LOCUS       NM_020088               8689 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus teneurin transmembrane protein 2 (Tenm2), mRNA.
ACCESSION   NM_020088 XM_346397
VERSION     NM_020088.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8689)
  AUTHORS   Silva,J.P., Lelianova,V.G., Ermolyuk,Y.S., Vysokov,N.,
            Hitchen,P.G., Berninghausen,O., Rahman,M.A., Zangrandi,A.,
            Fidalgo,S., Tonevitsky,A.G., Dell,A., Volynski,K.E. and
            Ushkaryov,Y.A.
  TITLE     Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a
            high-affinity transsynaptic receptor pair with signaling
            capabilities
  JOURNAL   Proc Natl Acad Sci U S A 108 (29), 12113-12118 (2011)
   PUBMED   21724987
  REMARK    GeneRIF: Latrophilin 1 and its endogenous ligand Lasso/teneurin-2
            form a high-affinity transsynaptic receptor pair with signaling
            capabilities.
REFERENCE   2  (bases 1 to 8689)
  AUTHORS   Feng,K., Zhou,X.H., Oohashi,T., Morgelin,M., Lustig,A.,
            Hirakawa,S., Ninomiya,Y., Engel,J., Rauch,U. and Fassler,R.
  TITLE     All four members of the Ten-m/Odz family of transmembrane proteins
            form dimers
  JOURNAL   J Biol Chem 277 (29), 26128-26135 (2002)
   PUBMED   12000766
REFERENCE   3  (bases 1 to 8689)
  AUTHORS   Otaki,J.M. and Firestein,S.
  TITLE     Neurestin: putative transmembrane molecule implicated in neuronal
            development
  JOURNAL   Dev Biol 212 (1), 165-181 (1999)
   PUBMED   10419693
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF086607.1.
            
            On Jan 12, 2005 this sequence version replaced XM_346397.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF086607.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..8689
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..8689
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /note="teneurin transmembrane protein 2"
                     /db_xref="GeneID:117242"
                     /db_xref="RGD:727907"
     exon            1..56
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            57..358
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..8430
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /note="ten-2; ten-m2; teneurin-2-like; tenascin-M2; odz,
                     odd Oz/ten-m homolog 2; protein Odd Oz/ten-m homolog 2;
                     neurestin"
                     /codon_start=1
                     /product="teneurin-2"
                     /protein_id="NP_064473.1"
                     /db_xref="GeneID:117242"
                     /db_xref="RGD:727907"
                     /translation="MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSE
                     TLKAYDHDSRMHYGNRVTDLVHRESDEFSRQGANFTLAELGICEPSPHRSGYCSDMGI
                     LHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNE
                     NKSDDDNGRPIPPTSSSSLLPSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDEEF
                     SPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNRNSLT
                     NRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSS
                     PGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLA
                     YFIAMHLLGLNWQLQPADGHTFNNGVRTGLPGNDDVATVPSGGKVPWSLKNSSIDSGE
