LOCUS       NM_001013110            2323 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus transferrin (Tf), mRNA.
ACCESSION   NM_001013110 NM_017055 XM_346836
VERSION     NM_001013110.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2323)
  AUTHORS   Youale,J., Bigot,K., Kodati,B., Jaworski,T., Fan,Y., Nsiah,N.Y.,
            Pappenhagen,N., Inman,D.M., Behar-Cohen,F., Bordet,T. and Picard,E.
  TITLE     Neuroprotective Effects of Transferrin in Experimental Glaucoma
            Models
  JOURNAL   Int J Mol Sci 23 (21), 12753 (2022)
   PUBMED   36361544
  REMARK    GeneRIF: Neuroprotective Effects of Transferrin in Experimental
            Glaucoma Models.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2323)
  AUTHORS   Carden,T.R., Correale,J., Pasquini,J.M. and Perez,M.J.
  TITLE     Transferrin Enhances Microglial Phagocytic Capacity
  JOURNAL   Mol Neurobiol 56 (9), 6324-6340 (2019)
   PUBMED   30758712
  REMARK    GeneRIF: Tf can be incorporated by all glial cells-i.e., microglia,
            astrocytes, and oligodendroglial precursor cell-and that, acting on
            microglial cells in vitro, Tf increases microglial proliferation
            rates and phagocytic capacity.
REFERENCE   3  (bases 1 to 2323)
  AUTHORS   DeGregorio-Rocasolano,N., Marti-Sistac,O., Ponce,J.,
            Castello-Ruiz,M., Millan,M., Guirao,V., Garcia-Yebenes,I.,
            Salom,J.B., Ramos-Cabrer,P., Alborch,E., Lizasoain,I., Castillo,J.,
            Davalos,A. and Gasull,T.
  TITLE     Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf
            confers protection against brain ischemia by modifying blood Tf
            saturation and subsequent neuronal damage
  JOURNAL   Redox Biol 15, 143-158 (2018)
   PUBMED   29248829
  REMARK    GeneRIF: our data establish that blood TSAT exerts a critical role
            in experimental stroke-induced brain damage. In addition, our
            findings suggest that the protective effect of iron-free
            transferrin (apotransferrin, ATf) at the neuronal level resides in
            preventing NMDA-induced HTf uptake and ROS production, which in
            turn reduces neuronal damage
REFERENCE   4  (bases 1 to 2323)
  AUTHORS   Kleven,M.D., Jue,S. and Enns,C.A.
  TITLE     Transferrin Receptors TfR1 and TfR2 Bind Transferrin through
            Differing Mechanisms
  JOURNAL   Biochemistry 57 (9), 1552-1559 (2018)
   PUBMED   29388418
REFERENCE   5  (bases 1 to 2323)
  AUTHORS   Gainey,M.A., Tatavarty,V., Nahmani,M., Lin,H. and Turrigiano,G.G.
  TITLE     Activity-dependent synaptic GRIP1 accumulation drives synaptic
            scaling up in response to action potential blockade
  JOURNAL   Proc Natl Acad Sci U S A 112 (27), E3590-E3599 (2015)
   PUBMED   26109571
REFERENCE   6  (bases 1 to 2323)
  AUTHORS   Cavanaugh,P.G. and Nicolson,G.L.
  TITLE     Lung-derived growth factor that stimulates the growth of
            lung-metastasizing tumor cells: identification as transferrin
  JOURNAL   J Cell Biochem 47 (3), 261-271 (1991)
   PUBMED   1791188
REFERENCE   7  (bases 1 to 2323)
  AUTHORS   Gelly,J.L., Richoux,J.P. and Grignon,G.
  TITLE     Immunolocalization of some plasmatic proteins in basement membranes
            during earliest rat morphogenesis with special reference to the
            gonadal differentiation
  JOURNAL   Histochemistry 96 (4), 323-326 (1991)
   PUBMED   1723977
REFERENCE   8  (bases 1 to 2323)
  AUTHORS   Purves,L.R., Purves,M., Linton,N., Brandt,W., Johnson,G. and
            Jacobs,P.
  TITLE     Properties of the transferrin associated with rat intestinal mucosa
  JOURNAL   Biochim Biophys Acta 966 (3), 318-327 (1988)
   PUBMED   3046665
REFERENCE   9  (bases 1 to 2323)
  AUTHORS   Huggenvik,J.I., Idzerda,R.L., Haywood,L., Lee,D.C., McKnight,G.S.
            and Griswold,M.D.
