LOCUS       NM_001108860            1394 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus trans-2,3-enoyl-CoA reductase-like (Tecrl), mRNA.
ACCESSION   NM_001108860 XM_001065402 XM_344227
VERSION     NM_001108860.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1394)
  AUTHORS   Devalla HD, Gelinas R, Aburawi EH, Beqqali A, Goyette P, Freund C,
            Chaix MA, Tadros R, Jiang H, Le Bechec A, Monshouwer-Kloots JJ,
            Zwetsloot T, Kosmidis G, Latour F, Alikashani A, Hoekstra M,
            Schlaepfer J, Mummery CL, Stevenson B, Kutalik Z, de Vries AA,
            Rivard L, Wilde AA, Talajic M, Verkerk AO, Al-Gazali L, Rioux JD,
            Bhuiyan ZA and Passier R.
  TITLE     TECRL, a new life-threatening inherited arrhythmia gene associated
            with overlapping clinical features of both LQTS and CPVT
  JOURNAL   EMBO Mol Med 8 (12), 1390-1408 (2016)
   PUBMED   27861123
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473981.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_344227.3, XM_001065402.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1394
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p21"
     gene            1..1394
                     /gene="Tecrl"
                     /gene_synonym="Srd5a2l2"
                     /note="trans-2,3-enoyl-CoA reductase-like"
                     /db_xref="GeneID:364134"
                     /db_xref="RGD:1304608"
     exon            1..424
                     /gene="Tecrl"
                     /gene_synonym="Srd5a2l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1282
                     /gene="Tecrl"
                     /gene_synonym="Srd5a2l2"
                     /note="steroid 5 alpha-reductase 2-like 2"
                     /codon_start=1
                     /product="trans-2,3-enoyl-CoA reductase-like"
                     /protein_id="NP_001102330.1"
                     /db_xref="GeneID:364134"
                     /db_xref="RGD:1304608"
                     /translation="MFKRHKSLERKRELLFQGLPQFTMKNNTRNFHSLSQLVLSAGPL
                     KTTTAVKHSKTTHFEIEILDAHTRKQICIVDKVTQTSTIYDVKQKFHKACPKWYPSRI
                     GLQLEYGGPYLKDYITIQSVAASSIITLYFTDLGQQVGWTTVFLAEYSGPLLIYLLFY
                     LRSSYIYDVKESFRWPRHTVVHLACFCHCIHYIRLLLETLFVHKVSTGHSPMKNLIKG
                     CAFYWGFTSWMAYYINHPRYTPPSFGNRQIIVSAINFLMCEAGNHFINTVLAHPSHTG
                     SNACFPSPTYNPFTWMFFLVSCPNYTYEIGTWISFTIMTQTLPVGIFTMLMTIQMSLW
                     ARKKHKIYRKKFNSYVHRKSAIIPFIL"
     exon            425..476
                     /gene="Tecrl"
                     /gene_synonym="Srd5a2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            477..521
                     /gene="Tecrl"
                     /gene_synonym="Srd5a2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            522..625
                     /gene="Tecrl"
                     /gene_synonym="Srd5a2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            626..741
                     /gene="Tecrl"
                     /gene_synonym="Srd5a2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            742..847
                     /gene="Tecrl"
                     /gene_synonym="Srd5a2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            848..920
                     /gene="Tecrl"
                     /gene_synonym="Srd5a2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            921..964
                     /gene="Tecrl"
                     /gene_synonym="Srd5a2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1022
                     /gene="Tecrl"
                     /gene_synonym="Srd5a2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1108
                     /gene="Tecrl"
                     /gene_synonym="Srd5a2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1154
                     /gene="Tecrl"
                     /gene_synonym="Srd5a2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1394
                     /gene="Tecrl"
                     /gene_synonym="Srd5a2l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcagcagtt ctcaatagtg ttatatatag aaatcagatc agacattgtt ttctagcctg
       61 ctaaataaaa ctagaccgct ggaatggcat gccacttgac ctccagggcg tccacagcag
      121 tatttaacag gcgcaacggg aggactcgtg caagtgtctc ctgtttacat gccagattcc
      181 cctgctagtt cacaaaatgt tcaaaaggca caagtccctg gaacgcaaga gggaattatt
      241 attccaggga cttccacagt tcacaatgaa gaataataca agaaatttcc actccttgtc
      301 acaacttgta ctctcagcag gcccgctaaa aactactaca gcagtcaaac attcaaaaac
      361 gactcacttt gagatcgaaa tactggatgc tcatacaaga aaacagatat gtattgtgga
      421 taaggtaaca caaacgtcaa ctatttatga tgtcaaacag aagtttcaca aagcatgtcc
      481 aaagtggtac ccttctcgaa ttggcctaca actagaatat ggtggtccgt acttgaagga
      541 ttatatcacg attcaaagtg ttgcagcttc ttcaattatc acactctatt ttacagactt
      601 gggtcagcaa gttggttgga ccacagtctt tttggctgaa tactcaggac ctctgttaat
      661 ataccttctt ttttatttga ggagctcata catatatgat gtcaaagaga gctttagatg
      721 gccccgacac actgtggtac acttggcttg tttctgccac tgtatccact acatccgact
      781 ccttctggaa actttatttg ttcacaaagt ttctacagga catagtccta tgaaaaactt
      841 gataaagggt tgtgcatttt attggggatt cacttcttgg atggcttatt atattaatca
      901 cccaagatat acgccaccat catttggaaa caggcaaata atagtgtctg ctatcaattt
      961 tttgatgtgt gaagctggaa atcatttcat caatacagtg ttggctcatc ccagtcacac
     1021 agggagcaat gcttgtttcc cgagtccaac ttataacccc ttcacatgga tgtttttcct
     1081 ggtttcctgt cctaactaca cctatgagat cggaacctgg attagtttca ctatcatgac
     1141 ccagacactt ccagttggta tttttacaat gttaatgacc atccagatgt ctttgtgggc
     1201 acgaaagaag cataagatat atcggaagaa attcaactca tacgttcata ggaaatcagc
     1261 cataattcca ttcatattat aagtaaatat agctatgctc atctgagcaa gaggtacagc
     1321 atatcaattc attcaaaaga attagaaaat agtgattaga tatcataatt aatgaataaa
     1381 aatattttaa taac
//
