LOCUS       NM_022591               8215 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Rattus norvegicus telomerase associated protein 1 (Tep1), mRNA.
ACCESSION   NM_022591
VERSION     NM_022591.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8215)
  AUTHORS   Jin,D.H., Kim,S., Kim,D.H. and Park,J.
  TITLE     Two genetic variants in telomerase-associated protein 1 are
            associated with stomach cancer risk
  JOURNAL   J Hum Genet 61 (10), 885-889 (2016)
   PUBMED   27305982
REFERENCE   2  (bases 1 to 8215)
  AUTHORS   Jung,S.W., Park,N.H., Shin,J.W., Park,B.R., Kim,C.J., Lee,J.E.,
            Shin,E.S., Kim,J.A. and Chung,Y.H.
  TITLE     Prognostic impact of telomere maintenance gene polymorphisms on
            hepatocellular carcinoma patients with chronic hepatitis B
  JOURNAL   Hepatology 59 (5), 1912-1920 (2014)
   PUBMED   23907815
REFERENCE   3  (bases 1 to 8215)
  AUTHORS   Liu,Y., Snow,B.E., Kickhoefer,V.A., Erdmann,N., Zhou,W.,
            Wakeham,A., Gomez,M., Rome,L.H. and Harrington,L.
  TITLE     Vault poly(ADP-ribose) polymerase is associated with mammalian
            telomerase and is dispensable for telomerase function and vault
            structure in vivo
  JOURNAL   Mol Cell Biol 24 (12), 5314-5323 (2004)
   PUBMED   15169895
REFERENCE   4  (bases 1 to 8215)
  AUTHORS   Chang,J.T., Chen,Y.L., Yang,H.T., Chen,C.Y. and Cheng,A.J.
  TITLE     Differential regulation of telomerase activity by six telomerase
            subunits
  JOURNAL   Eur J Biochem 269 (14), 3442-3450 (2002)
   PUBMED   12135483
REFERENCE   5  (bases 1 to 8215)
  AUTHORS   Liu,Y., Snow,B.E., Hande,M.P., Baerlocher,G., Kickhoefer,V.A.,
            Yeung,D., Wakeham,A., Itie,A., Siderovski,D.P., Lansdorp,P.M.,
            Robinson,M.O. and Harrington,L.
  TITLE     Telomerase-associated protein TEP1 is not essential for telomerase
            activity or telomere length maintenance in vivo
  JOURNAL   Mol Cell Biol 20 (21), 8178-8184 (2000)
   PUBMED   11027287
REFERENCE   6  (bases 1 to 8215)
  AUTHORS   Ozaki,S., Harada,K., Sanzen,T., Watanabe,K., Tsui,W. and
            Nakanuma,Y.
  TITLE     In situ nucleic acid detection of human telomerase in intrahepatic
            cholangiocarcinoma and its preneoplastic lesion
  JOURNAL   Hepatology 30 (4), 914-919 (1999)
   PUBMED   10498642
REFERENCE   7  (bases 1 to 8215)
  AUTHORS   Nakayama,J., Saito,M., Nakamura,H., Matsuura,A. and Ishikawa,F.
  TITLE     TLP1: a gene encoding a protein component of mammalian telomerase
            is a novel member of WD repeats family
  JOURNAL   Cell 88 (6), 875-884 (1997)
   PUBMED   9118230
REFERENCE   8  (bases 1 to 8215)
  AUTHORS   Harrington,L., McPhail,T., Mar,V., Zhou,W., Oulton,R., Bass,M.B.,
            Arruda,I. and Robinson,M.O.
  TITLE     A mammalian telomerase-associated protein
  JOURNAL   Science 275 (5302), 973-977 (1997)
   PUBMED   9020079
REFERENCE   9  (bases 1 to 8215)
  AUTHORS   Joly,E.C., Tremblay,E., Tanguay,R.M., Wu,Y. and Bibor-Hardy,V.
