LOCUS       NM_001106044            1546 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus L-threonine dehydrogenase (Tdh), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_001106044 XM_001065307 XM_214217
VERSION     NM_001106044.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1546)
  AUTHORS   He C, Huang X, Liu Y, Li F, Yang Y, Tao H, Han C, Zhao C, Xiao Y
            and Shi Y.
  TITLE     Structural insights on mouse L-threonine dehydrogenase: A
            regulatory role of Arg180 in catalysis
  JOURNAL   J Struct Biol 192 (3), 510-518 (2015)
   PUBMED   26492815
REFERENCE   2  (bases 1 to 1546)
  AUTHORS   Alexander PB, Wang J and McKnight SL.
  TITLE     Targeted killing of a mammalian cell based upon its specialized
            metabolic state
  JOURNAL   Proc Natl Acad Sci U S A 108 (38), 15828-15833 (2011)
   PUBMED   21896756
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474023.1.
            
            [WARNING] On Aug 29, 2024 this sequence was replaced by
            NM_001106044.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_214217.4, XM_001065307.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132264, SAMD00132265
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1546
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..1546
                     /gene="Tdh"
                     /note="L-threonine dehydrogenase"
                     /db_xref="GeneID:290315"
                     /db_xref="RGD:1310214"
     exon            1..63
                     /gene="Tdh"
                     /inference="alignment:Splign:2.1.0"
     exon            64..263
                     /gene="Tdh"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1201
                     /gene="Tdh"
                     /EC_number="1.1.1.103"
                     /codon_start=1
                     /product="L-threonine 3-dehydrogenase, mitochondrial"
                     /protein_id="NP_001099514.1"
                     /db_xref="GeneID:290315"
                     /db_xref="RGD:1310214"
                     /translation="MLFLGMLKQVVSRTAQSKASSCRKLVLPWQFLGSSQHRVPANVN
                     FHSTSFSEAEPPRVLITGGLGQLGVGLANLLRKRFGKDNVILSDIRKPPAHVFHSGPF
                     IYANILDYKNLREIVVNHRISWLFHYSALLSAVGEANVPLARDVNITGLHNILDVAAE
                     YNVRLFVPSTIGAFGPTSPRNPTPDLCVQRPRTIYGVSKVHTELMGEYYYYRYGLDFR
                     CLRYPGIISADSQPGGGTTDYAVQIFHAAAKNGTFECNLKASTRLPMMYISDCLRATL
                     EVMEAPAECLSMRTYNINAMSFTPEELALALRKHAPDFQITYCVDPLRQAIAESWPMI
                     LDDSNARKDWGWKHDFDLPELVATMLSFHGVSTRVAQVN"
     exon            264..306
                     /gene="Tdh"
                     /inference="alignment:Splign:2.1.0"
     exon            307..377
                     /gene="Tdh"
                     /inference="alignment:Splign:2.1.0"
     exon            378..527
                     /gene="Tdh"
                     /inference="alignment:Splign:2.1.0"
     exon            528..700
                     /gene="Tdh"
                     /inference="alignment:Splign:2.1.0"
     exon            701..791
                     /gene="Tdh"
                     /inference="alignment:Splign:2.1.0"
     exon            792..1061
                     /gene="Tdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1546
                     /gene="Tdh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacgtgctg ctcctccggc tccggctgtg gcattctcag catccagtct tccgcgtctg
       61 cagggtatca gaagatcaga tgctgttcct tgggatgcta aaacaggtgg tcagcaggac
      121 agcacagagc aaagcctcta gctgccggaa gcttgtcttg ccctggcagt ttctaggcag
      181 ctcccagcat cgagtcccag caaatgtcaa cttccactcc acctcattct cggaagcaga
      241 gcctcctagg gttttgatca cagggggtct tggccaactg ggagtaggac ttgctaacct
      301 cttgaggaaa cgatttggga aggacaatgt gatcctatca gacataagga agcctcctgc
      361 tcatgtcttc cacagtggcc catttattta tgccaacatc ttggattaca agaaccttcg
      421 tgagattgtg gtgaaccacc gtatcagctg gctgtttcac tacagtgccc tgctgagtgc
      481 cgtgggagaa gcaaatgtgc cgttggccag agatgtgaat ataactggac tgcataacat
      541 tctagatgtt gcagccgaat acaatgtgag attgtttgtg cccagcacga ttggagcctt
      601 tggacctacc tctcctcgaa accctacacc tgatctctgt gttcaaagac ctaggaccat
      661 ctatggggta tccaaggtcc acacggagct catgggagag tactattatt accggtatgg
      721 gttagatttc cggtgcctga gatatcctgg aatcatttct gccgattccc agcctggagg
      781 aggaacaact gactacgcag tccagatttt ccacgctgca gccaagaacg gcacatttga
      841 atgcaacctc aaggccagca ccaggctccc gatgatgtac atcagtgact gcctcagggc
      901 cacactggaa gtcatggaag cccctgcgga gtgcctgtcc atgaggacct acaacatcaa
      961 cgccatgagc ttcacccccg aagagctggc cctggcgctc cgcaagcacg cgcctgactt
     1021 ccagatcacc tactgcgttg atcctctccg acaggctata gcggagagct ggcccatgat
     1081 tctagatgac agcaatgcaa ggaaggactg gggctggaaa catgactttg atcttccaga
     1141 gttggtggct acaatgctca gcttccacgg agtcagcact agagttgccc aagtgaactg
     1201 aaagtggagg agcagccccc gtgtcctctc agtacaaggg acatggcagt cactaagttg
     1261 gagaactgga ctgagttcta gctgctcaca tggaggtcct ttacacattg cctttgttgt
     1321 gtatgcctaa attggtccag tacatatgcc agagaaatga agtcctaagt ggtggtggct
     1381 atctcttgga atttgcatca tttgtattta attaaattca atttaagcat cacacctgag
     1441 acttattctc ttgaccagag accaaagatt actttacatg ttaaggattt tcaaagatgt
     1501 tcttcatgtt caagacttgg atacttcttc aaaaaactat cacttg
//
