LOCUS       NM_001008372            1848 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus terminal nucleotidyltransferase 2 (Tent2), mRNA.
ACCESSION   NM_001008372 XM_342173
VERSION     NM_001008372.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1848)
  AUTHORS   Carlsten,J.O., Zhu,X. and Gustafsson,C.M.
  TITLE     The multitalented Mediator complex
  JOURNAL   Trends Biochem Sci 38 (11), 531-537 (2013)
   PUBMED   24074826
  REMARK    Review article
REFERENCE   2  (bases 1 to 1848)
  AUTHORS   Kinjo,E.R., Higa,G.S., de Sousa,E., Casado,O.A., Damico,M.V.,
            Britto,L.R. and Kihara,A.H.
  TITLE     A possible new mechanism for the control of miRNA expression in
            neurons
  JOURNAL   Exp Neurol 248, 546-558 (2013)
   PUBMED   23933240
REFERENCE   3  (bases 1 to 1848)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   4  (bases 1 to 1848)
  AUTHORS   de Sousa,E., Walter,L.T., Higa,G.S., Casado,O.A. and Kihara,A.H.
  TITLE     Developmental and functional expression of miRNA-stability related
            genes in the nervous system
  JOURNAL   PLoS One 8 (5), e56908 (2013)
   PUBMED   23700402
  REMARK    GeneRIF: XRN2 and PAPD4 and are highly expressed in the retina and
            have distinct gene expression profiles during development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1848)
  AUTHORS   Swanger,S.A., He,Y.A., Richter,J.D. and Bassell,G.J.
  TITLE     Dendritic GluN2A synthesis mediates activity-induced NMDA receptor
            insertion
  JOURNAL   J Neurosci 33 (20), 8898-8908 (2013)
   PUBMED   23678131
REFERENCE   6  (bases 1 to 1848)
  AUTHORS   D'Ambrogio,A., Gu,W., Udagawa,T., Mello,C.C. and Richter,J.D.
  TITLE     Specific miRNA stabilization by Gld2-catalyzed monoadenylation
  JOURNAL   Cell Rep 2 (6), 1537-1545 (2012)
   PUBMED   23200856
REFERENCE   7  (bases 1 to 1848)
  AUTHORS   Udagawa,T., Swanger,S.A., Takeuchi,K., Kim,J.H., Nalavadi,V.,
            Shin,J., Lorenz,L.J., Zukin,R.S., Bassell,G.J. and Richter,J.D.
  TITLE     Bidirectional control of mRNA translation and synaptic plasticity
            by the cytoplasmic polyadenylation complex
  JOURNAL   Mol Cell 47 (2), 253-266 (2012)
   PUBMED   22727665
  REMARK    GeneRIF: poly(A) polymerase Gld2, deadenylase PARN, and translation
            inhibitory factor neuroguidin (Ngd) are components of a dendritic
            CPEB-associated polyadenylation apparatus
REFERENCE   8  (bases 1 to 1848)
  AUTHORS   Mullen,T.E. and Marzluff,W.F.
  TITLE     Degradation of histone mRNA requires oligouridylation followed by
            decapping and simultaneous degradation of the mRNA both 5' to 3'
            and 3' to 5'
  JOURNAL   Genes Dev 22 (1), 50-65 (2008)
   PUBMED   18172165
REFERENCE   9  (bases 1 to 1848)
  AUTHORS   Nakanishi,T., Kumagai,S., Kimura,M., Watanabe,H., Sakurai,T.,
            Kimura,M., Kashiwabara,S. and Baba,T.
  TITLE     Disruption of mouse poly(A) polymerase mGLD-2 does not alter
            polyadenylation status in oocytes and somatic cells
  JOURNAL   Biochem Biophys Res Commun 364 (1), 14-19 (2007)
   PUBMED   17927953
REFERENCE   10 (bases 1 to 1848)
  AUTHORS   Kwak,J.E., Wang,L., Ballantyne,S., Kimble,J. and Wickens,M.