  TITLE     TRiC-P5, a novel TCP1-related protein, is localized in the
            cytoplasm and in the nuclear matrix
  JOURNAL   J Cell Sci 107 (Pt 10), 2851-2859 (1994)
   PUBMED   7876352
REFERENCE   10 (bases 1 to 8215)
  AUTHORS   Megyeri,P., Abraham,C.S., Temesvari,P., Kovacs,J., Vas,T. and
            Speer,C.P.
  TITLE     Recombinant human tumor necrosis factor alpha constricts pial
            arterioles and increases blood-brain barrier permeability in
            newborn piglets
  JOURNAL   Neurosci Lett 148 (1-2), 137-140 (1992)
   PUBMED   1300486
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U89282.1.
            
            On Aug 31, 2012 this sequence version replaced NM_022591.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U89282.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8215              U89282.1           2-8216
FEATURES             Location/Qualifiers
     source          1..8215
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="F344"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..8215
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /note="telomerase associated protein 1"
                     /db_xref="GeneID:64523"
                     /db_xref="RGD:3869"
     exon            1..174
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            175..765
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..8088
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /note="p230; p240; rTLP1; telomerase protein 1; p80
                     telomerase homolog"
                     /codon_start=1
                     /product="telomerase protein component 1"
                     /protein_id="NP_072113.1"
                     /db_xref="GeneID:64523"
                     /db_xref="RGD:3869"
                     /translation="MEKLCGYVPVHPDILSLKNRCLTMLSDIQPLEKIHGQRSVNPDI
                     LSLENRCLTLLPDLQPMEKIHGQRSVHPDILSSENRCLTLLPDLQSLEKLCGHMSSHP
                     DVLSLENRCLATLPTVKRTVSSGPLLQCLHRSHTAQADLRDPNFRNCLFPEPPTIEAP
                     CFLKELDLPTGPRALKSMSATARVQEVALGQRCVSEGKELQEEKESAEVPMPLYSLSL
                     GGEEEEVVGAPVLKLTSGDSDSHPETTDQILQEKKMALLTLLCSAMASSVNVKDASDP
                     TRASIHEVCSALAPLEPEFILKASLYARQQLNLRDIANIVLAVAALLPACRPHVRRYY
                     SAIVHLPSDWIQVAEFYQSLAEGDEKKLVPLPACLRAAMTDKFAQFDEYQLAKYNPRK
                     HRSKTRSRQPPRPQRTKPPFSESGKCFPKSVWPLKNEQISFEAAYNAVSEKKRLPRFT
                     LKKLVEQLHIHEPAQHVQALLGYRYPSTLELFSRSHLPGPWDSSRAGQRMKLQRPETW
                     ERELSLRGNRASVWEELIDNGKLPFMAMLRNLCNLLRTGISAHHHELVLQRLQHEKSV
                     IHSRQFPFRFLNAHDSLDRLEAQLRSKASPFPSNTTLMKRIMIRNSKKIKRPANPRYL
                     CTLTQRQLRAAMAIPVMYEHLKREKLRLHKARQWTCDLELLERYRQALETAVNISVKH
                     NLPPLPGRTLLVYLTDANANRLCPKSHLQGPPLNYVLLLIGMMMARAEQTTVWLCGTG
                     TVKTPVLTADEGILKTAIKLQAQVQELEENDEWPLETFEKYLLSLAVRRTPIDRVILF
                     GQRMDTELLNVAKQIIWQHVNSKCLFVSVLLRKMQYMSPNLNPNDVTLSGCTDGILKF
                     IAEHGASRLLEHVGQLDKIFKIPPPPGKTKVSPLRPLEENNPGPFVPISQHGWRNIRL
                     FISSTFRDMHGERDLLMRSVLPALQARAFPHRISLHAIDLRWGITEEETRRNRQLEVC
                     LGEVENSQLFVGILGSRYGYTPPSYDLPDHPHFHWTQRYPSGRSVTEMEVMQFLNRGQ
