LOCUS       NM_001031657            2096 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus tyrosyl-DNA phosphodiesterase 1 (Tdp1), mRNA.
ACCESSION   NM_001031657 XM_234379
VERSION     NM_001031657.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2096)
  AUTHORS   Gao,R., Huang,S.Y., Marchand,C. and Pommier,Y.
  TITLE     Biochemical characterization of human tyrosyl-DNA phosphodiesterase
            2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase
            specific for the repair of topoisomerase cleavage complexes
  JOURNAL   J Biol Chem 287 (36), 30842-30852 (2012)
   PUBMED   22822062
REFERENCE   2  (bases 1 to 2096)
  AUTHORS   Gao,Y., Katyal,S., Lee,Y., Zhao,J., Rehg,J.E., Russell,H.R. and
            McKinnon,P.J.
  TITLE     DNA ligase III is critical for mtDNA integrity but not
            Xrcc1-mediated nuclear DNA repair
  JOURNAL   Nature 471 (7337), 240-244 (2011)
   PUBMED   21390131
REFERENCE   3  (bases 1 to 2096)
  AUTHORS   Hirano,R., Interthal,H., Huang,C., Nakamura,T., Deguchi,K.,
            Choi,K., Bhattacharjee,M.B., Arimura,K., Umehara,F., Izumo,S.,
            Northrop,J.L., Salih,M.A., Inoue,K., Armstrong,D.L., Champoux,J.J.,
            Takashima,H. and Boerkoel,C.F.
  TITLE     Spinocerebellar ataxia with axonal neuropathy: consequence of a
            Tdp1 recessive neomorphic mutation?
  JOURNAL   EMBO J 26 (22), 4732-4743 (2007)
   PUBMED   17948061
REFERENCE   4  (bases 1 to 2096)
  AUTHORS   Katyal,S., el-Khamisy,S.F., Russell,H.R., Li,Y., Ju,L.,
            Caldecott,K.W. and McKinnon,P.J.
  TITLE     TDP1 facilitates chromosomal single-strand break repair in neurons
            and is neuroprotective in vivo
  JOURNAL   EMBO J 26 (22), 4720-4731 (2007)
   PUBMED   17914460
REFERENCE   5  (bases 1 to 2096)
  AUTHORS   El-Khamisy,S.F., Hartsuiker,E. and Caldecott,K.W.
  TITLE     TDP1 facilitates repair of ionizing radiation-induced DNA
            single-strand breaks
  JOURNAL   DNA Repair (Amst) 6 (10), 1485-1495 (2007)
   PUBMED   17600775
REFERENCE   6  (bases 1 to 2096)
  AUTHORS   Liu,C., Zhou,S., Begum,S., Sidransky,D., Westra,W.H., Brock,M. and
            Califano,J.A.
  TITLE     Increased expression and activity of repair genes TDP1 and XPF in
            non-small cell lung cancer
  JOURNAL   Lung Cancer 55 (3), 303-311 (2007)
   PUBMED   17118488
REFERENCE   7  (bases 1 to 2096)
  AUTHORS   Antony,S., Marchand,C., Stephen,A.G., Thibaut,L., Agama,K.K.,
            Fisher,R.J. and Pommier,Y.
  TITLE     Novel high-throughput electrochemiluminescent assay for
            identification of human tyrosyl-DNA phosphodiesterase (Tdp1)
            inhibitors and characterization of furamidine (NSC 305831) as an
            inhibitor of Tdp1
  JOURNAL   Nucleic Acids Res 35 (13), 4474-4484 (2007)
   PUBMED   17576665
REFERENCE   8  (bases 1 to 2096)
  AUTHORS   Raymond,A.C., Staker,B.L. and Burgin,A.B. Jr.
  TITLE     Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)
  JOURNAL   J Biol Chem 280 (23), 22029-22035 (2005)
   PUBMED   15811850
REFERENCE   9  (bases 1 to 2096)
  AUTHORS   Inamdar,K.V., Pouliot,J.J., Zhou,T., Lees-Miller,S.P.,
            Rasouli-Nia,A. and Povirk,L.F.
  TITLE     Conversion of phosphoglycolate to phosphate termini on 3' overhangs
            of DNA double strand breaks by the human tyrosyl-DNA
            phosphodiesterase hTdp1
  JOURNAL   J Biol Chem 277 (30), 27162-27168 (2002)
   PUBMED   12023295
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098739.1.
