LOCUS       NM_199089               2609 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus T-cell immune regulator 1, ATPase H+ transporting
            V0 subunit A3 (Tcirg1), mRNA.
ACCESSION   NM_199089 XM_006230727 XM_215205
VERSION     NM_199089.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2609)
  AUTHORS   Matsumoto,N., Sekiya,M., Tohyama,K., Ishiyama-Matsuura,E.,
            Sun-Wada,G.H., Wada,Y., Futai,M. and Nakanishi-Matsui,M.
  TITLE     Essential Role of the a3 Isoform of V-ATPase in Secretory Lysosome
            Trafficking via Rab7 Recruitment
  JOURNAL   Sci Rep 8 (1), 6701 (2018)
   PUBMED   29712939
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2609)
  AUTHORS   Ochotny,N., Voronov,I., Owen,C., Aubin,J.E. and Manolson,M.F.
  TITLE     The R740S mutation in the V-ATPase a3 subunit results in osteoclast
            apoptosis and defective early-stage autophagy
  JOURNAL   J Cell Biochem 114 (12), 2823-2833 (2013)
   PUBMED   23908015
REFERENCE   3  (bases 1 to 2609)
  AUTHORS   Belaid,A., Cerezo,M., Chargui,A., Corcelle-Termeau,E.,
            Pedeutour,F., Giuliano,S., Ilie,M., Rubera,I., Tauc,M., Barale,S.,
            Bertolotto,C., Brest,P., Vouret-Craviari,V., Klionsky,D.J.,
            Carle,G.F., Hofman,P. and Mograbi,B.
  TITLE     Autophagy plays a critical role in the degradation of active RHOA,
            the control of cell cytokinesis, and genomic stability
  JOURNAL   Cancer Res 73 (14), 4311-4322 (2013)
   PUBMED   23704209
REFERENCE   4  (bases 1 to 2609)
  AUTHORS   Kuno,A., Hori,Y.S., Hosoda,R., Tanno,M., Miura,T., Shimamoto,K. and
            Horio,Y.
  TITLE     Resveratrol improves cardiomyopathy in dystrophin-deficient mice
            through SIRT1 protein-mediated modulation of p300 protein
  JOURNAL   J Biol Chem 288 (8), 5963-5972 (2013)
   PUBMED   23297412
REFERENCE   5  (bases 1 to 2609)
  AUTHORS   Hosokawa,H., Dip,P.V., Merkulova,M., Bakulina,A., Zhuang,Z.,
            Khatri,A., Jian,X., Keating,S.M., Bueler,S.A., Rubinstein,J.L.,
            Randazzo,P.A., Ausiello,D.A., Gruber,G. and Marshansky,V.
  TITLE     The N termini of a-subunit isoforms are involved in signaling
            between vacuolar H+-ATPase (V-ATPase) and cytohesin-2
  JOURNAL   J Biol Chem 288 (8), 5896-5913 (2013)
   PUBMED   23288846
  REMARK    GeneRIF: The N termini of a-subunit isoforms are involved in
            signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2
REFERENCE   6  (bases 1 to 2609)
  AUTHORS   Blin-Wakkach,C., Wakkach,A., Sexton,P.M., Rochet,N. and Carle,G.F.
  TITLE     Hematological defects in the oc/oc mouse, a model of infantile
            malignant osteopetrosis
  JOURNAL   Leukemia 18 (9), 1505-1511 (2004)
   PUBMED   15284856
REFERENCE   7  (bases 1 to 2609)
  AUTHORS   Utku,N., Boerner,A., Tomschegg,A., Bennai-Sanfourche,F.,
            Bulwin,G.C., Heinemann,T., Loehler,J., Blumberg,R.S. and Volk,H.D.
  TITLE     TIRC7 deficiency causes in vitro and in vivo augmentation of T and
            B cell activation and cytokine response
  JOURNAL   J Immunol 173 (4), 2342-2352 (2004)
   PUBMED   15294947
REFERENCE   8  (bases 1 to 2609)
  AUTHORS   Toyomura,T., Murata,Y., Yamamoto,A., Oka,T., Sun-Wada,G.H., Wada,Y.
            and Futai,M.
