LOCUS       NM_001013143            2165 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus TERF2 interacting protein (Terf2ip), mRNA.
ACCESSION   NM_001013143 XM_226486
VERSION     NM_001013143.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2165)
  AUTHORS   Li,C.X., Lo,C.M., Lian,Q., Ng,K.T., Liu,X.B., Ma,Y.Y., Qi,X.,
            Yeung,O.W., Tergaonkar,V., Yang,X.X., Liu,H., Liu,J., Shao,Y. and
            Man,K.
  TITLE     Repressor and activator protein accelerates hepatic ischemia
            reperfusion injury by promoting neutrophil inflammatory response
  JOURNAL   Oncotarget 7 (19), 27711-27723 (2016)
   PUBMED   27050284
  REMARK    GeneRIF: Rap1 may induce hepatic ischemia reperfusion injury (IRI)
            through promoting neutrophils inflammatory response. Rap1 may be
            the potential therapeutic target of attenuating hepatic IRI.
REFERENCE   2  (bases 1 to 2165)
  AUTHORS   Chang,C.W., Cheong,M.L., Chang,G.D., Tsai,M.S. and Chen,H.
  TITLE     Involvement of Epac1/Rap1/CaMKI/HDAC5 signaling cascade in the
            regulation of placental cell fusion
  JOURNAL   Mol Hum Reprod 19 (11), 745-755 (2013)
   PUBMED   23867755
REFERENCE   3  (bases 1 to 2165)
  AUTHORS   Doksani,Y., Wu,J.Y., de Lange,T. and Zhuang,X.
  TITLE     Super-resolution fluorescence imaging of telomeres reveals
            TRF2-dependent T-loop formation
  JOURNAL   Cell 155 (2), 345-356 (2013)
   PUBMED   24120135
REFERENCE   4  (bases 1 to 2165)
  AUTHORS   Horn,H.F., Kim,D.I., Wright,G.D., Wong,E.S., Stewart,C.L., Burke,B.
            and Roux,K.J.
  TITLE     A mammalian KASH domain protein coupling meiotic chromosomes to the
            cytoskeleton
  JOURNAL   J Cell Biol 202 (7), 1023-1039 (2013)
   PUBMED   24062341
REFERENCE   5  (bases 1 to 2165)
  AUTHORS   Grolimund,L., Aeby,E., Hamelin,R., Armand,F., Chiappe,D.,
            Moniatte,M. and Lingner,J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   6  (bases 1 to 2165)
  AUTHORS   O'Connor,M.S., Safari,A., Liu,D., Qin,J. and Songyang,Z.
  TITLE     The human Rap1 protein complex and modulation of telomere length
  JOURNAL   J Biol Chem 279 (27), 28585-28591 (2004)
   PUBMED   15100233
REFERENCE   7  (bases 1 to 2165)
  AUTHORS   Liu,D., Safari,A., O'Connor,M.S., Chan,D.W., Laegeler,A., Qin,J.
            and Songyang,Z.
  TITLE     PTOP interacts with POT1 and regulates its localization to
            telomeres
  JOURNAL   Nat Cell Biol 6 (7), 673-680 (2004)
   PUBMED   15181449
REFERENCE   8  (bases 1 to 2165)
  AUTHORS   Tarsounas,M., Munoz,P., Claas,A., Smiraldo,P.G., Pittman,D.L.,
            Blasco,M.A. and West,S.C.
  TITLE     Telomere maintenance requires the RAD51D recombination/repair
            protein
  JOURNAL   Cell 117 (3), 337-347 (2004)
   PUBMED   15109494
REFERENCE   9  (bases 1 to 2165)
  AUTHORS   Li,B. and de Lange,T.
  TITLE     Rap1 affects the length and heterogeneity of human telomeres
  JOURNAL   Mol Biol Cell 14 (12), 5060-5068 (2003)
   PUBMED   14565979
REFERENCE   10 (bases 1 to 2165)
  AUTHORS   Loayza,D. and De Lange,T.
  TITLE     POT1 as a terminal transducer of TRF1 telomere length control
  JOURNAL   Nature 423 (6943), 1013-1018 (2003)
   PUBMED   12768206
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC090335.1.
