LOCUS       NM_031578               3578 bp    mRNA    linear   ROD 11-AUG-2024
DEFINITION  Rattus norvegicus testis associated actin remodelling kinase 1
            (Tesk1), mRNA.
ACCESSION   NM_031578 XM_346736
VERSION     NM_031578.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3578)
  AUTHORS   Lou,D., Sun,B., Wei,H., Deng,X., Chen,H., Xu,D., Li,G., Xu,H. and
            Wang,Y.
  TITLE     Spatiotemporal expression of testicular protein kinase 1 after rat
            sciatic nerve injury
  JOURNAL   J Mol Neurosci 47 (1), 180-191 (2012)
   PUBMED   22302232
  REMARK    GeneRIF: TESK1 plays important roles in promyelinating Schwann
            cells, potentially through subcellular localization change and
            participation in integrin-mediated actin reorganization.
REFERENCE   2  (bases 1 to 3578)
  AUTHORS   Johne,C., Matenia,D., Li,X.Y., Timm,T., Balusamy,K. and
            Mandelkow,E.M.
  TITLE     Spred1 and TESK1--two new interaction partners of the kinase
            MARKK/TAO1 that link the microtubule and actin cytoskeleton
  JOURNAL   Mol Biol Cell 19 (4), 1391-1403 (2008)
   PUBMED   18216281
REFERENCE   3  (bases 1 to 3578)
  AUTHORS   Chandramouli,S., Yu,C.Y., Yusoff,P., Lao,D.H., Leong,H.F.,
            Mizuno,K. and Guy,G.R.
  TITLE     Tesk1 interacts with Spry2 to abrogate its inhibition of ERK
            phosphorylation downstream of receptor tyrosine kinase signaling
  JOURNAL   J Biol Chem 283 (3), 1679-1691 (2008)
   PUBMED   17974561
  REMARK    GeneRIF: By selectively modulating the downstream effects of Spry2,
            Tesk1 may thus serve as a molecular determinant of the signaling
            outcome.
REFERENCE   4  (bases 1 to 3578)
  AUTHORS   LaLonde,D.P., Brown,M.C., Bouverat,B.P. and Turner,C.E.
  TITLE     Actopaxin interacts with TESK1 to regulate cell spreading on
            fibronectin
  JOURNAL   J Biol Chem 280 (22), 21680-21688 (2005)
   PUBMED   15817463
REFERENCE   5  (bases 1 to 3578)
  AUTHORS   Toshima,J.Y., Toshima,J., Watanabe,T. and Mizuno,K.
  TITLE     Binding of 14-3-3beta regulates the kinase activity and subcellular
            localization of testicular protein kinase 1
  JOURNAL   J Biol Chem 276 (46), 43471-43481 (2001)
   PUBMED   11555644
REFERENCE   6  (bases 1 to 3578)
  AUTHORS   Toshima,J., Tanaka,T. and Mizuno,K.
  TITLE     Dual specificity protein kinase activity of testis-specific protein
            kinase 1 and its regulation by autophosphorylation of serine-215
            within the activation loop
  JOURNAL   J Biol Chem 274 (17), 12171-12176 (1999)
   PUBMED   10207045
REFERENCE   7  (bases 1 to 3578)
  AUTHORS   Toshima,J., Ohashi,K., Okano,I., Nunoue,K., Kishioka,M., Kuma,K.,
            Miyata,T., Hirai,M., Baba,T. and Mizuno,K.
