LOCUS       NM_001105737            4559 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Rattus norvegicus TEK receptor tyrosine kinase (Tek), mRNA.
ACCESSION   NM_001105737 XM_001054185 XM_001054314 XM_001054732 XM_342863
VERSION     NM_001105737.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4559)
  AUTHORS   Liu,J. and Jiang,R.
  TITLE     [A low androgen state impairs erectile function by suppressing the
            expression of Tie2 in rat penile cavernosa]
  JOURNAL   Zhonghua Nan Ke Xue 29 (8), 675-681 (2023)
   PUBMED   38619512
  REMARK    GeneRIF: [A low androgen state impairs erectile function by
            suppressing the expression of Tie2 in rat penile cavernosa].
REFERENCE   2  (bases 1 to 4559)
  AUTHORS   Hu,E., Hu,W., Yang,A., Zhou,H., Zhou,J., Luo,J., Wang,Y., Tang,T.
            and Cui,H.
  TITLE     Thrombin promotes pericyte coverage by Tie2 activation in a rat
            model of intracerebral hemorrhage
  JOURNAL   Brain Res 1708, 58-68 (2019)
   PUBMED   30527680
  REMARK    GeneRIF: Results demonstrated that thrombin promotes pericyte
            coverage on microvessels following ICH by enhancing activation of
            Tie2, in which the downstream PI3K/Akt signaling pathway might be
            involved.
REFERENCE   3  (bases 1 to 4559)
  AUTHORS   Liu,L., Jiang,Y. and Steinle,J.J.
  TITLE     Compound 49b Restores Retinal Thickness and Reduces Degenerate
            Capillaries in the Rat Retina following Ischemia/Reperfusion
  JOURNAL   PLoS One 11 (7), e0159532 (2016)
   PUBMED   27439004
  REMARK    GeneRIF: Hypoxia significantly increased protein levels of VEGF,
            KDR, Angiopoiein 1, and Tie2, which were reduced following Compound
            49b treatment. These data strongly suggested that Compound 49b
            protected the retina against I/R-induced injury. This provides
            additional support for a role of beta-adrenergic receptor actions
            in the retina.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4559)
  AUTHORS   Fang,Z., He,Q.W., Li,Q., Chen,X.L., Baral,S., Jin,H.J., Zhu,Y.Y.,
            Li,M., Xia,Y.P., Mao,L. and Hu,B.
  TITLE     MicroRNA-150 regulates blood-brain barrier permeability via Tie-2
            after permanent middle cerebral artery occlusion in rats
  JOURNAL   FASEB J 30 (6), 2097-2107 (2016)
   PUBMED   26887441
  REMARK    GeneRIF: These findings suggested that miR-150 could regulate
            claudin-5 expression and endothelial cell survival by targeting
            Tie-2, thus affecting the permeability of BBB after permanent
            middle cerebral artery occlusion in rats, and that miR-150 might be
            a potential alternative target for the treatment of stroke.
REFERENCE   5  (bases 1 to 4559)
  AUTHORS   Sato,H., Kasai,S. and Maesawa,C.
  TITLE     Temporal expression in rats of receptor tyrosine kinase Tie2 during
            early wound healing after tooth extraction
  JOURNAL   J Oral Sci 57 (4), 313-318 (2015)
   PUBMED   26666854
  REMARK    GeneRIF: Tie2 extracellular domain initially inhibited
            angiogenesis, and its degradation relieved inhibition of new vessel
            formation
REFERENCE   6  (bases 1 to 4559)
  AUTHORS   Vikkula,M., Boon,L.M., Carraway,K.L. 3rd, Calvert,J.T.,
            Diamonti,A.J., Goumnerov,B., Pasyk,K.A., Marchuk,D.A., Warman,M.L.,
            Cantley,L.C., Mulliken,J.B. and Olsen,B.R.
  TITLE     Vascular dysmorphogenesis caused by an activating mutation in the
            receptor tyrosine kinase TIE2
  JOURNAL   Cell 87 (7), 1181-1190 (1996)
   PUBMED   8980225
REFERENCE   7  (bases 1 to 4559)
  AUTHORS   Davis,S., Aldrich,T.H., Jones,P.F., Acheson,A., Compton,D.L.,
            Jain,V., Ryan,T.E., Bruno,J., Radziejewski,C., Maisonpierre,P.C.
            and Yancopoulos,G.D.