                     RSEPSDQALIYFRDPGFLSSVPDVWKPDFISESEEAAHRVSELKRFLQEQKEVTCRRY
                     SCEWGGVAAGRPYTGGLEEFGQLVLQDVWSVIQKRYLQPGAQLEQPGSISEEDLIQAS
                     FQQLKSPPSPARPRLLQDTVQQLMLPHGRLSLVIGQAGQGKTAFLASLVSALKVPDQP
                     NVAPFVFFHFSAARPDQCLAFNLLRRLCTHLHQKLGEPSALPSTYRGLVWELQQKLLL
                     KSAQWLQPGQTLVLIIDGADKLVDHNGQLISDWIPKSLPRRVHLVLSVSSDSGLGETL
                     QQSQSAYVVALGSLVPSSRAQLVREELALYGKRLEESPFNNQMRLLLAKQGSSLPLYL
                     HLVTDYLRLFTLYEQVSERLRTLPATLPLLLQHILSTLEQEHGHNVLPQALTALEVTH
                     SGLTVDQLHAVLSTWLTLPKETKSWEEAVAASHSGNLYPLAPFAYLVQSLRSLLGEGP
                     VERPGARLCLSDGPLRTAVKRRYGKRLGLEKTAHVLIAAHLWKMCDPDASGTFRSCPP
                     EALKDLPYHLLQSGNHGLLAKFLTNLHVVAAYLEVGLVPDLLEAYELYASSKPEVNQK
                     LPEADVAVFHNFLKQQASLLTQYPLLLLQQAASQPEESPVCCQAPLLTQRWHNQCILK
                     WINKPQTLKGQQSLSLPISSSPTAVAFSPNGQRAAVGTAGGTIYLLNLRTWQEEKALV
                     SGCDGISSFAFLSDTALFLTTFDGLLELWDLQHGCWVFQTKAHQYQITGCCLSPDRRL
                     LATVCLGGYVKLWDTVQGQLAFQYTHPKSLNCITFHPEGQVVATGNWSGIVTFFQADG
                     LKVTKELGGPGPSVRTLAFSAPGKVVALGRIDGTVELWAWQEGTRLAAFPAQCGGVST
                     VLFLHAGGRFLTAGEDGKAQLWSGFLGRPRGCLGSLYLSPALSVALNPDGDQVAVGYR
                     GDGIKIYRISSGPQEAQCQELNVAVSALVWLSPSVLVSGAEDGSLHGWMLRRNSLQSL
                     WLSSVCQKPVLGLAASQEFLASASEDFTVRLWPRQLLTQPHAVEELPCAAELRGHEGP
                     VCCCSFSPDGRILATAGRDRNLLCWDVKVAQAPLLIHTFSSCHRDWITGCTWTKDNIL
                     ISCSSDGSVGLWNPEAGQQLGQFPGHQSAVSAVVAVEEHIVSVSRDGTLKVWDRQGVE
                     LTSIPAHSGPISQCAAALEPRPAGQPGSELMVVTVGLDGATKLWHPLLVCQIHTLQGH
                     SGPVTAAAASEASGLLLTSDNSSVRLWQIPKEADDTCKPRSSAVITAVAWAPDGSLVV
                     SGNEAGELTLWQKAQAVATARAPGRVSDLIWCSANAFFVLSANENVSEWQVELRKGST
                     CTNFRLYLKRVLQEDLGVLTGMALAPDGQSLILMKEDVELLQMKPGSTPSSICRRYAV
                     HSSILCTSKDYGLFYLQQGNSGSLSILEQEESGKFEKTLDFNLNLNNPNGSPVSITQA
                     EPESGSSLLCATSDGMLWNLSECTPEGEWVVDNIWQKKSRNPKSRTPGTDSSPGLFCM
                     DSWVEPTHLKARQCKKIHLGSVTALHVLPGLLVTASEDRDVKLWERPSMQLLGLFRCE
                     GPVSCLEPWMEPSSPLQLAVGDAQGNLYFLSWE"
     exon            766..957
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1092
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1254
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1416
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1494
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1619
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1777
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1887
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..1978
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2165
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2334
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2493
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2571
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2702
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2762
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..2921
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2922..3098
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3219
