LOCUS       NM_001169133           10972 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus teneurin transmembrane protein 3 (Tenm3), mRNA.
ACCESSION   NM_001169133 XM_001058907 XM_224841
VERSION     NM_001169133.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10972)
  AUTHORS   Berns,D.S., DeNardo,L.A., Pederick,D.T. and Luo,L.
  TITLE     Teneurin-3 controls topographic circuit assembly in the hippocampus
  JOURNAL   Nature 554 (7692), 328-333 (2018)
   PUBMED   29414938
REFERENCE   2  (bases 1 to 10972)
  AUTHORS   Aldahmesh,M.A., Mohammed,J.Y., Al-Hazzaa,S. and Alkuraya,F.S.
  TITLE     Homozygous null mutation in ODZ3 causes microphthalmia in humans
  JOURNAL   Genet Med 14 (11), 900-904 (2012)
   PUBMED   22766609
REFERENCE   3  (bases 1 to 10972)
  AUTHORS   Dharmaratne,N., Glendining,K.A., Young,T.R., Tran,H., Sawatari,A.
            and Leamey,C.A.
  TITLE     Ten-m3 is required for the development of topography in the
            ipsilateral retinocollicular pathway
  JOURNAL   PLoS One 7 (9), e43083 (2012)
   PUBMED   23028443
REFERENCE   4  (bases 1 to 10972)
  AUTHORS   Yu,Y., Kranzler,H.R., Panhuysen,C., Weiss,R.D., Poling,J.,
            Farrer,L.A. and Gelernter,J.
  TITLE     Substance dependence low-density whole genome association study in
            two distinct American populations
  JOURNAL   Hum Genet 123 (5), 495-506 (2008)
   PUBMED   18438686
REFERENCE   5  (bases 1 to 10972)
  AUTHORS   Leamey,C.A., Glendining,K.A., Kreiman,G., Kang,N.D., Wang,K.H.,
            Fassler,R., Sawatari,A., Tonegawa,S. and Sur,M.
  TITLE     Differential gene expression between sensory neocortical areas:
            potential roles for Ten_m3 and Bcl6 in patterning visual and
            somatosensory pathways
  JOURNAL   Cereb Cortex 18 (1), 53-66 (2008)
   PUBMED   17478416
REFERENCE   6  (bases 1 to 10972)
  AUTHORS   Leamey,C.A., Merlin,S., Lattouf,P., Sawatari,A., Zhou,X., Demel,N.,
            Glendining,K.A., Oohashi,T., Sur,M. and Fassler,R.
  TITLE     Ten_m3 regulates eye-specific patterning in the mammalian visual
            pathway and is required for binocular vision
  JOURNAL   PLoS Biol 5 (9), e241 (2007)
   PUBMED   17803360
REFERENCE   7  (bases 1 to 10972)
  AUTHORS   Feng,K., Zhou,X.H., Oohashi,T., Morgelin,M., Lustig,A.,
            Hirakawa,S., Ninomiya,Y., Engel,J., Rauch,U. and Fassler,R.