  TITLE     From lysosomes to the plasma membrane: localization of
            vacuolar-type H+ -ATPase with the a3 isoform during osteoclast
            differentiation
  JOURNAL   J Biol Chem 278 (24), 22023-22030 (2003)
   PUBMED   12672822
REFERENCE   9  (bases 1 to 2609)
  AUTHORS   Frattini,A., Orchard,P.J., Sobacchi,C., Giliani,S., Abinun,M.,
            Mattsson,J.P., Keeling,D.J., Andersson,A.K., Wallbrandt,P.,
            Zecca,L., Notarangelo,L.D., Vezzoni,P. and Villa,A.
  TITLE     Defects in TCIRG1 subunit of the vacuolar proton pump are
            responsible for a subset of human autosomal recessive osteopetrosis
  JOURNAL   Nat Genet 25 (3), 343-346 (2000)
   PUBMED   10888887
REFERENCE   10 (bases 1 to 2609)
  AUTHORS   Toyomura,T., Oka,T., Yamaguchi,C., Wada,Y. and Futai,M.
  TITLE     Three subunit a isoforms of mouse vacuolar H(+)-ATPase.
            Preferential expression of the a3 isoform during osteoclast
            differentiation
  JOURNAL   J Biol Chem 275 (12), 8760-8765 (2000)
   PUBMED   10722719
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Oct 6, 2022 this sequence version replaced
            XM_006230727.3, NM_199089.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1310819.1,
                                           SRR21887621.1113346.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760494 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                JAXUCZ010000001.1  210567899-210567935 c
            38-158              JAXUCZ010000001.1  210565606-210565726 c
            159-237             JAXUCZ010000001.1  210565243-210565321 c
            238-458             JAXUCZ010000001.1  210564499-210564719 c
            459-547             JAXUCZ010000001.1  210564320-210564408 c
            548-674             JAXUCZ010000001.1  210564021-210564147 c
            675-757             JAXUCZ010000001.1  210563859-210563941 c
            758-851             JAXUCZ010000001.1  210563580-210563673 c
            852-1064            JAXUCZ010000001.1  210563275-210563487 c
            1065-1209           JAXUCZ010000001.1  210562830-210562974 c
            1210-1349           JAXUCZ010000001.1  210559335-210559474 c
            1350-1507           JAXUCZ010000001.1  210559082-210559239 c
            1508-1598           JAXUCZ010000001.1  210558912-210559002 c
            1599-1717           JAXUCZ010000001.1  210558000-210558118 c
            1718-1931           JAXUCZ010000001.1  210557706-210557919 c
            1932-2063           JAXUCZ010000001.1  210557284-210557415 c
            2064-2171           JAXUCZ010000001.1  210557042-210557149 c
            2172-2289           JAXUCZ010000001.1  210556849-210556966 c
            2290-2467           JAXUCZ010000001.1  210556494-210556671 c
            2468-2609           JAXUCZ010000001.1  210556270-210556411 c
FEATURES             Location/Qualifiers
     source          1..2609
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2609
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /note="T-cell immune regulator 1, ATPase H+ transporting
                     V0 subunit A3"
                     /db_xref="GeneID:293650"
                     /db_xref="RGD:735136"
     exon            1..37
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /inference="alignment:Splign:2.1.0"
     exon            38..158
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..2546