  TITLE     Mammalian GLD-2 homologs are poly(A) polymerases
  JOURNAL   Proc Natl Acad Sci U S A 101 (13), 4407-4412 (2004)
   PUBMED   15070731
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001008372.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085771.1, SRR22399484.201278.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               JAXUCZ010000002.1  26166784-26167083   c
            301-474             JAXUCZ010000002.1  26160916-26161089   c
            475-564             JAXUCZ010000002.1  26160615-26160704   c
            565-802             JAXUCZ010000002.1  26158943-26159180   c
            803-917             JAXUCZ010000002.1  26151137-26151251   c
            918-1009            JAXUCZ010000002.1  26150967-26151058   c
            1010-1088           JAXUCZ010000002.1  26149934-26150012   c
            1089-1158           JAXUCZ010000002.1  26147407-26147476   c
            1159-1235           JAXUCZ010000002.1  26144564-26144640   c
            1236-1364           JAXUCZ010000002.1  26144110-26144238   c
            1365-1408           JAXUCZ010000002.1  26130268-26130311   c
            1409-1545           JAXUCZ010000002.1  26124392-26124528   c
            1546-1637           JAXUCZ010000002.1  26120180-26120271   c
            1638-1717           JAXUCZ010000002.1  26117755-26117834   c
            1718-1848           JAXUCZ010000002.1  26116405-26116535   c
FEATURES             Location/Qualifiers
     source          1..1848
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..1848
                     /gene="Tent2"
                     /gene_synonym="Papd4"
                     /note="terminal nucleotidyltransferase 2"
                     /db_xref="GeneID:361878"
                     /db_xref="RGD:1306438"
     exon            1..300
                     /gene="Tent2"
                     /gene_synonym="Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            301..474
                     /gene="Tent2"
                     /gene_synonym="Papd4"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..1792
                     /gene="Tent2"
                     /gene_synonym="Papd4"
                     /EC_number="2.7.7.19"
                     /note="PAP-associated domain-containing protein 4; PAP
                     associated domain containing 4; poly(A) RNA polymerase D4,
                     non-canonical"
                     /codon_start=1
                     /product="poly(A) RNA polymerase GLD2"
                     /protein_id="NP_001008373.1"
                     /db_xref="GeneID:361878"
                     /db_xref="RGD:1306438"
                     /translation="MFPNSILGRPPFTPTHQQHNNFFALSPTLYSHQQLIDAQFNFQN
                     VDLSRAVSLQPLTYGTVSPIQTSTSPLFRGRKRISDEKAFRLDGKRQRFHSPHQEPTI
                     INQLVPLSGDRRYSMPPLFHTHYVPEIVRCVPPLREIPLLEPREITLPEAKDKLSQQI
                     LELFETCQQQASDLKKKELCRAQLQREIQLLFPQSRLFLVGSSLNGFGARSSDGDLCL
                     VVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFRDKVSCV
                     EFDLNVNNTVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHEINDASRGTLSSYSLV
                     LMVLHYLQTLPEPILPSLQKIYPESFSTSVQLHLVHHAPCNVPPYLSKNESSLGDLLL
                     GFLKYYATEFDWNTQMISVREAKAIPRPDDMEWRNKYICVEEPFDGTNTARAVHEKQK
                     FDMIKDQFLKSWQRLKNKRDLNSVLPLRAATLKR"
     exon            475..564
                     /gene="Tent2"
                     /gene_synonym="Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            565..802
                     /gene="Tent2"
                     /gene_synonym="Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            803..917
                     /gene="Tent2"
