LOCUS       NM_001191628           12905 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus teneurin transmembrane protein 4 (Tenm4), mRNA.
ACCESSION   NM_001191628 XM_218927
VERSION     NM_001191628.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 12905)
  AUTHORS   Hor,H., Francescatto,L., Bartesaghi,L., Ortega-Cubero,S., Kousi,M.,
            Lorenzo-Betancor,O., Jimenez-Jimenez,F.J., Gironell,A.,
            Clarimon,J., Drechsel,O., Agundez,J.A., Kenzelmann Broz,D.,
            Chiquet-Ehrismann,R., Lleo,A., Coria,F., Garcia-Martin,E.,
            Alonso-Navarro,H., Marti,M.J., Kulisevsky,J., Hor,C.N.,
            Ossowski,S., Chrast,R., Katsanis,N., Pastor,P. and Estivill,X.
  TITLE     Missense mutations in TENM4, a regulator of axon guidance and
            central myelination, cause essential tremor
  JOURNAL   Hum Mol Genet 24 (20), 5677-5686 (2015)
   PUBMED   26188006
REFERENCE   2  (bases 1 to 12905)
  AUTHORS   Yamaguchi,M., Ogawa,R., Watanabe,Y., Uezumi,A., Miyagoe-Suzuki,Y.,
            Tsujikawa,K., Yamamoto,H., Takeda,S. and Fukada,S.
  TITLE     Calcitonin receptor and Odz4 are differently expressed in
            Pax7-positive cells during skeletal muscle regeneration
  JOURNAL   J Mol Histol 43 (5), 581-587 (2012)
   PUBMED   22562803
  REMARK    GeneRIF: Odz4 is expressed in quiescent satellite cells on the
            protein level, but not in activated/proliferating myoblasts.
REFERENCE   3  (bases 1 to 12905)
  AUTHORS   Suzuki,N., Fukushi,M., Kosaki,K., Doyle,A.D., de Vega,S.,
            Yoshizaki,K., Akazawa,C., Arikawa-Hirasawa,E. and Yamada,Y.
  TITLE     Teneurin-4 is a novel regulator of oligodendrocyte differentiation
            and myelination of small-diameter axons in the CNS
  JOURNAL   J Neurosci 32 (34), 11586-11599 (2012)
   PUBMED   22915103
REFERENCE   4  (bases 1 to 12905)
  AUTHORS   Prall,O.W., Menon,M.K., Solloway,M.J., Watanabe,Y., Zaffran,S.,
            Bajolle,F., Biben,C., McBride,J.J., Robertson,B.R., Chaulet,H.,
            Stennard,F.A., Wise,N., Schaft,D., Wolstein,O., Furtado,M.B.,
            Shiratori,H., Chien,K.R., Hamada,H., Black,B.L., Saga,Y.,
            Robertson,E.J., Buckingham,M.E. and Harvey,R.P.
  TITLE     An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart
            progenitor specification and proliferation
  JOURNAL   Cell 128 (5), 947-959 (2007)
   PUBMED   17350578
REFERENCE   5  (bases 1 to 12905)
  AUTHORS   Lossie,A.C., Nakamura,H., Thomas,S.E. and Justice,M.J.
  TITLE     Mutation of l7Rn3 shows that Odz4 is required for mouse
            gastrulation
  JOURNAL   Genetics 169 (1), 285-299 (2005)
   PUBMED   15489520
REFERENCE   6  (bases 1 to 12905)
  AUTHORS   Feng,K., Zhou,X.H., Oohashi,T., Morgelin,M., Lustig,A.,
            Hirakawa,S., Ninomiya,Y., Engel,J., Rauch,U. and Fassler,R.
  TITLE     All four members of the Ten-m/Odz family of transmembrane proteins
            form dimers
  JOURNAL   J Biol Chem 277 (29), 26128-26135 (2002)
   PUBMED   12000766
REFERENCE   7  (bases 1 to 12905)
  AUTHORS   Wang,X.Z., Kuroda,M., Sok,J., Batchvarova,N., Kimmel,R., Chung,P.,
            Zinszner,H. and Ron,D.
