LOCUS       NM_001415013            4949 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus terminal nucleotidyltransferase 4B (Tent4b),
            transcript variant 3, mRNA.
ACCESSION   NM_001415013 XM_006255261
VERSION     NM_001415013.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4949)
  AUTHORS   Lim J, Kim D, Lee YS, Ha M, Lee M, Yeo J, Chang H, Song J, Ahn K
            and Kim VN.
  TITLE     Mixed tailing by TENT4A and TENT4B shields mRNA from rapid
            deadenylation
  JOURNAL   Science 361 (6403), 701-704 (2018)
   PUBMED   30026317
REFERENCE   2  (bases 1 to 4949)
  AUTHORS   Shin J, Paek KY, Ivshina M, Stackpole EE and Richter JD.
  TITLE     Essential role for non-canonical poly(A) polymerase GLD4 in
            cytoplasmic polyadenylation and carbohydrate metabolism
  JOURNAL   Nucleic Acids Res 45 (11), 6793-6804 (2017)
   PUBMED   28383716
REFERENCE   3  (bases 1 to 4949)
  AUTHORS   Shukla S, Schmidt JC, Goldfarb KC, Cech TR and Parker R.
  TITLE     Inhibition of telomerase RNA decay rescues telomerase deficiency
            caused by dyskerin or PARN defects
  JOURNAL   Nat Struct Mol Biol 23 (4), 286-292 (2016)
   PUBMED   26950371
REFERENCE   4  (bases 1 to 4949)
  AUTHORS   Boele J, Persson H, Shin JW, Ishizu Y, Newie IS, Sokilde R, Hawkins
            SM, Coarfa C, Ikeda K, Takayama K, Horie-Inoue K, Ando Y, Burroughs
            AM, Sasaki C, Suzuki C, Sakai M, Aoki S, Ogawa A, Hasegawa A, Lizio
            M, Kaida K, Teusink B, Carninci P, Suzuki H, Inoue S, Gunaratne PH,
            Rovira C, Hayashizaki Y and de Hoon MJ.
  TITLE     PAPD5-mediated 3' adenylation and subsequent degradation of miR-21
            is disrupted in proliferative disease
  JOURNAL   Proc Natl Acad Sci U S A 111 (31), 11467-11472 (2014)
   PUBMED   25049417
REFERENCE   5  (bases 1 to 4949)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 4949)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 4949)
  AUTHORS   Berndt H, Harnisch C, Rammelt C, Stohr N, Zirkel A, Dohm JC,
            Himmelbauer H, Tavanez JP, Huttelmaier S and Wahle E.
  TITLE     Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent
            adenylation and PARN-dependent trimming
  JOURNAL   RNA 18 (5), 958-972 (2012)
   PUBMED   22442037
  REMARK    Erratum:[RNA. 2014 Aug;20(8):1349]
REFERENCE   8  (bases 1 to 4949)
  AUTHORS   Lubas M, Christensen MS, Kristiansen MS, Domanski M, Falkenby LG,
            Lykke-Andersen S, Andersen JS, Dziembowski A and Jensen TH.
  TITLE     Interaction profiling identifies the human nuclear exosome
            targeting complex
  JOURNAL   Mol Cell 43 (4), 624-637 (2011)
   PUBMED   21855801
REFERENCE   9  (bases 1 to 4949)
  AUTHORS   Mullen TE and Marzluff WF.
  TITLE     Degradation of histone mRNA requires oligouridylation followed by
            decapping and simultaneous degradation of the mRNA both 5' to 3'
            and 3' to 5'
  JOURNAL   Genes Dev 22 (1), 50-65 (2008)
   PUBMED   18172165
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000306.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001415013.2.
