LOCUS       NM_001413770            5940 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus transcription factor AP-2 beta (Tfap2b),
            transcript variant 1, mRNA.
ACCESSION   NM_001413770 XM_039083192
VERSION     NM_001413770.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5940)
  AUTHORS   Schmidt,M., Huber,L., Majdazari,A., Schutz,G., Williams,T. and
            Rohrer,H.
  TITLE     The transcription factors AP-2beta and AP-2alpha are required for
            survival of sympathetic progenitors and differentiated sympathetic
            neurons
  JOURNAL   Dev Biol 355 (1), 89-100 (2011)
   PUBMED   21539825
REFERENCE   2  (bases 1 to 5940)
  AUTHORS   Hong,S.J., Huh,Y.H., Leung,A., Choi,H.J., Ding,Y., Kang,U.J.,
            Yoo,S.H., Buettner,R. and Kim,K.S.
  TITLE     Transcription factor AP-2beta regulates the neurotransmitter
            phenotype and maturation of chromaffin cells
  JOURNAL   Mol Cell Neurosci 46 (1), 245-251 (2011)
   PUBMED   20875861
REFERENCE   3  (bases 1 to 5940)
  AUTHORS   Zhao,F., Bosserhoff,A.K., Buettner,R. and Moser,M.
  TITLE     A heart-hand syndrome gene: Tfap2b plays a critical role in the
            development and remodeling of mouse ductus arteriosus and limb
            patterning
  JOURNAL   PLoS One 6 (7), e22908 (2011)
   PUBMED   21829553
REFERENCE   4  (bases 1 to 5940)
  AUTHORS   Li,X., Glubrecht,D.D. and Godbout,R.
  TITLE     AP2 transcription factor induces apoptosis in retinoblastoma cells
  JOURNAL   Genes Chromosomes Cancer 49 (9), 819-830 (2010)
   PUBMED   20607706
REFERENCE   5  (bases 1 to 5940)
  AUTHORS   Nordquist,N., Gokturk,C., Comasco,E., Eensoo,D., Merenakk,L.,
            Veidebaum,T., Oreland,L. and Harro,J.
  TITLE     The transcription factor TFAP2B is associated with insulin
            resistance and adiposity in healthy adolescents
  JOURNAL   Obesity (Silver Spring) 17 (9), 1762-1767 (2009)
   PUBMED   19325541
REFERENCE   6  (bases 1 to 5940)
  AUTHORS   Damberg,M., Ekblom,J. and Oreland,L.
  TITLE     Chronic pharmacological treatment with certain antidepressants
            alters the expression and DNA-binding activity of transcription
            factor AP-2
  JOURNAL   Life Sci 68 (6), 669-678 (2000)
   PUBMED   11205881
REFERENCE   7  (bases 1 to 5940)
  AUTHORS   Satoda,M., Zhao,F., Diaz,G.A., Burn,J., Goodship,J., Davidson,H.R.,
            Pierpont,M.E. and Gelb,B.D.
  TITLE     Mutations in TFAP2B cause Char syndrome, a familial form of patent
            ductus arteriosus
  JOURNAL   Nat Genet 25 (1), 42-46 (2000)
   PUBMED   10802654
REFERENCE   8  (bases 1 to 5940)
  AUTHORS   Moser,M., Pscherer,A., Roth,C., Becker,J., Mucher,G., Zerres,K.,
            Dixkens,C., Weis,J., Guay-Woodford,L., Buettner,R. and Fassler,R.
  TITLE     Enhanced apoptotic cell death of renal epithelial cells in mice
            lacking transcription factor AP-2beta
  JOURNAL   Genes Dev 11 (15), 1938-1948 (1997)
   PUBMED   9271117
REFERENCE   9  (bases 1 to 5940)
  AUTHORS   Duan,C. and Clemmons,D.R.
  TITLE     Transcription factor AP-2 regulates human insulin-like growth
            factor binding protein-5 gene expression
  JOURNAL   J Biol Chem 270 (42), 24844-24851 (1995)
   PUBMED   7559606
REFERENCE   10 (bases 1 to 5940)
  AUTHORS   Moser,M., Imhof,A., Pscherer,A., Bauer,R., Amselgruber,W.,
            Sinowatz,F., Hofstadter,F., Schule,R. and Buettner,R.