  TITLE     Identification of novel stress-induced genes downstream of chop
  JOURNAL   EMBO J 17 (13), 3619-3630 (1998)
   PUBMED   9649432
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Aug 4, 2021 this sequence version replaced NM_001191628.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840119,
                              SAMN12840129 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               JAXUCZ010000001.1  159974017-159974143
            128-183             JAXUCZ010000001.1  160112154-160112209
            184-282             JAXUCZ010000001.1  160192294-160192392
            283-570             JAXUCZ010000001.1  160310038-160310325
            571-840             JAXUCZ010000001.1  160313684-160313953
            841-1096            JAXUCZ010000001.1  160458593-160458848
            1097-1195           JAXUCZ010000001.1  160469405-160469503
            1196-1431           JAXUCZ010000001.1  160470715-160470950
            1432-1602           JAXUCZ010000001.1  160495425-160495595
            1603-1817           JAXUCZ010000001.1  160501808-160502022
            1818-2028           JAXUCZ010000001.1  160503519-160503729
            2029-2130           JAXUCZ010000001.1  160536023-160536124
            2131-2325           JAXUCZ010000001.1  160537992-160538186
            2326-2526           JAXUCZ010000001.1  160541793-160541993
            2527-2712           JAXUCZ010000001.1  160562016-160562201
            2713-2739           JAXUCZ010000001.1  160569773-160569799
            2740-2886           JAXUCZ010000001.1  160576506-160576652
            2887-3103           JAXUCZ010000001.1  160587308-160587524
            3104-3223           JAXUCZ010000001.1  160601099-160601218
            3224-3485           JAXUCZ010000001.1  160606695-160606956
            3486-3753           JAXUCZ010000001.1  160609462-160609729
            3754-3897           JAXUCZ010000001.1  160611826-160611969
            3898-4147           JAXUCZ010000001.1  160616550-160616799
            4148-4168           JAXUCZ010000001.1  160618774-160618794
            4169-4401           JAXUCZ010000001.1  160626313-160626545
            4402-4556           JAXUCZ010000001.1  160630821-160630975
            4557-5434           JAXUCZ010000001.1  160636436-160637313
            5435-5607           JAXUCZ010000001.1  160648355-160648527
            5608-5843           JAXUCZ010000001.1  160651482-160651717
            5844-6140           JAXUCZ010000001.1  160655705-160656001
            6141-7755           JAXUCZ010000001.1  160657450-160659064
            7756-7898           JAXUCZ010000001.1  160666024-160666166
            7899-12905          JAXUCZ010000001.1  160669543-160674549
FEATURES             Location/Qualifiers
     source          1..12905
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..12905
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /note="teneurin transmembrane protein 4"
                     /db_xref="GeneID:308831"
                     /db_xref="RGD:1304658"
     exon            1..127
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            128..183
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            184..282
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..8657
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /note="odd Oz/ten-m homolog 4; odz, odd Oz/ten-m homolog
                     4"
                     /codon_start=1
                     /product="teneurin-4"
                     /protein_id="NP_001178557.1"
                     /db_xref="GeneID:308831"
                     /db_xref="RGD:1304658"
                     /translation="MEPDHSALSAARAQFVDVEEREPEAMDVKERKPYRSLTRRRDAE