  TITLE     Identification and characterization of a novel protein kinase,
            TESK1, specifically expressed in testicular germ cells
  JOURNAL   J Biol Chem 270 (52), 31331-31337 (1995)
   PUBMED   8537404
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031578.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D50864.1, BC081773.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1333              JAXUCZ010000005.1  62487763-62489095
            1334-1455           JAXUCZ010000005.1  62489240-62489361
            1456-1504           JAXUCZ010000005.1  62489493-62489541
            1505-1651           JAXUCZ010000005.1  62490047-62490193
            1652-1734           JAXUCZ010000005.1  62490521-62490603
            1735-1825           JAXUCZ010000005.1  62490748-62490838
            1826-1909           JAXUCZ010000005.1  62490998-62491081
            1910-1999           JAXUCZ010000005.1  62491204-62491293
            2000-2129           JAXUCZ010000005.1  62491408-62491537
            2130-3578           JAXUCZ010000005.1  62492044-62493492
FEATURES             Location/Qualifiers
     source          1..3578
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..3578
                     /gene="Tesk1"
                     /note="testis associated actin remodelling kinase 1"
                     /db_xref="GeneID:29460"
                     /db_xref="RGD:62059"
     exon            1..1333
                     /gene="Tesk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1130..3016
                     /gene="Tesk1"
                     /EC_number="2.7.12.1"
                     /note="testis specific protein kinase 1; testicular
                     protein kinase 1; testis-specific kinase 1"
                     /codon_start=1
                     /product="dual specificity testis-specific protein kinase
                     1"
                     /protein_id="NP_113766.1"
                     /db_xref="GeneID:29460"
                     /db_xref="RGD:62059"
                     /translation="MAGERPPLRGPGPGETPVEGPGGAGGGPGRGRPSSYRALRSAVS
                     SLARVDDFDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRSNTLREVQLMNRL
                     RHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIAQGLRY
                     LHAKGVFHRDLTSKNCLVRREDGGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYW
                     MAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGND
                     CPLPFLLLAIHCCSMEPSARAPFTEITQHLEQILEQLPEPTPLAKMPLAKAPLTYNQG
                     SVPRGGPSATLPRSDPRLSRSRSDLFLPPSPESPPSWGDNLTRVNPFSLREDLRGGKI
                     KLLDTPCKPATPLPLVPPSPLTSTQLPLVASPESLVQPETPVRRCRSLPSSPELPRRM
                     ETALPGPGPSPVGPSTEERMDCEGSSPEPEPPGPAPQLPLAVATDNFISTCSSASQPW
                     SARPGPSLNNNPPAVVVNSPQGWAREPWNRAQHSLPRAAALERTEPSPPPSAPREQEE
                     GLPCPGCCLSPFSFGFLSMCPRPTPAVARYRNLNCEAGSLLCHRGHHAKPPTPSLQLP
                     GARS"
     exon            1334..1455
                     /gene="Tesk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1504
                     /gene="Tesk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1651
                     /gene="Tesk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1734
                     /gene="Tesk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1825
                     /gene="Tesk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1909
                     /gene="Tesk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..1999
                     /gene="Tesk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2129
                     /gene="Tesk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..3578
                     /gene="Tesk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtagagg cctctgcacc tcctcctctg gcctgagggg ggcatacccg cgtctacaga
       61 cgcggggcgc aacctgccga aaggggtcac accgctgggc gagagctagg ggaggagtca
      121 ccttgagagg agcggtcaca atgattagcc gagtcactct gaaaggtctc ttttagtgaa
      181 aggaacacaa agaggagggg gtgcagcact aaggggctct ggatacacac tgatgtgcca
      241 gtgtcatccc aaggaaaggt ccccctgaag gagagcgggc tccgaggggc agcggccttt