  TITLE     Cloning and characterization of a second AP-2 transcription factor:
            AP-2 beta
  JOURNAL   Development 121 (9), 2779-2788 (1995)
   PUBMED   7555706
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 8, 2022 this sequence version replaced XM_039083192.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.34750.1,
                                           SRR26643298.48072.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000009.1  29283003-29283104
            103-561             JAXUCZ010000009.1  29287574-29288032
            562-622             JAXUCZ010000009.1  29292719-29292779
            623-842             JAXUCZ010000009.1  29300064-29300283
            843-961             JAXUCZ010000009.1  29302080-29302198
            962-1103            JAXUCZ010000009.1  29304670-29304811
            1104-5940           JAXUCZ010000009.1  29307732-29312568
FEATURES             Location/Qualifiers
     source          1..5940
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..5940
                     /gene="Tfap2b"
                     /gene_synonym="Tcfap2b"
                     /note="transcription factor AP-2 beta"
                     /db_xref="GeneID:301285"
                     /db_xref="RGD:1306321"
     exon            1..102
                     /gene="Tfap2b"
                     /gene_synonym="Tcfap2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1401
                     /gene="Tfap2b"
                     /gene_synonym="Tcfap2b"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transcription factor AP-2-beta isoform 1"
                     /protein_id="NP_001400699.1"
                     /db_xref="GeneID:301285"
                     /db_xref="RGD:1306321"
                     /translation="MHSPPRDQAAIMLWKLVENVKYEDIYEDRHDGVPSHSSRLSQLG
                     SVSQGPYSSAPPLSHTPSSDFQPPYFPPPYQPLPYHQSQDPYSHVNDPYSLNPLHQPQ
                     QHPWGQRQRQEVGSEAGSLLPQPRAALPQLSGLDPRRDYHSVRRPDVLLHSAHHGLDA
                     GMGDSLSLHGLGHPGMEDVQSVEDANNSGMNLLDQSVIKKVPVPPKSVTSLMMNKDGF
                     LGGMSVNTGEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAK
                     SKNGGRSLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYICETEFPAK
                     AVSEYLNRQHTDPSDLHSRKNMLLATKQLCKEFTDLLAQDRTPIGNSRPSPILEPGIQ
                     SCLTHFSLITHGFGAPAICAALTALQNYLTEALKGMDKMFLNNTTNRHTSGEGPGSKT
                     GDKEEKHRK"
     exon            103..561
                     /gene="Tfap2b"
                     /gene_synonym="Tcfap2b"
                     /inference="alignment:Splign:2.1.0"
     exon            562..622
                     /gene="Tfap2b"
                     /gene_synonym="Tcfap2b"
                     /inference="alignment:Splign:2.1.0"
     exon            623..842
                     /gene="Tfap2b"
                     /gene_synonym="Tcfap2b"
                     /inference="alignment:Splign:2.1.0"
     exon            843..961
                     /gene="Tfap2b"
                     /gene_synonym="Tcfap2b"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1103
                     /gene="Tfap2b"
                     /gene_synonym="Tcfap2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..5940
                     /gene="Tfap2b"
                     /gene_synonym="Tcfap2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacatctgc tgctcacatg aatgcactca cctcctagag accaggctgc catcatgctc
       61 tggaaactcg tggagaatgt caagtacgaa gacatctatg aggaccggca cgatggcgtc
      121 ccaagccata gctcgagact ctctcagctg ggctctgtgt ctcaaggacc ttactcgagc
      181 gccccgccgc tgtcccacac gccatcatcg gacttccagc caccctactt cccgcccccc