                     RRYTSSSADSEEGKGPQKSYSSSETLKAYDQDARLAYGSRVKDMVPQESEEFCRTGTN
                     FTLRELGLGEMTPPHGTLYRTDIGLPHCGYSMGASSDADLEADTVLSPEHPVRLWGRS
                     TRSGRSSCLSSRANSNLTLTDTEHENTETDHPSGLQNHPRLRTPPPPLPHAHTPNQHH
                     AASINSLNRGNFTPRSNPSPAPTDHSLSGEPPAGSAQEPTHAQDNWLLNSNIPLETRN
                     LGKQPFLGTLQDNLIEMDILSASRHDGAYSDGHFLFKPGGTSPLFCTTSPGYPLTSST
                     VYSPPPRPLPRSTFSRPAFNLKKPSKYCNWKCAALSAILISATLVILLAYFVAMHLFG
                     LNWHLQPMEGQMYEITEDTASSWPVPTDVSLYPSGGTGLETPDRKGKGAAEGKPSSLF
                     PEDSFIDSGEIDVGRRASQKIPPGTFWRSQVFIDHPVHLKFNVSLGKAALVGIYGRKG
                     LPPSHTQFDFVELLDGRRLLTQEARSLEGPQRQSRGTVPPSSHETGFIQYLDSGIWHL
                     AFYNDGKESEVVSFLTTTIESVENCPSNCYGNGDCISGTCHCFLGFLGPDCGRASCPV
                     LCSGNGQYMKGRCLCHSGWKGAECDVPTNQCIDVACSSHGTCIMGTCICNPGYKGESC
                     EEVDCMDPTCSSRGVCVRGECHCSVGWGGTNCETPRATCLDQCSGHGTFLPDTGLCNC
                     DPSWTGHDCSIEICAADCGGHGVCVGGTCRCEDGWMGAACDQRACHPRCAEHGTCRDG
                     KCECSPGWNGEHCTIAHYLDRVVKEGCPGLCNGNGRCTLDLNGWHCVCQLGWRGAGCD
                     TSMETACGDSKDNDGDGLVDCMDPDCCLQPLCHVNPLCLGSPDPLDIIQETQAPVSQQ
                     NLHSFYDRIKFLVGRDSTHVIPGENPFDGGHACVIRGQVMTSDGTPLVGVNISFINNP
                     LFGYTISRQDGSFDLVTNGGISIILRFERAPFITQEHTLWLPWDRFFVMETIIMRHEE
                     NEIPSCDLSNFARPNPVVSPSPLTSFASSCAEKGPIVPEIQALQEEIIIAGCKMRLSY
                     LSSRTPGYKSVLRISLTHPTIPFNLMKVHLMVAVEGRLFRKWFAAAPDLSYYFIWDKT
                     DVYNQKVFGLSEAFVSVGYEYESCPDLILWEKRTAVLQGYEIDASKLGGWSLDKHHAL
                     NIQSGILHKGNGENQFVSQQPPVIGSIMGNGRRRSISCPSCNGLADGNKLLAPVALTC
                     GSDGSLYVGDFNYIRRIFPSGNVTNILEMRNKDFRHSHSPAHKYYLATDPMSGAVFLS
                     DTNSRRVFKIKSTTVVKDLVKNSEVVAGTGDQCLPFDDTRCGDGGKATEATLTNPRGI
                     TVDKFGLIYFVDGTMIRRVDQNGIISTLLGSNDLTSARPLSCDSVMDISQVRLEWPTD
                     LAINPMDNSLYVLDNNVVLQISENHQVRIVAGRPMHCQVPGIDHFLLSKVAIHATLES
                     ATALAVSHNGVLYIAETDEKKINRIRQVTTSGEISLVAGAPSGCDCKNDANCDCFSGD
                     DGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFIRKNKPVLNTQNMYELSSPIDQE
                     LYLFDTSGKHLYTQSLPTGDYLYNFTYTGDGDITHITDNNGNMVNVRRDSTGMPLWLV
                     VPDGQVYWVTMGTNSALRSVTTQGHELAMMTYHGNSGLLATKSNENGWTTFYEYDSFG
                     RLTNVTFPTGQVSSFRSDTDSSVHVQVETSSKDDVTITTNLSASGAFYTLLQDQVRNS
                     YYIGADGSLRLLLANGMEVALQSEPHLLAGTVNPTVGKRNVTLPIDNGLNLVEWRQRK
                     EQARGQVTVFGRRLRVHNRNLLSLDFDRVTRTEKIYDDHRKFTLRILYDQAGRPSLWS
                     PSSRLNGVNVTYSPGGHIAGIQRGIMSERMEYDQAGRITSRIFADGKMWSYTYLEKSM
                     VLHLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGYYRNIYQPPEGNASVIQD
                     FTEDGHLLHTFYLGTGRRVIYKYGKLSKLAETLYDTTKVSFTYDESAGMLKTVNLQNE
                     GFTCTIRYRQIGPLIDRQIFRFTEEGMVNARFDYNYDNSFRVTSMQAVINETPLPIDL
                     YRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAYGRMKEVQYEIFRSLMYW
                     MTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNL
                     HLLSPGNSARLTPLRYDLRDRITRLGDVQYKMDEDGFLRQRGGDVFEYNSAGLLIKAY
                     NRASGWSVRYRYDGLGRRVSSKSSHSHHLQFFYADLTNPTKVTHLYNHSSSEITSLYY
                     DLQGHLFAMELSSGDEFYIACDNIGTPLAVFSGTGLMIKQILYTAYGEIYMDTNPNFQ
                     IIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDHELWKRLSSSSIVPFHLYMFKNN
                     NPISNSQDIKCFMTDVNSWLLTFGFQLHNVIPGYPKPDTDAMEPSYELVSTQMKTQEW
                     DNSKSILGVQCEVQKQLKAFVTLERFDQLFGSTITSCQQAPETKKFASSGSIFGKGVK
                     FALKDGRVTTDIISVANEDGRRIAAILNNAHYLENLHFTIDGVDTHYFVKPGPSEGDL
                     AILGLSGGRRTLENGVNVTVSQINTMLGGRTRRYTDIQLQYRALCLNTRYGTTVDEEK