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3220..3344
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3458
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3459..3576
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3577..3771
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3772..3947
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3948..4104
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4105..4284
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4285..4377
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4378..4510
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4511..4661
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4662..4795
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4796..4884
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4885..4999
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5000..5240
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5241..5358
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5359..5483
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5484..5583
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5584..5739
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5740..5952
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5953..6106
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            6107..6319
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            6320..6480
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            6481..6594
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            6595..6702
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            6703..6835
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            6836..6912
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            6913..7042
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            7043..7179
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            7180..7304
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            7305..7448
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            7449..7545
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            7546..7651
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            7652..7860
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            7861..7965
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
     exon            7966..8194
                     /gene="Tep1"
                     /gene_synonym="Tlp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctccgccc ctccccttgc ccagcctcgc cccttcgcct ctctagggtg ttggtttcct
       61 ttcagttctc tttcttcaac ctatccactg gctgacctag gccggtttct gctccttgtt
      121 gcggagaacc aacgcgcccc tcactgtgca cagcttttcc agtcccgagc gcaggcacat
      181 agagattgtg ctgccgctat ggagaaactc tgtggttatg tgcctgtcca cccagacatc
      241 ctctccttga agaatcggtg cctgaccatg ctctctgaca tccaacccct ggagaaaata
      301 catggacaga gatctgtcaa cccagacatc ctgtccttgg agaaccggtg cctgaccttg
      361 ctccctgatc tccagcccat ggagaaaata catggacaga gatctgtcca cccagacatc
      421 ctctcctcag agaaccggtg tctgaccttg ctccctgacc tccagtccct ggagaagcta
      481 tgtggacata tgtctagtca cccagacgtc ctctctttgg agaaccgatg tcttgctacc
