LOCUS       NM_001115043            1318 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus transcriptional and immune response regulator
            (Tcim), mRNA.
ACCESSION   NM_001115043 XM_001072266
VERSION     NM_001115043.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1318)
  AUTHORS   Zhu P, Wang Y, Du Y, He L, Huang G, Zhang G, Yan X and Fan Z.
  TITLE     C8orf4 negatively regulates self-renewal of liver cancer stem cells
            via suppression of NOTCH2 signalling
  JOURNAL   Nat Commun 6, 7122 (2015)
   PUBMED   25985737
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1318)
  AUTHORS   Jung Y, Kim M, Soh H, Lee S, Kim J, Park S, Song K and Lee I.
  TITLE     TC1(C8orf4) regulates hematopoietic stem/progenitor cells and
            hematopoiesis
  JOURNAL   PLoS One 9 (6), e100311 (2014)
   PUBMED   24937306
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1318)
  AUTHORS   Kim J, Kim Y, Kim HT, Kim DW, Ha Y, Kim J, Kim CH, Lee I and Song
            K.
  TITLE     TC1(C8orf4) is a novel endothelial inflammatory regulator enhancing
            NF-kappaB activity
  JOURNAL   J Immunol 183 (6), 3996-4002 (2009)
   PUBMED   19684084
REFERENCE   4  (bases 1 to 1318)
  AUTHORS   Wang YD, Bian GH, Lv XY, Zheng R, Sun H, Zhang Z, Chen Y, Li QW,
            Xiao Y, Yang QT, Ai JZ, Wei YQ and Zhou Q.
  TITLE     TC1 (C8orf4) is involved in ERK1/2 pathway-regulated G(1)- to
            S-phase transition
  JOURNAL   BMB Rep 41 (10), 733-738 (2008)
   PUBMED   18959821
REFERENCE   5  (bases 1 to 1318)
  AUTHORS   Park J, Jung Y, Kim J, Kim KY, Ahn SG, Song K and Lee I.
  TITLE     TC1 (C8orf4) is upregulated by cellular stress and mediates heat
            shock response
  JOURNAL   Biochem Biophys Res Commun 360 (2), 447-452 (2007)
   PUBMED   17603013
REFERENCE   6  (bases 1 to 1318)
  AUTHORS   Jung Y, Bang S, Choi K, Kim E, Kim Y, Kim J, Park J, Koo H, Moon
            RT, Song K and Lee I.
  TITLE     TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving
            antagonistic activity of Chibby
  JOURNAL   Cancer Res 66 (2), 723-728 (2006)
   PUBMED   16424001
REFERENCE   7  (bases 1 to 1318)
  AUTHORS   Sunde M, McGrath KC, Young L, Matthews JM, Chua EL, Mackay JP and
            Death AK.
  TITLE     TC-1 is a novel tumorigenic and natively disordered protein
            associated with thyroid cancer
  JOURNAL   Cancer Res 64 (8), 2766-2773 (2004)
   PUBMED   15087392
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158773.1.
            
            On Mar 2, 2008 this sequence version replaced XM_001072266.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC158773.1, CK476382.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1318
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..1318
                     /gene="Tcim"
                     /note="transcriptional and immune response regulator"
                     /db_xref="GeneID:684871"
                     /db_xref="RGD:6499724"
     exon            1..1294
                     /gene="Tcim"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..359
                     /gene="Tcim"
                     /codon_start=1
                     /product="transcriptional and immune response regulator"
                     /protein_id="NP_001108515.1"
                     /db_xref="GeneID:684871"
                     /db_xref="RGD:6499724"
                     /translation="MKAKPSHPATSMSTSLRVSPSIHGYHFDTAARKKAVGNIFENID
                     QESLQRLFRNSGDKKAEERAKIIFAIDQDLEEKTRALMALKKRTKDKLLQFLKLRKYS
                     IKVH"
ORIGIN      
        1 tggaagtgcc caagctgagc tgtgaaagac ccacatcgat gaaagcaaaa ccaagccacc
       61 cagccaccag catgtccact tctcttcgag taagcccgtc catccacggc taccacttcg
      121 acacagctgc tcgcaagaaa gctgtgggta acatctttga aaacatagac caggagtccc
      181 tgcagaggct cttcaggaac tcgggagaca agaaggcaga ggagcgggcc aagatcattt
      241 tcgccatcga ccaagatttg gaggagaaaa ctcgagccct catggccctg aagaagagga
      301 caaaagacaa gcttctccag ttcctcaaac tgcggaaata ctccatcaag gtacactgag
      361 cacagcagga tggctaagga gcttatccac caatgaacct ttaaagaccc agtgagcctg
      421 ccagtcttgg caggggcagt gtcccgcaca aaggcttgag agcttctccc gacaggactc
      481 cgaggatgga agggacatac ctcaccagct acacagactc ccaactcctt acagccctga
      541 gctgtcccac tgggagcaaa gtgccttcag caggtgttga gaactctcgc agcaggaaag
      601 gagcaacaca gcctgagaga atggaggcac ggaccagaac ttgcagaaca tggcatttgt
      661 ggggactgag tgcacgcatc cagggtcctg ggaaaggccc taaaactaaa ctcaaaccta
      721 acttggtttt tgttcttgtt gtttggtttg ttattttgtt ttctttcttt ttgaaaaata
      781 tcgaagtggg taaggagagg gaggaaagag aaggaatatg aaccgtaaat ggtttactga
      841 agttttgctt ttttgttttt taacccgaat gtcttaaaat gtggctaaac ctccgtgctg
      901 tttatggggt caagattttt acagatcagt aattgactgc ttgcatttca tacaatgcct
      961 aagacagtgc gccccctggt gttaaagtca aagaactgga tgccttgccc agcatggtgg
     1021 tcgtctatgg atttgtacac attccaaaat ggtttgccca aagttgaaag aatggggccc
     1081 ttcataaatc tgaaggactg tgaacgattt tctaatgttt ttttaaactt tctggctaat
     1141 gctaaaatat aatctaatta aatgtcctac agacaccgta gcgagcatta ggatatgaat
     1201 atgagagatt gtttagaagg atgctgtggt attttttata taatttatta tacattgtaa
     1261 gtgatacata gcctaataaa ttattatcaa cttaaaaaaa aaaaaaaaaa aaaaaaaa
//