                     VRVLELARQRAVRQAWAREQQRLREGEEGLRAWTDGEKQQVLNTGRVQGYDGFFVTSV
                     EQYPELSDSANNIHFMRQSEMGRR"
     exon            283..570
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            571..840
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1096
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1195
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1431
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1602
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1817
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..2028
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2130
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2325
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2526
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2712
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2739
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2886
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..3103
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3223
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3485
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            3486..3753
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            3754..3897
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            3898..4147
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            4148..4168
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            4169..4401
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            4402..4556
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            4557..5434
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            5435..5607
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            5608..5843
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            5844..6140
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            6141..7755
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            7756..7898
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
     exon            7899..12905
                     /gene="Tenm4"
                     /gene_synonym="Odz4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcctccg ccaccgcagc cccgggagtc cgccgcggac tggagcctgg gaaccagtgt
       61 tgggagagag gtgggagccg gccccagact ctggaccgcg ggtgggatgg aggttagctc
      121 gattcagatg gacagtctga ggctgagaga gggctagtga tttctcggac acttgggcaa
      181 tagaaagcaa accaccctgt cctctgggat ctgatggcct tggagagggg gctgcagggc
      241 ctgcggacac caactcttcc cagagtgctg gcatggagcc agaccactca gccctgagtg
      301 cggcaagggc ccaatttgtg gatgtggaag agcgtgagcc agaggccatg gacgtgaagg
      361 agaggaagcc ctatcgctcg ctgaccaggc gtcgcgatgc tgagcgccgc tacaccagct
      421 catcagccga cagcgaggag ggcaagggcc cacagaagtc ctacagctcc agcgagaccc
      481 tgaaggcata tgaccaagat gctcgcctag cctatggcag ccgcgtcaag gacatggtac
      541 cacaggagtc ggaggagttc tgccgcacag gcactaattt cactcttcga gaactgggac
      601 tgggagagat gactccccct catggaaccc tctacagaac agatatcggc ctcccacact
      661 gtggctattc catgggggcc agctctgatg cagacctgga agcagacact gtgctgtccc
      721 ctgaacaccc agtgcgcctg tggggccgga gcactcggtc agggcgaagt tcctgcctgt
      781 ctagccgggc taactccaac ctcacactca cggacacaga gcatgagaac accgaaaccg
      841 atcatcccag cggcctgcag aaccaccctc ggctccggac gcctccacca ccactccctc
      901 acgcccatac ccccaaccag caccacgcgg cctccatcaa ctctttgaac aggggtaact
      961 tcaccccaag gagcaacccc agcccagcac ccacagacca ttcactctcc ggggagcccc
     1021 cagcaggcag cgcccaggag ccaactcatg cccaggacaa ctggctactc aacagtaaca
     1081 tcccactgga gaccagaaac ctaggcaagc agccattcct agggacattg caggacaacc