  TITLE     All four members of the Ten-m/Odz family of transmembrane proteins
            form dimers
  JOURNAL   J Biol Chem 277 (29), 26128-26135 (2002)
   PUBMED   12000766
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Apr 25, 2014 this sequence version replaced NM_001169133.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760386,
                              SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-281               JAXUCZ010000016.1  50260789-50261069
            282-560             JAXUCZ010000016.1  50290598-50290876
            561-795             JAXUCZ010000016.1  50516180-50516414
            796-1034            JAXUCZ010000016.1  50540000-50540238
            1035-1157           JAXUCZ010000016.1  50564596-50564718
            1158-1372           JAXUCZ010000016.1  50582802-50583016
            1373-1583           JAXUCZ010000016.1  50588642-50588852
            1584-1685           JAXUCZ010000016.1  50589312-50589413
            1686-1880           JAXUCZ010000016.1  50589593-50589787
            1881-2081           JAXUCZ010000016.1  50590867-50591067
            2082-2267           JAXUCZ010000016.1  50596750-50596935
            2268-2294           JAXUCZ010000016.1  50620666-50620692
            2295-2441           JAXUCZ010000016.1  50623144-50623290
            2442-2658           JAXUCZ010000016.1  50631773-50631989
            2659-2778           JAXUCZ010000016.1  50632986-50633105
            2779-3040           JAXUCZ010000016.1  50633695-50633956
            3041-3308           JAXUCZ010000016.1  50639462-50639729
            3309-3452           JAXUCZ010000016.1  50640985-50641128
            3453-3702           JAXUCZ010000016.1  50646230-50646479
            3703-3723           JAXUCZ010000016.1  50647159-50647179
            3724-3956           JAXUCZ010000016.1  50654888-50655120
            3957-4111           JAXUCZ010000016.1  50656275-50656429
            4112-4986           JAXUCZ010000016.1  50657143-50658017
            4987-5162           JAXUCZ010000016.1  50675667-50675842
            5163-5398           JAXUCZ010000016.1  50677546-50677781
            5399-5695           JAXUCZ010000016.1  50689760-50690056
            5696-7307           JAXUCZ010000016.1  50693407-50695018
            7308-7438           JAXUCZ010000016.1  50705190-50705320
            7439-10972          JAXUCZ010000016.1  50707819-50711352
FEATURES             Location/Qualifiers
     source          1..10972
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..10972
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /note="teneurin transmembrane protein 3"
                     /db_xref="GeneID:306451"
                     /db_xref="RGD:1306641"
     exon            1..281
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..8194
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /note="odd Oz/ten-m homolog 3; odz, odd Oz/ten-m homolog
                     3; odz, odd Oz/ten-m homolog 3-like"
                     /codon_start=1
                     /product="teneurin-3"
                     /protein_id="NP_001162604.1"
                     /db_xref="GeneID:306451"
                     /db_xref="RGD:1306641"
                     /translation="MDVKERRPYCSLTKSRREKERRYTNSSADNEECRVPTQKSYSSS
