LOCUS       NM_022403               1687 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus tryptophan 2,3-dioxygenase (Tdo2), mRNA.
ACCESSION   NM_022403
VERSION     NM_022403.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1687)
  AUTHORS   Nagy-Grocz,G., Laborc,K.F., Veres,G., Bajtai,A., Bohar,Z.,
            Zadori,D., Fejes-Szabo,A., Spekker,E., Vecsei,L. and Pardutz,A.
  TITLE     The Effect of Systemic Nitroglycerin Administration on the
            Kynurenine Pathway in the Rat
  JOURNAL   Front Neurol 8, 278 (2017)
   PUBMED   28659861
  REMARK    Erratum:[Front Neurol. 2020 Sep 24;11:1049. doi:
            10.3389/fneur.2020.01049.. PMID: 33071936]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1687)
  AUTHORS   Ferreira,P., Shin,I., Sosova,I., Dornevil,K., Jain,S., Dewey,D.,
            Liu,F. and Liu,A.
  TITLE     Hypertryptophanemia due to tryptophan 2,3-dioxygenase deficiency
  JOURNAL   Mol Genet Metab 120 (4), 317-324 (2017)
   PUBMED   28285122
REFERENCE   3  (bases 1 to 1687)
  AUTHORS   Lewis-Ballester,A., Forouhar,F., Kim,S.M., Lew,S., Wang,Y.,
            Karkashon,S., Seetharaman,J., Batabyal,D., Chiang,B.Y., Hussain,M.,
            Correia,M.A., Yeh,S.R. and Tong,L.
  TITLE     Molecular basis for catalysis and substrate-mediated cellular
            stabilization of human tryptophan 2,3-dioxygenase
  JOURNAL   Sci Rep 6, 35169 (2016)
   PUBMED   27762317
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1687)
  AUTHORS   Yu,C.P., Pan,Z.Z. and Luo,D.Y.
  TITLE     TDO as a therapeutic target in brain diseases
  JOURNAL   Metab Brain Dis 31 (4), 737-747 (2016)
   PUBMED   27072164
  REMARK    Review article
REFERENCE   5  (bases 1 to 1687)
  AUTHORS   Woodling,N.S., Colas,D., Wang,Q., Minhas,P., Panchal,M., Liang,X.,
            Mhatre,S.D., Brown,H., Ko,N., Zagol-Ikapitte,I., van der Hart,M.,
            Khroyan,T.V., Chuluun,B., Priyam,P.G., Milne,G.L., Rassoulpour,A.,
            Boutaud,O., Manning-Bog,A.B., Heller,H.C. and Andreasson,K.I.
  TITLE     Cyclooxygenase inhibition targets neurons to prevent early
            behavioural decline in Alzheimer's disease model mice
  JOURNAL   Brain 139 (Pt 7), 2063-2081 (2016)
   PUBMED   27190010
REFERENCE   6  (bases 1 to 1687)
  AUTHORS   Merkulov,V.M. and Merkulova,T.I.
  TITLE     Nucleotide sequence of a fragment of the rat tryptophan oxygenase
            gene showing high affinity to glucocorticoid receptor in vitro
  JOURNAL   Biochim Biophys Acta 1132 (1), 100-102 (1992)
   PUBMED   1511007
REFERENCE   7  (bases 1 to 1687)
  AUTHORS   Maezono,K., Tashiro,K. and Nakamura,T.
  TITLE     Deduced primary structure of rat tryptophan-2,3-dioxygenase
  JOURNAL   Biochem Biophys Res Commun 170 (1), 176-181 (1990)
   PUBMED   2372286
REFERENCE   8  (bases 1 to 1687)
  AUTHORS   Okayama,A., Ogawa,Y., Goto,S., Yamatodani,A., Wada,H., Okuno,E.,
            Takikawa,O. and Kido,R.
  TITLE     Enzymatic studies on tryptophan metabolism disorder in rats
            chronically exposed to carbon disulfide
  JOURNAL   Toxicol Appl Pharmacol 94 (3), 356-361 (1988)
   PUBMED   3400092
REFERENCE   9  (bases 1 to 1687)
  AUTHORS   Danesch,U., Gloss,B., Schmid,W., Schutz,G., Schule,R. and
            Renkawitz,R.
  TITLE     Glucocorticoid induction of the rat tryptophan oxygenase gene is
            mediated by two widely separated glucocorticoid-responsive elements
  JOURNAL   EMBO J 6 (3), 625-630 (1987)
   PUBMED   3582368
REFERENCE   10 (bases 1 to 1687)
  AUTHORS   Salter,M. and Pogson,C.I.
  TITLE     The role of tryptophan 2,3-dioxygenase in the hormonal control of
            tryptophan metabolism in isolated rat liver cells. Effects of
            glucocorticoids and experimental diabetes
  JOURNAL   Biochem J 229 (2), 499-504 (1985)
   PUBMED   3899109
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M55167.1.