     1141 tcattgagat ggacattctc agcgcctccc gccatgatgg ggcttacagt gacgggcact
     1201 tcctcttcaa gcccggaggc acctccccac tcttctgcac cacgtcccca gggtaccccc
     1261 taacgtctag caccgtgtat tcgcccccac cccggcccct gccccgcagc accttttcga
     1321 gaccagcctt taacctcaag aagccttcca agtactgcaa ctggaagtgt gcggcactaa
     1381 gcgccatcct catctcagct acgctcgtca tcctgctcgc atactttgtg gccatgcacc
     1441 tgtttggcct aaactggcac ctgcagccga tggaggggca gatgtatgag atcacggagg
     1501 acacagccag cagctggcct gtgccaacgg acgtctccct gtatccctca gggggcactg
     1561 gcttagagac ccctgacagg aaaggcaaag gagccgcaga aggaaagcca agtagtttat
     1621 ttccagagga cagtttcata gactctggag aaatcgatgt ggggagacgg gcttcccaga
     1681 agatcccgcc tggaacgttc tggagatctc aggtgttcat agaccaccct gtgcatctga
     1741 agttcaatgt gtctctgggg aaagcagctc tggttggcat ttacggcaga aaaggccttc
     1801 ctccttctca tactcagttt gactttgtag agctactgga tggaagaagg ctgctaaccc
     1861 aagaggcaag gagcctggag ggtcctcagc gccagtctcg aggcaccgtc cccccatcca
     1921 gccatgagac cggtttcatc cagtatctgg attcaggaat ctggcacctg gccttttaca
     1981 atgatgggaa agagtctgaa gtggtttcct tcctcaccac caccattgaa tcagtggaga
     2041 actgccccag caactgctat ggtaacggtg actgcatttc cgggacctgc cactgcttcc
     2101 tgggttttct gggacccgac tgtggccgag catcctgccc cgtgctatgc agcgggaacg
     2161 gccagtacat gaagggcagg tgcctgtgcc acagtggctg gaagggtgca gagtgcgacg
     2221 tgcctaccaa ccagtgcatc gacgtggcct gcagcagcca cggcacctgc atcatgggca
     2281 cctgcatctg taaccctggc tacaagggcg agagctgtga ggaagtggac tgcatggacc
     2341 ccacgtgctc cagtaggggt gtctgtgtga gaggcgagtg ccactgctct gtgggatggg
     2401 gaggcaccaa ctgcgagaca cccagggcca cgtgcttgga ccagtgctca ggccatggaa
     2461 ccttcctccc agacaccggg ctctgcaact gtgacccaag ctggactgga catgactgtt
     2521 ccattgagat ctgtgctgct gactgtggtg gccacggcgt ctgtgtagga ggcacctgcc
     2581 gctgtgagga tggctggatg ggggctgcat gcgaccaacg ggcctgccac ccacgctgtg
     2641 cagaacacgg gacctgccgg gatggcaagt gcgaatgcag ccctggctgg aacggcgaac
     2701 actgcaccat tgctcactat ctggataggg tagttaaaga gggctgtcct ggcttgtgca
     2761 atgggaatgg cagatgtact ctggacctga atgggtggca ctgtgtctgc cagctgggct
     2821 ggcgaggagc tggctgcgac acctccatgg aaacagcctg tggagacagc aaagacaacg
     2881 atggagatgg cttagtagac tgcatggacc ctgactgctg cctccagccc ctctgccatg
     2941 tcaacccgct gtgcctaggc tcccctgatc ctctggacat catccaagag acacaggccc
     3001 cggtatccca gcagaacctg cactccttct acgaccgaat caagtttctc gtgggcaggg
     3061 acagcacgca tgtcatccct ggggagaacc cctttgatgg aggacatgct tgtgtcatcc
     3121 gtggacaagt gatgacttca gatgggaccc cactggttgg cgtgaacatc agtttcatca
     3181 ataaccctct ctttggatac acaatcagtc ggcaagatgg cagctttgac ctggtcacaa
     3241 acggcggcat ctccatcatc ctgagattcg aacgggcacc cttcatcaca caggagcata
     3301 ccctctggct accctgggac cgcttctttg tcatggaaac catcatcatg agacacgagg
     3361 agaatgagat ccccagctgt gacctgagca actttgcccg acccaaccca gtggtctctc
     3421 catccccact gacatccttc gctagctcct gtgctgagaa aggacccatt gtcccagaaa
     3481 tccaggctct gcaagaggaa atcatcattg ctggctgcaa gatgaggttg agctatctga
     3541 gcagccgcac ccctggctat aagtctgtcc tgaggatcag tctcacacat cccaccatcc
     3601 ccttcaacct catgaaggtc cacctcatgg tagcagttga gggtcggctc ttcaggaagt
     3661 ggtttgctgc ggctcctgac ctatcctatt acttcatctg ggacaagaca gacgtctaca
     3721 accagaaagt gtttgggctc tcagaagcct ttgtttccgt gggttatgaa tatgaatctt
     3781 gcccagatct gatcctgtgg gagaaaagga cagcggtgct gcagggctat gaaatcgatg
     3841 cctccaagct ggggggctgg agtctggata agcaccatgc cctgaacatc cagagtggca
     3901 tcctgcacaa agggaatgga gagaaccagt tcgtgtccca gcagccacca gtcatcggca
     3961 gcatcatggg caatgggcgc aggaggagca tctcctgccc cagctgcaat ggcctcgcgg
     4021 atggcaacaa gctcctagca cccgtggccc tcacctgtgg ttctgatggg agtctctacg