      541 ctcccgactg taaagagaac tgtttcgagt ggccccttgc tccagtgtct tcacagatct
      601 catacggcac aagctgatct gcgtgacccg aactttcgca actgcctgtt ccctgagcct
      661 cctaccatag aggctccatg tttcttgaag gaactagacc ttccaactgg acccagggcc
      721 ctgaaatcca tgtctgctac agctcgagtt caggaagtag ctttgggtca gcggtgcgtc
      781 tcagaaggaa aggaattgca ggaagaaaaa gaaagcgcag aagtcccgat gcctttgtac
      841 agtctaagct tggggggaga agaagaagaa gtggtggggg caccggtcct aaaactcaca
      901 tctggagact ctgactctca ccctgaaacc actgaccaga tcctgcagga gaagaagatg
      961 gctctcttga ccttgctgtg ctcagctatg gcctcaagtg tgaatgtgaa agatgcctcc
     1021 gatcctaccc gggcatctat ccatgaagtc tgcagtgcgc tggccccctt ggaacctgag
     1081 ttcatcctta aggcatcttt gtatgctagg cagcagctta acctccggga catagccaat
     1141 atagtgttgg ccgtggctgc cctcttgcca gcctgccgcc cccatgtacg acggtattac
     1201 tctgccattg ttcacctgcc ttcagactgg atccaggtag ccgagttcta ccagagcctg
     1261 gcagaagggg atgagaagaa gttggtgccc ctgcctgcct gcctccgtgc tgccatgact
     1321 gacaaatttg cccagtttga tgagtaccag ctagcgaagt acaacccacg gaaacaccga
     1381 tccaagacac gttcccgcca gccaccccgc cctcaaagga caaaacctcc attttcagag
     1441 agtgggaaat gttttccaaa gagcgtttgg ccccttaaaa acgaacagat ttcgttcgaa
     1501 gcagcttata atgcagtgtc agagaagaaa aggctaccaa ggttcactct gaagaagttg
     1561 gtagagcaac tgcatatcca tgagcctgcg cagcatgtcc aggccctgct gggctacagg
     1621 tacccatcca ccctagagct cttttctcgg agtcatctcc ctgggccatg ggactctagc
     1681 agggctgggc aacggatgaa gctccaaagg ccagagacct gggagcggga gctgagctta
     1741 cgtggaaaca gagcttctgt gtgggaggaa ctcatagaca atgggaaact ccccttcatg
     1801 gccatgctcc ggaacctgtg taacctgctg cggactggga tcagtgccca ccaccatgaa
     1861 ctcgttctcc agagactcca gcatgagaaa tctgtgattc acagtcggca gtttccattc
     1921 agattcctta atgctcacga ctctctcgat agactcgagg ctcagctcag aagtaaagca
     1981 tcgcccttcc cttccaatac aacattgatg aagcggataa tgattagaaa ctcaaaaaaa
     2041 atcaagagac ctgccaaccc gaggtacctg tgcaccctga cgcagcggca gcttcgggcg
     2101 gcaatggcta tcccggtgat gtatgagcat ctcaagcggg agaaactgag gctgcacaag
     2161 gccagacagt ggacctgtga ccttgagttg ctggagcggt atcgccaggc cctggaaacg
     2221 gccgtgaaca tctctgtaaa gcacaaccta cccccgctgc caggccgaac cctcttggtc
     2281 tatctcacag atgcaaatgc caacagactt tgtcccaaga gtcacttgca agggcctccc
     2341 ctgaactatg tgctgctgtt gatcgggatg atgatggctc gggcggagca gacgacagtt
     2401 tggctgtgtg ggacaggaac tgtgaagaca ccagtactta cagccgacga aggtatcctg
     2461 aagactgcca tcaaacttca ggctcaagtc caggagttag aagaaaatga tgagtggccc
     2521 ctggaaactt ttgagaagta cctgctatct ctggctgtgc gaaggacccc tattgacagg
     2581 gtcatcctgt tcggccaaag gatggatacg gagctgctga atgtagccaa acagattatc
     2641 tggcagcatg tgaattccaa gtgcctcttc gtcagtgtcc tcctacggaa aatgcagtac
     2701 atgtcaccaa atttgaatcc caatgatgtg acgctctcgg gctgcactga cgggatcctg
     2761 aagttcattg cggagcatgg agcctctcgt cttctggaac atgtgggcca actagataag
     2821 atattcaaga tccctccacc cccaggaaag acaaaggtct cacctctccg gccgctggag
     2881 gagaacaacc ctggtccctt cgttcctatt tcccagcatg gatggcgcaa catccggctt
     2941 ttcatttcgt ccactttccg agacatgcat ggggaacgag acttgctgat gcgatctgtt
     3001 ctgccagcgc tgcaggcccg agcgttcccc caccgcatca gccttcacgc cattgacctg
     3061 cgctggggaa tcacggagga agagacccgc aggaacagac aactggaagt gtgccttggg