                     ETLKAFDHDSSRLLYGNRVKDLVHREADEYPRQGQNFTLRQLGVCESATRRGVAFCAE
                     MGLPHRGYSISAGSDADTENEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSALTLTDT
                     EHENRSDSESEQPANNQGQPTLQPLPPSHKQHPAHHPSVTSLNRNSLTNRRNQSPAPP
                     AALPAELQTTPESVQLQDSWVLGSNVPLESRHFLFKTGTGTTPLFSTATPGYTMASGS
                     VYSPPTRPLPRNTLSRSAFKFKKSSRYCSWRCTALCAVGVSVLLAILLSYFIAMHLFG
                     LNWHLQQTENDTFENGKVNSDTVPTHTVSLPSGDNGKLGGFTHENNTIDSGELDIGRR
                     AIQEVPPGIFWRSQLFIDQPQFLKFNISLQKDALIGVYGRKGLPPSHTQYDFVELLDG
                     SRLIAREQRNLVDSERAGRQARSVSLHEAGFIQYLDSGIWHLAFYNDGKNPEQVSFNT
                     IVIESVVECPRNCHGNGECVSGTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCF
                     SGWKGTECDVPTTQCIDPQCGGRGICIMGSCACNSGYKGENCEEADCLDPGCSNHGVC
                     IHGECHCNPGWGGGNCEILKTMCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSV
                     DCGSHGVCMGGTCRCEEGWTGPACNQRACHPRCAEHGTCKDGKCECSQGWNGEHCTIA
                     HYLDKIVKEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGD
                     GLVDCMDPDCCLQSSCQNQPYCRGLPDPQDVISQSLQTPSQQAAKSFYDRISFLIGSD
                     STHVLPGESPFNKSLASVIRGQVLTADGTPLIGVNVSFLHYSEYGYTITRQDGMFDLV
                     ANGGASLTLVFERSPFLTQHHTVWIPWNVFYVMDTLVMKKEENDIPSCDLSGFVRPSP
                     VIVSSPLSTFFRSSPEDSPIIPETQVLHEETTIPGTDLKLSYLSSRAAGYKSVLKVTM
                     TQATIPFNLMKVHLMVAVVGRLFQKWFPASPNLAYTFIWDKTDAYNQKVYGLSEAVVS
                     VGYEYESCLDLTLWEKRTAILQGYELDASNMGGWTLDKHHVLDVQNGILYKGNGENQF
                     ISQQPPVVSSIMGNGRRRSISCPSCNGQADGNKLLAPVALACGIDGSLYVGDFNYVRR
                     IFPSGNVTSVLELRNKDFRHSSNPAHRYYLATDPVTGDLYVSDTNTRRIYRPKSLTGA
                     KDLTKNAEVVAGTGEQCLPFDEARCGDGGKAVEATLMSPKGMAIDKNGLIYFVDGTMI
                     RKVDQNGIISTLLGSNDLTSARPLTCDTSMHISQVRLEWPTDLAINPMDNSIYVLDNN
                     VVLQITENRQVRIAAGRPMHCQVPGVEYPVGKHAVQTTLESATAIAVSYSGVLYITET
                     DEKKINRIRQVTTDGEISLVAGIPSECDCKNDANCDCYQTGDGYAKDAKLSAPSSLAA
                     SPDGTLYIADLGNIRIRAVSKNKPLLNSMNFYEVASPTDQELYIFDINGTHQYTVSLV
                     TGDYLYNFSYSNDNDVTAVTDSNGNTLRIRRDPNRMPVRVVSPDNQVIWLTIGTNGCL
                     KSMTAQGLELVLFTYHGNSGLLATKSDETGWTTFFDYDSEGRLTNVTFPTGVVTNLHG
                     DMDKAITVDIESSSREEDVSITSNLSSIDSFYTMVQDQLRNSYQIGYDGSLRIFYASG
                     LDSHYQTEPHVLAGTANPTVAKRNMTLPGENGQNLVEWRFRKEQAQGKVNVFGRKLRV
                     NGRNLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSGHPTLWLPSSKLMAVNVTYSSTG
                     QIASIQRGTTSEKVDYDSQGRIVSRVFADGKTWSYTYLEKSMVLLLHSQRQYIFEYDM
                     WDRLSAITMPSVARHTMQTIRSIGYYRNIYNPPESNASIITDYNEEGLLLQTAFLGTS
                     RRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTVNLQSDGFICTIRYRQIGPLID
                     RQIFRFSEDGMVNARFDYSYDNSFRVTSMQGVINETPLPIDLYQFDDISGKVEQFGKF
                     GVIYYDINQIISTAVMTYTKHFDAHGRIKEIQYEIFRSLMYWITIQYDNMGRVTKREI
                     KIGPFANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLHLLNPSSSARLTPLRY
                     DLRDRITRLGDVQYRLDEDGFLRQRGTEIFEYSSKGLLTRVYSKGSGWTVIYRYDGLG
                     RRVSSKTSLGQHLQFFYADLTYPTRITHVYNHSSSEITSLYYDLQGHLFAMEISSGDE