      301 gagggggagg gatcctgtcg aggggtgggc tgtgacggag ggcgggactt tcttgcaggt
      361 gcaggcttcc cctaagaggg ttattaggac aaagaagtag gagggtggtc accgggcgga
      421 gcgcaggaat ctcaacttta ctcaggggaa tggagatgga gtgaggaggg gtcggggcag
      481 gtcagggatg cggaggccag aggctcccta cagccctggg taccacgacc ggagaaaaca
      541 ggtgttagcg agccccgaga tttagggtgt cggggtcaga agccccttga aatgggcagt
      601 cggagtgggg cgcagactgg gcaggcagcg ggcttgatcc gtggagccca gggcgcagga
      661 gaattcgcgc ctgcagtcaa cccttaagtc gtcctgttat tcacgccccg gcctacgcgc
      721 cgggacgcac ctgagggggc gtggccgggc cacagctcgg gctccaagga gttaaccgca
      781 gaccgggccc ggccccgccc cgggcaggcc gcgcagcctg agcccggcgg cgaagcggag
      841 cagcagccgc ccgcggggag cccgccgccg gcgcccggga gcgccgccgc cgcccggccc
      901 aggcccaggc ccaggccccg cgcagagcgg agagccgcgg cgttccacca ggcccaactc
      961 gccggcgcgg cgggggcggg cccaggacct tcggcaggtc ctcccggagt ccgccgggcg
     1021 ggagtcccgg cacccgggat caggttgggc cggcgcccat ggcgagcgcg gcctgcccgg
     1081 gtcccgggga tccggccatg tgaagcaggc cggggctggg ggcccggcca tggccgggga
     1141 acggccaccg ctgcggggcc ccgggcccgg agagactccg gtggaggggc cggggggcgc
     1201 aggcggaggc ccgggccggg gccggccctc ctcctaccgg gccctccgca gcgccgtgtc
     1261 cagcctggcg cgcgtggacg atttcgactg cgcagagaag atcggggctg gtttcttctc
     1321 tgaggtctat aaggttcggc accgacagtc gggacaagtc atggtgctga agatgaacaa
     1381 gctccccagt aaccggagca acactctaag ggaggtgcag ctgatgaacc ggctccggca
     1441 tcctaacatc ctcaggttca tgggggtctg tgtgcaccaa gggcagctgc acgcgcttac
     1501 agagtatatg aatgggggta ccctggaaca gctgctgagc tccccagaac ccctctcctg
     1561 gccagtcagg ctccacctag cactggacat tgcacaaggc ctacggtacc tacacgccaa
     1621 aggtgtgttt caccgagacc tcacatccaa gaactgtctg gtccgacggg aagacggagg
     1681 cttcacagct gttgtgggtg acttcggact ggctgaaaag atccctgtgt atagggaagg
     1741 ggcaaggaag gagccattgg ctgtggtggg ctccccatac tggatggccc cagaggtatt
     1801 gcggggagag ctgtatgatg agaaggccga cgtcttcgcc tttgggattg tcctctgtga
     1861 gctcatcgcc cgagtacctg cagaccctga ctacctaccc cgtactgagg actttggtct
     1921 ggatgtgcct gcttttcgaa ctctggtggg aaatgactgt ccgctacctt tcctgcttct
     1981 ggccatccac tgctgcagca tggaacccag cgcccgtgcc ccttttactg aaattaccca
     2041 gcacctggaa caaatcctgg agcagctgcc tgagcccacg cccctcgcca agatgcccct
     2101 tgccaaggct cccttgacat acaatcaggg gtctgttcca agaggaggtc cctctgccac
     2161 gcttcccagg tcagaccccc ggctctcccg aagccggtca gacctcttcc tgccaccttc
     2221 accagaatca ccccccagtt ggggggacaa tctaacacga gtcaacccct tctcactgcg
     2281 ggaagacctc aggggtggca agatcaaact tctggacaca ccctgcaagc cggccactcc
     2341 actgcccctg gtgccaccat caccactgac ctctacccag ctgcccttgg tggcctctcc
     2401 agagtccctg gtccagcctg agactcccgt ccgccgctgt cgttcactcc cttcatcccc
     2461 tgagctcccc cgacggatgg aaactgcact gccaggtcct ggcccgtccc ccgtgggccc
     2521 ctcgactgag gaaaggatgg actgtgaggg cagcagccct gagccagagc ccccagggcc
     2581 ggctccccag ctgcctctgg ctgtggccac tgacaacttc atcagtacgt gttcctcagc
     2641 ctctcagccc tggtctgcta gaccaggacc ttccctcaat aataaccccc ctgctgtggt
     2701 ggtgaattcc ccacaaggat gggcgaggga gccctggaac cgggcacagc atagccttcc
     2761 ccgggcagca gccctggagc ggacagaacc ctcaccaccc ccatcagctc cccgggagca
     2821 ggaggagggg cttccctgcc ctggctgctg cctcagcccc ttcagctttg gcttcctatc
     2881 catgtgcccc cgccctaccc cagctgttgc ccgctaccgc aacttgaact gtgaggcggg
     2941 cagtcttctc tgccaccgag ggcatcatgc caagccaccc acacccagcc tgcagctgcc
     3001 tggggcacgc tcttagcagt gaggcctgtg atctcaggct tccaaccttg gccttcggga
     3061 taccctgtaa ggacagagtg cacttgctgg acaatgccag ccccagatgg gctgactggc
     3121 tcttctcccc gtatagggga gcctcagcat ggtctcaatg gacagagcac ttcctgtcca
     3181 acccctggga tcactggact agacacagca ttgctgacac acaagactaa cacgtgcaaa
     3241 ttatttaaaa atatttcaat aaaactgcct ggctggctcc gggccatcca tccactcagc
     3301 ggagcgccct cccctgaccc atctctagtt cgggaagttc ttaaggaagg tcaaagtctt
     3361 ttctggaggc ttctttactc ttcccaagaa tagtttctgg agcagctttc aagcaagcag
     3421 caggtcgcca gaccagaatc agcccttagc tgggcgtgcc caagagtgag ggagtgctgg
     3481 aggaatagca gtcttgagaa ttggcaggcc ataggttaag gatgtaggtc acaaggtctt
     3541 gttgaagtgt ctggaaaaat aaagcaccag tgagctcc
//