                     AEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDF
                     MERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFN
                     TVVLDSVQDCPRNCHGNGECVSGLCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQC
                     YSGWKGAECDVPMNQCIDPSCGGHGSCIDGNCVCAAGYKGEHCEEVDCLDPTCSSHGV
                     CVNGECLCSPGWGGLNCELARVQCPDQCSGHGTYLPDSGLCNCDPNWMGPDCSVEVCS
                     VDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTI
                     DGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDP
                     DCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGDNP
                     FNSSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGSALTLH
                     FERAPFMSRERTVWPPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTF
                     FSASPAANPIVPETQVLHEEIELPGTNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLI
                     RVHLMVAVEGHLFQKSFQASPNLAYTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPS
                     LILWEKRTALLQGFELDPSNLGGWSLDKHHTLNVKSGILLKGTGENQFLTQQPAIITS
                     IMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLFVGDFNYIRRIFPSRNVTSI
                     LELRNKEFKHSNSPGHKYYLAVDPVTGSLYVSDTNSRRIYRVKSLSGAKDLAGNSEVV
                     AGTGEQCLPFDEARCGDGGKAVDATLMSPRGIAVDKNGLMYFVDATMIRKVDQNGIIS
                     TLLGSNDLTAVRPLSCDSSMDVAQVRLEWPTDLAVNPMDNSLYVLENNVILRITENHQ
                     VSIIAGRPMHCQVPGIDYSLSKLAIHSALESASAIAISHTGVLYITETDEKKINRLRQ
                     VTTNGEICLLAGAASDCDCKNDVNCICYSGDDAYATDAILNSPSSLAVAPDGTIYIAD
                     LGNIRIRAVSKNKPVLNAFNQYEAASPGEQELYVFNADGIHQYTVSLVTGEYLYNFTY
                     SADNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKAVSTQNLEL
                     GLMTYDGNTGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITVDI
                     ENSNRDNDVTVITNLSSVEASYTVVQDQVRNSYQLCSNGTLRVMYANGMGVSFHSEPH
                     VLAGTLTPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSIDY
                     DRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAM
                     SERTDIDKQGRIVSRMFADGKVWSYSYLDKSMVLLLQSQRQYIFEYDSSDRLHAVTMP
                     SVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTSFLGTGRQVFYKYGKL
                     SKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKVGPLVDKQIYRFSEEG
                     MINARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQ
                     IITTAVMTLSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLGPYANTT
                     KYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLHLLNPGNSARLMPLRYDLRDRITRL
                     GDVQYKIDDDGYLCQRGSDIFEYNSKGLLTRAYNKASGWSVQYRYDGVSRRASYKTNL
                     GHHLQYFYSDLHHPTRITHVYNHSNSEITSLYYDLQGHLFAMESSSGEEYYVASDNTG
                     TPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYD
                     VLAGRWTSPDYTMWRNVGKEPAPFNLYMFKNNNPLSNELDLKNYVTDVKSWLVMFGFQ
                     LSNIIPGFPRAKMYFVPPPYELSESQASENGQLITGVQQTTERHNQAFLALEGQVISK
                     KLHAGIREKAGHWFATTTPIIGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYY
                     LDKMHYSIEGKDTHYFVKIGAADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTR
                     RFTNIEFQYSTLLLSIRYGLTPDTLDEEKARVLDQARQRALGTAWAKEQQKARDGREG
                     SRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLRQNEMGKR"
     exon            359..634
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            635..844
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1079
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1318
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1441
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1647
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1843
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1945
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2140
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2341
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2527
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2674
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2885
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..3005
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3267
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..3535
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            3536..3679
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            3680..3929
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            3930..3950
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            3951..4183
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            4184..4338
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            4339..5213
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            5214..5389
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            5390..5625
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            5626..5922
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            5923..7537
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            7538..7668
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
     exon            7669..8689
                     /gene="Tenm2"
                     /gene_synonym="Lasso; Odz2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgagcattc ccggaaacgc agctgagttg ttggacaaca gacgtccacc cagtcggtgg
       61 gtaaagtgac aggtgccaca actccagcct ccccttttct gaaagtcgcg gagttccatt
      121 tcatctgcaa taatggatgt gaaggatcgg cgacatcgct ctttgaccag gggacggtgt
      181 ggcaaggagt gtcgctacac cagctcctct ctggacagtg aggactgccg tgtgcccacg
      241 cagaagtcct acagttccag tgagaccctg aaggcttatg accatgacag cagaatgcac
      301 tatggaaacc gagtcacaga cctggtgcac cgggagtccg atgagttttc tagacaaggg
      361 gctaatttca ccctggcaga attgggaatc tgcgagccct ccccacaccg aagtggttac
      421 tgttccgaca tggggatcct ccaccagggc tactccctga gcactgggtc tgatgcggac
      481 tcggacaccg agggagggat gtctccagaa catgccatca gactgtgggg acgagggata
      541 aaatcgaggc gcagctctgg cttgtccagc cgcgagaact cagcccttac tctgactgat
      601 tctgacaatg aaaataaatc ggatgacgac aatggtcgac ccattccacc tacatcctcg
      661 tctagcctcc tcccatctgc tcagctgcct agctcccata atcctccacc agttagctgc
      721 cagatgccat tgctagacag caacacctcc catcagatca tggacaccaa ccccgatgag
      781 gaattctccc ctaattcata cctgctcaga gcatgctcag ggccccagca agcctccagt
      841 agtggccctc cgaaccacca cagccagtca acgctgaggc cccctctgcc acctcctcat
