LOCUS       NM_022534               1962 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus transcobalamin 2 (Tcn2), mRNA.
ACCESSION   NM_022534
VERSION     NM_022534.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1962)
  AUTHORS   Alam,A., Woo,J.S., Schmitz,J., Prinz,B., Root,K., Chen,F.,
            Bloch,J.S., Zenobi,R. and Locher,K.P.
  TITLE     Structural basis of transcobalamin recognition by human CD320
            receptor
  JOURNAL   Nat Commun 7, 12100 (2016)
   PUBMED   27411955
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1962)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   3  (bases 1 to 1962)
  AUTHORS   Orozco-Barrios,C.E., Battaglia-Hsu,S.F., Arango-Rodriguez,M.L.,
            Ayala-Davila,J., Chery,C., Alberto,J.M., Schroeder,H., Daval,J.L.,
            Martinez-Fong,D. and Gueant,J.L.
  TITLE     Vitamin B12-impaired metabolism produces apoptosis and Parkinson
            phenotype in rats expressing the transcobalamin-oleosin chimera in
            substantia nigra
  JOURNAL   PLoS One 4 (12), e8268 (2009)
   PUBMED   20027219
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1962)
  AUTHORS   Pereira,A.C., Lourenco,D.M., Maffei,F.H., Morelli,V.M., Rollo,H.A.,
            Zago,M.A., Vannucchi,H. and Franco,R.F.
  TITLE     A transcobalamin gene polymorphism and the risk of venous
            thrombosis. The BRATROS (Brazilian Thrombosis Study)
  JOURNAL   Thromb Res 119 (2), 183-188 (2007)
   PUBMED   16530812
REFERENCE   5  (bases 1 to 1962)
  AUTHORS   Wuerges,J., Garau,G., Geremia,S., Fedosov,S.N., Petersen,T.E. and
            Randaccio,L.
  TITLE     Structural basis for mammalian vitamin B12 transport by
            transcobalamin
  JOURNAL   Proc Natl Acad Sci U S A 103 (12), 4386-4391 (2006)
   PUBMED   16537422
REFERENCE   6  (bases 1 to 1962)
  AUTHORS   Li,N., Rosenblatt,D.S., Kamen,B.A., Seetharam,S. and Seetharam,B.
  TITLE     Identification of two mutant alleles of transcobalamin II in an
            affected family
  JOURNAL   Hum Mol Genet 3 (10), 1835-1840 (1994)
   PUBMED   7849710
REFERENCE   7  (bases 1 to 1962)
  AUTHORS   Quadros,E.V., Sai,P. and Rothenberg,S.P.
  TITLE     Functional human transcobalamin II isoproteins are secreted by
            insect cells using the baculovirus expression system
  JOURNAL   Blood 81 (5), 1239-1245 (1993)
   PUBMED   8443384
REFERENCE   8  (bases 1 to 1962)
  AUTHORS   Biosca,M., Encabo,G., Garcia-Bragado,F., Mane,S., Ruibal,A. and
            Vilardell,Y.M.
  TITLE     Transcobalamin II. A specific marker of renal involvement in
            essential mixed cryoglobulinemia
  JOURNAL   Nephron 45 (3), 255-256 (1987)
   PUBMED   3574578
REFERENCE   9  (bases 1 to 1962)
  AUTHORS   Fiedler-Nagy,C., Rowley,G.R., Coffey,J.W. and Miller,O.N.
  TITLE     Binding of vitamin B12--rat transcobalamin II and free vitamin B12
            to plasma membranes isolated from rat liver
  JOURNAL   Br J Haematol 31 (3), 311-321 (1975)
   PUBMED   1201244
REFERENCE   10 (bases 1 to 1962)
  AUTHORS   Zittoun,J., Zittoun,R., Marquet,J. and Sultan,C.
  TITLE     The three transcobalamins in myeloproliferative disorders and acute
            leukaemia
  JOURNAL   Br J Haematol 31 (3), 287-298 (1975)
   PUBMED   1059479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Apr 28, 2015 this sequence version replaced NM_022534.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF054810.1, SRR26643285.39070.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000014.1  83051419-83051552   c
            135-327             JAXUCZ010000014.1  83047428-83047620   c
            328-497             JAXUCZ010000014.1  83046206-83046375   c
            498-659             JAXUCZ010000014.1  83045184-83045345   c
            660-832             JAXUCZ010000014.1  83043938-83044110   c
            833-1013            JAXUCZ010000014.1  83043647-83043827   c
            1014-1176           JAXUCZ010000014.1  83042330-83042492   c
            1177-1292           JAXUCZ010000014.1  83039331-83039446   c
            1293-1962           JAXUCZ010000014.1  83036935-83037604   c
FEATURES             Location/Qualifiers
     source          1..1962
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1962
                     /gene="Tcn2"
                     /gene_synonym="Tc2; Tcn2p"
                     /note="transcobalamin 2"
                     /db_xref="GeneID:64365"
                     /db_xref="RGD:620681"
     exon            1..134
                     /gene="Tcn2"
                     /gene_synonym="Tc2; Tcn2p"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1354
                     /gene="Tcn2"