      241 taccagccgc taccctacca ccaaagtcaa gacccgtact cccacgtcaa cgatccctac
      301 tccctgaacc ctctgcatca gccccagcag cacccgtggg ggcaacgaca acgccaagaa
      361 gtgggttcag aagccggctc tctcctgccc cagccccggg cagccttgcc ccagctctcc
      421 ggccttgacc ccagaaggga ctaccactct gtccgccggc cggacgtgct gctgcattcc
      481 gcacaccacg gcctggacgc cggcatgggc gacagcctct cattgcacgg ccttgggcat
      541 cccggcatgg aagacgtgca gtcagttgaa gatgccaata acagcggcat gaacctattg
      601 gaccagtcag tcattaaaaa agttcctgtc cctcccaaat ctgtgacttc tctaatgatg
      661 aataaagatg gcttcttggg aggaatgtca gtcaacaccg gcgaggtatt ttgctcagtc
      721 ccaggccgct tatctctact cagttcaact tccaagtaca aagttactgt gggcgaagtt
      781 cagagaaggc tctcgccccc tgaatgcctc aatgcgtctc tcctgggcgg cgtcctcaga
      841 agagccaaat cgaaaaatgg ggggagatcc ttgagagaaa ggctagaaaa aatcggtttg
      901 aatttacccg cgggcaggcg caaagcagca aatgtcacgt tactcacctc cctggtagaa
      961 ggggaagcgg ttcacttagc tcgggatttt gggtatattt gtgaaacaga gttccctgct
     1021 aaagccgtat ctgagtattt gaacagacag cacacggacc ccagtgatct gcactccaga
     1081 aagaatatgc tgctggccac caagcaactt tgtaaagaat ttacggatct gctggctcag
     1141 gaccggacac cgatcggaaa cagccggccc agccccatcc tggagccggg catccaaagc
     1201 tgtctcacgc acttcagtct catcacgcac ggcttcggtg ccccggccat ttgcgctgcg
     1261 ctcaccgccc tgcagaacta tctcaccgag gctctcaaag gcatggacaa gatgttcttg
     1321 aacaacacca ctaacaggca cacgtctggg gaaggcccag gtagtaaaac tggcgacaag
     1381 gaggagaaac acaggaaatg aaaaaaaatt aaagagaagg aaaatgtttt aaatacaaaa
     1441 ggaaaacaga aaaaaaataa atttagcttt aacatattgg attggctttg gaagaattat
     1501 attaggtaga atacacatac aatcaaaatt ttaaaagaaa gctaaataac ttaaaaaaaa
     1561 aaaaactgag gcgtacaacg gagcaacaaa ccagctctcg gtgtctattt caagatacac
     1621 gtggagacaa ccgtccggat tttccacttc ggttctttcg agtttagtaa tacagataat
     1681 aaaagaaaac tatgatcccc cttttggaaa ataaacgtga gactaaacat gagaacacgc
     1741 taacttattg gaagaaaatt ggagaaacgt tggtgtcaat gcttttgaga gctggttgac
     1801 tgagacgcac gaacttttaa agttttaatt ttaatttttt ttttcttaag gaaactcgca
     1861 ctccgcgccc tccatttctc ctcaatctcc tcactgttgc ctccctttct ccccctcctc
     1921 acagcaggac ggggaacctg ctgggtgatc accagtgtga ttagcctctc cgactttagc
     1981 ccctttggta tccagacctc gccctgcgtt ccttacagcc ctgtgcccaa gtccccacct
     2041 ccccgccacc cccccggccc cggtgtgttt aattagggag gccaggggtg ggggtggggg
     2101 acaggcggag gctcgagctt ttgatccagt cttgagagcc gaggctcccg cggcagagga
     2161 aaccgataag ttgattcatc atggttcctt tcagaaagat gttactagtt cccagacgtg
     2221 acagcacctg ttcacagaga atattgcatt tgttatactt gtgtcatcta gaaatatagt
     2281 ttaaaaaaaa gaaaagaaag aaaaaacaaa acatgaaaac tttgattagt atgtaattcc
     2341 ttcggagggg tatgtaccat ttactctctt ctgtttccca aagctttacc cgcatggttt
     2401 atgagcttct tcaaagaaga cttgggcttc ctacacaatc tataaggtac tgagaaaaaa
     2461 aaaaaaacga tccttttaaa gttaaagcct ccgtgtcaga ttcggcaggt tttacttctt
     2521 taaagaagct caaagagaat catttaggaa atggccagtg ttggggagca gcattgaatt
     2581 tcttgctaag gcacctcaac gggggaaatt ccagcagggg cggggcatgg caaaaagcat
     2641 tttaagggtg gtcgagtcag gaaggcatct tgcttgggaa cctatattct aatggtattg
     2701 tcttaactga aaaaaaaaaa tgaattccat gtcctcggac tctttgggga ccgatgttct
     2761 aatggggaaa gacgcagttc tgctgacgta attggggaag acagtcgtca aactaccatg
     2821 actctgcttt atgaatgaaa cagttttcct tctcagacac acagttgttt tggtgtctag
     2881 tttggtgcac aaaatgatgt atacacacac acacacacac acacacacac acacacacac
     2941 acatacacac cataaagcac agagcgaagg aacgagcttg tatttcagct ttgaattcat
     3001 gtccagatac attgagaata ttcccaatgg ataaagttcc atgcttttaa tgtatctctc