  TITLE     Transferrin messenger ribonucleic acid: molecular cloning and
            hormonal regulation in rat Sertoli cells
  JOURNAL   Endocrinology 120 (1), 332-340 (1987)
   PUBMED   3023031
REFERENCE   10 (bases 1 to 2323)
  AUTHORS   Schreiber,G., Dryburgh,H., Millership,A., Matsuda,Y., Inglis,A.,
            Phillips,J., Edwards,K. and Maggs,J.
  TITLE     The synthesis and secretion of rat transferrin
  JOURNAL   J Biol Chem 254 (23), 12013-12019 (1979)
   PUBMED   500689
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087021.1.
            
            On Mar 25, 2005 this sequence version replaced NM_017055.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087021.1, D38380.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2323
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2323
                     /gene="Tf"
                     /gene_synonym="Tfn; Trf"
                     /note="transferrin"
                     /db_xref="GeneID:24825"
                     /db_xref="RGD:3845"
     exon            1..74
                     /gene="Tf"
                     /gene_synonym="Tfn; Trf"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..2128
                     /gene="Tf"
                     /gene_synonym="Tfn; Trf"
                     /note="serotransferrin; siderophilin; beta-1 metal-binding
                     globulin; liver regeneration-related protein LRRG03"
                     /codon_start=1
                     /product="serotransferrin precursor"
                     /protein_id="NP_001013128.1"
                     /db_xref="GeneID:24825"
                     /db_xref="RGD:3845"
                     /translation="MRFAVGALLACAALGLCLAVPDKTVKWCAVSEHENTKCISFRDH
                     MKTVLPADGPRLACVKKTSYQDCIKAISGGEADAITLDGGWVYDAGLTPNNLKPVAAE
                     FYGSLEHPQTHYLAVAVVKKGTDFQLNQLQGKKSCHTGLGRSAGWIIPIGLLFCNLPE
                     PRKPLEKAVASFFSGSCVPCADPVAFPQLCQLCPGCGCSPTQPFFGYVGAFKCLRDGG
                     GDVAFVKHTTIFEVLPQKADRDQYELLCLDNTRKPVDQYEDCYLARIPSHAVVARNGD
                     GKEDLIWEILKVAQEHFGKGKSKDFQLFGSPLGKDLLFKDSAFGLLRVPPRMDYRLYL
                     GHSYVTAIRNQREGVCPEGSIDSAPVKWCALSHQERAKCDEWSVSSNGQIECESAEST
                     EDCIDKIVNGEADAMSLDGGHAYIAGQCGLVPVMAENYDISSCTNPQSDVFPKGYYAV
                     AVVKASDSSINWNNLKGKKSCHTGVDRTAGWNIPMGLLFSRINHCKFDEFFSQGCAPG
                     YKKNSTLCDLCIGPAKCAPNNREGYNGYTGAFQCLVEKGDVAFVKHQTVLENTNGKNT
                     AAWAKDLKQEDFQLLCPDGTKKPVTEFATCHLAQAPNHVVVSRKEKAARVSTVLTAQK
                     DLFWKGDKDCTGNFCLFRSSTKDLLFRDDTKCLTKLPEGTTYEEYLGAEYLQAVGNIR
                     KCSTSRLLEACTFHKS"
     exon            75..247
                     /gene="Tf"
                     /gene_synonym="Tfn; Trf"
                     /inference="alignment:Splign:2.1.0"
     exon            248..356
                     /gene="Tf"
                     /gene_synonym="Tfn; Trf"
                     /inference="alignment:Splign:2.1.0"
     exon            357..533
                     /gene="Tf"
                     /gene_synonym="Tfn; Trf"
                     /inference="alignment:Splign:2.1.0"
     exon            534..666
                     /gene="Tf"
                     /gene_synonym="Tfn; Trf"
                     /inference="alignment:Splign:2.1.0"
     exon            667..722
                     /gene="Tf"
                     /gene_synonym="Tfn; Trf"
                     /inference="alignment:Splign:2.1.0"
     exon            723..901
                     /gene="Tf"
                     /gene_synonym="Tfn; Trf"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1079
                     /gene="Tf"
                     /gene_synonym="Tfn; Trf"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1231
                     /gene="Tf"
                     /gene_synonym="Tfn; Trf"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1322
                     /gene="Tf"