     3121 gaggtggaga actctcagct gttcgtgggg atcctgggct cccgctatgg ctatactccc
     3181 cccagctatg atctgcctga ccacccccac tttcactgga cccagcgata cccttcgggg
     3241 cgctctgtaa cagagatgga ggtgatgcag ttcctgaacc gtggccaacg ctcggaaccc
     3301 tctgaccaag ctctcatcta cttccgagat cctggtttcc ttagctctgt gccagatgtc
     3361 tggaaacctg actttatttc cgagtcagaa gaggctgcac atcgggtctc agaactgaag
     3421 agattcctac aggaacagaa agaggttacc tgccgcaggt actcctgtga atggggaggc
     3481 gtagcagccg gccggcccta tactgggggc ctggaggagt ttggacagtt ggttctccaa
     3541 gatgtgtgga gcgtgatcca gaagcgttac ctgcagcctg gggcccagtt ggagcagcca
     3601 ggatccatct cagaagagga tttgatccag gccagctttc agcagctgaa gagcccaccg
     3661 agtcccgcac ggccacgcct tcttcaggat accgtgcaac agctgatgct gccccacggg
     3721 aggctgagcc tagtgattgg gcaggcagga cagggaaaga ctgccttcct ggcatccctt
     3781 gtgtcggccc tgaaggttcc cgaccagccc aatgtggccc cgttcgtttt cttccacttt
     3841 tcagcagccc gccctgacca gtgtcttgct ttcaacctcc tcagacgcct ctgtacccat
     3901 ctgcatcaaa aactgggaga gccgagcgct ctccccagca cttacagagg cctggtgtgg
     3961 gaactgcagc agaagctgct cctcaaatct gcccagtggc tgcaaccagg ccagactttg
     4021 gtccttatta tcgacggggc agataagttg gtggaccata atggacagct gatttcagac
     4081 tggatcccca agtctcttcc gcggcgagta cacctggtgc tgagtgtgtc tagtgactca
     4141 ggcctgggag agacccttca gcaaagtcag agtgcttatg tggtggcctt ggggtctttg
     4201 gtcccgtctt caagggctca gcttgtgaga gaagagctag cactgtatgg gaaacggctg
     4261 gaggagtcac cttttaacaa ccagatgcgg ctgctgctgg caaagcaggg gtcaagcctg
     4321 ccactgtacc tgcacctcgt cactgactac ctgaggcttt tcacactgta cgaacaggtg
     4381 tctgagagac ttcgaaccct gcccgccact ctcccactgc tgctgcagca catcctgagc
     4441 accttggagc aagagcatgg ccataacgtc cttcctcaag ctttgactgc ccttgaggtc
     4501 acgcacagtg gtctgactgt ggaccagctg catgcagtcc tgagcacgtg gttgactttg
     4561 cccaaggaga ctaagagctg ggaagaggca gtggctgcca gtcacagtgg aaacctctac
     4621 cccttggctc catttgccta ccttgtccag agtctacgca gtttactagg cgagggcccc
     4681 gtggagcgcc ctggcgcccg tctctgcctc tctgatgggc ctctgaggac agcagttaaa
     4741 cgtcgctatg ggaaaaggct ggggctagag aagactgcgc atgtcctcat tgcagctcac
     4801 ctctggaaga tgtgtgaccc tgatgcctca ggcaccttcc gaagttgccc tcccgaggct
     4861 ctgaaagatt taccttacca cctgctccag agcgggaacc atggtctcct tgcaaagttc
     4921 cttaccaacc tccatgtggt ggctgcatat ctggaagtgg gtctagtccc ggacctcttg
     4981 gaggcttacg agctctatgc ttcttcaaag cctgaagtga accagaagct cccggaggca
     5041 gatgttgctg tattccacaa cttcctgaaa caacaggctt cactccttac ccagtatcct
     5101 ttgctcctgc tccagcaggc agctagccag cctgaagagt cacctgtttg ctgccaggcc
     5161 cccctgctca cccagcggtg gcacaaccag tgcatactga aatggattaa taaaccccag
     5221 accttgaagg gtcagcaaag cttgtctctg ccaatttcct catccccaac tgctgtggcc
     5281 ttctctccta atgggcaaag agcagctgtg gggactgctg gtgggacaat ttacctgttg
     5341 aacttgagaa cctggcagga ggagaaggct ctggtgagtg gctgtgatgg gatttcctct
     5401 ttcgcgttcc tgtcagacac tgctcttttc cttaccacct tcgatgggct cctggagctt
     5461 tgggacctgc aacatggttg ttgggtgttc cagaccaagg cccaccagta ccaaatcact
     5521 ggctgctgcc tgagcccaga ccgccgcctg ctggccaccg tgtgtttggg aggatacgta
     5581 aagctgtggg acacagtcca gggccagctg gctttccagt acacccatcc caagtctcta