            
            On Dec 20, 2022 this sequence version replaced XM_006255261.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-978               JACYVU010000306.1  1068177-1069154     c
            979-1102            JACYVU010000306.1  1026328-1026451     c
            1103-1149           JACYVU010000306.1  1024439-1024485     c
            1150-1270           JACYVU010000306.1  1023729-1023849     c
            1271-1378           JACYVU010000306.1  1022647-1022754     c
            1379-1507           JACYVU010000306.1  1021025-1021153     c
            1508-1721           JACYVU010000306.1  1019969-1020182     c
            1722-1848           JACYVU010000306.1  1018781-1018907     c
            1849-1952           JACYVU010000306.1  1018583-1018686     c
            1953-2140           JACYVU010000306.1  1018292-1018479     c
            2141-2305           JACYVU010000306.1  1015902-1016066     c
            2306-4949           JACYVU010000306.1  1011339-1013982     c
FEATURES             Location/Qualifiers
     source          1..4949
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..4949
                     /gene="Tent4b"
                     /gene_synonym="Papd5"
                     /note="terminal nucleotidyltransferase 4B"
                     /db_xref="GeneID:307745"
                     /db_xref="RGD:1309587"
     exon            1..978
                     /gene="Tent4b"
                     /gene_synonym="Papd5"
                     /inference="alignment:Splign:2.1.0"
     CDS             380..2482
                     /gene="Tent4b"
                     /gene_synonym="Papd5"
                     /EC_number="2.7.7.19"
                     /note="isoform 3 is encoded by transcript variant 3;
                     PAP-associated domain-containing protein 5; poly(A) RNA
                     polymerase D5, non-canonical; non-canonical poly(A) RNA
                     polymerase PAPD5; PAP associated domain containing 5"
                     /codon_start=1
                     /product="terminal nucleotidyltransferase 4B isoform 3"
                     /protein_id="NP_001401942.1"
                     /db_xref="GeneID:307745"
                     /db_xref="RGD:1309587"
                     /translation="MDPRIAWFQPEQLGPSNSLWMQIWETTQGLRNLYFNHHCHSSGA
                     SSASGGSGSGPGSPGGTAPAPAGMFRSGERPLGGLAVPAEQRDFLPLETTNNNNNHHQ
                     PAAWARRAAAGPSASPVPSAPSSPRPAAPLPASESADPASGSSNKRKRDNKASTYGLN
                     YSLLQPSGGRAAGGGRADGGGGVYSGTPWKRRNYNQGVVGLHEEISDFYEYMSPRPEE
                     EKMRMEVVSRIESVIKELWPSADVQIFGSFKTGLYLPTSDIDLVVFGKWENLPLWTLE
                     EALRKHKVADEDSVKVLDKATVPIIKLTDSFTEVKVDISFNVQNGVRAADLIKDFTKK
                     YPVLPYLVLVLKQFLLQRDLNEVFTGGIGSYSLFLMAVSFLQLHPREDACIPNTNYGV
                     LLIEFFELYGRHFNYLKTGIRIKDGGSYVAKDEVQKNMLDGYRPSMLYIEDPLQPGND
                     VGRSSYGAMQVKQAFDYAYVVLSHAVSPIAKCYPNNETESILGRIIRVTDEVTTYRDW
                     ISKQWGLQNRPEPSCNGNGVTLIVETQQLDKCNNNLSEENEAPGKCRSKASESLSKHS
                     SNSSSGPVSSSSATQSSSSDVDSDATPCKTPKQVLCRPPTVSRVGSQDVSLEVSQAVG
                     KMQSTQTTNTANSTNKSQHGSARLFRSSSKGFQGTAQTSHGALMTSKQHPGKSNTQCY
                     HGKKRRHKRDAPLSELCR"
     exon            979..1102
                     /gene="Tent4b"
                     /gene_synonym="Papd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1149
                     /gene="Tent4b"
                     /gene_synonym="Papd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1270
                     /gene="Tent4b"
                     /gene_synonym="Papd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1378
