LOCUS       NM_001080782            2480 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus tectonic family member 2 (Tctn2), mRNA.
ACCESSION   NM_001080782 XM_001071967
VERSION     NM_001080782.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2480)
  AUTHORS   Liu,J., Lin,M., Qiao,F. and Zhang,C.
  TITLE     Exosomes Derived from lncRNA TCTN2-Modified Mesenchymal Stem Cells
            Improve Spinal Cord Injury by miR-329-3p/IGF1R Axis
  JOURNAL   J Mol Neurosci 72 (3), 482-495 (2022)
   PUBMED   34623606
  REMARK    GeneRIF: Exosomes Derived from lncRNA TCTN2-Modified Mesenchymal
            Stem Cells Improve Spinal Cord Injury by miR-329-3p/IGF1R Axis.
REFERENCE   2  (bases 1 to 2480)
  AUTHORS   Wang,C., Li,J., Takemaru,K.I., Jiang,X., Xu,G. and Wang,B.
  TITLE     Centrosomal protein Dzip1l binds Cby, promotes ciliary bud
            formation, and acts redundantly with Bromi to regulate ciliogenesis
            in the mouse
  JOURNAL   Development 145 (6) (2018)
   PUBMED   29487109
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2480)
  AUTHORS   Li,C., Jensen,V.L., Park,K., Kennedy,J., Garcia-Gonzalo,F.R.,
            Romani,M., De Mori,R., Bruel,A.L., Gaillard,D., Doray,B., Lopez,E.,
            Riviere,J.B., Faivre,L., Thauvin-Robinet,C., Reiter,J.F.,
            Blacque,O.E., Valente,E.M. and Leroux,M.R.
  TITLE     MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary
            Transition Zone
  JOURNAL   PLoS Biol 14 (3), e1002416 (2016)
   PUBMED   26982032
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2480)
  AUTHORS   Chih,B., Liu,P., Chinn,Y., Chalouni,C., Komuves,L.G., Hass,P.E.,
            Sandoval,W. and Peterson,A.S.
  TITLE     A ciliopathy complex at the transition zone protects the cilia as a
            privileged membrane domain
  JOURNAL   Nat Cell Biol 14 (1), 61-72 (2011)
   PUBMED   22179047
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2480)
  AUTHORS   Garcia-Gonzalo,F.R., Corbit,K.C., Sirerol-Piquer,M.S.,
            Ramaswami,G., Otto,E.A., Noriega,T.R., Seol,A.D., Robinson,J.F.,
            Bennett,C.L., Josifova,D.J., Garcia-Verdugo,J.M., Katsanis,N.,
            Hildebrandt,F. and Reiter,J.F.
  TITLE     A transition zone complex regulates mammalian ciliogenesis and
            ciliary membrane composition
  JOURNAL   Nat Genet 43 (8), 776-784 (2011)
   PUBMED   21725307
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2480)
  AUTHORS   Sang,L., Miller,J.J., Corbit,K.C., Giles,R.H., Brauer,M.J.,
            Otto,E.A., Baye,L.M., Wen,X., Scales,S.J., Kwong,M.,
            Huntzicker,E.G., Sfakianos,M.K., Sandoval,W., Bazan,J.F.,
            Kulkarni,P., Garcia-Gonzalo,F.R., Seol,A.D., O'Toole,J.F., Held,S.,
            Reutter,H.M., Lane,W.S., Rafiq,M.A., Noor,A., Ansar,M., Devi,A.R.,
            Sheffield,V.C., Slusarski,D.C., Vincent,J.B., Doherty,D.A.,
            Hildebrandt,F., Reiter,J.F. and Jackson,P.K.
  TITLE     Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy
            disease genes and pathways
  JOURNAL   Cell 145 (4), 513-528 (2011)
   PUBMED   21565611
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC107658.1.
