LOCUS       NM_001107345            3288 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus transcription factor AP-2 alpha (Tfap2a), mRNA.
ACCESSION   NM_001107345 XM_001062658 XM_225238
VERSION     NM_001107345.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3288)
  AUTHORS   Gao,Z., Zhang,J. and Wu,Y.
  TITLE     TFAP2A inhibits microRNA-126 expression at the transcriptional
            level and aggravates ischemic neuronal injury
  JOURNAL   Biochem Cell Biol 99 (4), 403-413 (2021)
   PUBMED   33264079
  REMARK    GeneRIF: TFAP2A inhibits microRNA-126 expression at the
            transcriptional level and aggravates ischemic neuronal injury.
REFERENCE   2  (bases 1 to 3288)
  AUTHORS   Adam,C. and Cyr,D.G.
  TITLE     Role of Specificity Protein-1 and Activating Protein-2
            Transcription Factors in the Regulation of the Gap Junction Protein
            Beta-2 Gene in the Epididymis of the Rat
  JOURNAL   Biol Reprod 94 (6), 120 (2016)
   PUBMED   27053364
  REMARK    GeneRIF: SP1 and TFAP2A regulate Gjb2 promoter activity during
            epididymal differentiation in rat.
REFERENCE   3  (bases 1 to 3288)
  AUTHORS   Feutlinske,F., Browarski,M., Ku,M.C., Trnka,P., Waiczies,S.,
            Niendorf,T., Stallcup,W.B., Glass,R., Krause,E. and Maritzen,T.
  TITLE     Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates
            focal adhesion dynamics and cell motility
  JOURNAL   Nat Commun 6, 8535 (2015)
   PUBMED   26437238
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3288)
  AUTHORS   Lin,H.H., Chen,Y.H., Chiang,M.T., Huang,P.L. and Chau,L.Y.
  TITLE     Activator protein-2alpha mediates carbon monoxide-induced stromal
            cell-derived factor-1alpha expression and vascularization in
            ischemic heart
  JOURNAL   Arterioscler Thromb Vasc Biol 33 (4), 785-794 (2013)
   PUBMED   23393395
  REMARK    GeneRIF: AKT-dependent upregulation of AP-2alpha is essential for
            carbon monoxide-induced SDF-1alpha expression and myocardial repair
            after ischemic injury.
REFERENCE   5  (bases 1 to 3288)
  AUTHORS   Borgonovo,J., Capella,P., Seltzer,A. and Sosa,M.A.
  TITLE     Expression of coat proteins changes during postnatal development in
            selected areas of the rat brain
  JOURNAL   Int J Dev Neurosci 30 (4), 333-341 (2012)
   PUBMED   22306374
  REMARK    GeneRIF: This study demonistrated that the expression of both
            subunits varies differently during postnatal development in some
            areas of rat brain. In striatum, alpha1 can be detected even at
            early ages, whereas alpha2 is highly expressed on the 15th day
            after birth.
REFERENCE   6  (bases 1 to 3288)
  AUTHORS   Schorle,H., Meier,P., Buchert,M., Jaenisch,R. and Mitchell,P.J.
  TITLE     Transcription factor AP-2 essential for cranial closure and
            craniofacial development
  JOURNAL   Nature 381 (6579), 235-238 (1996)
   PUBMED   8622765
REFERENCE   7  (bases 1 to 3288)
  AUTHORS   Duan,C. and Clemmons,D.R.
  TITLE     Transcription factor AP-2 regulates human insulin-like growth
            factor binding protein-5 gene expression
  JOURNAL   J Biol Chem 270 (42), 24844-24851 (1995)
   PUBMED   7559606
REFERENCE   8  (bases 1 to 3288)
  AUTHORS   Moser,M., Imhof,A., Pscherer,A., Bauer,R., Amselgruber,W.,
            Sinowatz,F., Hofstadter,F., Schule,R. and Buettner,R.
  TITLE     Cloning and characterization of a second AP-2 transcription factor:
            AP-2 beta
  JOURNAL   Development 121 (9), 2779-2788 (1995)
   PUBMED   7555706
REFERENCE   9  (bases 1 to 3288)
  AUTHORS   Buettner,R., Kannan,P., Imhof,A., Bauer,R., Yim,S.O.,
            Glockshuber,R., Van Dyke,M.W. and Tainsky,M.A.
  TITLE     An alternatively spliced mRNA from the AP-2 gene encodes a negative
            regulator of transcriptional activation by AP-2
  JOURNAL   Mol Cell Biol 13 (7), 4174-4185 (1993)
   PUBMED   8321221
REFERENCE   10 (bases 1 to 3288)
  AUTHORS   Williams,T. and Tjian,R.