  TITLE     Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by
            secretion-trap expression cloning
  JOURNAL   Cell 87 (7), 1161-1169 (1996)
   PUBMED   8980223
REFERENCE   8  (bases 1 to 4559)
  AUTHORS   Sato,T.N., Tozawa,Y., Deutsch,U., Wolburg-Buchholz,K., Fujiwara,Y.,
            Gendron-Maguire,M., Gridley,T., Wolburg,H., Risau,W. and Qin,Y.
  TITLE     Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in
            blood vessel formation
  JOURNAL   Nature 376 (6535), 70-74 (1995)
   PUBMED   7596437
REFERENCE   9  (bases 1 to 4559)
  AUTHORS   Dumont,D.J., Gradwohl,G., Fong,G.H., Puri,M.C., Gertsenstein,M.,
            Auerbach,A. and Breitman,M.L.
  TITLE     Dominant-negative and targeted null mutations in the endothelial
            receptor tyrosine kinase, tek, reveal a critical role in
            vasculogenesis of the embryo
  JOURNAL   Genes Dev 8 (16), 1897-1909 (1994)
   PUBMED   7958865
REFERENCE   10 (bases 1 to 4559)
  AUTHORS   Runting,A.S., Stacker,S.A. and Wilks,A.F.
  TITLE     tie2, a putative protein tyrosine kinase from a new class of cell
            surface receptor
  JOURNAL   Growth Factors 9 (2), 99-105 (1993)
   PUBMED   8217221
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473998.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_342863.3, XM_001054732.1, XM_001054185.1, XM_001054314.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4559
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..4559
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /note="TEK receptor tyrosine kinase"
                     /db_xref="GeneID:89804"
                     /db_xref="RGD:620980"
     exon            1..380
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     CDS             329..3691
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /EC_number="2.7.10.1"
                     /note="tyrosine kinases that contain immunoglobulin-like
                     loops and epidermal growth factor-similar domains 2;
                     endothelial-specific receptor tyrosine kinase; TEK
                     tyrosine kinase, endothelial"
                     /codon_start=1
                     /product="angiopoietin-1 receptor precursor"
                     /protein_id="NP_001099207.1"
                     /db_xref="GeneID:89804"
                     /db_xref="RGD:620980"
                     /translation="MDSLAGLVLCGVSLLLYGLVEGAMDLILINSLPLVSDAETSLTC
                     IASGWHPHEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFC
                     EGRVRGQAIRIRTMKMRQQASFLPATLTMTVDRGDNVNISFKKVLIKEEDAVIYKNGS
                     FIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGP
                     DCNRPCTTCKNNGVCHEDTGECICPPGFMGRTCEKACEPHTFGRTCKERCSGSEGCKS
                     YVFCLPDPYGCSCATGWRGLQCNEACPYGHYGPDCKLRCHCTNEEMCDRFQGCLCSQG
                     WQGLQCEKEGRPRMTPQIEDLPDHIEVNSGKFNPICKASGWPLPTSEEMTLVKPDGTV
                     LQPNDFNHTDHFSVAIFTVNRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPEPLHA
                     PNVIDTGHNFAIINISSEPYFGDGPIKSKKLFYKPVNQAWKYIQVMNEIVTLNYLEPR
                     TDYELCVQLVRPGEGGEGHPGPVRRFTTASIGLPPPRGLSLLPKSQTALNLTWQPIFT
                     SSEDEFYVEVERWSQQTRSDQQNIKVPGNLTSVLLNNLLPREQYSVRARVNTKAQGEW
                     SEELRAWTLSDILPPQPENIKITNITDYTALVSWTIVDGYSISSIIIRYKVQGKNEDQ
                     HIDVKIKNATITQYQLKGLEPETTYHVDIFAENNIGSSNPAFSQEIRTLPAPKDLGGG
                     KMLLIAILGSAGMTCITVLLAFLIMLQLKRANVQRRMAQAFQNVREEPAVQFNSGTLA
                     LNRKAKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEY
                     ASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSR
                     VLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENY
                     IAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSL
                     GGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL
                     NRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA"
     exon            381..692
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            693..803
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            804..956
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1088
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1229
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1358
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1510
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1655
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1811
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1946
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2234
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2525
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2680
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2891
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..3002
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3193
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            3194..3307
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            3308..3378
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            3379..3419
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            3420..3516
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            3517..3616
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
     exon            3617..4559
                     /gene="Tek"
                     /gene_synonym="Tie-2; Tie2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcaggagc agataagcgt ttggatgaag ggcaagatgg atagggctca ctctgcccca
       61 agccctgctg ataccaagtg cctttaagat acagcctttc gcatcctaat ctacaaagga
      121 aacaggaaaa aggaacttaa aactccctgt gctcagacag aaatgagact gttaccgcct
      181 gcttctgtgg tgttcctcct tgcctccaac ttgtaaacaa gagcgagtag accatgcgag
      241 tgggaagtgg caaagttgtg gggttttgaa aggctcccgg ggacctcatg ctcatctgtg
      301 gacgctggat ggggagatct ggggaagtat ggactcttta gccggcttag ttctctgtgg
      361 agtcagcttg ctcctttatg gactagtaga aggagccatg gacctgatct tgatcaattc
      421 cctacctctt gtgtctgatg ccgaaacatc cctcacctgc attgcttctg ggtggcaccc
      481 ccacgagccc atcaccatag gaagggactt tgaagcctta atgaaccagc accaagatcc
      541 actggaagtt actcaagatg tgaccagaga atgggcgaaa aaggttgttt ggaagagaga
      601 aaaggccagt aagattaatg gtgcttattt ctgtgaaggt cgagttcgag gacaggctat
      661 aaggatacga accatgaaga tgcgtcaaca agcttccttt ctacctgcta ctctaactat
      721 gaccgtggac aggggagata atgtgaacat atccttcaaa aaggtgttaa ttaaagaaga
      781 agatgcagtg atttacaaaa atggttcctt cattcattca gtgccccggc atgaagttcc
      841 tgatatttta gaagtgcatc tgcctcacgc tcagccccag gatgctggtg tgtactcggc
      901 caggtacata ggaggaaacc tgttcacctc ggccttcacc aggctgattg tccggagatg
      961 tgaagctcag aagtggggac ccgactgtaa ccgtccttgt actacttgca agaacaatgg
     1021 tgtctgccat gaagatactg gggagtgcat ttgccctcct gggtttatgg ggaggacatg
     1081 tgaaaaggct tgtgagccac acacatttgg caggacctgt aaggaacggt gtagtggatc
     1141 agagggatgc aagtcatatg tgttctgtct gccagacccc tatgggtgtt cctgtgccac
     1201 aggctggagg gggctgcagt gcaatgaagc atgtccatac ggtcactatg ggccagactg
     1261 taagctcagg tgccactgta ccaatgaaga gatgtgtgac cgcttccaag gatgcctctg
     1321 ctctcaagga tggcaagggc tgcagtgtga gaaagaaggc aggccaagga tgactccaca
     1381 gatagaggat ttgccagatc acatagaagt aaacagtggg aaatttaacc cgatctgcaa
     1441 ggcctctggc tggccactac ctactagtga agaaatgacc ctggtgaagc cggatgggac
     1501 agtgctccaa ccaaatgact tcaaccatac agatcatttc tcagtggcca tattcactgt
     1561 caaccggatc ttacctcctg actcaggagt ttgggtctgc agtgtgaaca cagtggctgg