                     /gene_synonym="Tc2; Tcn2p"
                     /note="transcobalamin II; TC-2; TCII; TC II"
                     /codon_start=1
                     /product="transcobalamin-2 precursor"
                     /protein_id="NP_071979.2"
                     /db_xref="GeneID:64365"
                     /db_xref="RGD:620681"
                     /translation="MELLKALLLLSGVLGALAEFCVIPKMDGQLVEKLGQRLLPWMDR
                     LSSEQLNPSIYVGLRLSSMQAGTKENLYLHNLKLHYQQCLLRSTSSDDNSGCQTKISG
                     GSLALYLLALRANCELLGSRKGDRMVSQLKWFLEDEKKAIGHHHEGHPHTSYYQYGLS
                     ILALCVHRKRVHDSVVGKLLYAVEHDYFTYQGHLSVDTEAMAGLAFTCLERFNFNSDL
                     RPRITTAIETVREKILKAQAPEGYFGNIYSTPLALQMLMTSPGVGLGPACLKARKSLL
                     LSLQDGAFQNPMMISQLLPVLNHKTYLNLISPDCQAPRVMLVPATEDPVHLSEVSVTL
                     KVSSVLPPYERTVSVFAGASLEDVLKRARDLGEFTYGTQASLSGPYLTSVLGKEAGDR
                     EYWQLLRVPDTPLLQGIADYKPKNGETIELRLVRW"
     exon            135..327
                     /gene="Tcn2"
                     /gene_synonym="Tc2; Tcn2p"
                     /inference="alignment:Splign:2.1.0"
     exon            328..497
                     /gene="Tcn2"
                     /gene_synonym="Tc2; Tcn2p"
                     /inference="alignment:Splign:2.1.0"
     exon            498..659
                     /gene="Tcn2"
                     /gene_synonym="Tc2; Tcn2p"
                     /inference="alignment:Splign:2.1.0"
     exon            660..832
                     /gene="Tcn2"
                     /gene_synonym="Tc2; Tcn2p"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1013
                     /gene="Tcn2"
                     /gene_synonym="Tc2; Tcn2p"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1176
                     /gene="Tcn2"
                     /gene_synonym="Tc2; Tcn2p"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1292
                     /gene="Tcn2"
                     /gene_synonym="Tc2; Tcn2p"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1962
                     /gene="Tcn2"
                     /gene_synonym="Tc2; Tcn2p"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgacaagttg ctgtcagaca agccctcaag gcgggttcca ggagtctctc acctcccacc
       61 tgtgcctgcc atggagctcc tgaaggcgct gctactcctg tctggagtcc tcggggctct
      121 tgctgaattc tgtgtaatac caaagatgga cggccagctg gtagagaagc tgggccagcg
      181 tctcttacct tggatggatc ggctttcctc agagcagttg aaccccagca tctacgtcgg
      241 cctgcggctt tccagcatgc aggctgggac caaggagaac ctctaccttc acaacctcaa
      301 actccattac cagcagtgcc tcctgcggtc cacctcgagt gatgataaca gtggttgcca
      361 gactaagatt tctgggggca gcttggccct ctacctgctt gctctcaggg ccaactgtga
      421 gctcctgggg agccgaaagg gtgacaggat ggtctcacag ctcaagtggt tcttggagga
      481 tgagaagaag gccattgggc accatcatga aggccacccc cacaccagct attaccagta
      541 tggcctcagt atcctggccc tgtgcgtcca ccggaagcgg gtccatgaca gtgtggtggg
      601 caagctcctg tatgctgttg aacatgacta ctttacctac cagggccacc tctctgtgga
      661 cacagaagcc atggccggct tggccttcac ctgtttggaa cgattcaatt tcaactctga
      721 cctgagacca cggatcacca cggccatcga gacagtgcga gagaagatcc tgaaggccca
      781 ggcccctgag ggctactttg gaaatatcta tagcactccg ctggcactac agatgctaat
      841 gacctctcct ggggtagggc tgggcccagc ttgcctcaag gcaaggaaat ccctgctgct
      901 cagcctacag gatggagcct tccagaatcc tatgatgatt tcccagctgc tacccgtcct
      961 gaaccacaag acctacttga atcttatctc cccagactgc caggcaccca gggtcatgtt
     1021 ggtgcccgcc actgaggacc ctgtccactt gtcagaagtc agcgtcacgc tgaaggtctc
     1081 cagtgtcttg ccaccatatg aacgaacagt ttccgtcttt gctggggcct ccttggaaga
     1141 tgtcctgaag agggcgcgag accttggaga attcacgtat gggacccagg cctccttgtc
     1201 aggtccctac ctgacatccg tactagggaa agaagctggg gatcgagaat actggcagct
     1261 tctccgagtc cctgataccc ctctgctaca aggcattgct gactacaaac ccaagaacgg
     1321 ggaaaccatc gaattgcggc tagttagatg gtagccctag gctccctcct gatgtcttcg
     1381 gaccctgctg ccacctcaag tgcgcttgga acaatgtccc ccagatcacc tcagctaact
     1441 tcccaaagag gacctaagcc actgtccacc ttagagcagg aaggaaaaca cctcctccct
     1501 tagggaggct gctagcttga gtgtggccct gcctgactcc acaggtcttt catgaagatt
     1561 gccccataag tctgaggaac aggatgccct caactccctc tacataaagg agtctgttgg
     1621 ccatgggtgt tgtgagtacc attgctctgg gactggggtc ctacaagaag gacctccatg
     1681 gcccaagtgc tgtggttctg acccacacac cctacccctg ctctctctca ggatggtggt
     1741 cccaaagctg gtcgtgaagc agcctttggc cctcaacagg gtcttccaac acaattaaag
     1801 ccttgattta ccttatgtgg ctgcagtgtc ctggtgcctc atgtttactg cctgggagga
     1861 gggggagcag agacagaaga gacctccggc aggactttga ttgctctctt tagtgtatcg
     1921 catggtgaac cggcataaac agagttgacg aatctttcta aa
//
