LOCUS       NM_001134740            3303 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus tudor domain containing 5 (Tdrd5), mRNA.
ACCESSION   NM_001134740
VERSION     NM_001134740.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3303)
  AUTHORS   Pek,J.W., Anand,A. and Kai,T.
  TITLE     Tudor domain proteins in development
  JOURNAL   Development 139 (13), 2255-2266 (2012)
   PUBMED   22669818
  REMARK    Review article
REFERENCE   2  (bases 1 to 3303)
  AUTHORS   Yabuta,Y., Ohta,H., Abe,T., Kurimoto,K., Chuma,S. and Saitou,M.
  TITLE     TDRD5 is required for retrotransposon silencing, chromatoid body
            assembly, and spermiogenesis in mice
  JOURNAL   J Cell Biol 192 (5), 781-795 (2011)
   PUBMED   21383078
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC168218.1.
            
            Summary: This gene encodes a member of the tudor domain-containing
            protein family. Tudor domain-containing proteins regulate a variety
            of processes including RNA metabolism, histone modification, and
            the DNA damage response. The tudor domain commonly functions to
            link methylated arginine or lysine marks to downstream effector
            proteins. In mouse, this gene is expressed in the primordial germ
            cells and in male germ cells during embryogenesis. In addition, it
            is expressed in adult testis cells where the protein is a component
            of the intermitochondrial cement and chromatoid bodies.
            Loss-of-function mutations in mouse result in arrest of
            spermatogenesis. [provided by RefSeq, Mar 2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3303              BC168218.1         1-3303
FEATURES             Location/Qualifiers
     source          1..3303
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..3303
                     /gene="Tdrd5"
                     /note="tudor domain containing 5"
                     /db_xref="GeneID:289129"
                     /db_xref="RGD:1307078"
     exon            1..234
                     /gene="Tdrd5"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..2990
                     /gene="Tdrd5"
                     /codon_start=1
                     /product="tudor domain-containing protein 5"
                     /protein_id="NP_001128212.1"
                     /db_xref="GeneID:289129"
                     /db_xref="RGD:1307078"
                     /translation="MSEQERIQDCLRKEIRSLLISTKDGLTPQQLEKEYLLMVGNHLP
                     LRILGYRSTMELVLDMPDVVSVCPCGDGTVILKAIPDESTKGIASLVAKQRRSHKVRN
                     SMQKGRSSVCSGRVPYRGRVPPILPAVVKSELKDLLALSPVLLSDFEKAFARRFGRSF
                     QYMQYGFLSMFEVLSAASDVICVEQTRAGSLLTLKKSASEEKQREWPAGKIFTQPFRM
                     KQQGSYSTGFPVTKTRFSQPISNMEPPKQVLSMEKIPMFNTVEASRLSHTEKLNQLES
                     TFKSVIAQIGPGGTVDPDLKHKIKFVVSKFPQGLFISKLLGEFELVFKEQLSPKQLGF
                     LNVTELVGALSDILRVEFSEEKQDLLVFDADLRPLLPAGPLSSVRNSCLVQPDKRIEA
                     NAWASSPSRNSLSTVAVKKTTWDCPLKNHKEAEQKAYKKPNLVVKPLQLQVETNKSQL
                     SLSMANHDIPPDAVRAKKLCRLPPLDTSTLVGVFVEYIISPSQFYVRIYSRDSSELLE
                     DMMIEMRRCYSNQLVSDRYVMPEYFIQPGHLCCVRISEDKWWYRVIIHRILGKKEVEV