                     /gene_synonym="Tfn; Trf"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1352
                     /gene="Tf"
                     /gene_synonym="Tfn; Trf"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1523
                     /gene="Tf"
                     /gene_synonym="Tfn; Trf"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1653
                     /gene="Tf"
                     /gene_synonym="Tfn; Trf"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1718
                     /gene="Tf"
                     /gene_synonym="Tfn; Trf"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1903
                     /gene="Tf"
                     /gene_synonym="Tfn; Trf"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2093
                     /gene="Tf"
                     /gene_synonym="Tfn; Trf"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2292
                     /gene="Tf"
                     /gene_synonym="Tfn; Trf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccccgctc ctcgccacac acaccgagag gatgaggttc gctgtgggtg ccctgctggc
       61 ttgtgccgcc ctgggactgt gtctggctgt ccctgacaaa acggtcaaat ggtgcgcagt
      121 gtctgagcat gagaacacca agtgtatcag tttccgtgac cacatgaaaa ccgtccttcc
      181 agctgatggc ccccggcttg cctgtgtgaa gaaaacctcc tatcaagatt gcatcaaggc
      241 catttctgga ggtgaagctg atgccattac cttggatggg ggttgggtgt acgatgcagg
      301 cctgactccc aacaacctga agcctgtggc agcagagttt tatggatcac ttgaacatcc
      361 acagacccac tacttggctg tggccgtggt gaagaaggga acagacttcc agctgaacca
      421 gctccagggc aagaagtcct gccacactgg cctgggcagg tctgcaggct ggattatccc
      481 cattggctta cttttctgta acttgccaga gccccgcaag cctcttgaga aagctgtggc
      541 cagtttcttc tcgggcagtt gtgtcccctg tgcagatcca gtggccttcc cccagctgtg
      601 tcaactgtgt ccaggctgtg gctgctcccc gactcaaccg ttctttggct acgtaggcgc
      661 cttcaagtgt ctgagagatg gaggtggaga tgtggccttt gtcaagcata caaccatatt
      721 tgaggtcttg ccacagaagg ctgacaggga tcaatatgag ctgctctgcc ttgacaatac
      781 ccgcaagcca gtggatcagt atgaggactg ctacctagcc cggatccctt ctcatgctgt
      841 tgtggctcga aatggagatg gcaaagagga cttgatctgg gagatcctca aagtggctca
      901 ggaacacttt ggcaaaggca aatcaaaaga cttccaactg ttcggctctc ctcttgggaa
      961 agacctgctg tttaaggatt ctgcctttgg gctgttacgg gtgcccccaa ggatggacta
     1021 caggctgtac ctcggccaca gctatgtcac tgccattcga aatcagcggg aaggcgtgtg
     1081 cccggagggc tccatcgaca gcgcgccagt gaaatggtgt gcactgagtc accaagagag
     1141 agccaagtgt gatgagtgga gcgtcagcag caatgggcag atagagtgtg agtcagcaga
     1201 gagcactgag gactgcattg acaagattgt gaatggagaa gcagatgcca tgagcttgga
     1261 tggaggtcat gcctacatag caggccagtg tggactagtg cccgtcatgg cagagaacta
     1321 tgatatctct tcgtgtacaa acccacaatc agatgtcttt cctaaagggt attatgccgt
     1381 ggctgtggtg aaggcatcag actccagcat caactggaac aacctgaaag gcaagaagtc
     1441 ctgccatact ggagtagaca gaaccgccgg ctggaacatc cctatgggcc tgctgttcag
     1501 caggatcaac cactgcaagt tcgatgaatt tttcagtcaa ggctgtgctc ctggctataa
     1561 gaagaattcc accctctgtg acctgtgtat tggcccagca aaatgtgctc cgaacaacag
     1621 agagggatat aatggttata caggggcttt ccagtgcctc gttgagaagg gagacgtagc
     1681 ctttgtgaag caccagactg tcctggaaaa cacgaacgga aagaacactg ctgcatgggc
     1741 taaggatctg aagcaggaag acttccagct gctgtgccct gatggtacca agaagcctgt
     1801 aaccgagttc gccacctgcc acctggccca agctccaaac catgttgtgg tctcacgaaa
     1861 agagaaggca gcccgggtta gcactgtgct gactgcccag aaggatttat tttggaaagg
     1921 tgacaaggac tgcactggca atttctgttt gttccggtct tccaccaagg accttctgtt
     1981 cagagatgac accaagtgtt tgactaaact tccagaaggt accacatatg aagagtactt
     2041 aggagcagag tacttgcaag ctgttggaaa cataaggaag tgttcaacct cacgactcct
     2101 agaagcctgc actttccaca aaagttaaaa tccaagaggt gggtgccact gtggtggagg
     2161 aggatgcccc cgtgatccat gggcttctcc tggcctccat gccctgagcg gctggggcta
     2221 actgtgtccg tcttcactgc tgtgtgttac cacatacaca gagcacaaaa taaaaaatga
     2281 ctgttgactt taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