            
            On Jan 27, 2007 this sequence version replaced XM_001071967.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107658.1, SRR8487230.46284.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2480
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q15"
     gene            1..2480
                     /gene="Tctn2"
                     /gene_synonym="Tect2"
                     /note="tectonic family member 2"
                     /db_xref="GeneID:689779"
                     /db_xref="RGD:1591895"
     exon            1..154
                     /gene="Tctn2"
                     /gene_synonym="Tect2"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..2175
                     /gene="Tctn2"
                     /gene_synonym="Tect2"
                     /note="tectonic-2"
                     /codon_start=1
                     /product="tectonic-2 precursor"
                     /protein_id="NP_001074251.1"
                     /db_xref="GeneID:689779"
                     /db_xref="RGD:1591895"
                     /translation="MGSLSPLSFLWGLLLLQGVLRPLRGDPVFIPPFIRMSSPEVRAS
                     LVGGSEDVTVSLTPLQIKEGVLPVPTCGGLRNETGDWNLTVSPQANMLEVTVRWKRGL
                     DWCSPDETASFSEAPCIVQTLLVSASHNASCLAHLLIQVEIYPNTSVTHNASENMTVI
                     PNQVYQPLGPCPCDLTAKACDIRCCCDQDCQPELRELFERFCFSGVFGGYVSPPSHHR
                     CAARTTHQTPDWFPFLCVQSPPSTSPFLGHFYHGAISPRHSPGFETHSHLDLRDFFAD
                     ASYKQGDPIMTTNGYFTIPQASLAGQCLQDAPVAFLRNFHSVCTTDLEVQERDRLIPE
                     DMRIRTTGGLVTPTVTYEEATDLDKLITSPDTILSAGSAPRNVTVEEHYVFRWQNNSI
                     SSLDITIIRAEINAHQRGTMTQRFTVKFLSPNSGGEKEFSGNPGYQLGKPVRALHTDG
                     MNVTTLHLWQPAGRGLCTSAALRPVLFGEDASSGCLLEVGIKENCTQLRENVLQRLDL
                     LIQATHVARRGNSDYGDLSDGWLEVIRVDAPDAGADLPLSSANGMCPEVPTHVTIRIL
                     TAEAGAVEGEAQREILAVETRFSTVTWQYQCGLTCEEDKADLLPLSASVKFINIPAQM
                     PRPTRFQINFTEYDCTRNELCWPQLLYPLTQYYQGEPRPQCVAKGLMLLSLLMLAILL
                     RHPWVGMCKAWSSASIQH"
     exon            155..262
                     /gene="Tctn2"
                     /gene_synonym="Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            263..339
                     /gene="Tctn2"
                     /gene_synonym="Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            340..535
                     /gene="Tctn2"
                     /gene_synonym="Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            536..636
                     /gene="Tctn2"
                     /gene_synonym="Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            637..833
                     /gene="Tctn2"
                     /gene_synonym="Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            834..960
                     /gene="Tctn2"
                     /gene_synonym="Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1099
                     /gene="Tctn2"
                     /gene_synonym="Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1165
                     /gene="Tctn2"
                     /gene_synonym="Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1300
                     /gene="Tctn2"
                     /gene_synonym="Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1378
                     /gene="Tctn2"
                     /gene_synonym="Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1456
                     /gene="Tctn2"
                     /gene_synonym="Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1568
                     /gene="Tctn2"
                     /gene_synonym="Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1675
                     /gene="Tctn2"
