LOCUS       NM_012670               1831 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus t-complex 1 (Tcp1), mRNA.
ACCESSION   NM_012670
VERSION     NM_012670.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1831)
  AUTHORS   Freund,A., Zhong,F.L., Venteicher,A.S., Meng,Z., Veenstra,T.D.,
            Frydman,J. and Artandi,S.E.
  TITLE     Proteostatic control of telomerase function through TRiC-mediated
            folding of TCAB1
  JOURNAL   Cell 159 (6), 1389-1403 (2014)
   PUBMED   25467444
REFERENCE   2  (bases 1 to 1831)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   3  (bases 1 to 1831)
  AUTHORS   Knee,K.M., Sergeeva,O.A. and King,J.A.
  TITLE     Human TRiC complex purified from HeLa cells contains all eight CCT
            subunits and is active in vitro
  JOURNAL   Cell Stress Chaperones 18 (2), 137-144 (2013)
   PUBMED   23011926
REFERENCE   4  (bases 1 to 1831)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 1831)
  AUTHORS   Dun,M.D., Smith,N.D., Baker,M.A., Lin,M., Aitken,R.J. and Nixon,B.
  TITLE     The chaperonin containing TCP1 complex (CCT/TRiC) is involved in
            mediating sperm-oocyte interaction
  JOURNAL   J Biol Chem 286 (42), 36875-36887 (2011)
   PUBMED   21880732
REFERENCE   6  (bases 1 to 1831)
  AUTHORS   Hynes,G., Kubota,H. and Willison,K.R.
  TITLE     Antibody characterisation of two distinct conformations of the
            chaperonin-containing TCP-1 from mouse testis
  JOURNAL   FEBS Lett 358 (2), 129-132 (1995)
   PUBMED   7828721
REFERENCE   7  (bases 1 to 1831)
  AUTHORS   Morita,T., Kubota,H., Murata,K., Nozaki,M., Delarbre,C.,
            Willison,K., Satta,Y., Sakaizumi,M., Takahata,N., Gachelin,G. et
            al.
  TITLE     Evolution of the mouse t haplotype: recent and worldwide
            introgression to Mus musculus
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 6851-6855 (1992)
   PUBMED   1495973
REFERENCE   8  (bases 1 to 1831)
  AUTHORS   Morita,T., Kubota,H., Gachelin,G., Nozaki,M. and Matsushiro,A.
  TITLE     Cloning of cDNA encoding rat TCP-1
  JOURNAL   Biochim Biophys Acta 1129 (1), 96-99 (1991)
   PUBMED   1756183
REFERENCE   9  (bases 1 to 1831)
  AUTHORS   Kubota,H., Morita,T., Nagata,T., Takemoto,Y., Nozaki,M.,
            Gachelin,G. and Matsushiro,A.
  TITLE     Nucleotide sequence of mouse Tcp-1a cDNA
  JOURNAL   Gene 105 (2), 269-273 (1991)
   PUBMED   1937024
REFERENCE   10 (bases 1 to 1831)
  AUTHORS   Willison,K., Lewis,V., Zuckerman,K.S., Cordell,J., Dean,C.,
            Miller,K., Lyon,M.F. and Marsh,M.
  TITLE     The t complex polypeptide 1 (TCP-1) is associated with the
            cytoplasmic aspect of Golgi membranes
  JOURNAL   Cell 57 (4), 621-632 (1989)
   PUBMED   2655925
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D90345.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D90345.1, SRR8487227.199773.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1831
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="F344"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..1831
                     /gene="Tcp1"
                     /gene_synonym="CCTalpha; Tcp-1"
                     /note="t-complex 1"
                     /db_xref="GeneID:24818"
                     /db_xref="RGD:3832"
     exon            1..141
                     /gene="Tcp1"
                     /gene_synonym="CCTalpha; Tcp-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1748
                     /gene="Tcp1"
                     /gene_synonym="CCTalpha; Tcp-1"
                     /note="CCT-alpha; TCP-1-alpha"
                     /codon_start=1
                     /product="T-complex protein 1 subunit alpha"
                     /protein_id="NP_036802.1"
                     /db_xref="GeneID:24818"
                     /db_xref="RGD:3832"
                     /translation="MEGPLSVFGDRSTGEAIRSQNVMAAASIANIVKSSLGPVGLDKM
                     LVDDIGDVTITNDGATILKLLEVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELLK
                     NADELVKQKIHPTSVISGYRLACKEAVRYINENLIINTDELGRDCLINAAKTSMSSKI
                     IGINGDFFANMVVDAVLAVKYTDIRGQPRYPVNSVNILKAHGRSQIESMLINGYALNC
                     VVGSQGMLKRIVNAKIACLDFSLQKTKMKLGVQVVITDPEKLDQIRQRESDITKERIQ
                     KILATGANVILTTGGIDDMCLKYFVEAGAMAVRRVLKRDLKRIAKASGASILSTLANL