            
            On Feb 21, 2013 this sequence version replaced NM_022403.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M55167.1, BC089802.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1687              M55167.1           1-1687
FEATURES             Location/Qualifiers
     source          1..1687
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1687
                     /gene="Tdo2"
                     /gene_synonym="Tdo; TO"
                     /note="tryptophan 2,3-dioxygenase"
                     /db_xref="GeneID:64206"
                     /db_xref="RGD:68370"
     exon            1..74
                     /gene="Tdo2"
                     /gene_synonym="Tdo; TO"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1260
                     /gene="Tdo2"
                     /gene_synonym="Tdo; TO"
                     /EC_number="1.13.11.11"
                     /note="tryptophan-23-dioxygenase; tryptophan
                     2,3-dioxygenase A; TRPO; tryptophanase; tryptophan
                     oxygenase; tryptophan pyrrolase; tryptamin
                     2,3-dioxygenase"
                     /codon_start=1
                     /product="tryptophan 2,3-dioxygenase"
                     /protein_id="NP_071798.1"
                     /db_xref="GeneID:64206"
                     /db_xref="RGD:68370"
                     /translation="MSGCPFSGNSVGYTLKNLSMEDNEEDGAQTGVNRASKGGLIYGD
                     YLQLEKILNAQELQSEIKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHV
                     RDERNMLKVMTRMHRVVVIFKLLVQQFSVLETMTALDFNDFREYLSPASGFQSLQFRL
                     LENKIGVLQSLRVPYNRKHYRDNFEGDYNELLLKSEQEQTLLQLVEAWLERTPGLEPH
                     GFNFWGKFEKNILKGLEEEFLKIQAKKDSEEKEEQMAEFRKQKEVLLCLFDEKRHDYL
                     LSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHR
                     MLGSKAGTGGSSGYYYLRSTVSDRYKVFVDLFNLSSYLVPRHWIPKMNPIIHKFLYTA
                     EYSDSSYFSSDESD"
     exon            75..180
                     /gene="Tdo2"
                     /gene_synonym="Tdo; TO"
                     /inference="alignment:Splign:2.1.0"
     exon            181..271
                     /gene="Tdo2"
                     /gene_synonym="Tdo; TO"
                     /inference="alignment:Splign:2.1.0"
     exon            272..342
                     /gene="Tdo2"
                     /gene_synonym="Tdo; TO"
                     /inference="alignment:Splign:2.1.0"
     exon            343..470
                     /gene="Tdo2"
                     /gene_synonym="Tdo; TO"
                     /inference="alignment:Splign:2.1.0"
     exon            471..657
                     /gene="Tdo2"
                     /gene_synonym="Tdo; TO"
                     /inference="alignment:Splign:2.1.0"
     exon            658..765
                     /gene="Tdo2"
                     /gene_synonym="Tdo; TO"
                     /inference="alignment:Splign:2.1.0"
     exon            766..877
                     /gene="Tdo2"
                     /gene_synonym="Tdo; TO"
                     /inference="alignment:Splign:2.1.0"
     exon            878..935
                     /gene="Tdo2"
                     /gene_synonym="Tdo; TO"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1015
                     /gene="Tdo2"
                     /gene_synonym="Tdo; TO"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1106
                     /gene="Tdo2"
                     /gene_synonym="Tdo; TO"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1687
                     /gene="Tdo2"
                     /gene_synonym="Tdo; TO"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctagcaaa cctgtgtgct cctgggacgc atcactacca tgagtgggtg cccattttca
       61 ggaaacagtg taggatatac tttgaaaaac ttatctatgg aagacaatga agaagacgga
      121 gctcaaactg gtgtaaacag agccagcaaa ggaggactta tctatgggga ctacttgcag
      181 ttggagaaga ttttgaatgc acaagaactt caaagtgaaa tcaaagggaa taaaatccac
      241 gacgagcacc tctttattat aactcaccaa gcttatgaac tttggtttaa acaaattctc
      301 tgggaacttg attctgttcg tgagattttt caaaatggcc atgtcaggga tgagaggaac
      361 atgctcaagg tgatgactcg gatgcaccgt gtggtggtca tcttcaagct cctggtacag
      421 cagttctcgg ttctggaaac aatgactgcc ttggacttca atgacttcag agagtacctg
      481 tctccagcat caggcttcca gagtcttcag ttccggctgc tagaaaataa gataggtgtt
      541 cttcagagct tgagagtccc ttacaacagg aaacactatc gtgataactt tgaaggagac
      601 tacaatgagc tgctgctgaa atcggagcag gagcagacgc tattgcagct ggtggaggca
      661 tggctggaac gcacacctgg cttagagcca catggattca atttctgggg aaagtttgaa
      721 aaaaatatct tgaagggtct ggaagaggag ttcctaaaga ttcaggcgaa aaaggactct
      781 gaagaaaaag aggaacagat ggcagagttc cggaagcaga aagaggtgct gctctgcttg
      841 ttcgatgaga agcgtcatga ctaccttctg agtaaaggtg aacgacgact gtcataccgt
      901 gcactccagg gagcactgat gatatatttt tacagggagg agcctcgatt ccaggtccct
      961 ttccagttgc tgacctcact tatggacatt gacacactca tgaccaaatg gagatataat
     1021 catgtgtgca tggtgcacag gatgctaggc agcaaggctg gcactggggg atcctcaggc
     1081 tattattatc tgcgctcaac tgtgagcgac aggtacaagg tgttcgtgga tttatttaac
     1141 ctctcatcgt acctggttcc ccgacactgg ataccaaaga tgaatccgat cattcacaag
     1201 ttcctttaca cagctgagta cagcgacagc tcctacttca gcagcgatga atcagattga
     1261 gttcttctga acatcagtcc aggctacagg attcccagtc aacttttatt ttataaattt
     1321 ttacaaatat gtgattggtg taacatattt atatttgtag ttcagagacg tgatgttgtg
     1381 gtccaatcct ggaaaaaatt atgatttcgc atatcatgat gatgtatgat taagcagatt
     1441 aagcattatg ataaaaataa cttggtaaaa tgttagcatc atcatacata tgatgtattc
     1501 tggttataac tcaatttacc ctgacactta cctccataga aacactttaa gtaattagtt
     1561 ccttattgct tcatacttta taaagcttgg tgagcagttc ttttatacta tagatgcaat
     1621 aaatactatt cttctgtaca aaatttattc aaatgaatct ttaattaata aatttagttt
     1681 ttgtctg
//