     4081 tgggagactt caactacatc cgaaggatct tcccctctgg aaatgtcacc aacatcctgg
     4141 agatgagaaa taaagatttc agacatagtc acagcccagc acacaaatac tacctggcta
     4201 cagaccccat gagcggggcc gtcttcctgt ctgacaccaa cagccggcgg gtcttcaaga
     4261 tcaagtccac caccgtggtg aaggacctgg tcaagaactc cgaggtggta gcagggactg
     4321 gtgaccagtg cctccccttc gatgatactc gctgcggaga cggtgggaaa gccacagaag
     4381 ccacgctcac taatcccagg ggaattacag tggacaagtt tgggctcatt tacttcgtgg
     4441 atggcaccat gatcagacgt gttgatcaaa atgggatcat ctcaactttg ctgggctcca
     4501 atgatctcac ctcagccagg cccctcagct gtgactctgt catggatatt tctcaggttc
     4561 gcctggagtg gcccacagac ttagccatca acccaatgga taattccctc tatgtcctcg
     4621 acaacaacgt ggtcctacaa atctccgaaa accaccaggt acgcattgtc gctgggaggc
     4681 ccatgcactg ccaggttcct ggcatcgacc acttcctgct gagcaaggta gccatccacg
     4741 caaccctgga gtcagccact gctttggccg tttcacacaa tggagtcttg tatatcgctg
     4801 agaccgacga gaagaagatc aaccgtatca ggcaggtcac gacaagtggt gagatctcac
     4861 tggttgctgg tgcccccagc ggctgcgact gtaaaaacga cgccaactgc gactgcttct
     4921 ctggagatga tggctacgcc aaggacgcaa agctgaacac cccatcttcc ttggccgtgt
     4981 gtgcagacgg ggagctctac gtggccgacc ttggaaacat ccggatccgg tttatccgga
     5041 agaacaagcc tgtcctgaac acccagaaca tgtatgagct gtcctccccc atcgaccagg
     5101 agctgtacct ctttgacacc agtggcaagc atctgtacac tcagagcctg cccacaggag
     5161 actacctgta caacttcact tacacggggg acggggacat cacacacatc acagacaaca
     5221 atggcaacat ggtgaacgtc cgccgagatt ctaccgggat gcctctctgg ctggtagtcc
     5281 cagatggcca ggtgtactgg gtaaccatgg gcaccaacag cgcactcaga agtgtgacca
     5341 cgcaaggaca cgagctggct atgatgacat accatggcaa ctctggcctc ttggcgacca
     5401 aaagcaatga aaacgggtgg acaacgtttt atgagtatga cagttttggt cgcctgacaa
     5461 acgtgacctt tccaactggc caggtgagca gtttccgaag cgatacagac agctcagtgc
     5521 acgtgcaggt agagacctca agcaaagacg atgtcaccat aaccaccaac ctgtctgcct
     5581 cgggtgcctt ctacactctg ttacaagacc aagtccggaa cagctactac atcggggccg
     5641 atggctccct gaggctgctg ctggccaatg gtatggaagt ggctctgcag agcgagccac
     5701 acctgctggc tggcactgtc aaccccactg taggcaagag gaatgtcacg ctgcccattg
     5761 ataatggcct caacctggtg gaatggcgac agcgcaagga gcaggctcgt ggtcaggtca
     5821 cagtctttgg acgccgtctg cgggttcaca accgaaacct cttatccttg gactttgacc
     5881 gtgtcacacg cacagagaag atctatgacg accatcggaa gttcaccctt cggatcctat
     5941 atgaccaggc ggggaggcct agcctctggt cacctagcag caggctgaat ggtgtcaatg
     6001 tgacctactc ccctggaggt cacattgctg gaatccaaag gggcatcatg tctgagagaa
     6061 tggagtatga ccaggcaggc cgcatcacat cccggatctt tgcggatggg aagatgtgga
     6121 gttacacgta cttagagaag tccatggtgc tccacctcca cagccagagg cagtacatct
     6181 tcgagtttga caagaacgac cgcctctctt ctgtgaccat gcccaacgta gcccggcaga
     6241 cgctggagac cattcgctca gtgggctact acaggaacat ctaccaaccg ccagagggca
     6301 atgcctcagt catacaggac ttcactgagg atggacacct gttacatacc ttctacttgg
     6361 gcactggccg cagggtgatt tacaagtacg gcaagttgtc aaagctggct gagaccctgt
     6421 acgacaccac caaggtaagc ttcacctacg acgagagtgc gggcatgctg aagacggtca
     6481 acctacagaa tgagggcttc acctgcacta tccgctaccg tcagattggg cccctgatcg
     6541 accgtcagat cttccgattc actgaagaag gcatggtcaa tgcccgtttt gattacaact
     6601 atgacaacag tttccgcgtg accagcatgc aggccgtgat caacgagacc ccgctgccca
     6661 tcgatctcta ccgctatgat gatgtgtcag ggaagacaga acagtttggg aagtttggtg
     6721 tcatctacta tgacatcaac cagatcatta ccacagccgt catgacgcac accaagcatt
     6781 tcgacgctta cggcaggatg aaggaagtgc agtacgagat tttccggtca ctcatgtact
     6841 ggatgactgt tcagtatgat aacatgggac gggtggtgaa gaaggagctc aaggtgggac
     6901 cctacgccaa caccacccgc tactcctatg agtacgacgc cgatggccag ctgcagacag
     6961 tctccatcaa tgacaagcca ctctggcggt acagctatga cctcaacgga aacctccact