                     FYPDFGNIGTVQKSSLRFLKCCYTKLPAQAIPCSLAWVRPAEEHWTSKAILHFQKLCG
                     LKPLVGVVDEYIDGILNIFLCDTSSNEDVYFHHVLRTEGHAIVCRENAPSKGFRDFNP
                     PALYTNSSAAPGDMVLTELGHPAQQHYLNEDGEILQQPQQDINDEKSISHLKSVSEEL
                     LKDSKLGPLKTRESCEEEPQWSILKPKDPKEENEDEVPTGMPCLESVTIGDDIWDENW
                     LPLQAKMGKAGGPASHLFTSSLVGKKQYQTRGETTRKDWCFSTSKDIWDDSWQPLGLA
                     NDVKGRTHTPEGPIAQEKNIGTTRIRKQPDLQYPLDSSTLPKLEEFYISLIKSQQSAE
                     GSQSEPASIQTPLKPGQASSTAPSSTPAAGDSPENHSGSAPDFSEALHSSKYSHGCLG
                     SSCAVSHVQEPPALVPQCERREA"
     exon            235..627
                     /gene="Tdrd5"
                     /inference="alignment:Splign:2.1.0"
     exon            628..821
                     /gene="Tdrd5"
                     /inference="alignment:Splign:2.1.0"
     exon            822..905
                     /gene="Tdrd5"
                     /inference="alignment:Splign:2.1.0"
     exon            906..962
                     /gene="Tdrd5"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1116
                     /gene="Tdrd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1325
                     /gene="Tdrd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1546
                     /gene="Tdrd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1759
                     /gene="Tdrd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1826
                     /gene="Tdrd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..2027
                     /gene="Tdrd5"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2165
                     /gene="Tdrd5"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2324
                     /gene="Tdrd5"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2507
                     /gene="Tdrd5"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2651
                     /gene="Tdrd5"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2862
                     /gene="Tdrd5"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..3274
                     /gene="Tdrd5"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3274
                     /gene="Tdrd5"
ORIGIN      
        1 caatgtctga gcaagagcgc atacaggact gtctgaggaa agagatacgg tctcttctta
       61 tttccactaa agatggtttg actccacaac agctggaaaa ggagtaccta ttgatggttg
      121 gcaaccatct acccctccga atccttggct atcggtccac tatggaactg gtgttggata
      181 tgcctgatgt ggttagtgtc tgcccctgtg gggatggtac cgtaatattg aaagccattc
      241 cagatgaatc caccaaagga atagcaagtt tggttgcaaa gcagagaagg agccataagg
      301 tccgaaactc catgcaaaag ggaagaagca gcgtttgctc cggccgcgtg ccttaccgcg
      361 gaagggtgcc ccctattctc ccggcagtag tgaagagtga gttgaaagac cttttggcat
      421 tgtctcctgt tctcctttct gactttgaaa aggcatttgc caggcgtttc ggacgatcct
      481 ttcagtatat gcagtatgga ttcctctcta tgtttgaagt gctgagtgct gcttcggatg
      541 tcatttgtgt agagcagacc agagcaggtt ctctgttgac actaaaaaag agtgcatcag
      601 aggaaaagca gagagaatgg ccagcaggta aaatttttac tcagccgttt agaatgaaac
      661 aacaggggtc atactctaca ggattcccag tcacgaagac acgcttttca caacccattt
      721 ccaatatgga gcccccaaag caagtactga gcatggagaa gatacccatg tttaacacag