      901 aaccacaccc tgtcccacca ccactcctct gccaactccc tcaacagaaa ctcactgacc
      961 aatcggcgga gtcaaatcca cgccccagct cctgcaccca atgacctggc caccacgccg
     1021 gagtccgttc agctccagga cagctgggtg ctgaacagta acgtgccgct ggagacgcgg
     1081 cacttcctct tcaagacgtc ctccggaagc acacccctgt tcagcagctc ttctccagga
     1141 taccccttga cctcagggac cgtttataca ccaccacccc gcctgctgcc acggaataca
     1201 ttctctagga aggccttcaa gctgaagaaa ccctccaaat actgcagttg gaaatgcgcc
     1261 gccctgtctg ccattgccgc tgccctcctt ctggccattt tgctggccta tttcatagca
     1321 atgcatctgc tcggactcaa ttggcaactc cagccggcag atggacacac ctttaacaat
     1381 ggcgtaagga ccggcttacc aggaaacgat gatgtggcaa cagtgccatc tggaggcaaa
     1441 gtgccctggt cgttgaaaaa cagcagcata gacagcggcg aggcagaagt cggtcgacgg
     1501 gtgacacagg aagtcccacc aggggtgttt tggaggtccc agattcacat cagtcagcct
     1561 cagttcttaa agttcaacat ctccctgggg aaggatgccc tcttcggcgt ctacataaga
     1621 agaggactgc caccatctca tgcacagtat gacttcatgg aacgcctgga cggaaaggag
     1681 aagtggagtg tggtcgagtc acccagggaa cgccggagca tccagaccct ggtgcagaac
     1741 gaggctgtgt tcgtgcagta cttggatgtg ggcctgtggc acctcgcctt ctacaatgac
     1801 ggcaaggaca aggagatggt ctccttcaat acggttgtct tagattcagt gcaggactgt
     1861 ccacgaaact gccacgggaa cggcgaatgc gtgtctggac tgtgtcactg tttcccagga
     1921 ttcctaggtg cagactgcgc taaagctgcc tgccctgttc tgtgcagtgg gaatggacag
     1981 tattccaaag ggacatgcca gtgctacagt ggctggaaag gagcagaatg cgatgtgccc
     2041 atgaaccagt gcatcgatcc ttcctgtggg ggccacggct cctgcattga tgggaactgc
     2101 gtgtgtgcag ctggctacaa gggcgagcac tgcgaagaag tggattgctt ggatccaacc
     2161 tgctccagcc atggtgtctg tgtgaacgga gagtgtctat gcagccccgg ctggggcggg
     2221 ctcaactgcg agctggcgag ggtccagtgc ccagaccagt gtagtgggca tggcacttac
     2281 ctccctgact ctggcctctg caactgtgat ccgaattgga tgggtcccga ctgctctgtt
     2341 gaagtgtgct cagtagactg tggcactcac ggcgtctgca tcgggggagc ctgccgctgt
     2401 gaagagggct ggacaggcgc ggcttgtgac cagcgcgtgt gccacccccg ctgcattgag
     2461 cacgggacct gtaaagatgg caaatgtgaa tgccgagagg gctggaatgg tgaacactgc
     2521 accattgatg gctgccctga tttgtgcaac ggtaacggga gatgcacact gggtcagaac
     2581 agctggcagt gtgtctgcca gaccggctgg agagggcccg gatgcaacgt tgccatggaa
     2641 acctcctgcg ctgataacaa ggataatgag ggagatggcc tggtggactg cctggaccct
     2701 gactgctgcc tccagtcagc ctgtcagaac agcctgctct gtcgggggtc tcgggacccc
     2761 ttggacatca ttcagcaagg ccagacagac tggcctgcgg tgaagtcctt ctatgatcgt
     2821 atcaagctct tggcaggcaa ggacagcacc cacatcattc ctggagacaa ccccttcaat
     2881 agcagcctgg tgtctctgat ccgaggccaa gtagtaacca cggatgggac ccccctggtg
     2941 ggtgtgaatg tgtcttttgt caagtaccca aaatatggct acaccatcac tcgccaggac
     3001 ggcacgtttg acctgattgc caatgggggc tctgccttga ctcttcactt tgagcgagcc
     3061 cctttcatga gccgggagcg cacagtatgg ccgccgtgga acagcttcta tgccatggac
     3121 accctggtaa tgaagacgga ggagaactcc atccccagct gtgacctcag tggctttgtc
     3181 cggcctgatc cgatcatcat ctcctctcct ctgtccacct tcttcagcgc ttcccctgcg
     3241 gcgaacccca ttgtgcctga gacccaggtt cttcatgagg agatcgagct ccctggcacc
     3301 aacgtgaagc tccgttacct cagctccaga acagcagggt acaagtcact gctgaagatc
     3361 accatgaccc agtccacggt gcccttgaac ctcatccggg ttcacttgat ggttgccgtg
     3421 gaggggcatc tcttccagaa gtcgttccag gcttctccca acctggccta cacattcatc