     1621 gatggtggaa aagcctttca acatttctgt caaagttctt ccagagcccc tgcatgcccc
     1681 aaatgttatt gacactggac acaactttgc tatcatcaac atcagctctg agccttactt
     1741 tggggatgga ccgatcaaat ccaagaagct cttctataaa cctgtcaatc aggcttggaa
     1801 atacattcaa gtgatgaatg agattgtcac actcaactac ctggagcctc ggactgacta
     1861 cgagctgtgt gtacagctgg tccgtcctgg agagggtgga gaaggacatc ctggacctgt
     1921 gagaagattc acaacagcgt ctatcggact ccctcctcca agaggtctca gtctcctacc
     1981 caaaagccag acagctctga atttgacttg gcaaccgata tttacaagct cagaagatga
     2041 attttatgtg gaagttgaga ggtggtccca gcaaacaaga agtgatcagc agaacatcaa
     2101 agtgcctggg aacctgactt ccgtgctgct gaacaactta ctccccaggg agcagtacag
     2161 cgtccgagct agagtcaaca ccaaggccca gggggagtgg agtgaagaac tcagggcctg
     2221 gacccttagt gacattctcc ctcctcagcc agaaaacatc aagatcacca acatcactga
     2281 ttacacagct ctggtttctt ggacaatcgt ggacggctat tcgatttctt ccatcatcat
     2341 ccggtataag gttcagggca aaaatgaaga ccagcacatt gacgtgaaga tcaagaatgc
     2401 caccatcact caataccagc tcaagggcct agagccagag actacatacc atgtggatat
     2461 ttttgctgag aacaacatag gatcaagcaa cccagccttt tcccaagaaa ttaggacact
     2521 tccagcccct aaagaccttg gagggggaaa gatgctactt atagccattc ttgggtcggc
     2581 tggaatgact tgcatcaccg tgctattggc gtttctgatt atgttgcaac tgaagagagc
     2641 aaatgtccaa agaagaatgg cccaggcctt ccagaacgtg agagaagaac cagctgttca
     2701 gttcaactca ggaactctgg ccctaaacag gaaggccaaa aacaatccgg atcccacaat
     2761 ttatcctgtg cttgactgga atgacatcaa gttccaagat gtgattggag agggcaactt
     2821 tggccaggtt ctgaaggcgc gcatcaagaa ggatgggtta cggatggacg ctgccatcaa
     2881 gaggatgaaa gaatatgcct ccaaagatga tcacagggac tttgcaggag aactggaggt
     2941 tctttgtaaa cttggacacc atccgaacat cattaatctc ttgggagcat gtgaacacag
     3001 aggctactta tacctggcta ttgagtatgc cccacatgga aacctcctgg actttctgcg
     3061 taagagccga gtgctagaga cagaccctgc ctttgccatc gccaacagca cggcttccac
     3121 actgtcctcc cagcagcttc ttcattttgc tgcagatgtg gcccggggga tggactactt
     3181 gagccaaaaa cagtttatcc acagggacct ggctgccaga aacattttag ttggcgaaaa
     3241 ctacatagcc aaaatagcag attttggatt gtcacgaggt caagaagtgt atgtgaaaaa
     3301 gacaatggga aggctcccag tgcgctggat ggcaattgag tctctgaact atagtgtcta
     3361 tacaaccaac agtgatgtat ggtcctatgg tgtattgctc tgggagatcg ttagcttagg
     3421 aggcactcca tactgcggca tgacatgtgc agaactctat gagaagctgc cccagggcta
     3481 cagattggag aagcccctga actgtgatga tgaggtgtat gatctaatga gacaatgctg
     3541 gagggagaag ccttatgaga gaccatcatt tgcccagata ttggtgtcct taaacagaat
     3601 gctggaagaa cgaaagacat acgtgaacac cacactttat gagaagttta cctacgcagg
     3661 aattgactgt tctgctgaag aagcagccta gggcagaatc cttcctgcat gattgccatt
     3721 tctcttcact ggcacgagag cgccttgaca cctgttctaa gcaagcaacc cactgccaag
     3781 agatgtgata tagaagtgta tatattgtgc tatgtgtttg ggaccctcat catatagctc
     3841 tcatggatct gtagtatgtt ctgactctaa tatgactgta tatactgttt ggagtaagaa
     3901 tgtgctaaga tcagaatgcc tgcttgtggt ttcatataat atatttttct aaaaacatgg
     3961 attgcccagg aaggtgtgag tacaaatact gtaatgcaga acttgttgtc ttagatattt
     4021 ttgatatttt ccttcataac tgaatgttat aaaagtgttt tgctgtttat acataagata
     4081 ctgttcatta accattccct tgacagcaca ggaagaaaag cgagggaact gtacgaattg
     4141 tgttagaatg tgggttacta cacaagagca gcagggaaga gggtctctca attctgctcc
     4201 tcacctacag aagacagttt gtcctgtgtt tctacagcat ccaaatcatt ccaaaatgtt
     4261 aacatctaaa aaatttctga gagatataag gtcaaaaaac aaattggtgg gacttacatt
     4321 ttgtttctct agtaatctgt tgtatatttt aagaagtaaa actaggaatt taggagcaac
     4381 gtgtgacatt tgtgacatgg agttaccatc cccacatgta tcgcacactg tcatattccc
     4441 acatgtatca cacagtgtaa aagtttgtag ttttgatcac ttgtgaattt attgttgatg
     4501 cggtagccac ccactgcaat ggttcctcct gtagatgaat aaatgtcttg tctacccac
//