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /EC_number="7.1.2.1"
                     /note="v-ATPase 116-kDa; v-H+ATPase subunit a3; T cell
                     immune response cDNA7 protein; osteoclastic proton pump;
                     ATPase, H+ transporting, lysosomal V0 protein a; T-cell,
                     immune regulator 1, ATPase, H+ transporting, lysosomal V0
                     protein a; T-cell, immune regulator 1, ATPase, H+
                     transporting, lysosomal V0 protein A3; V-type proton
                     ATPase 116 kDa subunit a; T-cell, immune regulator 1,
                     ATPase, H+ transporting, lysosomal V0 subunit A3; V-type
                     proton ATPase 116 kDa subunit a3"
                     /codon_start=1
                     /product="V-type proton ATPase 116 kDa subunit a 3"
                     /protein_id="NP_954520.3"
                     /db_xref="GeneID:293650"
                     /db_xref="RGD:735136"
                     /translation="MGSMFRSEEVALVQLLLPTASAYNCVSQLGELGLVEFRDLNESV
                     SAFQRRFVVEVRRCEELEKTFTFLREEVQRAGLTLTPPEGTLPAPPPRDLLRIQEETD
                     RLAQELRDVRGNQQALRAQLHQLQLHSAVLGQSHAPPMAAVHTEGPTTERTPLLSATP
                     GPHADLKVNFVAGAVEPCKAAALERLLWRACRGFLIASFKETEGQLEDPVTGEPATWM
                     TFVISYWGEQIGQKVRKITDCFHCHVFPYLEQEEARLRTLQQLQQQSQELQEVLGETE
                     RFLSQVLGRVQQLLPPGQVQIRKMKAVYLTLNQCSVNTTHKCLIAEVWCATRDLPTVQ
                     QALQSGSSEEGVSAVAHRIPCQDMPPTLIRTNRFTSSFQGIVDAYGVGRYREVNPAPY
                     TIITFPFLFAVMFGDVGHGLLMFLFALAMVLTENQPAVKTTQNEIWQTFFGGRYLLLL
                     MGLFSIYTGFIYNECFSRATTIFPSGWSVAAMANQSGWSDEYLSQHPMLTLNPNITGV
                     FLGPYPFGIDPIWSLATNHLSFLNSFKMKMSVILGVTHMAFGVFLSIFNHVHFGQAHR
                     LLLETVPELIFLLGLFGYLVFLIVYKWLYVSAASASSAPSILIHFINMFLFSQNPTNR
                     LLFHGQVVVQYALVVLALATVPILLLGTPLYLLRQHHRRNTQRRPTAGRQDEDSDKLL
                     ASPDASTLENSWSPDEEKAGSSGDEEAEFVPSEIFMHQAIHTIEFCLGCISNTASYLR
                     LWALSLAHAQLSEVLWAMVMRIGLGMGREIGVASVVLVPVFAAFAVLTVAILLVMEGL
                     SAFLHALRLHWVEFQNKFYSGTGYKLSPFAFTVDSD"
     exon            159..237
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /inference="alignment:Splign:2.1.0"
     exon            238..458
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /inference="alignment:Splign:2.1.0"
     exon            459..547
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /inference="alignment:Splign:2.1.0"
     exon            548..674
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /inference="alignment:Splign:2.1.0"
     exon            675..757
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /inference="alignment:Splign:2.1.0"
     exon            758..851
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1064
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1209
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1349
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1507
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1598
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1717
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1931
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2063
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2171
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2289
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2467
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2609