     3481 tgggacaaga cagacgctta tggccaaagg gtttatggcc tatcggatgc tgttgtgtct
     3541 gttggatttg aatatgagac ctgccccagt ctcatcctgt gggaaaaaag gacagcccta
     3601 cttcaaggat tcgagctgga cccttccaac cttggtggct ggtccctgga taagcaccac
     3661 accctcaatg tgaaaagcgg aatactactc aaaggcacag gggagaacca gttcctgacc
     3721 cagcagcccg ccatcatcac cagcatcatg ggtaacggtc gccgcagaag catctcctgt
     3781 cccagctgca atggccttgc tgaaggcaac aaactgttgg cccccgtggc cctggctgtg
     3841 gggatcgatg ggagcctctt tgtcggtgac ttcaattata tccggcgcat cttcccttct
     3901 cgaaacgtga ccagtatctt ggagttacga aataaagagt ttaaacatag caacagccca
     3961 ggacacaagt actacttggc tgtggaccct gtgactggct cgctctatgt ctctgacacc
     4021 aacagtcgcc ggatctaccg agtcaagtct ctaagcggag ccaaagacct ggctgggaat
     4081 tcggaagttg tggccgggac tggcgaacaa tgtctaccct ttgatgaagc ccgctgtggg
     4141 gatggcggga aggctgtgga tgccaccctg atgagcccta gaggtattgc agtagacaag
     4201 aacgggctta tgtattttgt tgatgccacc atgatccgga aggtcgacca aaatggaatc
     4261 atctccaccc tgctgggctc caatgacctc acagctgtcc gaccactgag ctgtgactct
     4321 agcatggacg tggcccaggt ccgtctagaa tggccgacag accttgcggt caaccccatg
     4381 gacaattccc tgtacgtcct ggagaacaac gtcatcctgc ggatcaccga gaatcaccag
     4441 gtcagcatca tcgcgggacg gcccatgcac tgccaggttc ccggcatcga ctactcgctc
     4501 agcaagctcg ccatccactc tgctctggag tcagccagcg ccatcgccat ttctcacacc
     4561 ggggtgctct acatcaccga gacggacgag aagaagatca accgcctacg ccaggtcacc
     4621 accaacggag agatctgcct cttagccggg gcagcctcag actgtgactg caaaaatgac
     4681 gtcaactgca tctgctattc gggagatgac gcatacgcca cggatgccat cttgaactcc
     4741 ccgtcctcct tagctgtggc tccggatggc accatctaca tcgcagacct cgggaatatc
     4801 cggatcaggg cggtcagcaa aaacaaacct gttcttaacg cgttcaacca gtatgaggct
     4861 gcgtctccgg gagaacagga actgtacgtg ttcaacgccg atggtatcca tcagtacacc
     4921 gtgagcctgg tgaccgggga gtacttatac aatttcacct acagcgctga caatgatgtc
     4981 accgagttga ttgacaacaa cgggaattcc ctaaagatcc gccgggacag cagtggcatg
     5041 ccccgacacc tgctcatgcc tgataatcag atcatcaccc ttacggtggg caccaacgga
     5101 ggcctcaaag ccgtgtcaac gcagaacctg gagctgggcc tcatgactta tgatgggaac
     5161 actggactcc tagccaccaa gagcgatgaa accggatgga caacttttta tgactatgac
     5221 cacgagggcc gtctgaccaa tgtgactcgc cccacggggg tggtgaccag cctgcaccgg
     5281 gaaatggaga aatccatcac cgttgacatt gagaactcca accgtgataa cgatgtcact
     5341 gtgattacca acctctcttc agtggaggcc tcctacaccg tggtacaaga tcaagtgcgg
     5401 aacagctacc agctctgcag caacgggacc ctgcgcgtca tgtacgccaa cggcatgggc
     5461 gtcagcttcc acagcgagcc ccacgtcctc gcaggcaccc tcacccccac catcgggcgc
     5521 tgtaacatct ccctgcccat ggagaacggc ctgaactcca tcgagtggcg cctgaggaag
     5581 gaacagatta aaggcaaagt caccatcttt gggaggaagc ttcgggtcca cggaaggaac
     5641 ctcctgtcca ttgattatga ccgaaatatc cgcactgaga agatctatga cgaccaccgg
     5701 aagttcaccc tgaggatcat ttatgaccag gtgggccgcc ccttcctgtg gctccccagc
     5761 agtggactgg cggccgtcaa tgtctcctac ttcttcaacg ggcgcctggc cggcctccag
     5821 cgcggggcca tgagcgagag gacagacatt gacaagcaag gccggattgt gtcccgaatg
     5881 ttcgccgacg ggaaagtctg gagctattcc taccttgaca agtccatggt cctcctgctg
     5941 cagagccagc gtcagtacat atttgaatat gactcctctg accgcctcca cgcagtcacc
     6001 atgcccagtg tcgcccggca cagcatgtcc acgcacacct ccattggcta catccggaac
     6061 atttacaacc caccggaaag caacgcctcg gtcatctttg actacagtga tgacggccgc