  TITLE     Characterization of a dimerization motif in AP-2 and its function
            in heterologous DNA-binding proteins
  JOURNAL   Science 251 (4997), 1067-1071 (1991)
   PUBMED   1998122
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000288.1.
            
            [WARNING] On Mar 30, 2024 this sequence was replaced by
            NM_001107345.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001107345.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16093046
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               JACYVU010000288.1  9477701-9478015
            316-750             JACYVU010000288.1  9479255-9479689
            751-802             JACYVU010000288.1  9482797-9482848
            803-1034            JACYVU010000288.1  9484662-9484893
            1035-1153           JACYVU010000288.1  9487095-9487213
            1154-1295           JACYVU010000288.1  9489233-9489374
            1296-3288           JACYVU010000288.1  9491249-9493241
FEATURES             Location/Qualifiers
     source          1..3288
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..3288
                     /gene="Tfap2a"
                     /gene_synonym="Tcfap2a"
                     /note="transcription factor AP-2 alpha"
                     /db_xref="GeneID:306862"
                     /db_xref="RGD:1310267"
     exon            1..315
                     /gene="Tfap2a"
                     /gene_synonym="Tcfap2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..1584
                     /gene="Tfap2a"
                     /gene_synonym="Tcfap2a"
                     /note="AP2-alpha; activator protein 2; AP-2 transcription
                     factor; activating enhancer-binding protein 2-alpha"
                     /codon_start=1
                     /product="transcription factor AP-2-alpha"
                     /protein_id="NP_001100815.1"
                     /db_xref="GeneID:306862"
                     /db_xref="RGD:1310267"
                     /translation="MLVHSFSAMDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPN
                     ADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLL
                     HTHRGLPHQLSGLDPRRDYRRHEDLLHGPHGLGSGLGDLPIHSLPHAIEDVPHVEDPG
                     INIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSST
                     SKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRK
                     AANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLA
                     TKQICKEFTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTAL
                     QNYLTEALKAMDKMYLSNNPNSHTDNSAKSSDKEEKHRK"
     exon            316..750
                     /gene="Tfap2a"
                     /gene_synonym="Tcfap2a"
                     /inference="alignment:Splign:2.1.0"
     exon            751..802
                     /gene="Tfap2a"
                     /gene_synonym="Tcfap2a"
                     /inference="alignment:Splign:2.1.0"
     exon            803..1034
                     /gene="Tfap2a"
                     /gene_synonym="Tcfap2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1153
                     /gene="Tfap2a"
                     /gene_synonym="Tcfap2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1295
                     /gene="Tfap2a"
                     /gene_synonym="Tcfap2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..3288
                     /gene="Tfap2a"
                     /gene_synonym="Tcfap2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgatcccgg gaggatagag atcgtgggtt cgaccagttg aaggcgccgc gcgactcggt
       61 gatacaagtt cggatggatc cgagcggggc tccgacgctc gcgggaacgt ccgcgcggtg
      121 actggagtcc tgggtggcgc ggggctctcg gcgccttttg tgtgtggctc tttcgggccg
      181 ccgggcagcc gggtgctcga ggcgtggtgc tttttgcttt ttgcttttgt tattgttgtt
