LOCUS       NM_001398681            1178 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus trans-2,3-enoyl-CoA reductase (Tecr), transcript
            variant 4, mRNA.
ACCESSION   NM_001398681 XM_039097453
VERSION     NM_001398681.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1178)
  AUTHORS   Wakashima,T., Abe,K. and Kihara,A.
  TITLE     Dual functions of the trans-2-enoyl-CoA reductase TER in the
            sphingosine 1-phosphate metabolic pathway and in fatty acid
            elongation
  JOURNAL   J Biol Chem 289 (36), 24736-24748 (2014)
   PUBMED   25049234
REFERENCE   2  (bases 1 to 1178)
  AUTHORS   Abe,K., Ohno,Y., Sassa,T., Taguchi,R., Caliskan,M., Ober,C. and
            Kihara,A.
  TITLE     Mutation for nonsyndromic mental retardation in the
            trans-2-enoyl-CoA reductase TER gene involved in fatty acid
            elongation impairs the enzyme activity and stability, leading to
            change in sphingolipid profile
  JOURNAL   J Biol Chem 288 (51), 36741-36749 (2013)
   PUBMED   24220030
REFERENCE   3  (bases 1 to 1178)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 1178)
  AUTHORS   Dai,C., Liang,D., Li,H., Sasaki,M., Dawson,T.M. and Dawson,V.L.
  TITLE     Functional identification of neuroprotective molecules
  JOURNAL   PLoS One 5 (11), e15008 (2010)
   PUBMED   21124846
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1178)
  AUTHORS   Moon,Y.A. and Horton,J.D.
  TITLE     Identification of two mammalian reductases involved in the
            two-carbon fatty acyl elongation cascade
  JOURNAL   J Biol Chem 278 (9), 7335-7343 (2003)
   PUBMED   12482854
REFERENCE   6  (bases 1 to 1178)
  AUTHORS   Johnston,I.G., Rush,S.J., Gurd,J.W. and Brown,I.R.
  TITLE     Molecular cloning of a novel mRNA using an antibody directed
            against synaptic glycoproteins
  JOURNAL   J Neurosci Res 32 (2), 159-166 (1992)
   PUBMED   1404491
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Dec 21, 2021 this sequence version replaced XM_039097453.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ215654.1, SRR26360194.563254.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               JAXUCZ010000019.1  41469902-41470111
            211-262             JAXUCZ010000019.1  41470664-41470715
            263-307             JAXUCZ010000019.1  41471126-41471170
            308-411             JAXUCZ010000019.1  41471258-41471361
            412-527             JAXUCZ010000019.1  41471438-41471553
            528-633             JAXUCZ010000019.1  41471646-41471751
            634-706             JAXUCZ010000019.1  41471832-41471904
            707-750             JAXUCZ010000019.1  41471993-41472036
            751-808             JAXUCZ010000019.1  41472132-41472189
            809-897             JAXUCZ010000019.1  41472273-41472361
            898-943             JAXUCZ010000019.1  41472523-41472568
            944-1178            JAXUCZ010000019.1  41472646-41472880
FEATURES             Location/Qualifiers
     source          1..1178
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..1178
                     /gene="Tecr"
                     /gene_synonym="Gpsn2; SC2"
                     /note="trans-2,3-enoyl-CoA reductase"
                     /db_xref="GeneID:191576"
                     /db_xref="RGD:620376"
     exon            1..210
                     /gene="Tecr"
                     /gene_synonym="Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1071
                     /gene="Tecr"
                     /gene_synonym="Gpsn2; SC2"
                     /EC_number="1.3.1.93"
                     /note="isoform 4 is encoded by transcript variant 4;
                     neuroprotective protein 13; TER; glycoprotein, synaptic 2;
                     synaptic glycoprotein SC2; very-long-chain enoyl-CoA
                     reductase"
                     /codon_start=1
                     /product="very-long-chain enoyl-CoA reductase isoform 4"
                     /protein_id="NP_001385610.1"
                     /db_xref="GeneID:191576"
                     /db_xref="RGD:620376"
                     /translation="MDISLSMAAKEAHQGLDGLPMPMPHKAAKKHKKAVLFFEVEIRD
                     AKTREKLCFLDKVEPQATISEIKTLFTKTHPQWYPARQSLRLDPKGKSLKDEDVLQKL
                     PVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGRKYDFTSSRHTV
                     VHLACMCHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLY
                     TPPTYGVQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLL
                     VSCPNYTYEVGSWIGFAIMTQCVPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLR
                     MPIIPFLL"
     exon            211..262
                     /gene="Tecr"
                     /gene_synonym="Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     exon            263..307
                     /gene="Tecr"
                     /gene_synonym="Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     exon            308..411
                     /gene="Tecr"
                     /gene_synonym="Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     exon            412..527
                     /gene="Tecr"
                     /gene_synonym="Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     exon            528..633
                     /gene="Tecr"
                     /gene_synonym="Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     exon            634..706
                     /gene="Tecr"
                     /gene_synonym="Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     exon            707..750
                     /gene="Tecr"
                     /gene_synonym="Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     exon            751..808
                     /gene="Tecr"
                     /gene_synonym="Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..897
                     /gene="Tecr"
                     /gene_synonym="Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     exon            898..943
                     /gene="Tecr"
                     /gene_synonym="Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1178
                     /gene="Tecr"
                     /gene_synonym="Gpsn2; SC2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcactgcagc caggaaggca gagcaggagg gctggcggtg gcatggatat aagcttgagc
       61 atggcagcca aagaggccca ccaaggcctc gatggccttc ccatgcccat gccccacaaa
      121 gcagccaaga agcataaaaa ggcggttctc ttcttcgagg tggagattcg ggatgcaaag
      181 acgagggaga agctgtgctt cctggacaag gtagagcctc aggccaccat ttctgaaatc
      241 aagacccttt tcaccaagac acacccgcag tggtatcctg cccgccagtc cctccgcctg
      301 gaccccaagg ggaagtccct gaaagatgaa gatgtgttgc agaagcttcc tgtgggcacc
      361 acagctacgc tctacttccg ggacctcggg gcccagatca gctgggtgac ggtcttcctg
      421 acggagtatg ctgggcccct tttcatctac ctgctcttct acttccgggt gcccttcatt
      481 tatggccgca aatacgactt tacatccagt cggcatactg tggtgcacct cgcctgcatg
      541 tgccactcct tccactacat caagcgcctg ctggagactc tcttcgtgca ccgattctct
      601 cacggaacca tgcccctgcg aaacatcttc aaaaactgca cctactactg gggctttgct
      661 gcgtggatgg cttattacat caaccaccct ctctacacac cccctaccta tggagttcag
      721 caggttaagc tggcactggc catttttgtg atctgtcagc ttgggaactt ctctatccac
      781 atggctctcc gggatcttcg accagcgggg tcgaaaacca ggaagatccc ataccccacc
      841 aagaacccct tcacctggct gtttctgttg gtgtcctgtc ccaactacac ttacgaggtc
      901 ggctcctgga ttggctttgc cattatgaca cagtgtgtcc cagtggccct cttctccctg
      961 gtgggcttca cccagatgac tatctgggcc aagggcaagc atcgcagcta cctgaaggag
     1021 ttccgtgact acccacccct gcgcatgccc ataatcccct tcctgctctg agcagctcct
     1081 cccgagctca gcccagtaat gccctccacc tactacccct gtcctgatgt ggctggccaa
     1141 ggctctccag cagcaacaat aaaacctgct tacccaaa
//
