LOCUS       NM_001415844            4483 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus terminal nucleotidyltransferase 4A (Tent4a),
            transcript variant 1, mRNA.
ACCESSION   NM_001415844 XM_006227782
VERSION     NM_001415844.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4483)
  AUTHORS   Lim,J., Kim,D., Lee,Y.S., Ha,M., Lee,M., Yeo,J., Chang,H., Song,J.,
            Ahn,K. and Kim,V.N.
  TITLE     Mixed tailing by TENT4A and TENT4B shields mRNA from rapid
            deadenylation
  JOURNAL   Science 361 (6403), 701-704 (2018)
   PUBMED   30026317
REFERENCE   2  (bases 1 to 4483)
  AUTHORS   Walowsky,C., Fitzhugh,D.J., Castano,I.B., Ju,J.Y., Levin,N.A. and
            Christman,M.F.
  TITLE     The topoisomerase-related function gene TRF4 affects cellular
            sensitivity to the antitumor agent camptothecin
  JOURNAL   J Biol Chem 274 (11), 7302-7308 (1999)
   PUBMED   10066793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 3, 2023 this sequence version replaced XM_006227782.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.782135.1,
                                           SRR26643292.483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-864               JAXUCZ010000001.1  35594380-35595243
            865-988             JAXUCZ010000001.1  35612051-35612174
            989-1035            JAXUCZ010000001.1  35612930-35612976
            1036-1156           JAXUCZ010000001.1  35613991-35614111
            1157-1264           JAXUCZ010000001.1  35616022-35616129
            1265-1393           JAXUCZ010000001.1  35617100-35617228
            1394-1607           JAXUCZ010000001.1  35619457-35619670
            1608-1734           JAXUCZ010000001.1  35621136-35621262
            1735-1835           JAXUCZ010000001.1  35622100-35622200
            1836-2008           JAXUCZ010000001.1  35622776-35622948
            2009-2167           JAXUCZ010000001.1  35623499-35623657
            2168-2332           JAXUCZ010000001.1  35625222-35625386
            2333-4483           JAXUCZ010000001.1  35625686-35627836
FEATURES             Location/Qualifiers
     source          1..4483
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..4483
                     /gene="Tent4a"
                     /gene_synonym="Papd7; Pols"
                     /note="terminal nucleotidyltransferase 4A"
                     /db_xref="GeneID:306672"
                     /db_xref="RGD:1307356"
     exon            1..864
                     /gene="Tent4a"
                     /gene_synonym="Papd7; Pols"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..2527
                     /gene="Tent4a"
                     /gene_synonym="Papd7; Pols"
                     /EC_number="2.7.7.19"
                     /note="isoform 1 is encoded by transcript variant 1; DNA
                     polymerase sigma; polymerase (DNA directed) sigma;
                     non-canonical poly(A) RNA polymerase PAPD7; PAP associated
                     domain containing 7; poly(A) RNA polymerase D7,
                     non-canonical"
                     /codon_start=1
                     /product="terminal nucleotidyltransferase 4A isoform 1"
                     /protein_id="NP_001402773.1"
                     /db_xref="GeneID:306672"
                     /db_xref="RGD:1307356"
                     /translation="MDPRVAWIQPEQKGPANALWMQIWETSQGVGRGGSGFASYFCLN
                     SPALDTAAAPGAAGRAAPAAGGPGPAPAASSPPPAPGPAALPPALLTALGPAADGARR
                     LHKSPSLSSSSSSSSNAESGTESPGCSSSSSSSTSLGRAGSGRTFFSFADGAAHAHPG
                     PRGPTPAGSPPQHQFHPGRRKRENKASTYGLNYLLSGSRAATLSGGGGPGAQAARPGT
                     PWKSRAYSPGIQGLHEEIIDFYNFMSPCPEEAAMRREVVKRIETVVKDLWPSADVQIF
                     GSFSTGLYLPTSDIDLVVFGKWERPPLQLLEQALRKHNVAEPCSIKVLDKATVPIIKL
                     TDQETEVKVDISFNMETGVRAAEFIKNYMKKYSLLPYLILVLKQFLLQRDLNEVFTGG
                     ISSYSLILMAISFLQLHPRIDARRADENLGMLLVEFFELYGRNFNYLKTGIRIKEGGA
