgaatag ataagacatg tttagtataa
     1261 acagcattta ttacaacctt ccaaaatgaa atgtctgcac attgtgcccc taaaccatgt
     1321 aaacataaat gtgctttaaa tgaagcaaaa actaacagcg caaagaaaat gcccaaagga
     1381 ctggggggag gggcctttaa aagctattaa tcacaacgtt cccaatctta tcccacataa
     1441 cttaaaataa ttagaatgca attttattac aagactaaaa atcatttgat tcctgctcaa
     1501 aagggataga agctagtaat ttacagattc tgaccaacta aatctagttt tctgattcac
     1561 aataaattaa aataacttaa atcttaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1621 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