                     FYIASDNTGTPLAVFSSNGLMLKQIQYTAYGEIYFDSNIDFQLVIGFHGGLYDPLTKL
                     IHFGERDYDILAGRWTTPDIEIWKRIGKDPAPFNLYMFRNNNPASKIHDVKDYITDVN
                     SWLVTFGFHLHNAIPGFPVPKFDLTEPSYELVKSQQWEDVPPIFGVQQQVARQAKAFL
                     SLGKMAEVQVSRRKAGGEQSWLWFATVKSLIGKGVMLAVSQGRVQTNVLNIANEDCIK
                     VAAVLNNAFYLENLHFTIEGKDTHYFIKTTTPESDLGTLRLTSGRKALENGINVTVSQ
                     STTVVNGRTRRFADVEMQFGALALHVRYGMTLDEEKARILEQARQRALARAWAREQQR
                     VRDGEEGARLWTEGEKRQLLSAGKVQGYDGYYVLSVEQYPELADSANNIQFLRQSEIG
                     KR"
     exon            282..560
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            561..795
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1034
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1157
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1372
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1583
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1685
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1880
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2081
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2267
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2294
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2441
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2658
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2778
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..3040
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3308
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            3309..3452
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            3453..3702
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            3703..3723
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            3724..3956
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            3957..4111
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            4112..4986
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            4987..5162
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            5163..5398
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            5399..5695
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            5696..7307
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            7308..7438
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
     exon            7439..10972
                     /gene="Tenm3"
                     /gene_synonym="Odz3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagttctaag aggccggacc gatgcgcaca gagaaggaat gaaggaagta tggatgtgaa
       61 ggaacgcagg ccttactgct ccttgaccaa gagcagacgg gaaaaagaac ggcgctatac
      121 aaactcgtcc gcggacaatg aggagtgtag ggtccccacg cagaagtctt acagttccag
      181 tgaaaccttg aaagctttcg atcatgattc ttcacggctg ctttacggaa acagagtaaa
      241 agatctggtc cacagagaag ccgacgagta tcctagacaa ggacagaatt ttaccctaag
      301 gcagttagga gtgtgtgaat ccgcaactcg aagaggagtg gcattctgtg cggaaatggg
      361 gctccctcac agaggttact ccatcagtgc agggtcagat gctgatacgg aaaacgaagc
      421 agtgatgtcc cctgagcatg ccatgagact ttggggcagg ggggtcaaat cgggccgcag
      481 ctcctgcctg tcaagccggt ccaactcagc cctcaccctg acagacacgg agcacgagaa
      541 caggtcggac agtgagagcg agcaacctgc aaacaaccaa gggcaaccta ccctgcagcc