     7021 tgctgagccc tgggaacagc gcgcggctca caccgttgcg gtacgacctc cgagaccgca
     7081 tcacgaggct gggcgatgtg cagtacaaga tggatgaaga cggcttccta aggcagcgag
     7141 gcggggatgt cttcgagtac aattcagccg gcctgctcat caaagcctac aaccgggcta
     7201 gtgggtggag tgtcaggtac cgctatgacg gcctggggcg gcgagtatcc agcaagagca
     7261 gccacagcca ccacctacag ttcttctacg cagacctgac caaccccacc aaggtcaccc
     7321 acctctacaa ccactccagc tctgagatca cgtccctcta ctatgatctg caagggcacc
     7381 tctttgccat ggagctgagc agcggcgatg agttttacat agcttgtgac aatatcggga
     7441 ccccccttgc tgtcttcagt ggaaccggcc tgatgattaa gcagatccta tacacagcct
     7501 atggggagat ctacatggac acgaacccca acttccagat catcattggc taccacggcg
     7561 gcctttatga tccactcacc aaacttgtcc acatgggccg acgggattat gatgtgctgg
     7621 ccggacgctg gacgagccca gaccacgaac tctggaaacg cctgagtagc agcagcatcg
     7681 tgccttttca cctctacatg tttaagaaca acaaccccat cagcaactct caggacatca
     7741 agtgcttcat gacagatgtc aacagctggc tgcttacctt cggattccag ctgcacaacg
     7801 tgatacctgg ctaccccaag ccagacacag atgccatgga gccctcctat gagctcgtga
     7861 gcacacagat gaaaactcag gaatgggaca acagcaagtc catcctcggg gtacagtgtg
     7921 aagttcagaa gcaactcaag gccttcgtta ccttagaacg ctttgaccag cttttcggct
     7981 ccaccatcac cagctgccaa caggccccag agacaaagaa gtttgcctcc agtggttcca
     8041 tctttggcaa gggggtcaag tttgccttga aagacggtcg agtgaccact gacatcatca
     8101 gtgtggctaa tgaggacggg cggaggattg cggccatctt gaacaatgcc cactatctag
     8161 agaaccttca cttcaccatc gacggggtgg acacccacta ctttgtgaaa ccaggacctt
     8221 cggaaggtga cctggccatc ctgggcctca gtggggggcg gagaactctg gagaacgggg
     8281 tcaacgtcac tgtgtcccaa atcaacacca tgctcggtgg caggactaga cgctacactg
     8341 acatccagct gcagtacagg gcactgtgcc tgaacacccg ctatgggaca accgtggacg
     8401 aggaaaaggt acgggtgctg gagctggcca ggcagagggc tgtacgccag gcctgggccc
     8461 gagagcagca gagactgcgg gaaggggaag agggcctgcg ggcctggaca gacggggaga
     8521 agcagcaggt gctgaacacg gggcgggtgc aaggctatga cggcttcttt gtgacttccg
     8581 tggagcagta cccagaactg tcagacagcg ccaacaacat ccacttcatg agacagagcg
     8641 agatgggccg aaggtgacag aaagggccaa ggcctggact tcttgccaaa gacagctact
     8701 cttgtgtggc cgtatacctg actgtgttgt acttaacaaa aaaacaaaaa caaaaaacaa
     8761 aatacaaaaa ctttttttta aacaagtgca gaaaacaaaa cagaaagata tttgttgcat
     8821 tgtttaattc atgcaacatc tttttttttt ttttaagaaa agaaaaacac aaatttggcc
     8881 ttcacacatt ttttgctaag aatggaaggg tttgttctgt tctttctgtt tttttttttc
     8941 tctgtagtgt gatcatgatg ataactttat tgtcttctgt tccccttttt ccttgaggaa
     9001 ttccccctgt cactgggggt acatttctcc tctcttgggg aaacacatct cctggggtga
     9061 ttcctcctcg gcccctaggt acccagtgtg atgtgagact cgagtgtctg tgctaacttg
     9121 tctcctatgt aaccctttct tctctgaggg caggagtgag gggtgcagag agccacggcc
     9181 cggtgggacc ttgggagctt tggttaggct cccacagaaa gtggtgagtt gctcttcacc
     9241 atgttttgtg cctcccgagg acctacatca tgctctggaa aattccatga tgttattcag
     9301 caccttgtca agccacccca aactcctgtt caagctttat attttgatgc taaatgaacc
     9361 cccccctccc ttttacaaat ctctagtgta gttgtcagtg ccacccctgc cccataatga
     9421 aatagagaaa gtgtctctga ggccctttcc ctaatctggt gataaaacat cctgggactg
     9481 tgagccccaa cctttccaag aggtgaaagt acccaggatg tctgtgagct gttgatcctc
     9541 catgacgtcc ctcgctcgtc tgttcctctc tcccaaagtc aggcatgaga accagcaaag
     9601 cacagcaagc cctcaatgtc cagggaaggc aaggaaaccc tttccccatg gctttgggtt
     9661 atcttccctc cagtgctcag acgccgccac tgacagtcag gagtgtggca agaaatgcct
     9721 gatagccttt gatcctggaa agatgcataa aaataaaaaa cacgtcagcc aaagaaagga
     9781 gccagcaaag gcatgagcca agaaccctaa cgcactcctg gagtctcctc tgcctcccct
     9841 gttcaggcta ttcccagagg ttctggagtc cccagagcct aggctttcag gaaattcctc
     9901 ctgtggaatt cttcactaga gaaccccagg cagtagtggt ggtgttttgt ttttaagtaa
