LOCUS       NM_001034947            1966 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus tyrosyl-DNA phosphodiesterase 2 (Tdp2), mRNA.
ACCESSION   NM_001034947 XM_574028
VERSION     NM_001034947.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1966)
  AUTHORS   Gomez-Herreros,F., Schuurs-Hoeijmakers,J.H., McCormack,M.,
            Greally,M.T., Rulten,S., Romero-Granados,R., Counihan,T.J.,
            Chaila,E., Conroy,J., Ennis,S., Delanty,N., Cortes-Ledesma,F., de
            Brouwer,A.P., Cavalleri,G.L., El-Khamisy,S.F., de Vries,B.B. and
            Caldecott,K.W.
  TITLE     TDP2 protects transcription from abortive topoisomerase activity
            and is required for normal neural function
  JOURNAL   Nat Genet 46 (5), 516-521 (2014)
   PUBMED   24658003
REFERENCE   2  (bases 1 to 1966)
  AUTHORS   Virgen-Slane,R., Rozovics,J.M., Fitzgerald,K.D., Ngo,T., Chou,W.,
            van der Heden van Noort,G.J., Filippov,D.V., Gershon,P.D. and
            Semler,B.L.
  TITLE     An RNA virus hijacks an incognito function of a DNA repair enzyme
  JOURNAL   Proc Natl Acad Sci U S A 109 (36), 14634-14639 (2012)
   PUBMED   22908287
REFERENCE   3  (bases 1 to 1966)
  AUTHORS   Gao,R., Huang,S.Y., Marchand,C. and Pommier,Y.
  TITLE     Biochemical characterization of human tyrosyl-DNA phosphodiesterase
            2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase
            specific for the repair of topoisomerase cleavage complexes
  JOURNAL   J Biol Chem 287 (36), 30842-30852 (2012)
   PUBMED   22822062
REFERENCE   4  (bases 1 to 1966)
  AUTHORS   Adhikari,S., Karmahapatra,S.K., Karve,T.M., Bandyopadhyay,S.,
            Woodrick,J., Manthena,P.V., Glasgow,E., Byers,S., Saha,T. and
            Uren,A.
  TITLE     Characterization of magnesium requirement of human 5'-tyrosyl DNA
            phosphodiesterase mediated reaction
  JOURNAL   BMC Res Notes 5, 134 (2012)
   PUBMED   22405347
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1966)
  AUTHORS   Zeng,Z., Cortes-Ledesma,F., El Khamisy,S.F. and Caldecott,K.W.
  TITLE     TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity
            in vertebrate cells and is critical for cellular resistance to
            topoisomerase II-induced DNA damage
  JOURNAL   J Biol Chem 286 (1), 403-409 (2011)
   PUBMED   21030584
REFERENCE   6  (bases 1 to 1966)
  AUTHORS   Cortes Ledesma,F., El Khamisy,S.F., Zuma,M.C., Osborn,K. and
            Caldecott,K.W.
  TITLE     A human 5'-tyrosyl DNA phosphodiesterase that repairs
            topoisomerase-mediated DNA damage
  JOURNAL   Nature 461 (7264), 674-678 (2009)
   PUBMED   19794497
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC101920.1.
            
            On Oct 21, 2005 this sequence version replaced XM_574028.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101920.1, SRR8487227.33592.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676788 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1966
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p11"
     gene            1..1966
                     /gene="Tdp2"
                     /gene_synonym="Ttrap"
                     /note="tyrosyl-DNA phosphodiesterase 2"
                     /db_xref="GeneID:498749"
                     /db_xref="RGD:1560342"
     exon            1..255
                     /gene="Tdp2"
                     /gene_synonym="Ttrap"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1170
                     /gene="Tdp2"
                     /gene_synonym="Ttrap"
                     /note="5'-tyrosyl-DNA phosphodiesterase; tyr-DNA
                     phosphodiesterase 2; 5'-Tyr-DNA phosphodiesterase; Traf
                     and Tnf receptor associated protein; TRAF and TNF
                     receptor-associated protein"
                     /codon_start=1
                     /product="tyrosyl-DNA phosphodiesterase 2"
                     /protein_id="NP_001030119.1"
                     /db_xref="GeneID:498749"