      601 tttgccaccc tcccataagc agcaccctgc acatcacccg tccgtcacct ccctcaatag
      661 aaactccctg accaatagaa ggaaccagag tccggccccg ccggctgctt tgcccgccga
      721 gctgcaaacc acacccgagt ccgtccagct gcaggacagc tgggtccttg gcagtaatgt
      781 accactggaa agcaggcact tcctattcaa aacagggaca gggacgacgc cactgttcag
      841 tacggcaacc ccgggataca caatggcatc tggctctgtt tattctccgc ctacccggcc
      901 acttcctaga aacaccctgt caagaagcgc tttcaaattc aagaagtctt caaggtactg
      961 cagctggagg tgcaccgccc tgtgtgctgt aggggtgtcg gtgctcctgg ctatcctgct
     1021 ctcctacttc atagcaatgc atctatttgg cctcaactgg cacttacagc agacggaaaa
     1081 tgacacattc gagaatggaa aagtgaactc tgacaccgtg ccaacacaca ctgtatcgtt
     1141 accttctggc gacaatggaa aattaggtgg atttacacac gaaaataaca ccatagattc
     1201 cggagaactt gatattggcc ggagagcaat tcaagaggtt ccccccggga tcttctggag
     1261 gtcgcagctc tttattgatc agccacagtt tcttaagttc aacatctctc ttcagaagga
     1321 tgcattgatc ggagtatatg gccggaaggg cttaccgcct tcccatactc agtacgactt
     1381 tgtggagctc ctggatggca gcaggttgat tgcaagagag cagcggaacc tggtggattc
     1441 cgaaagagcg gggcggcagg cgagatcagt cagcctgcac gaagctggct ttatccagta
     1501 cctggattct ggaatctggc acctggcttt ttataacgat gggaaaaacc cagagcaggt
     1561 ttcttttaac actattgtta tagagtctgt ggtggaatgc ccccgaaatt gccatggaaa
     1621 tggagagtgt gtttctggaa cttgtcattg tttccctggg tttctgggtc cggattgttc
     1681 aagagcagcc tgtcccgtgc tctgtagtgg caacgggcag tactccaagg gccgctgcct
     1741 gtgcttcagc ggctggaagg gcaccgagtg tgacgtgccg actacccagt gcattgaccc
     1801 gcagtgtggg ggtcgtggga tttgcatcat gggctcttgc gcttgtaact cgggatacaa
     1861 aggagagaac tgtgaagaag cggactgtct agaccctgga tgctctaatc acggggtgtg
     1921 tatccatggg gaatgtcact gcaatccagg atggggtggc ggcaactgtg aaatactgaa
     1981 gactatgtgc ccagaccagt gctcaggcca tgggacatac cttcaagaaa gcggctcctg
     2041 cacttgtgac ccaaattgga ctggccccga ctgctcaaat gaaatatgct cggtggactg
     2101 cggctcgcac ggtgtctgca tggggggcac ctgtcgctgt gaggaaggct ggacaggtcc
     2161 agcatgtaat cagagagctt gccaccctcg ctgtgcggaa cacgggacct gcaaggacgg
     2221 caaatgcgag tgcagtcaag gatggaacgg agaacactgc acaatcgctc actatttgga
     2281 taagatagtt aaagagggtt gccccggctt gtgcaacagc aatgggagat gtacactcga
     2341 ccaaaacggc tggcattgtg tctgccagcc agggtggaga ggagcgggct gtgatgtagc
     2401 catggagact ctctgtacag acagcaaaga caacgaagga gatggactcg tggactgcat
     2461 ggaccctgac tgctgcctcc agagctcctg ccaaaaccag ccctactgcc gtggcttgcc
     2521 cgatcctcag gacgtcatta gccagagcct tcagacgcca tctcagcaag ctgccaagtc
     2581 cttctatgac cgaatcagtt tcctgattgg gtcggatagc acccacgtgc tccctggaga
     2641 aagtccgttc aataagagcc tcgcgtccgt catcagaggc caagtactaa cggctgacgg
     2701 gaccccgctt atcggcgtca acgtgtcgtt tttgcattac tcggagtatg gatatactat
     2761 tacccgtcag gacggaatgt ttgacttggt ggcaaatggt ggcgcctctc tcaccttggt
     2821 gtttgagcgt tccccgttcc tcactcagca ccacactgtg tggattccct ggaatgtctt
     2881 ctatgtgatg gatacccttg tcatgaagaa agaagagaac gatattccca gctgtgacct
     2941 cagcgggttt gtgaggccga gtcccgtcat cgtgtcgtcg ccattgtcca ccttcttcag
     3001 gtcttctcct gaagacagcc ccatcatccc cgagacacag gtcctgcatg aagaaaccac
     3061 aattccaggg acagatttga agctttccta cctgagttcc cgagcggcag ggtacaagtc
     3121 cgttctgaag gtcaccatga cccaggccac cataccgttt aacctcatga aggtccatct