      241 ggtttttttt tttcctcacc ctgactggtt accccagatt cttcgcagat gttagttcac
      301 agtttttcag ctatggaccg tcacgacggc accagcaacg ggacggcacg gttgccccag
      361 ctgggcactg taggtcaatc tccctacacc agcgccccgc cgctgtccca cacccctaat
      421 gccgacttcc agcctcccta ctttcccccg ccctaccagc ctatctaccc ccagtcgcaa
      481 gatccttact cccacgtcaa cgacccctac agcctgaatc ccctgcacgc ccagccgcag
      541 ccgcagcacc cgggctggcc cggccagagg cagagccagg agtctgggct cttacacaca
      601 caccgggggc taccccacca actgtcaggc ctggaccctc gcagggacta tcggcggcac
      661 gaggacctct tacacggccc gcacgggctc ggctccgggc tcggggacct cccgatccac
      721 tccttacctc acgccatcga ggacgtcccg catgtagaag acccgggtat taacatccca
      781 gatcaaactg taattaagaa aggccctgtg tccctgtcca agtccaacag caatgccgtc
      841 tccgccatcc ctatcaacaa ggacaacctc ttcggtggcg tggtgaaccc caacgaagtc
      901 ttctgttcag ttccgggtcg cctgtcgctc ctcagctcca cctcgaagta caaggtcacg
      961 gtggcggaag tacagcggcg cctctcaccg cccgagtgtc tcaacgcttc gctcctgggc
     1021 ggagtactgc ggagagcgaa gtctaagaat ggagggcgat ctttaagaga aaaactggac
     1081 aaaataggac tgaatctgcc cgcagggaga cgtaaagccg ccaacgtcac ccttctcacg
     1141 tcactagtgg aaggagaagc cgtccaccta gccagggact ttgggtacgt gtgtgaaacc
     1201 gagttccctg ccaaagcagt agcagaattt ctcaaccgac aacattccga tcccaacgag
     1261 caagtgacaa gaaaaaacat gcttctggct acaaaacaga tctgcaaaga gttcactgac
     1321 ctgctggctc aggaccgatc tcccctgggg aactcgcggc ccaaccctat cctggagcct
     1381 ggcatccaga gttgcttgac ccacttcaac ctcatctccc atggcttcgg cagcccggcg
     1441 gtgtgtgcag cggtcaccgc cctgcagaac tatctcaccg aggccctcaa ggccatggac
     1501 aaaatgtacc tcagcaacaa tcccaacagc cacacggaca acagcgccaa aagcagtgac
     1561 aaagaagaga aacacagaaa gtgaggctct cctcccgccc gcccccgccc gcctcaccgg
     1621 ccggcgtccc cactcgcccc tcccccaccc ggcaggtgac agctccggga ccagccactc
     1681 ctactgctgc tgctactctc tgcgctgccg cgccgccctt cgtctccgca gtcctccgga
     1741 ttgctctctc gactgccagt ggggctgccg cttcctactc agcgccttgc ctcaacttcc
     1801 ccatcagcac caacaccccc tttaccctcg tgtggagcct aagagaacag aacaggtcgt
     1861 gaagccagca aagaaaagtt ctgtcgcgtt tgtgaaactt ttttttttta aatcaacaac
     1921 aaacattaaa actttttttt ttaaaaaaag gacgtaaaaa atttaaaaag tatatgagct
     1981 tcatgggact aactcatcgc cttcccttgc atacttcaga ttgtagccat actttaaaaa
     2041 aaaaaaggca aagaggataa tgacattttt tatcagtatt gtgaataaac ttgaacacaa
     2101 atccagaagt tctatgtcct gtcttcagtt gtagaagttg tctctgcaag gtacaaccac
     2161 ccatttgaac ttcctctgat gacacaatcc acaattctat aagggaatca gtgttcacgt
     2221 ctctgtatat atttatttat gtgtaattta atgggatttg taaatatggt gagtctgcct
     2281 ttttttattt atctggtgat ctcgtttacc tccttgttta gtgggctttg gatcgatcgt
     2341 ccttcttagt tcttcagtgg ttttacttag aaatccaagg tttgggtaat accccccccc
     2401 cgcccccttt ctggaattca tggatttagc cccgtggtag catgttaaca atgataatga
     2461 aacagctgaa caaaacattt ttaaggtaaa ataaaaattt atatataatt agtattacat
     2521 ttagcttttc attgaactga caagaaaaaa aatcagtgat attgggacac tggaaaaaat
     2581 tttcttaaac tggagtgatt tgataatcct tctatggtat catggggaga aaaaaaataa
     2641 agtttatttg agttcactgt cctcccttca aagcgtcctc tgagcaataa agaatattgt
     2701 ctttaaacca agggttaggg atttctctgc tctctctctc tctctctctc tctctctctc
     2761 tctctctctc tctctctctc tttgttcaac tgtcttcact ggccacatcg gaagcagttc
     2821 tagatgtact gtgttgagtt gctctggcag tagcctctat gcctgtcaat gtatcatagt
     2881 cctttgttgc ccagataaat aaatatttga tacgctttat gtcgattttt tttttattca
     2941 gtggctgtct ttacccaggc gtatttttgt tcttggcagt attttttatt cagtatggtt
     3001 acagtaattg agtttaactc tcccttggca atcgctcttt gcaataagca gctgaaccca
     3061 ttgtttccct caagtataat aaaaacttac tttcaacttg gagttcagag cagggtatca
     3121 tttagatatt ccactgagtc tgtattcaga caaatgaccc aataaagccc gatgtattct
     3181 tttggataaa agattgtttg taatgctaaa ggaatggcac actactgctt cctggctggg
     3241 agcattaact ttattaatta aaaataaagt tttattttat ttatgttg
//