                     EGEETFEATMLGQAEEVVQERICDDELILIKNTKARTSASIILRGANDFMCDEMERSL
                     HDALCVVKRVLESKSVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLLVIPN
                     TLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLDLVHGKPRDNKQAGVFEPTI
                     VKVKSLKFATEAAITILRIDDLIKLHPESKDDKHGGYENAVHSGALDD"
     exon            142..227
                     /gene="Tcp1"
                     /gene_synonym="CCTalpha; Tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            228..356
                     /gene="Tcp1"
                     /gene_synonym="CCTalpha; Tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..454
                     /gene="Tcp1"
                     /gene_synonym="CCTalpha; Tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..565
                     /gene="Tcp1"
                     /gene_synonym="CCTalpha; Tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..747
                     /gene="Tcp1"
                     /gene_synonym="CCTalpha; Tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..874
                     /gene="Tcp1"
                     /gene_synonym="CCTalpha; Tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1050
                     /gene="Tcp1"
                     /gene_synonym="CCTalpha; Tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1174
                     /gene="Tcp1"
                     /gene_synonym="CCTalpha; Tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1367
                     /gene="Tcp1"
                     /gene_synonym="CCTalpha; Tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1531
                     /gene="Tcp1"
                     /gene_synonym="CCTalpha; Tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1831
                     /gene="Tcp1"
                     /gene_synonym="CCTalpha; Tcp-1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1831
                     /gene="Tcp1"
                     /gene_synonym="CCTalpha; Tcp-1"
ORIGIN      
        1 ggccgctatc cggtctcaga gcggagctat cgcttagttg tctgcgttgg tagtgagatt
       61 tgcttcgttt cctgaagatg gagggtcctt tgtccgtgtt cggggaccgc agcactgggg
      121 aagcgatccg ctcccagaac gttatggctg cagcctctat tgccaacatt gttaaaagtt
      181 ctcttgggcc agttggcttg gataaaatgt tggtggatga tattggtgat gtaactatta
      241 ctaatgatgg ggccaccatt ctgaaattat tggaggtgga acatcctgca gccaaagttc
      301 tgtgtgaact ggctgacctg caagacaaag aagttggaga tggaactacc tcagtggtaa
      361 tcattgcagc ggagcttctg aaaaatgctg atgagctagt caagcagaaa attcatccga
      421 catcagttat tagtggctat cgtcttgcct gcaaggaagc agtgcgatat atcaatgaga
      481 acctaattat caacacagac gaacttggaa gagactgtct gatcaatgct gctaagacat
      541 ccatgtcttc caaaattatt ggaataaatg gtgatttctt cgctaatatg gtggtagacg
      601 ctgtgcttgc tgttaaatac acagatatac gaggccagcc tcgctatcca gtcaattctg
      661 ttaatattct aaaagcccac gggagaagtc agatagaaag catgctgatc aatggctatg
      721 cactcaactg tgtggttgga tctcagggca tgctcaagag aatagttaat gcaaaaattg
      781 cttgtcttga cttcagcctg cagaaaacaa aaatgaagct tggtgtacag gtggttatta
      841 cagaccctga gaaactggac cagattagac agagagaatc cgatatcacc aaggagagaa
      901 ttcagaagat cctggcaact ggtgccaacg ttattctaac caccggtggg attgatgaca
      961 tgtgtctgaa gtattttgtg gaagctggtg ccatggctgt taggagagtt ttaaaaagag
     1021 acctcaaacg tattgcaaaa gcttctggag caagtatcct gtctacactg gccaatttgg
     1081 aaggtgaaga gacttttgag gcaacaatgt tgggacaagc ggaagaggtc gtacaggaga
     1141 ggatttgtga cgatgagctg atcttaatca aaaatactaa ggctcgtacg tcagcttcaa
     1201 ttatcttacg aggggcaaac gacttcatgt gtgatgaaat ggaacgctcc ttacatgacg
     1261 ctctttgtgt ggtgaagaga gttttggagt caaagtctgt ggtcccaggt ggaggtgctg
     1321 tagaagcggc cttgtctata taccttgaaa actatgcgac cagtatggga tctcgggaac
     1381 agcttgctat tgcagagttt gcaagatctc tgcttgtgat tcctaataca ctggcagtga
     1441 atgctgccca agactccact gacctggttg ccaagttaag agcttttcac aatgaggctc
     1501 aagttaaccc agaacgtaaa aatctaaagt ggattggtct tgatttggtc catgggaaac
     1561 cacgagacaa taagcaagcg ggggtgtttg aaccaaccat agttaaagta aagagcctga
     1621 agtttgcaac agaggctgca atcaccatac ttcggattga tgatctgata aaattacacc
     1681 cagaaagcaa agacgacaaa cacggaggtt atgaaaatgc tgttcactct ggagcccttg
     1741 atgactgatt ggacttccct tttatttatg acagtgttgg gtgtaatgtc ttagccttgg
     1801 gtgtctcaca ttaaagtaca acgagctgtc g
//