     5641 aactgcatca ccttccaccc agaggggcag gtggtagcca caggcaactg gtctggcatc
     5701 gtgaccttct tccaggcaga tggactcaaa gtcaccaagg aactaggggg cccaggaccc
     5761 tctgttcgta cgctggcatt cagtgcaccc gggaaggttg tggctctagg ccggatagat
     5821 gggacagtgg agctgtgggc ctggcaagag ggcacacggc tggcagcctt ccctgcacag
     5881 tgtggcggtg tctccaccgt tcttttcttg catgctggag gccggttcct gacggctggg
     5941 gaagatggca aggctcagtt atggtcagga tttcttggcc ggcccagggg ttgcctgggc
     6001 tctctttatc tttctcctgc gctctctgtg gctctcaacc cagacggtga ccaggtggct
     6061 gttgggtacc gaggagatgg cattaaaatc tacagaattt cttcaggtcc ccaggaggct
     6121 caatgccaag agctaaatgt ggcggtgtct gcactggtct ggctgagtcc cagcgtcttg
     6181 gtgagtggtg cagaagatgg ctccctgcat ggctggatgc tcaggagaaa ctcccttcag
     6241 tccctgtggc tgtcatccgt gtgccagaag cctgtgctgg ggctggctgc ctcccaggag
     6301 ttcttggctt ctgcctcaga ggacttcacg gtgcgactgt ggccaagaca gctgctgaca
     6361 cagccacatg cagtagaaga gttgccctgt gcggctgaac tccggggaca cgaggggccg
     6421 gtgtgctgct gtagcttcag cccggatgga cgcatcttgg ccacagcggg cagggatcgg
     6481 aatctcctct gctgggacgt caaggtagcc caagcccctc tcctgattca cacgttctcg
     6541 tcctgtcatc gagactggat cactggctgt acgtggacca aagacaacat cctgatctcc
     6601 tgctctagtg atggctctgt gggactctgg aacccagagg caggacagca acttggccag
     6661 ttcccaggtc accagagtgc cgtgagcgct gtggttgctg tggaggaaca cattgtatct
     6721 gtgagtcggg atgggacctt gaaagtgtgg gaccgtcagg gtgtggagct gaccagcatc
     6781 cctgcccatt ccggacccat tagccagtgt gcggctgctc tggaaccccg tccagctgga
     6841 cagcctggat cagagcttat ggtggtgact gttggactgg atggggccac aaagctgtgg
     6901 catcccctgt tggtgtgcca aatacatacc ctgcagggac acagtggtcc agtcacagct
     6961 gctgctgctt cagaggcctc aggcctcctg ctgacctcag acaatagctc tgtacgactc
     7021 tggcagatcc ctaaggaagc agatgatacc tgcaaaccta ggagttctgc ggtcatcacc
     7081 gctgtggcgt gggcaccaga tggttctctg gtggtgtctg gaaatgaagc tggggaacta
     7141 acgctgtggc agaaagcgca ggctgtggct acggcacggg ctccaggccg cgtcagtgac
     7201 ctgatctggt gctccgcaaa tgcattcttt gttctcagtg ctaatgaaaa tgtcagtgag
     7261 tggcaagtgg aactgaggaa aggttcaaca tgcaccaatt tcagacttta tctgaagaga
     7321 gttctgcagg aggacttggg agtcttgaca ggtatggccc tggcgcctga cggccagtct
     7381 ctcattttga tgaaagagga tgtagaattg ctacagatga agcccgggtc tactccatct
     7441 tcgatctgca ggaggtatgc agtgcattct tctatactgt gcaccagcaa agactatggc
     7501 ctgttttacc tgcagcaggg aaactctgga tctctttcta tcttggagca ggaggagtca
     7561 gggaagtttg aaaagaccct ggacttcaat ctgaacttaa ataatcctaa tgggtcccca
     7621 gtatcaatca ctcaggctga acctgagtct gggtcctcgc ttttgtgtgc tacctctgat
     7681 gggatgctgt ggaacttatc tgagtgtacc ccagaaggag agtgggtcgt agataacatc
     7741 tggcagaaaa aatcaagaaa ccctaaaagt cgaactccgg ggacagattc gtccccaggc
     7801 ttattctgca tggatagctg ggtagaaccc acacatttaa aggcacggca gtgtaaaaag
     7861 attcacttgg gctctgtcac ggccctccat gtgctgcccg gattgctggt gactgcttca
     7921 gaggacagag atgttaagct gtgggagaga cccagtatgc agctgctcgg cttgttccga
     7981 tgtgaagggc cggtgagctg tctggaacct tggatggagc ccagctctcc cctgcagctt
     8041 gctgtgggag atgcacaagg aaacttgtat tttctatctt gggaatgaag atgaagaatc
     8101 aggacaaaga tggtgtcacc ggatgatggt cacctgaaga caccagtgtc tatattctta
     8161 ataaggttat aaaataaagt gttggaagat ctaaaaaaaa aaaaaaaaaa aaaaa
//