                     /db_xref="RGD:1560342"
                     /translation="MASGSSSDAAESAEPAAAPAAAETEEDQVKRRRLQSLGFALVTS
                     CDTTVASTFLSENNWQTKKALSAFFEQPENDLARPHQPPTSSKSEDYVDLTNEDANDT
                     TILETSPSGTPLEDSSTISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVI
                     PSYCAYLRKRARTYNIITGNEEGYFTAILLKKGRVKFKGQEIIPFPNTKMMRNLLCVN
                     VSLGGNEFCLMTSHLESTRKHSAERINQLKTVFQKMQEATDSTTVIFAGDTNLRDQEV
                     IKCGGLPDNVFDAWEFLGKPKHCRYTWDTKANDNLRIPAACKHRFDRIFFRAEEGHLI
                     PQSLDLIGLERLDCGRFPSDHWGLLCTLNVVL"
     exon            256..341
                     /gene="Tdp2"
                     /gene_synonym="Ttrap"
                     /inference="alignment:Splign:2.1.0"
     exon            342..512
                     /gene="Tdp2"
                     /gene_synonym="Ttrap"
                     /inference="alignment:Splign:2.1.0"
     exon            513..604
                     /gene="Tdp2"
                     /gene_synonym="Ttrap"
                     /inference="alignment:Splign:2.1.0"
     exon            605..723
                     /gene="Tdp2"
                     /gene_synonym="Ttrap"
                     /inference="alignment:Splign:2.1.0"
     exon            724..894
                     /gene="Tdp2"
                     /gene_synonym="Ttrap"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1924
                     /gene="Tdp2"
                     /gene_synonym="Ttrap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctaggccttt gcgatcggtc gcgcggaaag tggggtgaag agcgggtatt ttgaggagac
       61 cctgcagcga tggcgtctgg cagcagttcc gatgcggcgg agtcggcaga gccggcggcg
      121 gcgcccgcag cagcagagac ggaggaggat caggtgaaga ggcggcggct tcagtccctg
      181 ggatttgcgt tggtgacgag ctgcgacact acggtggctt ccactttcct gtcggagaac
      241 aactggcaga cgaaaaaagc gttgagcgcc ttcttcgagc agccagagaa cgacctagcg
      301 cggcctcacc agcctccgac atcctccaag tccgaggact atgttgatct aaccaatgag
      361 gatgcaaatg ataccaccat tttagaaacc agtccatctg gaactcctct agaagatagc
      421 agcactatct ctttcattac ctggaatatt gatggattag atggatgcaa tctcccagag
      481 agggctcgag gggtgtgttc ctgccttgct ttgtacagtc cggacgtggt atttctacag
      541 gaagtgattc cctcctactg tgcctaccta aggaagagag cacgcactta caacattatt
      601 acaggtaatg aagaaggata tttcacagct atattattga agaaaggaag agtgaaattt
      661 aaaggtcaag aaattattcc ttttccaaat accaaaatga tgagaaacct tctgtgtgta
      721 aatgtgagtt tgggtggaaa tgaattttgc cttatgacat cccatttgga gagcacaaga
      781 aaacattctg ctgaacgaat aaatcaatta aaaactgttt ttcaaaaaat gcaagaggct
      841 acagattcaa ctactgttat atttgcagga gatacaaatt taagagatca agaagttatc
      901 aaatgtggtg gtttacctga caatgttttt gatgcctggg aatttttggg caaacctaag
      961 cattgccggt atacatggga tacgaaagca aacgataatc tcaggattcc tgccgcttgt
     1021 aagcatcgtt ttgatcgaat attcttcaga gcagaagagg gacaccttat tccccaaagt
     1081 ttagacctaa ttgggttgga aagactggac tgtggtagat ttcctagtga tcactggggg
     1141 ctcctgtgta ccttgaatgt agtattgtga aaagcttccc aaattccagc tctgtttgca
     1201 ctagttctga atttgtacag atctcaacct ttaggaaagc taggtctaat acagaagatt
     1261 taataaactg aatgattaat tcaccaaaaa caactgacct tttactttgt atcttgtgtc
     1321 ctcagagtta agaacccatg tttgtaacag atcaaagcat gcttatgatc agaatgtgtg
     1381 ggcttttgtc tacaggacat tgcctctctc ttggcttgta acagactcat tgtgccatca
     1441 ggacttcaag taatggctga tatctcagga ctcactcttt tttgaattta ctaagagaaa
     1501 aagtaagcct ttgcattctt gagaccgcat tgtcttacat tctgtaggtt cggaaactta
     1561 agtgaaaaag ccatgaccat ctgtagtaaa ggagaggaca gctgttgtat agcagagtta
     1621 atttgtcagc tgtagtatat agtgactaca tgatgaatta catttgcact ttgaattcca
     1681 gtgcctgttc tgatgggtgt tagtgatttg ctgataacag ataacgttca gcttgacaat
     1741 gactggatcc agcttagcaa catgaggttt tttttctaag aggaaaattc agaagaaaag
     1801 tagctttcag tttagttact ggtaaaatgg aaatactttg cagagactga ataaataata
     1861 cttttgtaaa tgttctgtaa agaaatgtac cataaataaa gtgttttatt tgtttgtaca
     1921 ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
