LOCUS       NM_053432               2646 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus tec protein tyrosine kinase (Tec), mRNA.
ACCESSION   NM_053432 XM_001069086 XM_001069141 XM_001069188 XM_001069237
            XM_341208
VERSION     NM_053432.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2646)
  AUTHORS   Liang,Y., Cucchetti,M., Roncagalli,R., Yokosuka,T., Malzac,A.,
            Bertosio,E., Imbert,J., Nijman,I.J., Suchanek,M., Saito,T.,
            Wulfing,C., Malissen,B. and Malissen,M.
  TITLE     The lymphoid lineage-specific actin-uncapping protein Rltpr is
            essential for costimulation via CD28 and the development of
            regulatory T cells
  JOURNAL   Nat Immunol 14 (8), 858-866 (2013)
   PUBMED   23793062
REFERENCE   2  (bases 1 to 2646)
  AUTHORS   Li,F., Jiang,Y., Zheng,Q., Yang,X. and Wang,S.
  TITLE     TEC protein tyrosine kinase is involved in the Erk signaling
            pathway induced by HGF
  JOURNAL   Biochem Biophys Res Commun 404 (1), 79-85 (2011)
   PUBMED   21094130
  REMARK    GeneRIF: TEC promotes hepatocyte proliferation and regeneration and
            is involved in Hepatocyte Growth Factor-induced Erk signaling
            pathway.
REFERENCE   3  (bases 1 to 2646)
  AUTHORS   Xu,W., Wang,S., Wang,G., Wei,H., He,F. and Yang,X.
  TITLE     Identification and characterization of differentially expressed
            genes in the early response phase during liver regeneration
  JOURNAL   Biochem Biophys Res Commun 278 (2), 318-325 (2000)
   PUBMED   11097837
REFERENCE   4  (bases 1 to 2646)
  AUTHORS   Ohya,K., Kajigaya,S., Kitanaka,A., Yoshida,K., Miyazato,A.,
            Yamashita,Y., Yamanaka,T., Ikeda,U., Shimada,K., Ozawa,K. and
            Mano,H.
  TITLE     Molecular cloning of a docking protein, BRDG1, that acts downstream
            of the Tec tyrosine kinase
  JOURNAL   Proc Natl Acad Sci U S A 96 (21), 11976-11981 (1999)
   PUBMED   10518561
REFERENCE   5  (bases 1 to 2646)
  AUTHORS   Hamazaki,Y., Kojima,H., Mano,H., Nagata,Y., Todokoro,K., Abe,T. and
            Nagasawa,T.
  TITLE     Tec is involved in G protein-coupled receptor- and
            integrin-mediated signalings in human blood platelets
  JOURNAL   Oncogene 16 (21), 2773-2779 (1998)
   PUBMED   9652744
REFERENCE   6  (bases 1 to 2646)
  AUTHORS   Laffargue,M., Monnereau,L., Tuech,J., Ragab,A., Ragab-Thomas,J.,
            Payrastre,B., Raynal,P. and Chap,H.
  TITLE     Integrin-dependent tyrosine phoshorylation and cytoskeletal
            translocation of Tec in thrombin-activated platelets
  JOURNAL   Biochem Biophys Res Commun 238 (1), 247-251 (1997)
   PUBMED   9299487
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166730.1.
            
            On or before Aug 28, 2008 this sequence version replaced
            XM_001069237.1, XM_001069141.1, XM_001069188.1, XM_001069086.1,
            XM_341208.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166730.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2646
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..2646
                     /gene="Tec"
                     /note="tec protein tyrosine kinase"
                     /db_xref="GeneID:84492"
                     /db_xref="RGD:620973"
     exon            1..54
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            55..128
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            129..313
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..2065
                     /gene="Tec"
                     /EC_number="2.7.10.1"
                     /note="cytoplasmic tyrosine kinase, Dscr28C related"
                     /codon_start=1
                     /product="tyrosine-protein kinase Tec"
                     /protein_id="NP_445884.1"
                     /db_xref="GeneID:84492"
                     /db_xref="RGD:620973"
                     /translation="MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSVLTYYEGR
                     AEKKYRKGFIDISKIKCVEIVKNDDGIIPCQNKFPFQVVHDANTLYIFAPSPQSRDRW
                     VKKLKEEIKNNNNIMIKYHPKFWADGSYQCCRQTEKLAPGCEKYNLFESSIRKTLPPA
                     PEIKRRPPPPIPPEEENTEEIVVAMYDFQATEAHDLRLERGQEYIILEKNDTHWWRAR
                     DKYGSEGYIPSNYVTGKKSNNLDQYEWYCRNTNRSKAEQLLRTEDKEGGFMVRDSSQP
                     GLYTVSLYTKFGGEGSSGFRHYHIKETATSPKKYYLAEKHAFGSIPEIIEYHKHNAAG
                     LVTRLRYPVSTKGKNAPTTAGFSYDKWEINPSELTFMRELGSGLFGVVRLGKWRAQYK
                     VAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLN
                     FLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKVSDFGM
                     ARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPFEK
                     NTNYEVVTMVTRGHRLPRPKLASKYLYEVMLRCWQERPEGRPSFEDLLRTIDELVECE
                     ETFGR"
     exon            314..418
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            419..500
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            501..629
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            630..667
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            668..840
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            841..906
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            907..961
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1041
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1175
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1250
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1422
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1639
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1704
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1823
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1981
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2618
                     /gene="Tec"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcagtttg gcccgcgctg tctcctgtcc tgtgtcagca cgcgctcggt caaggtgtca
       61 catgacactg aggatgtctg aagaatgaag tgatggaact ttgaagaccg agtcaacggg
      121 cagaagggaa tcccaggatc ttcaatggca ggagaaagag caacagaaga ccgagatgaa
      181 ttttaacact atcctagaag agattcttat taaaaggtcc cagcagaaaa agaagacatc
      241 acccttaaac tacaaagaga gactttttgt acttacaaaa tccgtgttaa cctactatga
      301 gggtcgagcg gagaaaaaat acagaaaggg attcattgat atttcaaaaa tcaagtgtgt
      361 ggagatagtg aagaacgacg atgggatcat tccctgtcaa aataaatttc cattccaggt
      421 tgttcacgat gctaacacac tttatatttt tgcacctagt ccacaaagca gggaccggtg
      481 ggtgaagaag ttaaaagaag agataaagaa caacaataat atcatgatta aatatcatcc
      541 taaattttgg gctgacggaa gttaccagtg ctgtagacaa acggaaaaac tggcgcctgg
      601 atgtgaaaag tacaatcttt ttgagagtag tataagaaag accctgcctc ctgcaccgga
      661 aataaagaga aggcctcctc caccaatccc tccagaggaa gaaaatactg aagaaatagt
      721 tgtagcgatg tatgacttcc aagcaacaga agcacatgac ctcaggttag agagaggcca
      781 agagtatatc atcctcgaaa agaatgacac ccattggtgg agagcaagag ataagtatgg
      841 gagtgaagga tatatcccaa gtaattatgt cacaggaaag aagtccaaca acttagatca
      901 atatgagtgg tattgccgaa acaccaacag aagcaaagca gagcagctcc tccggacaga
      961 agacaaggaa gggggtttta tggtgagaga ctccagtcaa ccaggcttgt acacagtctc
     1021 cctttacaca aagttcgggg gagaaggctc atcaggcttc aggcattatc acataaagga
     1081 aacagcaaca tccccaaaga agtattacct ggcagaaaag catgcttttg ggtccattcc
     1141 tgagatcatt gagtatcaca agcacaacgc agcaggactt gtcaccaggc tgaggtaccc
     1201 ggttagtaca aaggggaaga acgcgcccac tactgctggc ttcagctatg ataagtggga
     1261 gattaacccc tcagagctga cctttatgag ggagttgggg agtggactct ttggagtggt
     1321 gaggcttggc aagtggcggg cccagtacaa agtagccatc aaagctatcc gggaaggcgc
     1381 catgtgtgaa gaggatttca tagaggaagc taaagtcatg atgaagctga cacaccccaa
     1441 gctggtacag ctctacggcg tgtgcaccca gcagaagccc atttacatcg ttaccgagtt
     1501 catggaacgg ggctgccttc tgaatttcct ccggcagaga caaggccatt tcagcagaga
     1561 tgtcctgctg agcatgtgcc aggatgtgtg tgaagggatg gagtacctgg agagaaacag
     1621 cttcatccac agagacttgg ctgctagaaa ttgtctagtg aatgaagcag gagttgtcaa
     1681 agtatctgat ttcggaatgg ccaggtacgt cctggacgat cagtacacaa gttcctctgg
     1741 tgccaagttc cctgtgaagt ggtgtccccc agaagtgttt aattacagcc gctttagcag
     1801 caagtcagac gtctggtcat tcggtgtgct aatgtgggag atattcacag aaggcaggat
     1861 gccctttgag aagaacacca attacgaagt ggtaaccatg gttactcgag gtcaccgact
     1921 tccccggcca aagttggctt ccaaatattt gtatgaggtg atgctgaggt gctggcaaga
     1981 gagaccagag ggaaggcctt cgtttgaaga cttgctacgt acgatagatg aactagtcga
     2041 atgcgaagaa acttttggaa gataaacggc ggccccagtt tccaaggcaa gaggaagaaa
     2101 cggcgtgcca ttggaacgag actcccttgg tgcttgggaa tagagactgc tctgctcaca
     2161 gtgtggaagc tggaaagcgt ccgctcctga tccagcctca gctacgtggc tgctttgcag
     2221 gatgcacaga tggtctctta gagctgggga cttgaagcac tcattttgct catcccttca
     2281 agagtttgag caccagccat gcaccaggca ctgtgcccag gcctcgggag atgagcatgg
     2341 gtctgtgcta gctggcgcta gtagaaagcc agggtgttcg agatgagaag gagccatgcc
     2401 ccaacattct tctgtgccct ttggcttcta ataaaatggg cctggggtgt tgtctaccgc
     2461 cgagttctag gtaaagcagg aacccacctc gacaagtagt aatcctttgt tttgaaaaca
     2521 tctctttcca aacctgttct tagtagtacg tttaaaaatt tgtatactgt atatattgta
     2581 aatgcatata atatataaag ttatatattt ataagtaaaa aaaaaaaaaa aaaaaaaaaa
     2641 aaaaaa
//