     9961 gaagaaagag ctccttcgtg tggcctatca gtgtcatacg accccacggg gatcagggat
    10021 ggtggtgccg gaggctggtt cccatggatc cagaaggcca ggctagcact gtccctgtga
    10081 agacctgtgc acacatcgtt tggaagaggg taggcgcagg tgcaacagtg ctggaggact
    10141 gcccagacgg aggcagcaat cagcaggcag ggactacgga gggcagagga ctgtgacaac
    10201 cagagccagg agctcactgg aggattcctt tcctggtttg tctgcctaga taccattgtc
    10261 attagcactc acagtgtctg ggagacaggg gggaagccaa atgcttcctt ctgagctggg
    10321 cttcttagga aatgggactt ttatggctta catttacatt aagtgtggaa aatgaattcc
    10381 aagtcgaagc tattccccgt gggaaccttg ttggactgaa agctcatggc acctttatag
    10441 ccttacagag tcttcagaat atgacatgag ttaatgaaac caagaaggtc tcttaccatg
    10501 agagtctgag cattgtgtag tctgcctgta cttccgcctg gcagagagag gtgtccaaag
    10561 cttattgggg aggggagatc tcgccttata ttgtcccgct gggattagag gatgtgtttc
    10621 gttaagtgct cttcctgatt ccaaaagaat ctgtcacact gctgcaacag tatgccacag
    10681 cctgctttct ccgcccttgc tcactgcctc tgggtcaaag ctctgctggg tcagatttga
    10741 tgccccctca ggccaccgta cccagcacga gctggtaatg gggacttctt tctggcatgg
    10801 tcactcttgg atgggatgga aaatagtttg acctgaaaaa caccaggtct ttctgtatct
    10861 aaaagacata tgcccctcaa aatgtacttt ggctgcaagg gtcctgtgag ttggcctagt
    10921 tgatcagtcc catactggga ctgcctgaca ttggccgaga tccgctgggg accatttact
    10981 tgtaacacag agagacagca tgtgactcaa gggaaccatc tccttgtagc tatctagccc
    11041 aagtcttcct cctctgctat ctccctcctc caaagaatat atttttcagg gtcagtgaac
    11101 accatgagtt attgggtaac tctatttgaa agaacaatcc tgtattcttc ctgggttcca
    11161 tcccagagag agtatctcga ttccatgggg gaaacacgca agcatcctta agctgtaaag
    11221 gtcttcctca ctggtggacg tttgtgattc tgatgggagt tagcttctga acctctaagg
    11281 tttgttgttg tgttgttccc accttctctg ccctccacaa ctgccaatta atccctcagc
    11341 ctcagcccct cctccatgac cttaaacaag acttcgttag ttctcagcct catcttttat
    11401 accccgagac acactccccc tttgtagtca tcttggggac aggcatcact cgagggtgct
    11461 gtggtgatat tgactctgta tacactgcac gttagccttc gacacttggc tcagaatcgc
    11521 cggcagaaaa ctagcccaag gtccagacca gtgcctgact ccactggggg atgctgggtt
    11581 tgaaagaaac cctatgaagc taacgggaga ctgaggccgg acaagtgcct gtaaacagca
    11641 gggatgggga gaggagcaaa tgatgcagaa cggagtgagc tgggtagggc tttataggca
    11701 tggagtaagg gaggaagaag aaagggcctt tcagtggtga cttttaagta cctgcctttc
    11761 cagagaaggt tttcaatgtg acatcttaga acacagcttt gccatccgca gccctcgcat
    11821 ttctggtggc catgtggtga gagcagtgac gctgggcttt gtgcccaggg agatgagctt
    11881 gctggcttcc agcagagggc tgggctttgg ggttaaatca cccatcacac aaagatgagc
    11941 gtgttcttca tccctcacag cagccactta gcccaagagg ttatgtggat cttgggggca
    12001 ggaggattca cctcccatgg ggtcccagtc tctcctctct cctgggatct tcatcaggac
    12061 taaaagccct ccatgagagg catgctatcc ccagctaggt caaaaccatt gtctgtattt
    12121 tatgggaggg gacagaaatt aacaaaagaa ctctgtgtgg ttcgagacct ttttatttag
    12181 ccttccccca aaacagcaaa ctcattttaa agactcatcg ctcaggtgac agaactctat
    12241 cctctccaac ctttcattct caaaaaacca gccttgtgta cttgactgcc cggaacagtg
    12301 gtgggctctg aggttgtgga agggtgggga ggcatggggt ggagacgctg cgttgtgctt
    12361 cggaggcctt ggtggggccc cgtgttgtat ttcttaccct ctggggaatg ccaaaggcgt
    12421 gagaccgggc tacttcctag tccctaagaa aaatgtgatt gattctaagg gctgatggtt
    12481 cagggatgac tcagctgtcc caggagaagc tgacccacag atgtctggtg gtccccagca
    12541 gctctaatcc actcatcacc agaaccccac tgttctaaat gtgcccatca ttctgaggac
    12601 ttctgaacct gcagctccgg caaaggacga ttgtgagctg cctctggatg gctaacactg
    12661 gagactctgg ccttaccatg tggaaatagt tttcctgaag tctggaacta attttgagaa
    12721 gtttttttct caatactttt gtgtttctaa cactgtattc ttgactgtgt aaataccaac
    12781 aaggctgtaa ataaatgcag atgtagatac cttctagaaa aaaaggggga aaaagcataa
    12841 aaacaaaacc agaagtgatc ccgtgtagcc ttcgttgaca aataaaagac tattttgtgt
    12901 ttaaa
//
