LOCUS       NM_001108448            1982 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus telomeric repeat binding factor 2 (Terf2),
            transcript variant 1, mRNA.
ACCESSION   NM_001108448 XM_001076545 XM_341683
VERSION     NM_001108448.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1982)
  AUTHORS   Grammatikakis I, Zhang P, Panda AC, Kim J, Maudsley S, Abdelmohsen
            K, Yang X, Martindale JL, Motino O, Hutchison ER, Mattson MP and
            Gorospe M.
  TITLE     Alternative Splicing of Neuronal Differentiation Factor TRF2
            Regulated by HNRNPH1/H2
  JOURNAL   Cell Rep 15 (5), 926-934 (2016)
   PUBMED   27117401
  REMARK    GeneRIF: HNRNPH is a splicing regulator of Trf2 pre-mRNA that
            prevents the expression of TRF2-S, a factor implicated in neuronal
            differentiation.
REFERENCE   2  (bases 1 to 1982)
  AUTHORS   Zhang P, Abdelmohsen K, Liu Y, Tominaga-Yamanaka K, Yoon JH,
            Ioannis G, Martindale JL, Zhang Y, Becker KG, Yang IH, Gorospe M
            and Mattson MP.
  TITLE     Novel RNA- and FMRP-binding protein TRF2-S regulates axonal mRNA
            transport and presynaptic plasticity
  JOURNAL   Nat Commun 6, 8888 (2015)
   PUBMED   26586091
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1982)
  AUTHORS   Ribes-Zamora A, Indiviglio SM, Mihalek I, Williams CL and Bertuch
            AA.
  TITLE     TRF2 interaction with Ku heterotetramerization interface gives
            insight into c-NHEJ prevention at human telomeres
  JOURNAL   Cell Rep 5 (1), 194-206 (2013)
   PUBMED   24095731
REFERENCE   4  (bases 1 to 1982)
  AUTHORS   Doksani Y, Wu JY, de Lange T and Zhuang X.
  TITLE     Super-resolution fluorescence imaging of telomeres reveals
            TRF2-dependent T-loop formation
  JOURNAL   Cell 155 (2), 345-356 (2013)
   PUBMED   24120135
REFERENCE   5  (bases 1 to 1982)
  AUTHORS   Grolimund L, Aeby E, Hamelin R, Armand F, Chiappe D, Moniatte M and
            Lingner J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   6  (bases 1 to 1982)
  AUTHORS   Ancelin K, Brunori M, Bauwens S, Koering CE, Brun C, Ricoul M,
            Pommier JP, Sabatier L and Gilson E.
  TITLE     Targeting assay to study the cis functions of human telomeric
            proteins: evidence for inhibition of telomerase by TRF1 and for
            activation of telomere degradation by TRF2
  JOURNAL   Mol Cell Biol 22 (10), 3474-3487 (2002)
   PUBMED   11971978
REFERENCE   7  (bases 1 to 1982)
  AUTHORS   Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H and Komuro
            I.
  TITLE     Endothelial cell senescence in human atherosclerosis: role of
            telomere in endothelial dysfunction
  JOURNAL   Circulation 105 (13), 1541-1544 (2002)
   PUBMED   11927518
REFERENCE   8  (bases 1 to 1982)
  AUTHORS   Zhu XD, Kuster B, Mann M, Petrini JH and de Lange T.
  TITLE     Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and
            human telomeres
  JOURNAL   Nat Genet 25 (3), 347-352 (2000)
   PUBMED   10888888
REFERENCE   9  (bases 1 to 1982)
  AUTHORS   Griffith JD, Comeau L, Rosenfield S, Stansel RM, Bianchi A, Moss H
            and de Lange T.
  TITLE     Mammalian telomeres end in a large duplex loop
  JOURNAL   Cell 97 (4), 503-514 (1999)
   PUBMED   10338214
REFERENCE   10 (bases 1 to 1982)
  AUTHORS   Broccoli D, Smogorzewska A, Chong L and de Lange T.