     3181 gatggtagct gtggtcggga gactcttcca gaagtggttc cctgcctcac caaacctggc
     3241 ctacacgttc atctgggata agacagacgc atataatcag aaagtctacg gcctgtcaga
     3301 ggcagttgtg tctgttgggt atgagtatga gtcgtgcttg gacctgactc tgtgggaaaa
     3361 gaggactgcc attttgcaag gctatgagtt ggatgcttcg aacatgggtg gctggacctt
     3421 ggacaagcat catgtcctgg atgttcagaa tggtatactg tacaaaggaa acggggaaaa
     3481 tcagttcatc tctcagcagc ctccggtggt cagcagcatc atgggtaacg gccggaggcg
     3541 gagcatctcg tgcccgagtt gcaatggtca agccgatgga aacaagcttc tggccccagt
     3601 ggcgctagcc tgtgggatcg acggcagtct ctacgtaggg gatttcaatt acgtccggcg
     3661 aatattccct tctgggaatg tgacaagtgt tttagaacta agaaataaag attttagaca
     3721 tagtagcaac ccagctcaca gatactacct ggctacagac ccagtcactg gagatttgta
     3781 cgtttctgat actaacaccc gcagaatcta tcggccaaaa tcactcacag gagcaaaaga
     3841 cttgaccaaa aatgctgaag tggttgcagg caccggggag cagtgccttc cctttgacga
     3901 ggcccggtgt ggggatggag ggaaagctgt agaagcaaca ctcatgagtc ccaaaggaat
     3961 ggcgatcgat aagaatgggc tgatctactt tgttgatgga accatgatca gaaaggttga
     4021 tcaaaatgga atcatatcca ctctcctggg ctccaatgac ctcacgtcag cccgaccttt
     4081 aacctgtgac accagcatgc acatcagcca ggtacgactg gaatggccca ccgatctggc
     4141 catcaacccc atggataact ccatttacgt cctggataat aacgtagttt tacagatcac
     4201 cgaaaaccgg caagttcgca tcgctgccgg gcggcccatg cactgtcagg tccctggagt
     4261 ggagtacccc gtggggaagc atgcggttca gaccaccctg gagtcggcca ctgccatcgc
     4321 cgtgtcctac agcggggtcc tttacatcac cgaaactgat gagaagaaga tcaaccgaat
     4381 aaggcaggtc acgaccgacg gggagatctc cttagtggct gggataccct cggaatgtga
     4441 ctgcaagaac gacgccaact gtgactgcta ccaaaccgga gatggctacg ccaaagacgc
     4501 caaactcagc gccccgtcct ccctagccgc ctctccagac ggcaccctgt acattgcaga
     4561 tctggggaat atccggatcc gggccgtgtc aaagaacaaa cctttactta actccatgaa
     4621 cttttatgaa gttgcctccc caactgatca agagctctat atctttgaca tcaatggtac
     4681 tcaccagtac accgtgagcc tagtcacggg tgactacctg tataacttta gttacagcaa
     4741 cgacaacgat gtcaccgccg taacagacag caacggcaat accctccgaa tccgaaggga
     4801 tccaaatcgg atgccggtgc gggtggtgtc tcctgataac caggtgatat ggttgaccat
     4861 aggcaccaac gggtgtctaa aaagcatgac cgctcagggg ctggaactgg ttttgtttac
     4921 ttaccatggc aacagtgggc ttttagccac caaaagtgac gaaactggat ggacaacatt
     4981 ttttgactac gacagtgaag gtcgcctaac caatgttacc ttcccaactg gggtggttac
     5041 aaacctgcac ggggacatgg acaaggccat cacggtagac attgagtcat ccagccgaga
     5101 ggaagacgtc agcatcactt ctaatttgtc ctccatcgat tcgttctaca ccatggtcca
     5161 agaccagtta agaaacagtt accagattgg gtatgatggc tcccttagaa tcttctatgc
     5221 cagtggtcta gactctcact accagacaga gccccacgtt ctggcaggca ccgcgaatcc
     5281 cacggtagcc aaaagaaata tgacgcttcc tggtgagaac ggacagaacc tggtggaatg
     5341 gaggttccgg aaagagcagg cccaaggcaa agtcaatgta ttcggccgaa agctcagggt
     5401 caacggacgc aacctcctct cggtggactt tgatcggacc accaagacag aaaagatcta
     5461 tgatgaccac cggaaatttc tcctgaggat tgcttacgac acatcgggtc acccgactct
     5521 ctggctgcct agtagcaagc tgatggcggt caacgtcacc tactcatcca ctggtcaaat
     5581 tgccagcatc cagagaggga ccactagtga aaaggtggac tatgatagcc aggggaggat
     5641 cgtatctcgg gtctttgccg atgggaaaac gtggagttac acgtacttgg aaaagtccat
     5701 ggtccttctg ctccatagcc agcggcagta catcttcgaa tacgatatgt gggaccgcct
     5761 gtctgccatc accatgccca gcgtggctcg ccacaccatg cagaccatcc ggtccattgg