                     YIAKEEIMKAMTSGYRPSMLCIEDPLLPGNDVGRSSYGAMQVKQVFDYAYIVLSHAVS
                     PLARSYPNRDSESTLGRIIKVTQEVIDYRRWIKEKWGSRIVPSPDLDNRIKIKERVTT
                     CNGEQMQSREPSSPYSQRLTLSLSSPQLLSSGSSASSVSSLSGSDIDSDTPPCTTPSV
                     YQFSLQAPTTLMAGLPTALPVPSSKPQPAASRTLIMTTNNQTRVTIPPPTLGVAPVPC
                     RQAGVDGTTSLKAVHNVTSPAIPSASPNPLSSPHLYHKQHNGMKLSMKGSHNHTQGGG
                     YSSVGSGAVRPPVGNRGHHQYNRTGWRRKKHAHTRDSLPVSLSR"
     exon            865..988
                     /gene="Tent4a"
                     /gene_synonym="Papd7; Pols"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1035
                     /gene="Tent4a"
                     /gene_synonym="Papd7; Pols"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1156
                     /gene="Tent4a"
                     /gene_synonym="Papd7; Pols"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1264
                     /gene="Tent4a"
                     /gene_synonym="Papd7; Pols"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1393
                     /gene="Tent4a"
                     /gene_synonym="Papd7; Pols"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1607
                     /gene="Tent4a"
                     /gene_synonym="Papd7; Pols"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1734
                     /gene="Tent4a"
                     /gene_synonym="Papd7; Pols"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1835
                     /gene="Tent4a"
                     /gene_synonym="Papd7; Pols"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..2008
                     /gene="Tent4a"
                     /gene_synonym="Papd7; Pols"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2167
                     /gene="Tent4a"
                     /gene_synonym="Papd7; Pols"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2332
                     /gene="Tent4a"
                     /gene_synonym="Papd7; Pols"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..4483
                     /gene="Tent4a"
                     /gene_synonym="Papd7; Pols"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccggatcg tagctgcgcc gcgcgcccca ccgagcgccg cccgcgccca tccgcgcgca
       61 ccggagcgcg gcccaggccc gtccgtccgt ccgtccgtcc gcgcggccgg cccggggcgc
      121 ggcgggggcg gggcgcggcg ggcggcgcgg gccccgcggg ggcggcgcgt ggatggatcc
      181 gcgcgtggcc tggatccagc ccgagcagaa ggggccggcc aatgccctgt ggatgcagat
      241 ctgggagacc tcgcagggcg tgggccgcgg cggctccggc ttcgcgtcct acttctgcct
      301 caactcgccg gcgctggaca cggcggccgc gcccggggcg gcggggcgcg cagcaccagc
      361 agcaggaggc ccggggccgg cacccgccgc ctcatccccg ccgcctgcac ccggccccgc
      421 cgcgctgccc ccggcgctgc tgaccgcgct cgggcccgcg gcagacggcg cgcggcgcct
      481 gcacaagtcc ccgtcgctgt cgtcgtcgtc ttcgtcgtcg tccaacgcgg agtcgggcac
      541 cgagagtccg ggctgctcgt cgtcgtcctc cagcagcacc tcgctcggcc gcgccggcag
      601 cggccgcacc ttcttcagct tcgccgacgg cgctgcccac gcgcacccgg gcccacgcgg
      661 ccccacgccc gccggctcgc cgccgcagca ccagttccac ccgggccggc ggaaacgcga
      721 gaacaaggcc agcacgtacg gtctcaacta cctactgtcc ggcagccgcg cggccacgct
      781 gagcggaggg ggcggccccg gggcccaggc ggcgcggccc ggcacgccgt ggaagagccg
      841 tgcgtacagc ccaggcatcc aggggctcca tgaggagata attgactttt ataacttcat
      901 gtccccttgt cctgaagaag cagccatgag aagggaggtg gtgaagcgca tcgaaactgt
      961 ggtgaaagac ctctggccct cggctgacgt gcagatattt ggcagcttta gcacaggcct
     1021 ctatcttcca acaagtgaca tagacctagt ggtctttgga aagtgggagc gacctccatt
     1081 acagctgctg gaacaagccc tgcggaagca caacgtggct gaaccatgct ccatcaaagt
     1141 ccttgacaaa gctacagtgc ccattataaa gctcacagat caggagactg aagttaaagt
     1201 cgacatcagc tttaacatgg agactggtgt acgggcggca gagttcatca agaattacat
     1261 gaagaagtac tcgctactgc catacttgat tttagtgttg aaacagttcc tcctgcagag
     1321 ggacctgaat gaagtcttca caggcgggat cagctcctac agcctcatct taatggccat