  TITLE     Human telomeres contain two distinct Myb-related proteins, TRF1 and
            TRF2
  JOURNAL   Nat Genet 17 (2), 231-235 (1997)
   PUBMED   9326950
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473972.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341683.3, XM_001076545.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1982
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1982
                     /gene="Terf2"
                     /gene_synonym="Trf2"
                     /note="telomeric repeat binding factor 2"
                     /db_xref="GeneID:361403"
                     /db_xref="RGD:1310881"
     exon            1..290
                     /gene="Terf2"
                     /gene_synonym="Trf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1531
                     /gene="Terf2"
                     /gene_synonym="Trf2"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="telomeric repeat-binding factor 2 isoform 1"
                     /protein_id="NP_001101918.1"
                     /db_xref="GeneID:361403"
                     /db_xref="RGD:1310881"
                     /translation="MAGGGGSSDNGGRAANRRASRSGGRARRGRHEPGLGGAAERGAG
                     EARLEEAVNRWVLKFYFHEALRAFRSSRYRDFRQIRDIMQALLVRPLGKEHTVSRLLR
                     VMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTDSMVESSRRLVKEA
                     AVIICIKNKEFEKASKILKKYMSKDPTTQKVRTDLLNIIREKNLAHPVIQNFSYEIFQ
                     QKMLRFLESHLDDTEPYLLTMAKKALRSESAASSTMKEEKHTEPVEKPLREPPRQPRN
                     PPTTIGLRTVKAAFKALSTAQDSEAAFAKLDQKDLVLPNLASPSSPTHKNKRPRKDEN
                     ESSAPAEGEGGSERQPRNNRMTISRLVLEEDSQSSEPSPDLNSSRQALSASPSKPRAL
                     NQPHTGEKNPKASKDKWNSPNGLEEKEVWSEEDQLFEVRAPGEDKSSNLARKQKWTIE
                     ESEWVKDGVQKYGEGNWVAISKSYPFVNRTAVMIKDRWRTMKKLGLN"
     exon            291..386
                     /gene="Terf2"
                     /gene_synonym="Trf2"
                     /inference="alignment:Splign:2.1.0"
     exon            387..517
                     /gene="Terf2"
                     /gene_synonym="Trf2"
                     /inference="alignment:Splign:2.1.0"
     exon            518..604
                     /gene="Terf2"
                     /gene_synonym="Trf2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..751
                     /gene="Terf2"
                     /gene_synonym="Trf2"
                     /inference="alignment:Splign:2.1.0"
     exon            752..852
                     /gene="Terf2"
                     /gene_synonym="Trf2"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1245
                     /gene="Terf2"
                     /gene_synonym="Trf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1331
                     /gene="Terf2"
                     /gene_synonym="Trf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1372
                     /gene="Terf2"
                     /gene_synonym="Trf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1982
                     /gene="Terf2"
                     /gene_synonym="Trf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acggcccggc ggggagggcg ctcggcggtc gaacacgatg gcgggaggag gcgggagcag
       61 cgacaacggc gggagggcgg cgaaccggcg agcatcgcgc agcggcggga gggctcgacg
      121 ggggcggcac gagccggggc tgggaggcgc ggcagagcgg ggcgcggggg aagctcgtct
      181 ggaggaggcg gtcaaccgct gggtgctcaa gttctacttc cacgaggcgc tgcgggcctt
      241 tcggagtagc cggtaccggg acttcaggca gatccgggac atcatgcagg cgttgcttgt
      301 caggcccttg gggaaggagc atacggtgtc ccggttgctg cgggttatgc agtgtctatc
      361 gcgcattgaa gaaggagaaa atttagactg ttcctttgat atggaggccg agctcacacc
      421 cctggagtca gctatcaatg tgctggagat gattaaaaca gagttcacac tgacagactc
      481 aatggttgaa tccagcagga gactggtgaa ggaggctgct gtcattattt gtatcaaaaa
      541 caaagaattt gaaaaggctt caaaaatttt gaaaaaatac atgtccaagg accccacaac
      601 tcagaaagta agaactgatc tcctgaacat tatccgggaa aagaacttgg ctcaccctgt
      661 tatccagaac ttttcctacg agatcttcca gcagaagatg ttgcgcttcc tggagagcca
      721 cctggatgac acggagccct acctcctcac gatggctaaa aaagctttga gatcagaatc
      781 agctgcttca agtacaatga aggaggaaaa gcacacagag ccagtggaga aaccactcag
      841 agagcctcca cgacagcctc ggaaccctcc aaccaccatc ggactcagga cagtgaaggc
      901 agctttcaaa gctctgtcta ctgcacaaga ctcagaagcg gcttttgcaa aactggacca
      961 gaaagatctg gtacttccta acctagcatc cccatcatca ccgacccaca aaaacaagag
     1021 acccaggaaa gatgaaaatg aaagctcagc tcctgctgag ggtgagggag gctcagaacg
     1081 acagcccagg aacaatcgca tgacaataag cagattggtg ttggaggagg acagccagag
     1141 ttctgagccc agcccagacc tcaattcctc ccggcaggcc ttatcagcat caccatccaa
     1201 gcccagagct ctcaaccaac cccacacagg ggagaagaat cccaaagcat cgaaagacaa
     1261 gtggaacagc cctaacgggc ttgaagaaaa ggaagtttgg tcggaagagg accagctgtt
     1321 tgaagtgcgg gcaccaggtg aagacaagtc atccaattta gcaagaaagc agaagtggac
     1381 catagaagaa agcgagtggg tgaaggatgg agtgcagaaa tacggggaag gaaactgggt
     1441 tgccatttct aaaagttacc cctttgttaa ccgaacagct gtgatgatta aagatcgctg
     1501 gcggaccatg aaaaaacttg gcttgaactg agaaaggttt tcagagccac aggactcaca
     1561 agaacatgat tctcaacagt agtccctgag gctgtgatgt ctccttcaaa agctggagaa
     1621 ttgcggcaac ctcctcctgt gctgggaggt ccggggacac tcctgtcact gttgatggag
     1681 atcatggagc taagcggcaa agccaggtct acccatggct gcggcagagg cgcgggcagg
     1741 cacatggctt gtacagtgcc ggaacatcat tagtgtttcc cttcagtggt ttgcttcagt
     1801 ttgaatccct agtaacccag aagtcttcta agaaatgacg gaatccatta ggagcacata
     1861 ggctctcatg acctgttaaa accagaaatg agagtcatcg ggaataaact taatcctcat
     1921 tgagttttgg actctgactc aaatacaaag gaactccgtg tgttgaaccc agatgagaga
     1981 tt
//