      781 tggaggcttc aaggcttagc cacactgaaa aattaaacca gttggagagc acattcaaat
      841 cagtaattgc acaaattgga cctggaggaa ctgttgatcc agacctaaag cacaagataa
      901 aatttgtcgt gtctaagttt ccacaaggct tgttcatttc taaactgctt ggcgagtttg
      961 agctagtttt taaagaacaa ctttcaccaa aacaactagg gttcttaaac gtgacagaac
     1021 ttgttggcgc tctcagtgac attctccgag ttgagttcag tgaagaaaag caagacttgc
     1081 ttgtgtttga tgctgacctg agacctctgc tacctgctgg accgctttca tcagtcagaa
     1141 attcgtgtct agttcaacca gacaagagaa tagaagctaa cgcgtgggcc tccagtccct
     1201 ctagaaattc actatccact gtagcagtta agaagaccac atgggattgc cctttgaaga
     1261 accacaagga ggcagagcag aaggcctaca agaagcctaa tcttgtggtg aagcctttgc
     1321 agctgcaagt agaaacaaac aaatcccagc tgagcttgtc gatggcaaac cacgatatcc
     1381 caccagatgc tgtgcgtgct aagaagctgt gccgactccc accgctagac accagcaccc
     1441 tcgtgggggt cttcgtggag tacataatct ctccgagcca gttctacgtc cgcatctaca
     1501 gcagagactc gtcggaattg cttgaagaca tgatgattga aatgcggcgc tgttactcta
     1561 accagctggt ttctgatcgg tatgttatgc cagaatactt tatccagcca ggacatctgt
     1621 gctgtgtcag gatctctgag gacaagtggt ggtaccgggt tattatccat cgaatccttg
     1681 ggaaaaagga ggttgaagtg ttctacccgg atttcggaaa tataggaacg gtgcagaagt
     1741 cctcgctgag gttcctcaaa tgctgctaca cgaagcttcc agctcaggcc atcccttgct
     1801 ctttggcgtg ggtgaggccg gcagaggaac actggacatc caaagctata ttgcacttcc
     1861 agaaactgtg tggtttgaag ccattagtgg gtgtggtgga tgagtacata gacggaatcc
     1921 ttaatatctt tctttgtgat acgtcctcaa atgaagatgt ctattttcat cacgtcttga
     1981 ggacagaagg ccatgctatt gtgtgccgag aaaacgcccc atccaagggc ttcagggact
     2041 tcaacccacc agcactgtac actaactcga gcgcagcgcc gggcgacatg gtcctgaccg
     2101 agctgggaca tcccgctcag cagcactatt tgaacgaaga cggggagatc ctgcagcaac
     2161 cccagcaaga tattaatgac gagaagtcta taagtcacct taaatctgta tctgaggaat
     2221 tattaaagga ttctaaattg ggtccattga aaacccggga gagctgtgaa gaggagccac
     2281 agtggtccat cctgaagcca aaggatccga aggaagagaa tgaggatgag gtccctactg
     2341 gaatgccatg cctggagtca gtgaccatcg gtgatgacat ttgggatgag aactggcttc
     2401 ctctacaggc caaaatgggg aaggcagggg gtcctgcctc ccatctattt acgtcaagcc
     2461 ttgttgggaa gaaacagtat cagacacgtg gagaaactac acgaaaggac tggtgttttt
     2521 caacatctaa agatatatgg gatgattcct ggcagccctt aggcctggca aacgatgtga
     2581 aaggaagaac tcacacacca gaagggccca ttgctcaaga aaaaaatatt ggcacaaccc
     2641 gaattcgaaa gcagccagat ttacagtatc ctttggattc ttccacactg cccaaactgg
     2701 aagagttcta catctctctg atcaagtcac agcagtcagc agaaggcagc cagtctgaac
     2761 ctgccagcat tcagactccg cttaaacccg ggcaggcgtc ctcaacagca cccagctcaa
     2821 cccctgcggc gggcgactct ccagaaaacc actccggctc tgcaccagat ttctcagaag
     2881 ctctacattc ctcgaagtac agccacggct gtcttgggag cagctgcgcg gttagccacg
     2941 tccaggagcc tcctgcactg gtaccccagt gtgaaaggag ggaagcttga gggacaagag
     3001 gcagagagag atggggtgaa gtagtggttg ggagggtcgc ttggtcttct ttctgcgtga
     3061 ccatgtgcta gctttgtttt gctaactgat cactttgacg tgtaagtatt gatattttac
     3121 gttaattctt atttttgttc atgattagac gtcattctga atggtttggt tcacctttgt
     3181 tttaatgaag tactttaaag gagtttgtgt agatgtttct gtgagtgttg ttcttgtaca
     3241 tatcatgact gataaatgaa aattgaaaaa ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3301 aaa
//