                     /gene="Tent4b"
                     /gene_synonym="Papd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1507
                     /gene="Tent4b"
                     /gene_synonym="Papd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1721
                     /gene="Tent4b"
                     /gene_synonym="Papd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1848
                     /gene="Tent4b"
                     /gene_synonym="Papd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1952
                     /gene="Tent4b"
                     /gene_synonym="Papd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2140
                     /gene="Tent4b"
                     /gene_synonym="Papd5"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2305
                     /gene="Tent4b"
                     /gene_synonym="Papd5"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..4949
                     /gene="Tent4b"
                     /gene_synonym="Papd5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgagcagc acggacgcta cggagcaggc gcgtcccgct gccgccgccg ccgccgccgc
       61 cgccgctgcc gctgccgccg ccgccgcctc cgccgccgcc accgctcgcc cttctcggga
      121 gccgccgccg ccatttgcac gggaaccccg gtgacagggg ctcggcggag gggcggaggg
      181 aggggggagg gcctgcgagc cccgagggcg ggagcgacgc cgccggcgcc ggccaggctc
      241 cctgcgctac cgcgccgccc gtggcggaac ccgggtggca gcggcggcgg cggccgaggg
      301 cgggcgtgcg cctgaggcgg cggcggcggc ggccctgcgg gcggccggga ggggcggggg
      361 cagcggccgc cgccgtttga tggatccgag gatcgcctgg ttccagccag agcagctcgg
      421 accgtccaat agtctgtgga tgcagatctg ggagacgacc caggggctga ggaacctcta
      481 cttcaaccac cactgtcaca gcagcggcgc gagcagcgcg agcggcggga gcggcagcgg
      541 ccccggcagc cccggcggca cggccccggc tccggccggc atgttccgct cgggggagcg
      601 cccactgggc ggcctcgccg tgcccgcgga gcagcgggac ttcctgcccc tggagacgac
      661 caacaacaac aacaatcacc accagccggc ggcctgggca cggcgggcag cggcgggccc
      721 ctcggcgtca ccggtcccat cggcaccctc gtccccgcgt cccgcggccc cactccctgc
      781 ctccgagtct gcggacccag cctcgggcag cagcaacaag aggaaacgtg acaacaaggc
      841 cagcacctac ggactcaact acagcctgct gcaacccagc ggagggcgcg cggccggggg
      901 cggccgggcg gacggcggcg ggggcgtgta cagcgggacc ccgtggaaga gacggaacta
      961 caaccaggga gtcgtgggtc tgcatgaaga aatcagtgat ttttatgagt acatgtctcc
     1021 cagacccgag gaggagaaga tgcggatgga ggtggtgagc aggatcgaga gtgtgattaa
     1081 ggagctctgg cccagtgctg acgtccagat atttggaagt tttaaaactg gcctgtattt
     1141 acctactagc gacatcgatc ttgtggtgtt tgggaagtgg gagaacctgc ctctttggac
     1201 cctggaagaa gcccttcgga aacacaaagt cgctgacgag gattccgtga aagttctaga
     1261 caaagcaacg gttcctatta ttaaattaac agattctttt actgaagtga aagttgatat
     1321 cagctttaat gtccagaatg gcgtgagagc agcagacctc attaaagatt ttactaagaa
     1381 atatcctgtc ctgccatact tggttttagt attgaaacag ttcttactac agagggacct
     1441 taatgaagta ttcacaggtg gaattggctc ttacagtctt tttttaatgg cagtcagctt
     1501 cctccagtta catcccaggg aagatgcttg catccccaat acaaactatg gtgttctctt
     1561 aatagaattt tttgaattat atggacggca cttcaattac ttaaagactg gcatccggat
     1621 aaaggatggt ggttcctatg tggccaaaga tgaagtacag aaaaacatgc ttgatggcta
     1681 ccggccatca atgctttata tcgaagatcc tttacagcca ggtaatgatg ttgggaggag
     1741 ttcgtatggg gccatgcagg taaagcaggc ctttgactac gcctatgtgg tgctgagcca
     1801 cgcagtgtcg ccgattgcaa agtgctatcc caacaacgag acagagagca tattgggtag
     1861 aataattaga gtgacggatg aagttaccac atacagagat tggatatcaa aacagtgggg
     1921 cttgcagaat aggcccgagc cttcatgcaa tggaaatggt gttaccttga tagtagagac
     1981 gcagcagtta gataagtgta ataataatct gtctgaagag aatgaagccc cgggaaaatg