            
            On Apr 20, 2005 this sequence version replaced XM_226486.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090335.1, CB745139.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2165
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2165
                     /gene="Terf2ip"
                     /note="TERF2 interacting protein"
                     /db_xref="GeneID:307861"
                     /db_xref="RGD:1309684"
     exon            1..711
                     /gene="Terf2ip"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1232
                     /gene="Terf2ip"
                     /note="RAP1 homolog; TRF2-interacting telomeric protein 1;
                     TERF2-interacting telomeric protein 1; repressor/activator
                     protein 1 homolog; telomeric repeat binding factor 2,
                     interacting protein"
                     /codon_start=1
                     /product="telomeric repeat-binding factor 2-interacting
                     protein 1"
                     /protein_id="NP_001013161.1"
                     /db_xref="GeneID:307861"
                     /db_xref="RGD:1309684"
                     /translation="MAEVMDLGKDPNGPTHSSTLFVREDGSAMSFYVRPSSAKRRLST
                     LILHGGGILCRVQKPGAVLLAQPGEALAEASGDFISTQYILDCVERNEKLELEAYRLG
                     LTEQASDPKPGASAEGSTEPEPQPLTGRIAYTDADDVAILTYVKENARSPSSVTGNAL
                     WKAMEKSSLTQHSWQSLKDRYLKHLQGQEHKYLLGNAPVSPSSQKLKRKAEQDPEAAD
                     SGEPQNKRTPDLPEEECVKGETKENGEADNKLFEEATPELGEAVVDESPDFEIHITMC
                     DGDPPTPEEDSETQPDEEEEEPKVSTQEVGTAIKIIRQLMEKFNLDLSTVTQALLKNS
                     GELEATSSFLESGRRPDGFPIWCRQDDLDLQKDDDDTRNALVKKYGAQNVARRIEFRK
                     K"
     exon            712..836
                     /gene="Terf2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            837..2141
                     /gene="Terf2ip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcttctcag tgttgtccct ttgcttttct tgggcagcgg agcgacaggt atggcggagg
       61 taatggatct gggtaaagat cccaatgggc ccacccactc ctccactctg tttgtgagag
      121 aagacggcag cgccatgtcg ttttacgtgc ggcccagctc ggccaagcgc cggctgtcaa
      181 cgctcatcct gcacggcggc ggcatcttgt gtcgggtgca gaagcccggg gcggtgctgc
      241 tagcccagcc cggggaggcg ctggccgagg cttcgggcga cttcatctcc acgcagtaca
      301 tcctagactg cgtggagcgc aacgagaagc tggaactgga ggcctatcgg ctgggcctga
      361 cggagcaggc gtccgaccct aagcccgggg cttctgcgga gggctccacg gaacccgagc
      421 ctcagcccct gaccgggcgc attgcctaca ctgacgcaga cgatgtggcc atcctaacct
      481 acgtaaagga aaatgcccgt tcgcccagct cagtcacagg caatgccttg tggaaagcga
      541 tggagaagag ctcgctcacg cagcactcct ggcagtcgct caaggaccgc tacctcaagc
      601 acctgcaggg ccaggagcac aagtacctgc tcgggaacgc tccggtcagc ccgtcctccc
      661 agaagctcaa acggaaggcg gagcaggacc cggaggctgc ggatagcggg gagccacaga
      721 acaagaggac gccagacttg cctgaagagg agtgtgtgaa gggggagacc aaggagaatg
      781 gagaggcaga caacaagcta tttgaggaag ctactccgga gttgggggaa gccgtggtgg
      841 atgagagccc tgactttgaa atacacataa ccatgtgtga tggtgatcca cccacacctg
      901 aggaagattc agaaacacag ccagacgagg aggaagagga accaaaagtt tctacacaag
      961 aagtgggaac tgccattaag atcatccggc agctaatgga aaagtttaac ttggatctct
     1021 caacagttac acaggccttg ctgaaaaaca gtggtgaact ggaggccact tcctctttct
     1081 tagagtctgg acggagacct gatggtttcc caatttggtg ccgacaagat gacttagatt
     1141 tgcaaaagga cgatgatgac actagaaatg cactggtcaa aaaatatgga gctcagaatg
     1201 ttgctcggag gatcgaattt cgaaagaaat aaggacaaga taaccaagac aggtgaccat
     1261 gtaagcatct tgtgaccatt gaagctgacg ggtgctgccg ctctgtgaac cccaggtttt
     1321 gtagccaagc agtataatgt agcaggataa aacaaaagaa actggattag agctgtcggt
     1381 ggccagtatc ccatgtttat gataggcaaa tctaagccag agaggttggt ctgtgtagta
     1441 gtgagccttg gttggaatgt ggctcccatt gtacaggaga cagcagccaa gtgacaaagt
     1501 caagattaga aatgaaagga aacttgattg gtgagtgaat aaccttctgt cttctggcag
     1561 aaattgcttt aggtggaggg tcccaaacca aaagtctaga agtaagattt aattgtagag
     1621 cttatacatg gactgtccca aactatccca ttccccaggg agctctgggc tctgtttcga
     1681 tggtgttgaa ttatcccaca ggcatcttgc taacagtctt tgaaatctcc tctccttccg
     1741 tggctcttgc tgtttgagtt ttgaatcaag tctctatagc atgtatttgg ttacttacca
     1801 tccactctgt gtacacgaag ccctaggcct gggggagctt ccaccctttc caacataaaa
     1861 gatgtcatat acagacttca cagtcaggaa tcaaagagaa aatcaagtta tagacacacg
     1921 cacagatctt aaagctctgt gctgtaagtt tgtgattctg tgtttcaccc ttgtcgctat
     1981 cctcagacaa ggtaggttgg agactcttaa ttgtgatatg tttgtaaatt ttatggaacg
     2041 taagttttct gctgaaaatt atgtagactt aaaatttagt tgattggtcc actttgttgt
     2101 gttgtttttg tcattgaaaa taaatataat tttgtgtttg aaaaaaaaaa aaaaaaaaaa
     2161 aaaaa
//