     3061 ttctcttaat ccaacatttc actatgcccc gtcttaatat taccatgaag taaagcctgc
     3121 acctttaaca agatcaagga atagagtatt tgattggtgc acacatttag tttgggtaca
     3181 cgtggttctt ttacaaccac ctggacggga atctttacaa aagccattgg gataaacatt
     3241 cacatgtttt ctgtgattta cagacaatct cttcccccca ataatctgga ctctctctca
     3301 gtcttcctat tcttttccaa tccattttgt agcaagggaa ggggtttcag ttttagggac
     3361 cctctggggg ctttgctcaa aggattttat ttgaggaaaa ggaaagtgag tgggtttgag
     3421 atccaggaag gttgtaaaca aaaatagagg tcaggcaaca tctcctttcc tgtctctaac
     3481 tgctgctgag tccggtaggt tttcaggaca cagcctcagg caagctgaaa ggagtagaaa
     3541 gggcaggaaa gaaggcattg tgcgaattat tgactcacat ctttcctcag tttagaagcc
     3601 cacccctttt gtccgagagc ctggacgctt gcattagttg aattctgatt gcacaaggcc
     3661 agcagaaaac acattgaaaa acatcgtctc ctttccttgc agggcaacgc gccccacgcg
     3721 tgtgacatcg agagacgcga tggatgcgcc ttgctcttac tgtgcaggtc ctgagaacat
     3781 gtgggccact gaagcccagt ggtgttgagg acatagaatc agcagctgct gggggctcaa
     3841 gccgcacagt cccttcttgc tctcggcctc accctaaggg ctaaggcaac tgagaaaggc
     3901 tggttcccga gtaggtaaaa gggcggcgcc ccactggctg ctggggggag ggatcccaga
     3961 gctccgtcgg taaaacccct ttgccgcaag cggtcactcc cggccggccc tactcttaga
     4021 gaggctgtag tttggaaaag tccaaggact ttgaaacttt catgtattct ttattgccag
     4081 gaaggaaact gtccccaccc taactctcct gaagtgtgga catgaataag aactgtcatt
     4141 ctagggtagg tagactccct tagacgccct ggtgtccacc ggagcatcgc gaaggtgcgg
     4201 ctagatagac cgggtttgag ccccctcccc cacctccggt gttgtcttct gtttctgtct
     4261 ttttttctct cgccctcttt cacttcggac cttccgcccc atgctgtctt tagctaagcc
     4321 ggctacattt atctgataat tgagttatta aaagatttgt ttttttgggg ggggtgttta
     4381 aatcaataaa cagtaggatt aacacaagag tttgcctttt aagtcaagga aaacgtttaa
     4441 ggccagaccc tttgagtttt gttttcaaac caaacaggtg agttatagcc ccatcttctc
     4501 ccctgcactc agtagacgcc ttatctaggc cctcaacccc ttcccgccac gcccccacta
     4561 aatgctgggt tccaaaacca agtaactaaa gactgaagag taagcctgta agtactggag
     4621 ttctctctag gctcttttag ccccttcttt ttgaatgaaa cattctccta cttgtattct
     4681 gggtctcatg gagtttgttc ctagtgagga ttccctctcc agagaccttt aacttttaac
     4741 ttccaaccca actaggaggt aactttcttt tcttcctttc cccgacttac cttgcaagcg
     4801 cccacctgcc tcttactcat tcccgcaacc ctatctacct cttcaccgct agctttctcc
     4861 aaccctatat aaagagctca acgggctttc aaaaaatccg acttctgttg gcattgccca
     4921 aggaactttc tcttaagcaa ttatttcata tcctttggaa gctggtcgaa tggaaaaccc
     4981 caacacccca acttttctac acacttcctt tatggttaca agatccatcc ctagttagtg
     5041 tattgataga aaagttgtca ccatacctga tatcctgtac gtgtaataca ttctgtggga
     5101 agaaaatgat gaccttagtc catcagacac tgcctcaaga gttctgagaa acaagagctc
     5161 ccctccttta gtgatgtata ttaaattatt gacaaaagaa aaaaagtatt ggaatttgtt
     5221 ttcttaaaaa aaaaaacgga gtgaacacca tttcttcttt aaatacagac attgattctc
     5281 cttttaagtt ggcctctaat tcagtaatat tgtttttacc acccagtcaa gaggtaccaa
     5341 ctgcctcttc ctgagagcac tctggagggt atccgtgtta agtttgtata tatttattta
     5401 tgcttaattt aatgggaatg tgtaaatatt atgagcaagt agtttgggat tatttatctg
     5461 tgaatctata cctctgtgaa tgggtggtta aaaaaaaaaa caaaaaaaaa aaaccacaca
     5521 aaaaaaaaaa acaaaaaaaa acgcttgacc ctagctagaa tcctatccga atttttctgt
     5581 tctttataga caagctgtta tggtattggg tagaaattgg tttgttgtcc agtgttaatc
     5641 tgatttacat aaataaaaaa ttgttgtgtt cttgttgtgt tctcctcttt agttccttaa
     5701 acaaggacat tgtatcattc tacagacaga aaagagatat agcaaaaggc tttcttcttt
     5761 ttgcaccctc ccctcactga agtacataca gtgtttttgt tacaaagaaa tacaataaat
     5821 tttgcttatc agaaaaatga acactttagt ttctagtagg aggtgctttt tttttacttt
     5881 taaaatttca aatggatact agtcccaatc atatttgtaa taaaagttca tattaactac
//