     5821 ctactaccgc aacatataca accccccaga aagcaatgct tcgatcatca cagactacaa
     5881 cgaggaaggg ctgcttctgc aaacggcttt cctggggacg agtcggaggg tcttattcaa
     5941 gtacagaagg cagaccaggc tatcggaaat tttatacgac agcacaagag tcagttttac
     6001 ctacgatgag acagcaggag tcctgaaaac agtaaacctt cagagcgatg gttttatttg
     6061 caccattaga tacaggcaaa ttggtcccct gattgacaga cagattttcc gcttcagtga
     6121 ggatggaatg gtaaacgcaa gatttgacta tagctatgac aacagctttc gagtgaccag
     6181 catgcagggt gtcatcaatg aaacgccact gcccattgat ctgtaccagt ttgatgacat
     6241 ttctggcaaa gttgagcagt tcggaaaatt cggagttata tactatgaca tcaaccagat
     6301 catttccacg gccgtaatga cttacacgaa gcacttcgac gctcacgggc gcatcaagga
     6361 gatccaatat gagatattca ggtcactcat gtactggatt acaattcaat atgataatat
     6421 gggccgggta accaagagag agattaaaat agggcctttt gccaacacta ccaaatacgc
     6481 ctatgaatac gacgttgatg gacagctgca gacggtttac ctcaacgaga agatcatgtg
     6541 gaggtacaac tatgacctga acggcaacct ccacctgctg aaccccagca gcagcgcccg
     6601 cctgacgcct cttcgctacg accttcgaga cagaatcacg cgcctgggcg atgtccagta
     6661 ccggctggat gaagatggct ttctgcgaca acggggcaca gaaattttcg aatacagctc
     6721 caaggggctt ctgactcggg tctacagtaa aggtagtggc tggacagtga tctatcggta
     6781 tgacggcctg ggaaggcgtg tttctagcaa aaccagcctg ggacagcacc ttcagttctt
     6841 ctatgctgac ctgacgtacc ccactaggat tactcacgtc tacaaccatt caagttcaga
     6901 aatcacctcc ctctactatg acctccaagg acatcttttt gccatggaga tcagcagcgg
     6961 ggacgagttc tacattgcct cagataacac ggggacgccg ctggctgttt ttagtagcaa
     7021 cgggcttatg ctgaaacaga ttcagtacac tgcctatggt gagatctact ttgattccaa
     7081 tattgacttt cagctggtaa ttgggttcca tggaggcctg tatgacccgc tcaccaaatt
     7141 aatccacttt ggagaaagag attacgatat tttggcagga agatggacaa caccggacat
     7201 tgaaatctgg aaaagaatcg gaaaggaccc ggctccattt aacctgtaca tgtttcggaa
     7261 caacaaccct gcaagcaaaa tccatgatgt gaaagactac atcacagatg ttaacagctg
     7321 gctggtgaca tttggcttcc atctgcacaa tgctattcct ggattccccg ttcccaaatt
     7381 tgatctaaca gaaccttcct acgaactcgt gaagagtcaa cagtgggaag acgtgccgcc
     7441 catctttgga gttcagcagc aagtggcaag gcaagccaag gccttcctgt ccctggggaa
     7501 gatggcggag gtgcaggtga gccgacgcaa ggctgggggc gagcagtcgt ggctgtggtt
     7561 cgccacggtc aagtcgctca tcggcaaggg cgtcatgctg gccgtgagcc aaggccgcgt
     7621 gcagaccaac gtgctcaaca tcgccaacga ggactgcatc aaggtggcgg cggtgctcaa
     7681 caatgccttc tacctggaga acctgcactt caccatcgag ggcaaggaca cgcactactt
     7741 catcaagacc accacgccag agagcgacct gggcacgctg cggctgacga gtggtcgcaa
     7801 ggcgctggag aacggtatca acgtgaccgt gtcgcaatcc accacggtgg tgaacggcag
     7861 gactcgcagg ttcgctgacg tggagatgca gttcggcgcc ctggcgctgc acgtccgcta
     7921 cggcatgacc ctggacgagg agaaggcgcg catcctggag caggcgcgcc agcgcgctct
     7981 cgcccgggcg tgggcgcgcg agcagcagcg cgtgcgcgac ggcgaggagg gtgcgcgcct
     8041 ctggacggag ggtgagaagc ggcagctgct gagcgccggc aaggtgcagg gctacgatgg
     8101 gtactacgta ctgtccgtgg agcagtaccc cgagctggct gacagtgcca acaacatcca
     8161 gttcctgaga caaagcgaga tcggcaagag gtaacccccg ggccacccct gcgcagattc
     8221 tcctgtagca caaaccgaac cggactctcc aaagagcctt ccagaatgac actgctctgc
     8281 agacaccctc ggcgcagaca caggcaacac aaaccagaaa caaagacgac tttttttttc
     8341 tctaaatgac cttaaaggtg atcggcttta aagaatatgt ttacatacgc atatcgctgc