            
            On Aug 12, 2005 this sequence version replaced XM_234379.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098739.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132293
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2096
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..2096
                     /gene="Tdp1"
                     /note="tyrosyl-DNA phosphodiesterase 1"
                     /db_xref="GeneID:314380"
                     /db_xref="RGD:1309618"
     exon            1..9
                     /gene="Tdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            10..578
                     /gene="Tdp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1846
                     /gene="Tdp1"
                     /EC_number="3.1.4.-"
                     /note="tyr-DNA phosphodiesterase 1"
                     /codon_start=1
                     /product="tyrosyl-DNA phosphodiesterase 1"
                     /protein_id="NP_001026827.1"
                     /db_xref="GeneID:314380"
                     /db_xref="RGD:1309618"
                     /translation="MSQESSYGKWTISSSDDSEDEKPKPVKPSTSSGPQAGQGVSKEP
                     TYTCSEARKAAHKRQISPVKFNNTDSVLPHKKQKMDSPEGLGWCLSSSDDEQQPDVTQ
                     QEQPKGVPPQEKKYAPSANVTTAQKVEDRSPPDSHRAQRADEEYETSGEGQDIWDMLD
                     KENPFQFYLTRVSGIKAKYNSKALHIKDILSPLFGTLVSSAQFNYCFDVNWLIKQYPP
                     EFRKKPILLVHGDKREAKADLHAQAKPYANISLCQAKLDIAFGTHHTKMMLLLYEEGL
                     RVVIHTSNLIREDWHQKTQGIWLSPLYPRIYQGNHTSGESSTHFKADLTSYLMAYNAP
                     PLQEWIDIIQEHDLSETNVYLIGSTPGRFQGSHKDNWGHFRLRKLLQAHAPSAPRGEC
                     WPVVGQFSSIGSLGPDESKWLCSEFKESLLAVREEGRTPGRSAVPLHLIYPSVENVRT
                     SLEGYPAGGSLPYGIQTAEKQRWLHPYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKL
                     AWFLVTSANLSKAAWGALEKNGAQLMIRSYELGVLFLPSAFGLDTFKVKQKFFSSSSE
                     PMASFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS"
     exon            579..622
                     /gene="Tdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..678
                     /gene="Tdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            679..775
                     /gene="Tdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            776..810
                     /gene="Tdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..903
                     /gene="Tdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1071
                     /gene="Tdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1150
                     /gene="Tdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1336
                     /gene="Tdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1385
                     /gene="Tdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1452
                     /gene="Tdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1560
                     /gene="Tdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1663
                     /gene="Tdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1772
                     /gene="Tdp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..2066
                     /gene="Tdp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggtcaga agtacaatgt cccaggaaag cagctacgga aagtggacaa tatccagtag
       61 tgacgacagc gaggatgaaa agcccaaacc tgtcaaacca tcaacatcct ctggccccca
      121 ggctgggcag ggagtgtcga aggagcccac gtacacctgc tcagaggccc gcaaggctgc
      181 acacaagaga cagatctcac ctgtgaaatt caacaacaca gactccgtgt taccccacaa
      241 gaagcagaag atggattccc cggaaggtct gggctggtgt ctgtccagca gcgatgatga
      301 gcagcagccg gatgtgacac agcaggagca gcctaaggga gtgccacctc aagagaaaaa
      361 atatgccccc tcagccaatg tgactactgc ccagaaagtt gaggatcgaa gccctcctga
      421 cagccatagg gcccaaaggg cagacgaaga gtacgagacc tcaggggaag gccaggacat
      481 ctgggacatg ctggataagg agaacccctt ccagttttat ctcactagag tctcggggat
      541 taaggcaaag tacaactcca aagccctcca catcaaggat attttatccc ctctgtttgg
      601 gacacttgtc tcttcagctc agtttaacta ctgctttgat gtgaactggc tcataaagca
      661 atatccacca gaattcagga agaagccgat cctgcttgtg cacggcgata agagggaagc
      721 caaggcagac ttgcatgccc aggcgaagcc ctatgcaaac atttccctct gccaggcaaa
      781 gttggatatt gcatttggaa cacaccacac gaaaatgatg ctcttgctct atgaagaagg
      841 cctccgagtc gtcatccaca cctccaacct catccgggaa gactggcacc agaaaaccca
      901 aggaatatgg ttgagccctt tgtacccacg aatttaccag ggaaaccaca catccggaga
      961 gtcaagcacc catttcaaag cggacctcac cagttatttg atggcgtata atgccccccc
     1021 tctccaggaa tggatagaca tcatccaaga acacgatctc tctgaaacca atgtttacct
     1081 tattggttca acccctggac gctttcaagg aagtcacaaa gataattggg gacattttag
     1141 acttagaaag cttctgcagg cgcatgcgcc atctgcaccc aggggcgagt gctggcccgt
     1201 cgtgggtcag ttttcaagca ttggctccct ggggcctgat gaatccaagt ggttgtgctc
     1261 agagtttaaa gagagcttgc tggcagtgag agaggaaggc cggaccccgg gcagaagcgc
     1321 agttcctctt catctgatct atccctctgt ggaaaatgtg cggaccagct tagaaggata
     1381 tcctgctggg ggctctcttc cctatggcat ccagacggct gagaaacaga ggtggctgca
     1441 cccctacttc cacaagtggt cagcagagac atccggccga agcaatgcca tgccacatat
     1501 taagacgtac atgaggccct caccagactt cagtaaactg gcttggttcc ttgtcacaag
     1561 tgcaaatctg tccaaggctg cctggggagc actggagaag aacggcgctc aactgatgat
     1621 ccgctcctat gagctggggg tccttttcct cccgtcggcc tttggcctgg acaccttcaa
     1681 agtgaaacag aaattcttct ccagcagcag tgagccaatg gcctcctttc ctgtgcccta
     1741 tgacctgccc ccagagctct acgggagtaa agatcggcca tggatttgga acattcctta
     1801 tgtcaaagca ccagacacac atggcaacat gtgggtgccc tcctgagacg cagtgctgtg
     1861 acatttgagt gtaagacact ggatgtcctt atctgtactg aacattcacc tcccttaaag
     1921 tcttccaccc atacaagact cctcgcaaaa gtcaatcttg gctgtgtgtc tgatggtcat
     1981 tgtcttatta aagaagaggt gttattttct taattcattt ttatatgtcc ttaaaatcaa
     2041 gctattaaac ttcatagtac ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