     6121 atcctgaaga cgtctttcct gggcaccggg cgccaggtgt tctataagta cggaaaactg
     6181 tccaagttat cggagatcgt ctacgacagc actgccgtca ccttcggcta tgacgagacc
     6241 actggcgtcc tgaagatggt gaatctccaa agcgggggct tctcctgtac catcaggtac
     6301 cgaaaggtcg ggcccctcgt ggacaagcag atttacaggt tctctgagga aggcatgatc
     6361 aacgccaggt tcgattacac ctaccacgac aacagcttcc gcatcgccag catcaagccc
     6421 gtcatcagtg agactcccct tcccgttgac ctctaccgct acgatgagat ttctggcaag
     6481 gtggaacact tcggcaagtt cggggtcatc tactacgaca tcaaccagat catcaccact
     6541 gccgtcatga cactcagcaa gcactttgac acccatgggc gcatcaagga agtgcagtat
     6601 gagatgttcc ggtccctcat gtactggatg acggtgcaat atgacagtat gggcagggtc
     6661 atcaagaggg aactgaaact ggggccctat gccaacacca caaagtacac ctatgactac
     6721 gacggggacg gccagctcca gagtgtggcc gtcaatgacc ggcctacctg gcgttatagc
     6781 tatgacctca atgggaacct gcacctgcta aacccaggaa acagtgctcg cctcatgccg
     6841 ttacgctatg acctccgtga ccggataacc aggctagggg acgtgcagta caaaatcgat
     6901 gatgatggct atttatgcca gagaggatct gacatctttg aatacaactc caagggcctt
     6961 ctaacgagag cgtacaacaa ggccagcggg tggagtgtgc agtaccgcta tgatggcgtg
     7021 agccgccggg cttcctacaa gaccaacctg ggccaccacc tacagtactt ctattccgac
     7081 ctccaccacc ccacacgtat cacccatgtt tacaaccact ccaactctga gatcacctca
     7141 ctctactatg acctccaggg ccacctcttt gccatggaga gcagtagtgg ggaagagtac
     7201 tatgttgcct cagataacac cgggactcct ctggctgttt ttagtatcaa tggcctcatg
     7261 atcaagcaac tccaatacac agcctatggg gagatttact atgactccaa tccagacttt
     7321 cagatggtca tcggcttcca cggaggcctc tacgaccccc tcaccaagct cgttcacttt
     7381 acgcagcgtg attatgacgt gctggcagga cggtggacgt cccccgacta caccatgtgg
     7441 aggaatgtgg gcaaggagcc agcccccttc aacctgtaca tgttcaagaa caacaatcca
     7501 ctcagtaatg agctggattt aaagaactac gtgacagacg tgaagagctg gctcgtgatg
     7561 tttggatttc agctcagcaa catcattcct ggattcccaa gagccaaaat gtattttgtg
     7621 cctcccccct atgaactgtc agagagccaa gcaagtgaga atggacagct cattacaggt
     7681 gtccagcaga caacagagag gcataaccag gcctttctgg ctctagaagg acaggtcatc
     7741 tctaaaaagc tccatgcagg catccgagag aaagcaggcc actggtttgc tacgaccacg
     7801 cccatcatcg gcaaaggcat catgttcgcc atcaaagaag ggcgggtgac cacaggcgtg
     7861 tctagcatcg ccagtgagga cagccgcaag gtagcatccg tgttgaacaa cgcctactac
     7921 ttggacaaga tgcactacag catcgagggc aaggacacac actacttcgt gaagatcggt
     7981 gcagcggacg gtgacctggt tacgctgggg accaccattg ggcgcaaggt gctggagagc
     8041 ggggtgaacg tgaccgtgtc acagcccacg ctgctggtga acggcaggac tcgaaggttc
     8101 accaacattg aattccagta ctccacgctg ctgctcagca tacgctacgg cctcaccccc
     8161 gacacactgg atgaagagaa ggcccgcgtc ctggaccaag cgcgacagag ggccctgggt
     8221 actgcctggg ccaaggagca gcagaaagcc agggacggga gagagggcag ccgtctgtgg
     8281 acggagggcg agaagcagca actcctgagc acgggacggg tgcaaggtta tgagggctat
     8341 tacgtgcttc cggtggaaca gtacccagag ctggcagaca gtagcagcaa catccagttc
     8401 ttaagacaga atgagatggg aaagaggtaa caaaataacc tgctgccacc tcttctctgg
     8461 gtggctcagc aggagcaact gtgacctcct ctcctaagga gacgaagacc taacaggggc
     8521 actgaggccg ggctgcttta ggaccccaag tggcaagaaa gctcacattt tttgagttca
     8581 aatgctactg tccaagcgca aagtccctca tcctgaagta gactagagct cggccacaaa
     8641 ttctgaggaa aacaaaacta aaggatgaac gaatgaacca acgaacgaa
//