     8401 actcaattgg actggaagta tgagaaggaa aaaaaagcat taaaaaggca acgttttgcc
     8461 atgaccctct gtaccttcga ggcactgtat ttaacaaaag ttttaaaaag aaaaaaaaaa
     8521 atgcgtacca tgtttccaga tattgctgaa ttgtcgacct ttgcttacag gaagtaatct
     8581 ctacttagga tgtgatatac atagatctgt tcattttaaa atgtgggaca acgttactgt
     8641 ttatagaacc caactgcttt cccatgctgc tttgtaaaag gacattggcg caagggacgt
     8701 ctgcttcggc ggggatttaa taatggattt tactaacatg gcttgccctg ggaggggaaa
     8761 aaaaaacgac aaatagaatc attgtcactg ataagcaaag gaaaccccga tttttttgta
     8821 aattatgtga gacaagttgt ttatggattt tttatatgaa ttacaattta ctgtacatcg
     8881 aatattagtc tcagaggagt taatttatgt aaagtgttta aaaagtttat acttaaaaaa
     8941 taaaatgata aaaacatgtg aactgtgtga tttttttaaa aaaaaggatt gcaccttttg
     9001 ttatctgtta taactgtaca gtataactta ttatattgta gagatataac aacttacacc
     9061 tatcatgtcc agaagtgtta atatttttgt attaggttga aaacaaaaac aatgtgcaac
     9121 tttctatcac ttagatagat aggactgtgc aatcctcagt gggtggctaa tcggagaact
     9181 ttttcttcgt ccccctttct taacaagcca ctggcctcag ccattaccaa ccaagaggcg
     9241 cagtcgacat ccaaggctgg tggaatgtga tggagggtgt gggggagggg agcagagaga
     9301 gaagaacccg agggggagaa gaggctctct aggcccttaa aggtcaagcc aagttcatca
     9361 accagagctt ttaatagtgt atggtcgtcc ctccatgctc cacttgtgat ggagaagaga
     9421 ccacagtctg atgctcggga acatttgtgg ggagggacgg acttgatgtc atggtaacca
     9481 tgaacatgta tcttaatgtc taggagcgat agcaataacc gagtggtcat gagccagggg
     9541 cgaccggcca gtcagggtca ctctctgtgg ggcttggagt tggaccctta ggtcagccag
     9601 tgggatcgaa acaggaaggc aagctcctgt taagcccgaa tggcccaacc atcacaggga
     9661 atggtttgag cggcagccta tgctggccag gggtagcctg gggtattggg cagggtagga
     9721 agaaaactga catcagtgcc cccacccccc acccccgacc gaaagcttgg ggttccacca
     9781 tagacaccat ctgcacttcc gtgccaaccc agccactctg gagtctttcg tgagcactga
     9841 attcagccac aaaaatattt ttagaagata tttctcagtt cattgagcta tatagtacac
     9901 actgttttcc tctctatatg atggtgataa atatagcaag tgaacatgtc gtaaatataa
     9961 aggttcaagt gatgtattga aagtaatttt ctaactgctt tgtgtgtatc acatactcta
    10021 aatacacagt aggcgtgttt attaaacaga ctggctggga gcgttctcag acagcgacgg
    10081 aacttacggt ctcagcgctg ctcctgttgc tgtgtatgtg gtagggtata ctgaagtaat
    10141 taatcttcta atgaatgctg atattttact agaatgaaag cacagattag cattaaatat
    10201 tttttatcct gaaaatcctt tggcaagtac tggggagccc aaatttagaa aactatgaga
    10261 ttttcaaaca tggctgtcgg acgttttatt ttttaactgt taccttaggt gtttgcagtt
    10321 ctgctgagtg ggacttccgc agggctgtta tgtagcatgc tgtaagtact ctggggtgaa
    10381 acgggccccg agtctcaatt ctcagaaatg tctgtgatgt attgaccatg aatagcttgt
    10441 accacatgac ggaaatgaaa ttacactctt aaccccttct caacatggac tggtctttac
    10501 aggggcacca ataaatgaca aatttggaga gtctcctggt gcttatttta gaagtcaaac
    10561 caacccaatt agtatcttgt tagtagatat aatgagccta tttctttcta aaaaggcttg
    10621 tggtctggac gtgcttttac aagaaatagt gaccttgggg aatatataaa caagagatct
    10681 ttttctaaga gtttgggggg aggttgggga cctgtataat gacaaaaatt agcttacaat
    10741 aatgacaaca acaaaaagta aaaataaaaa caaaagaaat tgatattcaa agtattttag
    10801 gcaaagccag tcaagatgct ttcatgatat tttgagatgt aaatttttgt ctgatttgta
    10861 ttgttctttt catttgcctt cttaactttc tatgtgacct gaattttcca taacttgatg
    10921 actatagact gcatctaggc attccaataa aagccaaccc aatgtgtgtg cg
//