     2041 tagaagtaaa gcctcggagt ctcttagtaa acactcttca aactcttcat caggtcctgt
     2101 gtcctcctcc tctgccacac agtccagctc tagtgacgtt gattctgacg caacaccatg
     2161 caaaaccccc aaacaagtgc tctgccgccc acccactgtc agccgggtag gctcacagga
     2221 tgtctccttg gaggtctctc aggcagttgg gaaaatgcag agcacccaaa ccaccaacac
     2281 ggccaacagc accaacaagt cacagcatgg atcagcaagg ctcttccgtt cttccagcaa
     2341 aggcttccaa ggtacagctc aaaccagcca tggtgccttg atgacaagca aacagcatcc
     2401 aggcaaatcc aatactcagt gttaccatgg caaaaagagg agacacaaga gggacgcgcc
     2461 cctctcagag ctttgtaggt agtcggcgct ctgcgacgga ctgtcttctg tgcgcagtga
     2521 tctcgtgctc aggacacttg cacagggact cctgggacgg caggagcctc acactgttca
     2581 gacgttgatt tagcaactgc gttttttccc agctcgccac ggaatggatc atgaagactg
     2641 acaactgcaa aaacaaaaag caagcaaaac agggggaaaa ggctgcttat gcgataagtc
     2701 atgtgctaca acagggtcat tctaagattc taagcttgaa tgtaaagtaa atctctctct
     2761 cattggctct atgcagagtt atagggacta gtgctcagcg tgggtagctg tagggacaaa
     2821 gagcagttcc aggagatggg tgggaaggtc ggcaggagca cctcataggt aggaagtcag
     2881 actccaagag cgaaagtgat ttgtgcatgg gttttttttt ttttaaataa ttttgcatat
     2941 atttgccatt ttattgtgtg tatatataga agaccatata ggaaattgat atttgtaata
     3001 gtggatttgt taatactttt tacataacat tactatttga attgtaaaca gatttttttc
     3061 tcaggattag tttgaagaat aatctgagtt gtcattctaa cacatgcagg gaagtgatta
     3121 gctctggtcc tgtttgtttt cttcagcatt gaaatgactt catagaaccc ttgtgacctg
     3181 cttcaaaatt ctttcctctc taaagaaaag gtttatggtg gcaaatgatg tttattttat
     3241 tttgtaaaaa agagaaaatg tactatgtac ttgtgtatac actgaacacc ctctagtcat
     3301 ctcagagtta aggcacctgc tctaagtgct gctgtcctct gggcgctggg ccttagcagg
     3361 acttgtgtgt gtttcctagc agtctttttt cccctcccct actcttcccc aaaggaaaca
     3421 aaaggcctcc ctgggcctgg gctgtttctg tcacagtgcg accgaccgac ctctagctcc
     3481 acagccctcg ctcggctcgc tcactcactc gctcgcatgc tggctcctct gaccctgcgt
     3541 cccgtcctgt gtgcttgtgg tgtcctctct cattcttttt aggttcatgc ttactactgt
     3601 gggagagtaa ctgtaaacag ctttaattaa atcatactta taaaaaaact attttcttat
     3661 actccacttt atgcttttgg tattgttgat ctttaaaaat taaatggtct ttgataatgg
     3721 atcgattttg tattgcctta ttaagaccaa atacttcttg tcatcccatt ctttatcctc
     3781 tcctttaatg gaattgctgt ctttaattaa aactttgtaa acactggctt gttttaatca
     3841 tcctgtaact tttggctgtg gtcagctata agtgcaaccg tgtaatcctg ttactcatcg
     3901 cctgctgagt cctgagactc aggtggggta tttaacacga tggattgtac gctctgctcg
     3961 ctcgtcatca gagtggtctt aggaggtgaa agccctcctg tctgtccagc atcggtgtgt
     4021 gtgtggctct gttcagtacg gccatttcca agatggattc ttttatatgt gtgtgtgtga
     4081 agtactgttg gcttttaggg gtttcttttc tattcacata ggaaatactg aagaccaatc
     4141 agaccattaa tggacactta gtgaaacttt ttataatgag aataatgcta taaagtaaga
     4201 ccaaaaccgg tgtcatcact gaaattaaca attttcaata tgttcatatt ttaatttaca
     4261 atgggggaaa atgtgttcca caactggaaa cttacagtac tgtgtaaacg gtggacgatt
     4321 ttaatgtgat gttactttga ctgttttcaa ttttagagtc acattttatt ctgatcagag
     4381 tttttatcaa gatgttgaag ttttgttgtt ttgaaactag tttgtcataa cctattgtgc
     4441 gtaatcacag tatttatttt gtagggcttg tgaatgtgta gacttatgtt tactgctaag
     4501 ggaacaatta tttataaaat aatattaaat ccagtattag ctgcctattt cagacactta
     4561 acacctgcag agatcggtgt tacatttacc acactggttt tttttaaaga atcaccctca
     4621 ttgtcggaag caaatgtact cttaggtggg gttttagtgt ccagtacgca tgtgattata
     4681 ttacggtggt agcgggaaga taatcttgat tccattggga atcttaggtt ttcgtaaatt
     4741 tattgggaaa atagtttttc ctgtactgct gacgtttctt tttggtaaac agtatctttc
     4801 taaaagaaaa aagcatgaag gagaattgag gtgtgtatac atttccccag atgacagcat
     4861 tgtattcgtg agtactgtgt atctggactg agcagcgagc aacgctgttc atttttcaat
     4921 ctgaagtaaa atactttgaa gaactttca
//