     1381 cagctttctg cagttacatc caagaattga tgcccggaga gctgatgaaa acctgggaat
     1441 gcttcttgta gaattttttg aactttatgg aaggaatttt aattacttga aaactggtat
     1501 tagaataaaa gaaggaggtg cctatatcgc caaggaagag attatgaaag ccatgaccag
     1561 tgggtaccga ccgtcgatgc tgtgcattga ggacccccta ctgcctggaa acgatgttgg
     1621 gcggagttcc tatggggcca tgcaggtgaa gcaggtgttt gactatgcgt acattgtgct
     1681 cagccatgcc gtgtcaccgc tcgccaggtc ttaccccaac agggattctg aaagtacttt
     1741 aggaagaata atcaaagtca cccaggaagt gatcgactac cggaggtgga tcaaagaaaa
     1801 atggggtagc agaatcgtcc cgtctccaga cctagacaac aggattaaga taaaggagag
     1861 agtcaccacg tgcaatgggg agcagatgca gagccgggag cccagctccc cttacagcca
     1921 gcgcctgact ctgtccctgt ccagccccca gctgctgtct tcaggctcct ctgcttcttc
     1981 tgtgtcctcg ctttctggaa gtgacattga ttcagacaca ccaccctgca ccacgcccag
     2041 tgtttatcag ttcagcctgc aagcacccac caccctgatg gccggcctgc ccacagcctt
     2101 gccagtgccc agcagcaagc cccagccagc tgcttccaga acgttgatca tgacaaccaa
     2161 caatcagacc agagtaacta tccctccacc gaccctcgga gttgcccctg taccttgcag
     2221 acaggctggt gtcgacggaa ccacatcttt gaaggccgtt cacaacgtaa cttccccagc
     2281 cattccctcg gcatccccca acccactgtc tagtcctcat ctctatcata agcagcacaa
     2341 tggcatgaaa ctgtccatga aaggttccca caaccacact cagggtggtg gctacagctc
     2401 tgtgggcagt ggagctgtga ggcctcctgt tggtaaccga ggacaccatc agtacaaccg
     2461 taccggctgg aggaggaaaa agcatgcaca cacaagggac agcctgcctg tgagtctcag
     2521 cagataatgg tcctgactgc tccctccccc agactgccca caggcctcgg gcacctcggg
     2581 aaccgagacc agcatccagc acctccaccg tgggctgccg agtgccgccc accactggtc
     2641 actctgcatg tttgtgtggt ggccgcatcc atcctacaga acagctcctt gtgctcatct
     2701 gtgaagcctt actacatgtg gatgtgcgtc tgcctgccta gaagtcttca tccgtgccca
     2761 gcagggcagg cctaggagtg tcagggactg gatgtgcggc tttgcagccg tgtctgctag
     2821 gtggtgattt ggggttttca tcatgtctgt cccaggcaga ggtgccaagc cttgctccat
     2881 gtctttctga tggagtgggc aggctgctgt tttactgccc tcatgtcttg tttgaaaatt
     2941 taggactgtt tttctatgta aatattgaaa acttatgatt tgtgcaataa cagatatttt
     3001 ttatttaatt tcatattttc acataagtta tatttaaggg aggagggaat tttttttaaa
     3061 acacgcttag atcctttccc aatttgcatt ttctaagttg ggttcctcgt gttggctggt
     3121 tatctgatag catcatgacg tgagcaccgt gaggaggggc cagtgggctt tagttctact
     3181 cttttctttt ggtcagatgc agagagggag ccaagttctg tgaggccagt gtgtacctgg
     3241 cagcctcact gtaggccttg ggctgttgtc ctgctctgac cacgagttct gacattttgg
     3301 tttgggtttt taaaaactag acagcaaatc cagcatttaa agtgccagaa gtaaaaacct
     3361 caaaggggag aagaggttgt catggtataa ctcgtaaagc attgtaactg tgggcgtgct
     3421 tcggtccgtc atgtgacgtg gtctagagtc atgggcctgg tgagtatcgt acagacaatg
     3481 gcacccagat ttaggaatgt ggagaaaggc atttcgttga ttccattgag gaatctgcat
     3541 aggtatgcac tcgttctgtt aagagcaaat atctgaaaag gacctccgct gtgctgttca
     3601 gggcacacgg ggagtatttt aatgcaccac aggagagcac agcccagtgt gggcccagga
     3661 gcactggtgc ctgcgtcaga agcatacagg tgtactatgc aagtgtattc tgccacaacc
     3721 accactgtct ttgttacttt ttttgaacaa gaatatatcc atcgcctgat cctgagtctg
     3781 tggagtacca cagttgtcct ggagtgcttg cacttgtagg ccctctgact tccatttcta
     3841 aaatgggggt ctggccctgc taaacactac aggtaggttg gtcttaagtc cactagtaca
     3901 gaatgtcaag acgagaagcc gagtgctgtg ccatctgatt gacttgcagc agtgtgaatt
     3961 ctgaatggat tctgagttga cggacacctc gccaaggaca agctgtctat ccgggtctgc
     4021 ctcctgctgc tgtggtgggg ctgttgactc tgggagatat tccagagtag cacatggggt
     4081 ctgcagctca tgaggatcgg aatcatccag aatagttaaa attatttaaa ttgtgaagcc
     4141 tgttgctaaa gaatatttat gaacactggt ccatagcctg tactaattca cacattagca
     4201 atattgactg tatctgcatt aaggagccac cgtggggccg ttcgagtgac ccgcaaatgt
     4261 gcgttttaaa gttctgtcat ccacaggcac aggtatgtgt gtccatcccc gtaatggtga
     4321 accagatgaa ttggcctggc taccactgtg gccatatgct acagtttgac aaaaagatat
     4381 catgtttcaa ttttctgtgt ggacaacaat gtggacacta aaattgacat atttttatgt
     4441 aaagtttttc tattctttga tttttaataa actttagaaa cca
//
