LOCUS       NM_001039344            2396 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Rattus norvegicus testin LIM domain protein (Tes), mRNA.
ACCESSION   NM_001039344
VERSION     NM_001039344.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2396)
  AUTHORS   Wang,D.D., Chen,Y.B., Zhao,J.J., Zhang,X.F., Zhu,G.C., Weng,D.S.,
            Pan,K., Lv,L., Pan,Q.Z., Jiang,S.S., Wang,L.L. and Xia,J.C.
  TITLE     TES functions as a Mena-dependent tumor suppressor in gastric
            cancer carcinogenesis and metastasis
  JOURNAL   Cancer Commun (Lond) 39 (1), 3 (2019)
   PUBMED   30728082
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2396)
  AUTHORS   Wang,M., Wang,Q., Peng,W.J., Hu,J.F., Wang,Z.Y., Liu,H. and
            Huang,L.N.
  TITLE     Testin is a tumor suppressor in non-small cell lung cancer
  JOURNAL   Oncol Rep 37 (2), 1027-1035 (2017)
   PUBMED   28000866
REFERENCE   3  (bases 1 to 2396)
  AUTHORS   Steponaitis,G., Kazlauskas,A., Skiriute,D., Valiulyte,I.,
            Skauminas,K., Tamasauskas,A. and Vaitkiene,P.
  TITLE     Testin (TES) as a candidate tumour suppressor and prognostic marker
            in human astrocytoma
  JOURNAL   Oncol Lett 12 (5), 3305-3311 (2016)
   PUBMED   27899997
REFERENCE   4  (bases 1 to 2396)
  AUTHORS   Li,H., Huang,K., Gao,L., Wang,L., Niu,Y., Liu,H., Wang,Z., Wang,L.,
            Wang,G. and Wang,J.
  TITLE     TES inhibits colorectal cancer progression through activation of
            p38
  JOURNAL   Oncotarget 7 (29), 45819-45836 (2016)
   PUBMED   27323777
REFERENCE   5  (bases 1 to 2396)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2396)
  AUTHORS   Ma,H., Weng,D., Chen,Y., Huang,W., Pan,K., Wang,H., Sun,J.,
            Wang,Q., Zhou,Z., Wang,H. and Xia,J.
  TITLE     Extensive analysis of D7S486 in primary gastric cancer supports
            TESTIN as a candidate tumor suppressor gene
  JOURNAL   Mol Cancer 9, 190 (2010)
   PUBMED   20626849
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2396)
  AUTHORS   Weeks,R.J., Kees,U.R., Song,S. and Morison,I.M.
  TITLE     Silencing of TESTIN by dense biallelic promoter methylation is the
            most common molecular event in childhood acute lymphoblastic
            leukaemia
  JOURNAL   Mol Cancer 9, 163 (2010)
   PUBMED   20573277
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2396)
  AUTHORS   Sarti,M., Sevignani,C., Calin,G.A., Aqeilan,R., Shimizu,M.,
            Pentimalli,F., Picchio,M.C., Godwin,A., Rosenberg,A., Drusco,A.,
            Negrini,M. and Croce,C.M.