                     /gene_synonym="Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1832
                     /gene="Tctn2"
                     /gene_synonym="Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1958
                     /gene="Tctn2"
                     /gene_synonym="Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2047
                     /gene="Tctn2"
                     /gene_synonym="Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2400
                     /gene="Tctn2"
                     /gene_synonym="Tect2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgggcggc aaaggccgcc gctttttctc tcccaggtta tcctgggttt ctgaggcaaa
       61 tcggccccgg gtatgggttc tctgtcgccg ctcagcttcc tgtggggact cctcctgctg
      121 cagggcgtcc tgaggccgct gcgcggcgac ccggttttca tcccaccttt catccggatg
      181 tccagtcctg aggtccgcgc gtccctggtc ggaggcagcg aggatgtcac cgtgtcactg
      241 actccactgc aaatcaagga aggagtgttg ccagttccta cttgtggtgg cctcaggaat
      301 gagaccgggg attggaatct gactgtgagc ccccaagcga acatgctgga agtgaccgta
      361 aggtggaaga ggggtctgga ctggtgctct ccagatgaga cagcctcgtt ctcagaggcc
      421 ccatgcatcg tgcagactct gctggtctca gcatcccaca atgcatcctg cttagcacat
      481 ctgctcatcc aggtggagat ttatcccaac acgtctgtga cccacaatgc atcagagaac
      541 atgactgtca ttcctaacca agtctatcag cccctgggtc cctgcccgtg tgacttgaca
      601 gccaaggcct gtgacattcg ctgctgctgt gaccaagact gtcagccgga gctaagagag
      661 ctgttcgaac ggttctgctt ctccggcgtg tttggcgggt acgtcagccc tccgtcccac
      721 catcgctgtg cagcccgcac tactcaccag actcctgact ggtttccctt cctgtgtgtg
      781 cagtcaccac cctccacctc tccgttcctc ggtcacttct accacggcgc catttccccc
      841 agacattccc ccggctttga aacccattcg cacttggacc taagagactt ctttgctgac
      901 gccagctaca aacaagggga tcccattatg accactaatg ggtattttac catccctcag
      961 gcgtctctag ctgggcagtg cctacaggat gcccctgtgg ctttcctgag gaattttcac
     1021 agtgtatgta ccacggacct ggaagtgcaa gaacgagatc ggcttatccc tgaagacatg
     1081 aggatccgca cgacaggagg cctggtcaca ccaaccgtaa cctatgagga agccactgac
     1141 ctggacaagc tcatcactag tccagacaca attttaagtg ccggatcggc tcccagaaat
     1201 gtgactgtgg aagaacatta tgttttcaga tggcaaaata attctatcag cagcctagac
     1261 atcacaatca tcagggcaga aatcaacgcc caccagagag gaacaatgac ccagagattt
     1321 acagtgaagt ttttaagccc taacagtggt ggtgagaagg aattttctgg aaatccaggt
     1381 taccagcttg gcaagccggt ccgagctctg cataccgatg gcatgaatgt caccacgttg
     1441 cacctctggc agccggctgg aaggggcctg tgcacatcag ccgccctcag acctgttttg
     1501 tttggagaag atgcctcctc tggctgcctt ttggaagttg ggattaagga gaactgtaca
     1561 caactcaggg agaatgtcct tcagagacta gatttgctga tccaggcaac gcacgttgcg
     1621 aggagaggca actcggacta cggtgatctg agcgatggct ggctggaggt catacgcgtc
     1681 gacgcccctg atgcaggcgc cgacctgcct ctgagcagcg caaatggcat gtgcccggaa
     1741 gttccaaccc acgtcaccat ccgcatcctc actgctgagg ctggcgctgt ggaaggggag
     1801 gctcagcggg agatcctggc tgtggagaca aggttctcca cagtaacctg gcagtaccaa
     1861 tgtgggctca cctgtgagga ggacaaagcc gaccttctcc ccctcagtgc ctctgttaag
     1921 ttcattaaca tccctgcgca gatgccccgc ccgaccagat tccagatcaa cttcacagag
     1981 tacgattgta cccggaatga gctgtgctgg ccccaacttc tgtaccctct gacccaatat
     2041 tatcaagggg agccccggcc tcagtgtgtc gccaaaggcc tgatgctgct gtcactcctc
     2101 atgttggcca tactcctcag gcacccttgg gtcgggatgt gcaaagcctg gtcctccgct
     2161 tccatccagc attaagtttc ctcgaagact cagagcagcc actcagtggc tccccgtagg
     2221 cctgtgtgcc cctctgaaac ctctttgatt gagacagggt ctctctatgt aggcctggct
     2281 tgcgtctaag ctcacagaga tctgcctgtc tctgcctctc gggtgctggg attaaaggca
     2341 tgtcccacat gcctggcctt ctgaaacact ttaataaaca aaatgtctat ttttgtagaa
     2401 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2461 aaaaaaaaaa aaaaaaaaaa
//