                     /gene_synonym="Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1009
                     /gene="Tent2"
                     /gene_synonym="Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1088
                     /gene="Tent2"
                     /gene_synonym="Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1158
                     /gene="Tent2"
                     /gene_synonym="Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1235
                     /gene="Tent2"
                     /gene_synonym="Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1364
                     /gene="Tent2"
                     /gene_synonym="Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1408
                     /gene="Tent2"
                     /gene_synonym="Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1545
                     /gene="Tent2"
                     /gene_synonym="Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1637
                     /gene="Tent2"
                     /gene_synonym="Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1717
                     /gene="Tent2"
                     /gene_synonym="Papd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1848
                     /gene="Tent2"
                     /gene_synonym="Papd4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggtatctc tgacagggtt gtctacgccg ccttttcggc gattttttag tcttccgcct
       61 tttttttttt tcccctttct ttttgttgtc gataccccca acttaacacg cccgcgcggg
      121 cctggccttg ggctcgcgac tttccgccgc cctgccgggt cctaggttgc ccgcccgagc
      181 tgggcctcgc tgtgccgcgg gctgctccta cctctgcctg ctcgggcggc agctcgggcc
      241 tgggagcgtg ttggcgggca gtgcccctgg gccctgctcg gcccttcggc gtggacgccg
      301 gtagaagaat acatgtttac ctttagtgaa caagagcatg ttcccaaact caattttggg
      361 tcgtccaccc ttcactccaa cccaccaaca gcataacaac ttctttgctc tctcaccaac
      421 tctttattca caccagcaac ttatagatgc acaattcaac tttcaaaatg tagacttgtc
      481 tagagctgtg tccttacagc ccctgacata cggaactgtt agtccaatac agacctcaac
      541 atccccatta tttcgaggaa ggaagagaat aagcgatgaa aaagcctttc gtcttgatgg
      601 taaacggcag cgtttccatt caccccacca agagccaact ataatcaacc agctagtgcc
      661 tttgtcaggt gaccgaagat actccatgcc accgttgttt catacacact atgtaccaga
      721 gatagtcaga tgtgttccac ctcttcgaga aattccactg ttagaaccta gagaaatcac
      781 actgcctgag gccaaagata agctgagtca gcagatacta gagttgtttg aaacttgtca
      841 acagcaagca agtgacttga agaagaaaga actctgtaga gcacagctgc agagagagat
      901 ccagctgctc ttcccacaaa gcagactctt tttggttgga tcgtctttaa atggatttgg
      961 tgcccgaagc agcgatggcg atttatgctt agttgttaaa gaagaaccat gttttttcca
     1021 ggtaaatcag aagactgaag cacgacatat cctcacctta gtccataagc acttctgtac
     1081 tagactttct ggctatattg agagacctca gctgattcgt gcaaaagtgc caattgtgaa
     1141 gttcagggat aaagtcagtt gtgtggaatt cgacttaaat gtaaacaata ccgttggaat
     1201 tagaaacaca ttccttctca gaacttatgc ataccttgaa aatcgagttc gtccattagt
     1261 cctggtgatt aagaagtggg caagtcatca cgagataaat gatgccagtc gaggcacttt
     1321 aagcagctat agtcttgtat tgatggtttt gcactattta caaaccctac ctgaacccat
     1381 ccttccatcc ctccaaaaaa tttacccaga atcttttagt acttctgtac agctgcacct
     1441 tgttcatcat gccccatgta atgttcctcc ttacctctca aagaatgaat ccagtcttgg
     1501 ggacctctta ctgggctttc ttaaatacta tgctacagaa tttgactgga atactcagat
     1561 gatttcagtc cgtgaggcca aagccatccc aaggccagat gatatggaat ggagaaataa
     1621 atacatctgt gttgaagaac cttttgatgg aactaatacc gccagagctg tgcatgagaa
     1681 gcagaagttt gatatgatca aggatcaatt tctaaagtca tggcagagat tgaaaaacaa
     1741 gagagatctg aacagtgttc tacctttgag agctgctacc ctgaaaagat aactggtctc
     1801 taattctaaa attcttccaa gaaataaaga acaatacata cgtcataa
//