  TITLE     Adenoviral transduction of TESTIN gene into breast and uterine
            cancer cell lines promotes apoptosis and tumor reduction in vivo
  JOURNAL   Clin Cancer Res 11 (2 Pt 1), 806-813 (2005)
   PUBMED   15701871
REFERENCE   9  (bases 1 to 2396)
  AUTHORS   Thomas,J.W., Touchman,J.W., Blakesley,R.W., Bouffard,G.G.,
            Beckstrom-Sternberg,S.M., Margulies,E.H., Blanchette,M.,
            Siepel,A.C., Thomas,P.J., McDowell,J.C., Maskeri,B., Hansen,N.F.,
            Schwartz,M.S., Weber,R.J., Kent,W.J., Karolchik,D., Bruen,T.C.,
            Bevan,R., Cutler,D.J., Schwartz,S., Elnitski,L., Idol,J.R.,
            Prasad,A.B., Lee-Lin,S.Q., Maduro,V.V., Summers,T.J., Portnoy,M.E.,
            Dietrich,N.L., Akhter,N., Ayele,K., Benjamin,B., Cariaga,K.,
            Brinkley,C.P., Brooks,S.Y., Granite,S., Guan,X., Gupta,J.,
            Haghighi,P., Ho,S.L., Huang,M.C., Karlins,E., Laric,P.L.,
            Legaspi,R., Lim,M.J., Maduro,Q.L., Masiello,C.A., Mastrian,S.D.,
            McCloskey,J.C., Pearson,R., Stantripop,S., Tiongson,E.E.,
            Tran,J.T., Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D.,
            Wiggins,L.S., Young,A.C., Zhang,L.H., Osoegawa,K., Zhu,B., Zhao,B.,
            Shu,C.L., De Jong,P.J., Lawrence,C.E., Smit,A.F., Chakravarti,A.,
            Haussler,D., Green,P., Miller,W. and Green,E.D.
  TITLE     Comparative analyses of multi-species sequences from targeted
            genomic regions
  JOURNAL   Nature 424 (6950), 788-793 (2003)
   PUBMED   12917688
REFERENCE   10 (bases 1 to 2396)
  AUTHORS   Tobias,E.S., Hurlstone,A.F., MacKenzie,E., McFarlane,R. and
            Black,D.M.
  TITLE     The TES gene at 7q31.1 is methylated in tumours and encodes a novel
            growth-suppressing LIM domain protein
  JOURNAL   Oncogene 20 (22), 2844-2853 (2001)
   PUBMED   11420696
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC129069.1.
            
            On Jan 10, 2007 this sequence version replaced NM_001039344.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129069.1, DQ339047.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2396
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..2396
                     /gene="Tes"
                     /note="testin LIM domain protein"
                     /db_xref="GeneID:500040"
                     /db_xref="RGD:1566346"
     exon            1..95
                     /gene="Tes"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1328
                     /gene="Tes"
                     /note="testis derived transcript"
                     /codon_start=1
                     /product="testin"
                     /protein_id="NP_001034433.1"
                     /db_xref="GeneID:500040"
                     /db_xref="RGD:1566346"
                     /translation="MDLETKMKKMGLGHEQGFGAPCLKCKENCEGFELHFWRKICRNC
                     KCGQEEHDVLLSTEEDRKVGRLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKK
                     NVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQD
                     PSKCHELSPKEVKEMEQFVKKYKSEALGVGDVKLPSEMNAQGDKVHNPAGDRNTPAAV
                     GSKDKSAEAKKTQYSCYCCKNTMREGDPAIYAERAGYDKLWHPACFICSTCGELLVDM
                     IYFWKNGKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDNILA
                     GKIYVMVRDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCC
                     SKCLIGQKFMPVEGMVFCSVECKKMMS"
     exon            96..181
                     /gene="Tes"
                     /inference="alignment:Splign:2.1.0"