                     /gene="Tcirg1"
                     /gene_synonym="OC116; TIRC7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatcctaagt cctgagttga gagacgagtc tacgtaggat catgggctcc atgttccgga
       61 gtgaagaggt ggccttggtc cagctcctgt tgcccacagc atctgcctac aactgtgtga
      121 gccagctggg tgagctgggc ctcgtggagt ttagagacct caacgaatcg gtgagtgcct
      181 tccagagacg cttcgtggta gaggtccggc gctgcgagga gctggagaag accttcacct
      241 tcttgcggga agaagtgcag cgggcaggcc tgacactgac cccacccgag gggacactgc
      301 cagcaccacc tccccgagac ctgctgcgca tccaggagga aacggaccgc ttggcccagg
      361 agcttcggga tgttcgaggc aaccaacagg cacttcgggc ccagctgcac cagctacagc
      421 tccactcagc cgtgctgggc cagagccacg cccctccgat ggcagctgtc catacggagg
      481 gacccaccac tgagagaaca cccctgcttt cagccacccc agggccacat gcagacctga
      541 aggtcaattt tgtggcaggt gctgtggagc cttgcaaggc tgcagccctg gagcgcctgc
      601 tttggagagc ttgccgcggc ttcctcattg ccagctttaa ggagactgag gggcagctgg
      661 aggacccggt gacgggtgag cctgcaactt ggatgacctt tgtcatctcc tactggggtg
      721 agcagatcgg acagaaggtt cggaagatca cagactgctt tcactgtcat gtcttcccgt
      781 acctggagca ggaggaagcc cggctcagga ccttgcagca gctgcagcag cagagccagg
      841 agcttcagga ggtcctgggg gagacagaac ggttcctgag ccaggtgttg ggccgggtgc
      901 agcagctgct gcccccaggg caggtgcaga tccggaagat gaaggccgtg tacctgaccc
      961 tcaaccagtg cagtgtgaac accacacaca agtgcctcat tgcggaggtc tggtgtgcca
     1021 cgagggacct tcccactgta cagcaggcgc tgcagagcgg ctcgagtgag gaaggagtga
     1081 gtgctgtggc tcaccgtatc ccttgccagg acatgcctcc aactctcatc aggaccaacc
     1141 gcttcacctc cagcttccag ggcattgtgg atgcctatgg tgtgggccga tacagggaag
     1201 tcaaccctgc tccctacacc atcatcacat tccccttcct ctttgctgtg atgtttggcg
     1261 atgtgggcca cggactgctc atgtttctct tcgccctggc tatggtcctc actgagaacc
     1321 aaccagctgt aaagaccacg caaaatgaga tctggcagac cttctttggg ggtcgctacc
     1381 tactcctgct catgggtctg ttctccatct acacgggctt catctacaac gagtgcttca
     1441 gccgagccac cactattttc ccctcaggct ggagtgtggc tgccatggcc aaccagtcag
     1501 gctggagtga cgagtatctg tcccagcacc ccatgcttac cctgaaccct aacatcactg
     1561 gtgtcttcct cggaccttat cccttcggca ttgacccgat ctggagcctg gccaccaacc
     1621 acctgagctt cctcaactcc ttcaagatga agatgtctgt catccttggg gtcacacaca
     1681 tggcctttgg ggtgttcctc agcatcttca accatgtgca ctttggccag gcccaccggc
     1741 tactgctgga gaccgtgcct gagctcatct tcctgttggg cctctttggc taccttgttt
     1801 tcctcattgt ctacaagtgg ctctacgtct cagctgccag cgcctcctcg gcccccagta
     1861 tcctcattca cttcatcaat atgttcctct tctcccaaaa ccccaccaat cggctgctct
     1921 tccacgggca ggtagtggta cagtatgcgc tggtggtcct ggctttggcc acagttccta
     1981 tcctgctgct gggcacaccc ttgtaccttc tgcgccagca ccaccgaaga aacactcaga
     2041 gaaggcctac agcaggcaga caggatgagg acagtgacaa gcttctggcc tccccggatg
     2101 cttccacctt ggagaacagc tggagccctg atgaggagaa ggctgggagc tcaggagatg
     2161 aagaagctga gtttgtccct tcggagatct tcatgcacca agccatccac accattgagt
     2221 tctgcctggg ctgcatctcc aacacagcct cctacttgcg tctctgggcc ctgagcctgg
     2281 ctcatgctca gctgtctgag gtcctgtggg ccatggtgat gcgcataggc ctaggcatgg
     2341 gccgagagat tggtgtggca tctgtggtgc tggtccctgt gtttgctgcc tttgctgtgt
     2401 tgactgtggc catcttgcta gtgatggagg ggctctcagc cttcctacat gccctgcggt
     2461 tgcactgggt ggagttccag aacaagttct attcagggac cggctacaag ctcagcccct
     2521 tcgccttcac tgtggacagt gactagcacc tacttcgatt cctgcttctt caaaatggga
     2581 caggaataaa aagctggctg gcccaggaa
//