     exon            182..434
                     /gene="Tes"
                     /inference="alignment:Splign:2.1.0"
     exon            435..764
                     /gene="Tes"
                     /inference="alignment:Splign:2.1.0"
     exon            765..980
                     /gene="Tes"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1139
                     /gene="Tes"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..2364
                     /gene="Tes"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcggc gctggagttc ccgcagcgga gatccgggac gcgggactga gcccatccga
       61 cgcccagcat ggacctggaa accaaaatga agaagatggg cttaggtcac gagcaaggat
      121 ttggagcccc ctgtctaaaa tgcaaagaga actgtgaagg gtttgaacta cacttctgga
      181 ggaaaatatg tcgtaactgc aaatgtggtc aagaagagca tgacgtcctc ctgagcactg
      241 aggaggaccg gaaggtgggg agactctttg aagacaccaa gtacaccacc ctgatcgcca
      301 agctgaagtc agatggaatc cccatgtata aacgcaatgt tatgatattg accaatccag
      361 tggctgccaa gaagaacgtc tccatcaaca ccgttaccta tgagtgggct cccccggttc
      421 agaaccaggc actggccagg cagtacatgc agatgctccc taaagagaag cagccagtgg
      481 cgggttcaga gggggcgcag taccggaaga agcagctggc gaagcagctc cctgcacatg
      541 accaggaccc ttctaagtgc cacgagctgt ctcccaaaga ggtgaaggag atggaacagt
      601 tcgtgaagaa atataagagt gaagctctgg gcgtgggcga cgtgaagctt ccttccgaga
      661 tgaatgctca aggtgacaag gtgcacaacc ctgccggaga cagaaacacc ccagcagcag
      721 tgggttccaa ggacaagtct gcagaagcca agaagaccca atattcctgt tactgctgca
      781 aaaacaccat gagggaagga gacccagcca tctatgctga aagagctggc tacgacaaac
      841 tctggcaccc ggcatgtttt atctgcagca cctgtggtga actcttggtc gacatgattt
      901 acttctggaa gaatgggaag ctgtactgtg gcagacatta ctgtgacagc gagaagcccc
      961 gctgtgctgg ctgtgatgag ctgatattca gcaatgagta tacccaggca gaaaaccaga
     1021 attggcatct gaagcacttc tgctgctttg actgcgacaa catcctggcc ggaaaaatat
     1081 acgtgatggt ccgtgacaag cctgtgtgca agccgtgcta tgtgaagaac catgctgtgg
     1141 tgtgtcaagg gtgccacaat gccatcgacc cggaagtgca gcgagtgacg tacaataact
     1201 tcagctggca cgcgtccacg gagtgcttcc tctgctcctg ctgcagcaag tgcctgatcg
     1261 ggcagaagtt catgcctgtg gaagggatgg ttttctgttc tgtggagtgt aagaagatga
     1321 tgtcctgagt gaacaccaag cagtattgag ccatagctgt ctacagtggc ctgcatttca
     1381 tgataaactg cagtttaaaa aaaaaataaa aaataaaagg aaaaaaaaaa gctacataac
     1441 gaaccggaag attttgtcca atatttttct ctttttaacc attatgaatt ttgtctgtct
     1501 tatttttaaa tgactgcttt aagcgcatga tttaaaaaaa acagtaaaga attatagctt
     1561 ttatttctgc acattaaata tttgagttgg aagcttgaat ttaatcaatc cttataaccg
     1621 catactccta gtgctagata tattatatat atatatatat ataaaatcac ttaaaattag
     1681 tgtcctggga gagatgaaca ttttaacttc catgcttgtc ccccatggga aatgtaaagg
     1741 aagttacaac cgcctgtcga gcggtttgat gatggtgacg tcagctcagt gaggagttcc
     1801 ttgtggcagg cagtgtggtc cacgttgggt gttccagtgc ctaagccttt gcatccccca
     1861 tggaggcaga ggggcctctc cctcctgcat ctctctctgg ttactttacc tctcagtatc
     1921 ctcttttgtc atctagcgac ctccatctgt ggccttgaat attttatatg tatgtggtta
     1981 ggacaatatg tgcactttgc tcttagagat tttttttttt tgtttttttg tccagaagat
     2041 aaaagtaggc cattcattta atttttttga aacccaaaga atatataggt tttgtaccca
     2101 gggaattata actcatgctg atgtcacctt aatgccatgc cttgactcag ttgtttgcat
     2161 gatttccaat gttaccagat ggatactctc ttgtgctacc tctgagcttg ctatagacac
     2221 aaaggctgtc ttctttgcct gtgcacgcgc atccttgggt attttttaat gttttccgtg
     2281 tatgctttca tacataacta tgcactataa atattaaatg gaatgactta tatgatattg
     2341 aaaataaagc ctctttcact ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
